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A Novel Total Synthesis of (±)Shikonin

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Chinese Chemical Letters 2006年第7期17卷 871-873页

作者： De Feng xu Xiao Juan guo Zhao hui xu Shao Shun LI School of Pharmacy Shanghai Jiaotong University Shanghai 200030

A novel total synthesis of （±）shikonin 1 was presented. The key intermediate 6 was achieved by the formylation of 1,8：4,5-bis（methylenedioxy）naphthalene 5 with N-methylformanilide in good yield. It was first reported that the addition of prenyllithium to 2-formyl-1,8：4,5- bismethylenedioxy naphthalene 6 gave 2-（1-hydroxy-4-methylpentyl） 1,8：4,5-bis（methylenedioxy） naphthalene 8 in 45% yield and 2-（1-hydroxy-2,2-dimethyl-3-butenyl）-1,8：4,5-bis（methylenedioxy）naphthalene 9 in 48% yield. After the electrooxide deprotection of 8, （±）shikonin 1 was prepared in high yield.

关键词： (±)Shikonin total synthesis prenyllithium.

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Solitary fibrous tumors in abdomen and pelvis:Imaging characteristics and radiologic-pathologic correlation

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World Journal of Gastroenterology 2014年第17期20卷 5066-5073页

作者： xue-Ming Li Jing Reng Peng Zhou Ying Cao Zhu-Zhong Cheng Yan Xiao guo-hui xu Department of Radiology Sichuan Cancer Hospital

AIM: To describe the imaging features of solitary fibrous tumors (SFTs) in the abdomen and pelvis, and the clinical and pathologic correlations.

关键词： Abdominal imaging Solitary fibrous tumors Computed tomography Magnetic resonance imaging

Surface expression and cytolytic function of natural killer cell receptors Is altered In recent-onset type 2 diabetic patients

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Surface expression and cytolytic function of natural killer ...

Platelet count combined with right liver volume and spleen volume measured by magnetic resonance imaging for identifying cirrhosis and esophageal varices

中华医学会第十次全国内分泌学学术会议

作者： hui guo,Bingchuan xu 吉大一院内分泌科

Aim:Diabetes mellitus is one of the most serious and challenging health problems in 2 1 st century and type 2 diabetes mellitus (T2DM)accounts 90%-95%of all *** insulin resistance and progressive pancreatic beta cell ...

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来源： cnki会议评论

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World Journal of Gastroenterology 2015年第35期21卷 10184-10191页

作者： Xiao-Li Chen Tian-Wu Chen Xiao-Ming Zhang Zhen-Lin Li Nan-Lin Zeng Ping Zhou Hang Li Jing Ren guo-hui xu Jia-Ni Hu Sichuan Key Laboratory of Medical Imaging and Department of RadiologyAffiliated Hospital of North Sichuan Medical College Department of Radiology Sichuan Cancer Hospital Institute and The Second People's Hospital of Sichuan Province Department of Radiology West China Hospital of Sichuan University Department of Pathology Affiliated Hospital of North Sichuan Medical College Department of Radiology Wayne State University

AIM: To determine whether the combination of platelet count(PLT) with spleen volume parameters and right liver volume(RV) measured by magnetic resonance imaging(MRI) could predict the Child-Pugh class of liver cirrhosis and esophageal varices(EV).METHODS: Two hundred and five cirrhotic patients with hepatitis B and 40 healthy volunteers underwent abdominal triphasic-enhancement MRI and laboratory examination of PLT in 109/L. Cirrhotic patients underwent endoscopy for detecting EV. Spleen maximal width(W), thickness(T) and length(L) in mm together with spleen volume(SV) and RV in mm3 were measured by MRI, and spleen volume index(SI) in mm3 was obtained by W × T × L. SV/PLT, SI/PLT and RV × PLT/SV(RVPS) were calculated and statistically analyzed to assess cirrhosis and ***: SV/PLT(r = 0.676) and SI/PLT(r = 0.707) increased, and PLT(r =-0.626) and RVPS(r =-0.802) decreased with the progress of Child-Pugh class(P < 0.001 for all). All parameters could determine the presence of cirrhosis, distinguish between each class of Child-Pugh class, and identify the presence of EV [the areas under the curve(AUCs) = 0.661-0.973]. A m o n g p a ra m e t e r s, R V P S c o u l d b e s t d e t e r m i n e presence and each class of cirrhosis with AUCs of 0.973 and 0.740-0.853, respectively; and SV/PLT could best identify EV with an AUC of ***: The combination of PLT with SV and RV could predict Child-Pugh class of liver cirrhosis and identify the presence of esophageal varices.

关键词： Cirrhosis Spleen Hepatic lobe Magnetic resonance i

Tamoxifen-resistant breast cancer cells possess cancer stem-like cell properties

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Chinese Medical Journal 2013年第16期126卷 3030-3034页

作者： LIU hui ZHANG Heng-wei SUN Xian-fu guo xu-hui HE Ya-ning CUI Shu-de FAN Qing-xia Department of Oncology the First Affiliated Hospital of Zhengzhou University Zhengzhou Henan 450052 China Department of Breast Affiliated Cancer Hospital of Zhengzhou University Zhengzhou Henan 450008 China

Background Cancer stem cells （CSCs） are the cause of cancer recurrence because they are resistant to conventional therapy and contribute to cancer growth and *** is the most common breast cancer therapy and acquired tamoxifen （TAM） resistance is the main reason for endocrinotherapy failure during such *** acquired resistance to endocrine treatment has been extensively studied,the underlying mechanisms are *** hypothesized that breast CSCs played an important role in TAM-induced resistance during breast cancer ***,we investigated the biological characteristics of TAM-resistant （TAM-R） breast cancer *** Mammosphere formation and tumorigenicity of wild-type （WT） and TAM-R MCF7 cells were tested by a mammosphere assay and mouse tumor xenografts ***-cell markers （SOX-2,OCT-4,and CD133） and epithelial-mesenchymal transition （EMT） markers were tested by quantitative real-time （qRT）-*** observation was performed to characterize *** After induction of TAM resistance,TAM-R MCF7 cells exhibited increased proliferation in the presence of TAM compared to that of WT MCF7 cells （P ＜0.05）,indicating enhanced TAM resistance of TAM-R MCF7 cells compared to that of WT MCF7 ***-R MCF7 cells showed enhanced mammosphere formation and tumorigenicity in nude mice compared to that of WT MCF7 cells （P ＜0.01）,demonstrating the elevated CSC properties of TAM-R MCF7 ***,qRT-PCR revealed that TAM-R MCF7 cells expressed increased mRNA levels of stem cell markers including SOX-2,OCT-4,and CD133,compared to those of WT MCF7 cells （P ＜0.05）.Morphologically,TAM-R MCF7 cells showed a fibroblastic phenotype,but WT MCF7 cells were *** induction of TAM resistance,qRT-PCR indicated that MCF7 cells expressed increased mRNA levels of Snail,vimentin,and N-cadherin and decreased levels of E-cadherin,which are considered as EMT characteristics （P ＜0.05）.Conclusion TAM-R

关键词： breast cancer tamoxifen resistance cancer stem cells epithelial-mesenchymal transition

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Rock fracture mechanism of buffer blasting with cushion layer at the borehole bottom

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 325-334页

作者： Xinguang Zhu Chenxi Ding Zhe Sui Hong Su xu guo School of Civil and Resources Engineering University of Science and Technology BeijingBeijing 100083China Key Laboratory for Mechanics in Fluid Solid Coupling Systems Institute of MechanicsChinese Academy of SciencesBeijing 100190China School of Mechanics and Civil Engineering China University of Mining and Technology(Beijing)Beijing 100083China School of Chemical and Blasting Engineering Anhui University of Science and TechnologyHuainan 232001China

This study primarily investigates the rock fracture mechanism of bottom cushion layer blasting and explores the effects of the bottom cushion layer on rock *** involves analyses of the evolution patterns of blasting stress,characteristics of crack distribution,and rock fracture features in the ***,blasting model experiments were carried out using the dynamic caustics principle to investigate the influence of bottom cushion layers and initiation methods on the integrity of the bottom rock *** experimental results indicate that the combined use of bottom cushion layers and inverse initiation effectively protects the integrity of the bottom rock ***,the process of stress wave propagation and dynamic crack propagation in rocks was simulated using the continuum-discontinuum element method(CDEM)and the Landau explosion source model,with varying thicknesses of bottom cushion *** numerical simulation results indicate that with increasing cushion thickness,the absorption of energy generated by the explosion becomes more pronounced,resulting in fewer cracks in the bottom rock *** illustrates the positive role of the cushion layer in protecting the integrity of the bottom rock mass.

关键词： bottom cushion layer blasting crack propagation continuum-discontinuum element method dynamic stress intensity factor

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Reducing the measurement errors in nonadiabatic holonomic quantum computers

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 64-70页

作者： guo-Fu xu Department of Physics Shandong University

Nonadiabatic holonomic quantum computers serve as the physical platform for nonadiabatic holonomic quantum *** quantum computation has entered the noisy intermediate-scale era, building accurate intermediate-scale nonadiabatic holonomic quantum computers is clearly necessary. Given that measurements are the sole means of extracting information, they play an indispensable role in nonadiabatic holonomic quantum computers. Accordingly, developing methods to reduce measurement errors in nonadiabatic holonomic quantum computers is of great importance. However, while much attention has been given to the research on nonadiabatic holonomic gates, the research on reducing measurement errors in nonadiabatic holonomic quantum computers is severely lacking. In this study, we propose a measurement error reduction method tailored for intermediate-scale nonadiabatic holonomic quantum computers. The reason we say this is because our method can not only reduce the measurement errors in the computer but also be useful in mitigating errors originating from nonadiabatic holonomic gates. Given these features,our method significantly advances the construction of accurate intermediate-scale nonadiabatic holonomic quantum computers.

关键词： quantum holonomy quantum computation measurement errors

Validation and evaluation of clinical prediction systems for first and repeated transarterial chemoembolization in unresectable hepatocellular carcinoma: A Chinese multicenter retrospective study

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World Journal of Gastroenterology 2020年第6期26卷 657-669页

作者： Zhe-xuan Wang En-Xin Wang Wei Bai Dong-Dong Xia Wei Mu Jing Li Qiao-Yi Yang Ming Huang guo-hui xu Jun-hui Sun Hai-Liang Li hui Zhao Jian-Bing Wu Shu-Fa Yang Jia-Ping Li Zi-Xiang Li Chun-Qing Zhang Xiao-Li Zhu Yan-Bo Zheng Qiu-He Wang Jing Li Jie Yuan Xiao-Mei Li Jing Niu Zhan-Xin Yin Jie-Lai Xia Dai-Ming Fan guo-Hong Han China HCC-TACE Study Group Department of Liver Disease and Digestive Interventional Radiology National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive DiseasesFourth Military Medical UniversityXi’an 710032Shaanxi ProvinceChina Department of Radiology the Southwest HospitalThird Military Medical UniversityChongqing 400037China Department of Hepatobiliary Surgery the Second Affiliated Hospital of Third Military Medical UniversityChongqing 400037China Department of Minimally Invasive International Therapy the Third Affiliated Hospital of Kunming UniversityTumor Hospital of Yunnan ProvinceKunming 650000Yunnan ProvinceChina Department of Interventional Radiology Tumor Hospital of Sichuan ProvinceChengdu 610000Sichuan ProvinceChina Department of Hepatobiliary and Pancreatic Interventional Cancer the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Department of Interventional Radiology Henan Cancer Hospitalthe Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450008Henan ProvinceChina Department of Interventional Radiology the Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina Department of Oncology the Second Affiliated Hospital of Nanchang UniversityNanchang 330000Jiangxi ProvinceChina Department of Interventional Radiology the Affiliated Tumor Hospital of Xinjiang Medical UniversityUrumqi 830001Xinjiang Uygur Autonomous RegionChina Department of Interventional Radiology the First Affiliated Hospital of Sun Yatsen UniversityGuangzhou 510080Guangdong ProvinceChina Department of Interventional Medical Center the Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina Department of Gastroenterology and Hepatology Shandong Province Hospital affiliated to Shandong UniversityJinan 250021Shandong ProvinceChina Department of Interventional Radiology The First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Department of Interventional Radi

BACKGROUND The treatment outcome of transarterial chemoembolization(TACE)in unresectable hepatocellular carcinoma(HCC)varies greatly due to the clinical heterogeneity of the ***,several prognostic systems have been proposed for risk stratification and candidate identification for first TACE and repeated TACE(re-TACE).AIM To investigate the correlations between prognostic systems and radiological response,compare the predictive abilities,and integrate them in sequence for outcome *** This nationwide multicenter retrospective cohort consisted of 1107 unresectable HCC patients in 15 Chinese tertiary hospitals from January 2010 to May *** Hepatoma Arterial-embolization Prognostic(HAP)score system and its modified versions(mHAP,mHAP2 and mHAP3),as well as the six-and-twelve criteria were compared in terms of their correlations with radiological response and overall survival(OS)prediction for first *** same analyses were conducted in 912 patients receiving re-TACE to evaluate the ART(assessment for re-treatment with TACE)and ABCR(alpha-fetoprotein,Barcelona Clinic Liver Cancer,Child-Pugh and Response)systems for post re-TACE survival(PRTS).RESULTS All the prognostic systems were correlated with radiological response achieved by first TACE,and the six-and-twelve criteria exhibited the highest correlation(Spearman R=0.39,P=0.026)and consistency(Kappa=0.14,P=0.019),with optimal performance by area under the receiver operating characteristic curve of 0.71[95%confidence interval(CI):0.68-0.74].With regard to the prediction of OS,the mHAP3 system identified patients with a favorable outcome with the highest concordance(C)-index of 0.60(95%CI:0.57-0.62)and the best area under the receiver operating characteristic curve at any time point during follow-up;whereas,PRTS was well-predicted by the ABCR system with a C-index of 0.61(95%CI:0.59-0.63),rather than ***,combining the mHAP3 and ABCR systems identified candidates suitable for TA

关键词： Transarterial chemoembolization Hepatocellular carcinoma Prognostic system Radiological response Overall survival Predictive ability

Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma(CHANCE001)

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Signal Transduction and Targeted Therapy 2023年第3期8卷 1198-1207页

作者： Hai-Dong Zhu Hai-Liang Li Ming-Sheng Huang Wei-Zhu Yang guo-Wen Yin Bin-Yan Zhong Jun-hui Sun Zhi-Cheng Jin Jian-Jian Chen Nai-Jian Ge Wen-Bin Ding Wen-hui Li Jin-Hua Huang Wei Mu Shan-Zhi Gu Jia-Ping Li hui Zhao Shu-Wei Wen Yan-Ming Lei Yu-Sheng Song Chun-Wang Yuan Wei-Dong Wang Ming Huang Wei Zhao Jian-Bing Wu Song Wang xu Zhu Jian-Jun Han Wei-Xin Ren Zai-Ming Lu Wen-Ge Xing Yong Fan Hai-Lan Lin Zi-Shu Zhang guo-hui xu Wen-Hao Hu Qiang Tu Hong-Ying Su Chuan-Sheng Zheng Yong Chen xu-Ya Zhao Zhu-Ting Fang Qi Wang Jin-Wei Zhao Ai-Bing xu Jian xu Qing-Hua Wu Huan-Zhang Niu Jian Wang Feng Dai Dui-Ping Feng Qing-Dong Li Rong-Shu Shi Jia-Rui Li Guang Yang Hai-Bin Shi Jian-Song Ji Yu-E Liu Zheng Cai Po Yang Yang Zhao Xiao-Li Zhu Li-Gong Lu Gao-Jun Teng Center of Interventional Radiology&Vascular Surgery Department of RadiologyZhongda HospitalMedical SchoolSoutheast UniversityNanjing 210009China Department of Minimally invasive Intervention The Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450008China Department of Interventional Radiology the Third Affiliated HospitalSun Yat-Sen UniversityGuangzhou 510630China Department of Interventional Radiology Union Hospital of Fujian Medical UniversityFuzhou 350001China Department of Interventional Radiology Jiangsu Cancer Hospital&Jiangsu Institute of Cancer Research&The Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210009China Department of Interventional Radiology The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Hepatobiliary and Pancreatic Interventional Treatment Center Division of Hepatobiliary and Pancreatic SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Interventional Radiology Eastern Hospital of Hepatobiliary SurgeryNavy Medical University(Second Military Medical University)Shanghai 200438China Department of Interventional Radiology Nantong First People’s HospitalNantong 226001China Department of Interventional Radiology Yancheng Third People’s HospitalYancheng 224008China Department of Minimally Invasive Interventional Therapy Sun YatSen University Cancer CenterGuangzhou 510060China Department of Vascular Surgery Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China. Department of Interventional Radiology Hunan Cancer HospitalChangsha 410031China Department of Interventional Oncology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Department of Interventional Radiology The Hospital of Nantong UniversityNantong 226001China Department of Interventional Therapy Shanxi Tumor HospitalTaiyuan 030001China Department of Interventional Radiology Tibet Autonomous Region People’s

There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1(PD-[L]1)inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1 inhibitors and MTT in real-world *** this nationwide,retrospective,cohort study,826 HCC patients receiving either TACE plus PD-(L)1 blockades and MTT(combination group,n=376)or TACE monotherapy(monotherapy group,n=450)were included from January 2018 to May *** primary endpoint was progression-free survival(PFS)according to modified *** secondary outcomes included overall survival(OS),objective response rate(ORR),and *** performed propensity score matching approaches to reduce bias between two *** matching,228 pairs were included with a predominantly advanced disease *** PFS in combination group was 9.5 months(95%confidence interval[CI],8.4-11.0)versus 8.0 months(95%CI,6.6-9.5)(adjusted hazard ratio[HR],0.70,P=0.002).OS and ORR were also significantly higher in combination group(median OS,19.2[16.1-27.3]vs.15.7 months[13.0-20.2];adjusted HR,0.63,P=0.001;ORR,60.1%vs.32.0%;P<0.001).Grade 3/4 adverse events were observed at a rate of 15.8%and 7.5%in combination and monotherapy groups,*** results suggest that TACE plus PD-(L)1 blockades and MTT could significantly improve PFS,OS,and ORR versus TACE monotherapy for Chinese patients with predominantly advanced HCC in real-world practice,with an acceptable safety profile.

关键词： hepatocellular targeted matching