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产品生命周期中的单/多层BOM表示与应用

计算机集成制造系统-CIMS 2004年第1期10卷 59-64页

作者：郭钢程静波刘飞重庆大学机械工程学院重庆400044

在产品生命周期中,BOM作为描述产品结构与配置关系的表单,以多视图形式描述了产品形态的变化过程。许多文献对产品生命周期中BOM的某一视图或某几个视图进行了表述,但对产品生命周期BOM全过程的演进与内在联系,还缺少详尽的研究。本文... 详细信息

在产品生命周期中,BOM作为描述产品结构与配置关系的表单,以多视图形式描述了产品形态的变化过程。许多文献对产品生命周期中BOM的某一视图或某几个视图进行了表述,但对产品生命周期BOM全过程的演进与内在联系,还缺少详尽的研究。本文提出一种面向产品生命周期管理的单层BOM基本视图和多层BOM表达技术,揭示了产品生命周期中BOM多视图的内在联系,并在汽车产品的生命周期管理中得到应用。

关键词：产品生命周期单/多层物料清单物料清单多视图配置管理

Mutual regulation of microglia and astrocytes after Gas6 inhibits spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 557-573页

作者： Jiewen Chen Xiaolin Zeng Le Wang Wenwu Zhang gang Li Xing cheng Peiqiang Su Yong Wan Xiang Li Department of Spine Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Province Key Laboratory of Orthopedics and Traumatology GuangzhouGuangdong ProvinceChina

Invasive inflammation and excessive scar formation are the main reasons for the difficulty in repairing nervous tissue after spinal cord *** and astrocytes play key roles in the spinal cord injury micro-environment and share a close ***,the mechanisms involved remain *** this study,we found that after spinal cord injury,resting microglia(M0)were polarized into pro-inflammatory phenotypes(MG1 and MG3),while resting astrocytes were polarized into reactive and scar-forming *** expression of growth arrest-specific 6(Gas6)and its receptor Axl were significantly down-regulated in microglia and astrocytes after spinal cord *** vitro experiments showed that Gas6 had negative effects on the polarization of reactive astrocytes and pro-inflammatory microglia,and even inhibited the cross-regulation between *** further demonstrated that Gas6 can inhibit the polarization of reactive astrocytes by suppressing the activation of the Yes-associated protein signaling ***,in turn,inhibited the polarization of pro-inflammatory microglia by suppressing the activation of the nuclear factor-κB/p65 and Janus kinase/signal transducer and activator of transcription signaling *** vivo experiments showed that Gas6 inhibited the polarization of pro-inflammatory microglia and reactive astrocytes in the injured spinal cord,thereby promoting tissue repair and motor function ***,Gas6 may play a role in the treatment of spinal cord *** can inhibit the inflammatory pathway of microglia and polarization of astrocytes,attenuate the interaction between microglia and astrocytes in the inflammatory microenvironment,and thereby alleviate local inflammation and reduce scar formation in the spinal cord.

关键词： astrocytes Axl cell polarization Gas6 Hippo signal inflammatory micro-environment intercellular interaction microglia single-cell sequencing spinal cord injury

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中国足球协会的性质界定

体育学研究 2003年第2期17卷 31-34页

作者：郭成岗上海体育学院研究生部上海200438

从法律与实践的角度对中国足协的性质进行分析 ,认为中国足协作为登记注册的非营利性社团法人 ,从事着管理经营如足球职业联赛等各种商业活动 ,并从中获取利润。同时 ,中国足协经《体育法》授权 ,也拥有全面管理全国足球运动发展的行政... 详细信息

从法律与实践的角度对中国足协的性质进行分析 ,认为中国足协作为登记注册的非营利性社团法人 ,从事着管理经营如足球职业联赛等各种商业活动 ,并从中获取利润。同时 ,中国足协经《体育法》授权 ,也拥有全面管理全国足球运动发展的行政职能。中国足协做出的处罚行为是不平等主体之间的行政处罚行为。中国足协是具有行政管理职能的社团法人。

关键词：中国足协社团法人法律性质足球产业

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从伦敦奥运会报道看我国体育新闻价值新取向

南京体育学院学报（社会科学版） 2012年第3期26卷 18-21页

作者：郭成岗山东体育学院体育社会科学系山东济南250102

以中国媒体伦敦奥运会报道总体情况为研究对象,从新闻价值要素入手,分析了我国体育新闻价值新取向的表现形式、社会基础及对体育新闻发展的重要性,从体育的独特性出发,拓展和补充了体育新闻价值传统五要素。

关键词：奥运会报道体育新闻新闻价值取向

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法学视角下的体育“假赛”

军事体育进修学院学报 2009年第3期28卷 15-17,38页

作者：郭成岗山东体育学院体育社会科学系办公室山东日照276826

体育竞赛中的"假赛"认定目前仍存在技术上难题。体育竞赛参与各方之间达成事实上的合同关系。体育竞赛中的"假赛"是不法者获取不当利益的手段,不仅违反体育道德,更是不忠实履行合同的违法行为,需要相关法律法规对"假赛"进行认定和处理,... 详细信息

体育竞赛中的"假赛"认定目前仍存在技术上难题。体育竞赛参与各方之间达成事实上的合同关系。体育竞赛中的"假赛"是不法者获取不当利益的手段,不仅违反体育道德,更是不忠实履行合同的违法行为,需要相关法律法规对"假赛"进行认定和处理,才能从根本上打击"假赛",保护参赛各方的合法权益,使体育产业得以健康发展。目前我国处理"假赛"法律条件尚需完善。

关键词：体育假赛法律认定法学视角

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浮选柱在磷矿选矿中的应用研究

企业技术开发 2013年第7期32卷 47-49页

作者：郭成刚瓮福(集团)有限责任公司瓮福磷矿贵州都匀550508

文章结合笔者的实际工作经验,选择对一些中低品位的磷矿浮选柱的选矿工艺进行研究,为浮选柱在磷矿选矿中的应用提供一些依据。

关键词：浮选柱磷矿选矿浮选

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论体育新闻的娱乐化趋势

南京体育学院学报（社会科学版） 2003年第1期17卷 29-32页

作者：郭成岗上海体育学院研究生部上海200438

在建设社会主义市场经济的社会大背景下 ,体育新闻的娱乐化既是全球媒介娱乐化趋势的表现 ,同时又是体育新闻自身得以持续发展的内在要求。体育新闻娱乐化趋势制约着体育新闻内容的选择和制作方式的改变 ,体育新闻娱乐化应以传播体育文... 详细信息

在建设社会主义市场经济的社会大背景下 ,体育新闻的娱乐化既是全球媒介娱乐化趋势的表现 ,同时又是体育新闻自身得以持续发展的内在要求。体育新闻娱乐化趋势制约着体育新闻内容的选择和制作方式的改变 ,体育新闻娱乐化应以传播体育文化为宗旨 ,坚持社会效益第一 ,避免庸俗化。

关键词：体育新闻文化传播体育文化发展趋势新闻内容制作方式

Rapid isolation of placenta extracellular vesicles via affinity chromatography

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Rapid isolation of placenta extracellular vesicles via affin...

Ni-catalyzed cross-electrophile alkyl-alkyl coupling reactions

中国生理学会生殖科学专业委员会—中国动物学会生殖生物学分会第二次联合学术年会暨“生殖科学专业委员会第二次学术交流会”和“生殖生物学分会第十六次学术年会”

作者： guo-gang cheng Ju-zuo Zhang Hua-shan Zhao Bao-zhen Zhang Jin-yu Han Jie Chen Bao-bei Wang Meng-xia Li Tian-xia Xiao Jian Zhang Xiu-jun Fan Laboratory for Reproductive Health Shenzhen Institute of Advanced TechnologyChinese Academy of Sciences Key Laboratory of Microbiology School of Life ScienceHeilongjiang University

Extracellular vesicles(EVs) can mediate intercellular communication by transferring cargo proteins and nucleic acids between *** biophysical and biochemical properties can be used to isolate EVs,including size,mass density,shape,charge,and antigen ***,rapid isolation of specific organs EVs,particularly for placenta EVs,from plasma is still a big *** preliminary researches have demonstrated that the chondroitin sulfate A presented on the surface of trophoblast cells and some EVs secreted by trophoblast *** protein rVAR2 can specifically bind to trophoblast cells expressing the chondroitin sulfate *** this study,we used the rVAR2 protein as a substrate to separate extracellular vesicles in plasma by affinity *** we examined the morphology,number,and purity of isolated EVs by TEM and *** results show that,after home-made affinity chromatography,a certain amount of exosomes which expressing CD63 marker can be *** the same time,we also developed the new technique for EVs immune localization and analyzed the nucleic acids and proteins in trophoblast cells to ensure isolated EVs and trophoblast cells have ’homology’.More study need to be performed in order to improve the accuracy and efficiency isolation of placental EVs and to provide an novel noninvasive diagnosis method for placental diseases research.

关键词： extracellular vesicles placenta affinity chromatography noninvasive diagnosis

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Science China Chemistry 2025年

作者： Li-Xu You Lan Tian Chun-Ling guo Shun-Xi Li Yu-cheng Liu Yu-Long Li Wei Shu College of Chemistry and Environmental Engineering Key Laboratory of Green Catalysis of Higher Education Institutes of Sichuan Sichuan University of Science and Engineering Guangming Advanced Research Institute Shenzhen Grubbs Institute Department of Chemistry and Guangdong Provincial Key Laboratory of Catalysis Southern University of Science and Technology

Introducing saturated carbon-carbon bonds into organic molecules significantly increases the three-dimensional configuration,thus altering the physical and chemical properties as well as the functions of molecules. Transition-metal-catalyzed carboncarbon cross-couplings represent one of the most straightforward, efficient and modular alternatives to build saturation in a single step. However, the efficient construction of alkyl-alkyl bonds remains a formidable challenge due to the precise manipulation of multiple alkyl metallic intermediates as well as associated competitive side reactions and selectivity control. Over the past years, Ni-catalyzed cross-coupling under reductive conditions has gained more and more attention for alkyl-alkyl crosscoupling partially attributing to the low-valent state of metal centers under reducing conditions, which suppresses the competitive β-hydride elimination process, thus facilitating the formation of alkyl-alkyl bonds. In this review, the initiative and progress of Ni-catalyzed cross-electrophile alkyl-alkyl cross-coupling, including the efforts in racemic and enantioselective formation of alkyl-alkyl bonds, have been summarized and discussed. Moreover, the challenges and further opportunities in this area have also been discussed.

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