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Outcomes and prognostic factors of patients with stage? ⅠB and? ⅡA pancreatic cancer according to the 8^(th) edition American Joint Committee on Cancer criteria

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World Journal of Gastroenterology 2017年第15期23卷 2757-2762页

作者： Yang Li Chuan-gang Tang Yu Zhao Wu-You Cao guo-feng qu Department of Hepatobiliary Surgery Organ Transplantation Center Tianjin First Center Hospital Department of Breast Surgery Xuzhou Central Hospital The Affiliated Xuzhou Hospital of Medical College of Southeast University Department of Surgery Tianjin Second People's Hospital School of Medicine Southeast University

AIM To evaluate the changes in the 8^(th) edition American Joint Committee on Cancer(AJCC) for defining stage?ⅠB and?ⅡA pancreatic cancer and identify their prognostic *** Pancreatic cancer patients were selected from the Surveillance Epidemiology and End Results database(1973-2013). The enrolled patients were divided into?ⅠB and?ⅡA groups based on tumor size according to the 8^(th) edition AJCC criteria. Clinical characteristics, including age, gender, race, tumor size, primary site, and grade were summarized. Univariate and multivariate analyses were performed to explore the prognostic factors of the?ⅠB and?ⅡA stages of pancreatic cancer under new *** A total of 1349 pancreatic cancer patients were included. More patients had stage?ⅠB rather than stage?ⅡA. Stage?ⅠB tumors(54.85%) were mainly located in the head of the pancreas, while stage?ⅡA tumors were more often located in the tail and head of the pancreas(35.21% and 31.75%, respectively). The survival time of stage?ⅠB and?ⅡA patients had no significant difference. Univariate and multivariate analyses indicated that the prognostic factors of survival for stage?ⅠB and?ⅡA patients were different. for stage?ⅠB patients, age and primary site were the independent prognostic factors; for stage?ⅡA patients, age and grade were the independent prognostic factors. The risk of death was lower among patients aged ≤ 65 years than those aged > 65 *** The prognostic factors for stage?ⅠB and?ⅡA patients are different, but age is the independent prognostic factor for all patients. The survival time of stage?ⅠB and?ⅡA patients has no significant difference.

关键词： Pancreatic cancer Prognostic factor 8th American Joint Committee on Cancer TNM Tumor size

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Experimental study on the gas-stripping chamber of an E//B neutral particle analyzer

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Nuclear Science and Techniques 2024年第11期35卷 98-107页

作者： Long Ma De-Hao Xie Yan-Xi Wang Shuo Wang Ji-feng Han Wei-Ping Lin Jian-Li Liu Xing-quan Liu Yu-guo Liu Xiao-Bing Luo Yuan Luo guo-feng qu Yu-Fan qu Pei-Pei Ren Roy Wada Lin-Ge Zang Jing-Jun Zhu Key Laboratory of Radiation Physics and Technology of the Ministry of Education Institute of Nuclear Science and TechnologySichuan UniversityChengdu 610064China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Southwestern Institute of Physics Chengdu 610218China Cyclotron Institute Texas A&M UniversityCollege StationTX 77843USA

Stripping units take a key role in the neutral particle analyzer(NPA).A renovated gas-stripping unit was constructed for the newly designed E//B *** H_(2)as the working gas,we measured the gas inlet pressure(P_(0))and vacuum chamber pressure(P_(3)).The pressure distribution inside the gas-stripping room was calculated with Ansys Fluent,using the measured P_(0)and P_(3)as boundary *** stripping efficiency of the stripping unit was then simulated utilizing the Geant4 Monte Carlo code for the H and D *** pressure P_(0)=40 Pa,which is one-sixth of what found in the previous design and corresponds to a thickness of 1.27×10^(17)atoms∕cm^(2),was obtained as the optimum working pressure for the upgraded stripping *** 50 kV electron cyclotron resonance(ECR)ion source platform was designed and constructed for E//B NPA calibration,and its performance has been *** the ECR ion source platform,we measured the efficiency of the stripping unit through an inverse experiment with proton *** compared the current ratios of measurements with and without H_(2)gas to Geant4 simulation *** found adequate agreement between the overall trends of the experiment and the *** significant deviation for incident energies below 20 keV may result from the scattering effects of low-energy protons,leading to reduced accuracy in single-scattering physics in Geant4 *** the scattering corrections observed in the reverse experiments obtains more accurate stripping efficiencies for H and D atoms in the energy range of 20–200 keV and the global efficiency with the maximum values of 95.0%for H atoms and 78.9%for D atoms at 200 keV.

关键词： NPA Gas-stripping ECR ion source Stripping efficiency Geant4

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A simulation study of a windowless gas-stripping room in an E//B neutral particle analyzer

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Nuclear Science and Techniques 2021年第7期32卷 22-30页

作者： Yuan Luo Wei-Ping Lin Pei-Pei Ren guo-feng qu Jing-Jun Zhu Xing-quan Liu Xiao-Bing Luo Zhu An Roy Wada Lin-Ge Zang Yu-Fan qu Zhong-Bing Shi Key Laboratory of Radiation Physics and Technology of the Ministry of Education Institute of Nuclear Science and TechnologySichuan UniversityChengdu 610064China Cyclotron Institute Texas A&M UniversityCollege StationTX 77843USA School of Physics Henan Normal UniversityXinxiang 453007China Southwestern Institute of Physics Chengdu 610064China

The neutral particle analyzer(NPA)is one of the crucial diagnostic devices in a Tokamak *** stripping unit is one of the main parts of the NPA.A windowless gas-stripping room with two differential pipes has been constructed in a parallel electric and magnetic fields(E//B)*** pressure distributions in the stripping chamber are simulated by ANSYS Fluent together with MolFlow+.Based on the pressure distributions obtained from the simulation,the stripping efficiency of the E//B NPA is studied using *** reaction physics is modified to track the charge state of each particle in a cross-section-based method in *** transmission rates(R)and stripping efficiencies f_(+1)are examined for particle energies ranging from 20 to 200 keV with the input pressure(P_(0)),ranging from 20 to 400 *** to the combined global efficiency,R×f_(+1),P_(0)=240 Pa is obtained as the optimum pressure for the maximum global efficiency in the incident energy range investigated.

关键词： Neutral particle analyzer Windowless gas-stripping chamber Stripping efficiency Ansys Fluent MolFlow+ GEANT4

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Two-plane painting injection scheme for BRing of HIAF

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Nuclear Science and Techniques 2017年第8期28卷 47-53页

作者： guo-feng qu Wei-Ping Chai Jia-Wen Xia Jian-Cheng Yang Heng Du Zhong-Shan Li Wen-Wen Ge Wen-Heng Zheng Peng Shang Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000 China University of Chinese Academy of Sciences Beijing 100046China

The high-intensity heavy-ion accelerator facility(HIAF)is under design at the Institute of Modern Physics(IMP)and will provide an intense ion beam for nuclear physics,atomic mass measurement research,and other *** the main ring of HIAF,the BRing accumulates beams to high intensity and accelerates them to high *** achieve high intensities up to 1×10^(11)(^(238)U^(34+)),the injection gain of the BRing must be as high as ***,multiple multiturn injection supported by the electron cooling system takes a long time,causing substantial beam loss under a strong space charge ***,a two-plane painting injection scheme is proposed for beam accumulation in the *** scheme uses a tilted injection septum and horizontal and vertical bump magnets to paint the beam into horizontal and vertical phase space *** this paper,the two-plane painting injection parameters are optimized,and the resulting injection process is simulated using the Objective Ring Beam Injection and Tracking(ORBIT)*** injection gain of up to 110.3 with a loss rate of 2:3%is achieved,meeting the requirements of BRing.

关键词：绘画平面近代物理研究所注射过程重离子加速器电子冷却系统束流损失纵向相空间

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Beam dynamics,RF measurement,and commissioning of a CW heavy ion IH-DTL

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Nuclear Science and Techniques 2018年第3期29卷 143-155页

作者： Heng Du You-Jin Yuan Zhong-Shan Li Zhi-Jun Wang Peng Jin Xiao-Ni Li guo-Zhu Cai Wen-Wen Ge guo-feng qu Yuan He Jia-Wen Xia Jian-Cheng Yang Xue-Jun Yin Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China

A 53.667 MHz CW(continuous-wave) heavy ion IH-DTL has been designed for the SSC-LINAC injector of HIRFL-CSR(Heavy Ions Research Facility at Lanzhou-Cooling Storage Ring). It accelerates ions with maximum mass-to-charge ratio of 7.0 from 143 to 295 ke V/u. Low-power RF measurement of the IH-DTL1 has been taken to investigate the RF performance and the quality of the electric field distribution on the beam *** measured Q_0 value and the shunt impedance are 10,400 and 198 MX/m, respectively. The electric field distributions on and around the beam axis were evaluated and compared with the design value. By a new approach,the dipole field component is also estimated. The beam dynamics simulation using measured field distribution was presented in this paper. Based on the dynamics analysis in both transverse and longitudinal phase space, the field distribution can meet the design requirement. Finally, the RF conditioning and very first beam commissioning on the IH-DTL1 were finished. The beam test results agree well with the simulation results; what's more, the property of the variable output beam energy about the separated functions DTL was verified.

关键词： Linac RF measurement Beam dynamic simulation Commissioning

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Interaction of H2+ molecular beam with thin layer graphene foils

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Chinese Physics B 2019年第9期28卷 164-168页

作者： Min Li guo-feng qu Yi-Zhou Wang Zhou-Sen Zhu Mian-Gong Shi Mao-Lei Zhou Dong Liu Zi-Xu Xu Ming-Jiang Song Jun Zhang Fan Bai Xiao-Dong Liao Ji-feng Han Key Laboratory of Radiation Physics and Technology of the Ministry of Education Institute of Nuclear Science and TechnologySichuan UniversityChengdu 610064China College of Physics and Electronic Engineering Sichuan Normal UniversityChengdu 610066China

The interaction of MeV H2^+ molecular ions with thin layer graphene and graphite foils was studied by using a highresolution electrostatic analyzer.A large number of fragment protons were observed at zero degree(along the beam direction) when the H2^+ beam was passing through the monolayer graphene foil, which indicates that the electron of the H2^+ molecular ions can be stripped easily even by the monolayer graphene *** trailing than leading protons were found in the energy spectrum, which means significant wake effect was observed in the monolayer graphene *** ratio of the numbers of trailing protons over leading protons first increased with the thickness for the much thinner graphene foils, and then decreased with the thickness for the much thicker graphite foils, which indicates that the bending effect of the wake field on the trailing proton varied with the foil thickness.

关键词： H2^+ molecular ions graphene electron stripping wake effect

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A rare case of purulent pericarditis secondary to subdiaphragmatic abscess

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World Journal of Emergency Medicine 2023年第3期14卷 244-246页

作者： Song Yang Chao Cui Wen-peng Yin Yu-dong Fu Guang-li Tang Xiao-jun Yang guo-feng qu Zhi-jun Jia Lin-na Cao Ke-song Tang Bao-jian Zhang Xia-lei Du Department of Emergency Medicine Beijing Huairou HospitalBeijing 101499China Department of Emergency Medicine Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China

Subdiaphragmatic abscess is the accumulation of pus in the space between the diaphragm and the transverse colon and its mesentery.[1]Subdiaphragmatic abscess is clinically characterized by fever and local *** clinical manifestations are often vague and diverse,and its symptoms and signs together constitute thoracoabdominal syndrome,leading to delayed diagnosis and a high incidence rate and mortality.[2]Subdiaphragmatic abscess is often secondary to acute peritonitis or remote infection with hematogenous *** bacteriological characteristics of these abscesses include aerobic and facultative bacteria,such as Escherichia coli,group D Enterococcus and Staphylococcus aureus,as well as less common anaerobic organisms,such as Bacteroides.

关键词： abscess diagnosis mortality

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Interaction of supersonic molecular beam with low-temperature plasma

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Chinese Physics B 2020年第6期29卷 349-357页

作者： Dong Liu guo-feng qu Zhan-Hui Wang Hua-Jie Wang Hao Liu Yi-Zhou Wang Zi-Xu Xu Min Li Chao-Wen Yang Xing-quan Liu Wei-Ping Lin Min Yan Yu Huang Yu-Xuan Zhu Min Xu Ji-feng Han Key Laboratory of Radiation Physics and Technology of the Ministry of Education Institute of Nuclear Science and TechnologyCollege of PhysicsSichuan UniversityChengdu 610064China Southwestern Institute of Physics Chengdu 610041China

The interaction between the supersonic molecular beam(SMB)and the low-temperature plasma is a critical issue for the diagnosis and fueling in the Tokamak *** this work,the interaction process between the argon SMB and the argon plasma is studied by a high-speed camera based on the Linear Experimental Advanced Device(LEAD)in Southwestern Institute of Physics,*** is found that the high-density SMB can extinct the plasma temporarily and change the distribution of the plasma density significantly,while the low-density SMB can hardly affect the distribution of plasma *** can be used as an effective diagnostic technique to study the evolution of plasma density in the interaction between the SMB and ***,the related simulation based on this experiment is carried out to better understand the evolution of electron density and ion density in the *** simulation results can be used to analyze and explain the experimental results well.

关键词： supersonic molecular beam low-temperature plasma emission electron density diagnosis highspeed camera

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Exosomes:the next-generation therapeutic platform for ischemic stroke

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Neural Regeneration Research 2025年第5期20卷 1221-1235页

作者： Wenjing Yin Hongyin Ma Yang qu Jiaxin Ren Yingying Sun Zhen-Ni guo Yi Yang Stroke Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional ***,there is an urgent need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological *** have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain *** physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic *** rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages *** in technology have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction ***,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified *** optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic stroke mesenchymal stem cells microglia neuroprotection stents

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Exploration of Gas-Dependent Self-Adaptive Reconstruction Behavior of Cu₂O for Electrochemical CO₂ Conversion to Multi-Carbon Products

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NANO-MICRO LETTERS 2025年第1期17卷 1-17页

作者： Zhang, Chaoran Gu, Yichuan Jiang, qu Sheng, Ziyang feng, Ruohan Wang, Sihong Zhang, Haoyue Xu, Qianqing Yuan, Zijian Song, Fang Shanghai Jiao Tong Univ Sch Mat Sci & Engn State Key Lab Met Matrix Composites Shanghai 200240 Peoples R China

Structural reconstruction of electrocatalysts plays a pivotal role in catalytic performances for CO2 reduction reaction (CO2RR), whereas the behavior is by far superficially understood. Here, we report that CO2 accessibility results in a universal self-adaptive structural reconstruction from Cu2O to Cu@CuxO composites, ending with feeding gas-dependent microstructures and catalytic performances. The CO2-rich atmosphere favors reconstruction for CO2RR, whereas the CO2-deficient one prefers that for hydrogen evolution reaction. With the assistance of spectroscopic analysis and theoretical calculations, we uncover a CO2-induced passivation behavior by identifying a reduction-resistant but catalytic active Cu(I)-rich amorphous layer stabilized by *CO intermediates. Additionally, we find extra CO production is indispensable for the robust production of C2H4. An inverse correlation between durability and FECO/FEC2H4 is disclosed, suggesting that the self-stabilization process involving the absorption of *CO intermediates on Cu(I) sites is essential for durable electrolysis. Guided by this insight, we design hollow Cu2O nanospheres for durable and selective CO2RR electrolysis in producing C2H4. Our work recognizes the previously overlooked passivation reconstruction and self-stabilizing behavior and highlights the critical role of the local atmosphere in modulating reconstruction and catalytic processes.

关键词： CO2 reduction reaction Electrocatalysts Cu2O Reconstruction Self-adaptive electrocatalysis

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