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Biology of Hippo signaling pathway:Skeletal muscle development and beyond

Journal of Integrative Agriculture 2024年第6期23卷 1825-1838页

作者： Shuqi Qin Chaocheng li Haiyan Lu Yulong feng Tao guo Yusong Han Yongsheng Zhang Zhonglin Tang Xinjiang Characteristic livestock Breeding and Reproduction Team College of Animal Science and TechnologyShihezi UniversityShihezi 832003China Lanzhou Veterinary Research Institute Chinese Academy of Agricultural SciencesLanzhou 730046China Kunpeng Institute of Modern Agriculture at Foshan Foshan 528226China Shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518124China

Global demand for farm animals and their meat products i.e.,pork,chicken and other livestock meat,is steadily *** the ongoing life science research and the rapid development of biotechnology,it is a great opportunity to develop advanced molecular breeding markers to efficiently improve animal meat production *** is an important study subject because of its crucial role in the regulation of organ *** recent years,with the increase of research on Hippo signaling pathway,the integrative application of multi-omics technologies such as genomics,transcriptomics,proteomics,and metabolomics can help promote the in-depth involvement of Hippo signaling pathway in skeletal muscle development *** Hippo signaling pathway plays a key role in many biological events,including cell division,cell migration,cell proliferation,cell differentiation,cell apoptosis,as well as cell adhesion,cell polarity,homeostasis,maintenance of the face of mechanical overload,*** influence on the development of skeletal muscle has important research value for enhancing the efficiency of animal husbandry *** this study,we traced the origin of the Hippo pathway,comprehensively sorted out all the functional factors found in the pathway,deeply analyzed the molecular mechanism of its function,and classified it from a novel perspective based on its main functional domain and mode of *** aim is to systematically explore its regulatory role throughout skeletal muscle *** specifically focus on the Hippo signaling pathway in embryonic stem cell development,muscle satellite cell fate determination,myogenesis,skeletal muscle meat production and organ size regulation,muscle hypertrophy and atrophy,muscle fiber formation and its transformation between different types,and *** roles in proliferation and regeneration are methodically summarized and analyzed *** summary and prospect of the Hippo signaling pathway within this a

关键词： Hippo skeletal muscle organ size myogenesis C2C12 livestock animals

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Two sandwich-type uranyl-containing polytungstates catalyze aerobic synthesis of benzimidazoles

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Rare Metals 2024年第3期43卷 1316-1322页

作者： Yu-feng liu Qi-Long Hu Xue-Jiao Chen Ke li Pei Luo guo-Ping Yang School of Chemistry and Material Science Jiangxi Province Key Laboratory of Synthetic ChemistryJiangxi Key Laboratory for Mass Spectrometry and InstrumentationEast China University of TechnologyNanchang330013China School of Environmental Science and Engineering Southern University of Science and TechnologyShenzhen518055China

Diversified synthetic strategies are extremely important for the structural diversity of uranium-containing polyoxometalates(U-POMs)and their functional ***,two sandwich-type U-POMs were reported,which are Na_(5.6)K_(6.4)[(UO_(2))(H_(2)O)(TeW_(9)O_(33))]_(2)·21H_(2)O(UTeW_(9))and Na_(8.9)K_(2.7)H_(1.19)[K_(0.79)(UO_(2))_(2.21)(PW_(9)O_(34))_(2)]·12H_(2)O(UPW_9)using in-situ strategy and lacunary precursor strategy,***_9 shows a typical Keggin-typeopen or half-sandwich configuration.

关键词： configuration expansion sandwich

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Recent progress of Pt-based oxygen reduction reaction catalysts for proton exchange membrane fuel cells

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Rare Metals 2024年第6期43卷 2444-2468页

作者： feng Zhan Kun-Song Hu Jin-Hua Mai li-Sheng Zhang Zhen-guo Zhang Huan He Xin-Hua liu School of Resources Environment and MaterialsGuangxi UniversityNanning530004China School of Transportation Science and Engineering Beihang UniversityBeijing 102206China IDTECH(Suzhou)Co.Ltd Suzhou 215217China Dyson School of Design Engineering Imperial College LondonLondon SW72AZUK

With the increasing consumption of fossil fuels,proton exchange membrane fuel cells(PEMFCs)have attracted considerable attention as green and sustainable energy conversion *** slow kinetics of the cathodic oxygen reduction reaction(ORR)has a major impact on the performance of PEMFCs,and although platinum(Pt)can accelerate the reaction rate of the ORR,the scarcity and high cost of Pt resources still limit the development of ***,the development of low-cost high-performance ORR catalysts is essential for the commercial application and development of *** paper reviews the research progress of researchers on Pt-based ORR catalysts in recent years,including Pt/C catalysts,Pt-based alloy catalysts,Pt-based intermetallic compounds,and Pt-based single-atom catalysts(SACs),with a focus on Pt-based alloy catalysts with different *** described in detail the difficulties and solutions in the research process of various ORR catalysts and explained the principle of their activity enhancement with density functional theory(DFT).In addition,an outlook on the development of Pt-based catalysts is given,and reducing the amount of Pt used and improving the performance of catalysts are the directions to work on in the coming period.

关键词： Pt-based catalysts PEMFCs Pt-based intermetallic compounds Single-atom catalysts

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Evolution of inclusions in vacuum induction melting of superalloys containing 70%return material

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Journal of Iron and Steel Research International 2024年第3期31卷 719-728页

作者： Jin-guo Gao Shu-lei Yang Shu-feng Yang Jing-she li Wei liu Meng-jing Zhao An-ren Wang School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China Metallurgical and Building Materials Business Department China International Engineering Consulting CorporationBeijing 100048China

The variation law of inclusions type and size in the vacuum induction melting process and ingot of Ni-based superalloy containing 70%return material was studied by industrial test sampling,and the mechanism of inclusions formation was analyzed with thermodynamic *** results show that there are mainly two types of composite inclusions in the vacuum induction melting of Ni-based superalloys,which are nitride-and oxide-based composite inclusions,like Al_(2)O_(3)-SiO_(2)-Cr_(2)O_(3),TiN-(Mo,Nb)C,*** type and proportion of inclusions from the center to the edge of the vacuum induction ingot did not change *** number density of inclusions from the center to the edge of the ingot varied less,and the size of inclusions became smaller from the center to the *** addition,thermodynamic calculations show that oxides(M_(2)O_(3))are present in the liquid phase and mainly contain Al,Ti,Cr,Fe and O *** nitride consists mainly of Ti and N and contains small amounts of Cr,C,Nb,and Mo *** is consistent with the results of industrial *** the temperature decreases,the precipitation phases such as M_(2)O_(3),MN,γ,MC,δ,γ'andμphases are gradually precipitated,where oxides and nitrides are present in the liquid *** contents of O and N elements are the main influencing factors for the inclusions content and precipitation temperature;when the nitrogen content is reduced to below 0.0015%,it can make MN precipitate below the liquid-phase line.

关键词： Ni-based superalloy Vacuum induction melting Return material Inclusion Thermodynamic

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Delay-optimal multi-satellite collaborative computation offloading supported by OISL in LEO satellite network

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Journal of Systems Engineering and Electronics 2024年第4期35卷 805-814页

作者： ZHANG Tingting guo Zijian li Bin feng Yuan FU Qi HU Mingyu QU Yunbo School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijing 100081China Yangtze Delta Region Academy Beijing Institute of TechnologyJiaxing 314000China School of Information and Electronics Beijing Institute of TechnologyBeijing 100081China China Research and Development Academy of Machinery Equipment Beijing 100089China

By deploying the ubiquitous and reliable coverage of low Earth orbit(LEO)satellite networks using optical inter satel-lite link(OISL),computation offloading services can be provided for any users without proximal servers,while the resource limita-tion of both computation and storage on satellites is the impor-tant factor affecting the maximum task completion *** this paper,we study a delay-optimal multi-satellite collaborative computation offloading scheme that allows satellites to actively migrate tasks among themselves by employing the high-speed OISLs,such that tasks with long queuing delay will be served as quickly as possible by utilizing idle computation resources in the *** satisfy the delay requirement of delay-sensi-tive task,we first propose a deadline-aware task scheduling scheme in which a priority model is constructed to sort the order of tasks being served based on its deadline,and then a delay-optimal collaborative offloading scheme is derived such that the tasks which cannot be completed locally can be migrated to other idle *** results demonstrate the effective-ness of our multi-satellite collaborative computation offloading strategy in reducing task complement time and improving resource utilization of the LEO satellite network.

关键词： low Earth orbit(LEO)satellite network computation offloading task migration resource allocation

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Cracking on a nickel-based superalloy fabricated by direct energy deposition

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China Foundry 2024年第4期21卷 311-318页

作者： Xue Zhang Ya-hang Mu liang Ma Jing-jing liang Yi-zhou Zhou Xiao-feng Sun Jin-guo li School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering Northeastern UniversityShenyang 110819China

Cracks have consistently been a significant challenge limiting the development of additive manufactured nickel-based *** is essential to investigate the location of cracks and their forming *** study extensively examines the impact of solidification process,microstructural evolution,and stress concentration on crack initiation during direct energy deposition(DED).The results emphasize that the crack formation is significantly related to large-angle grain boundaries,rapid cooling *** caused by large-angle grain boundaries and a fast-cooling rate predominantly appear near the edge of the deposited *** cracks are more likely to form near the top of the deposited sample,due to the presence ofγ/γ'*** secondary dendritic arm and the carbides in the interdendritic regions can obstruct liquid flow during the final stage of solidification,which results in the formation of solidification cracks and *** work paves the way to avoid cracks in nickel-based superalloys fabricated by DED,thereby enhancing the performance of superalloys.

关键词： location cracks direct energy deposition nickel-based superalloys

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Unveiling the rolling texture variations ofα-Mg phases in a dual-phase Mg-li alloy

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Journal of Magnesium and Alloys 2024年第6期12卷 2557-2568页

作者： Xiaoyan li Luyao Jiang Fei guo Yanlong Ma Hang Yu Qiuyu Chen Haiding liu Dingfei Zhang College of Materials Science and Engineering Chongqing University of TechnologyChongqing 400054China Chongqing Materials Research Institute Co. Ltd.Chongqing 400707China College of Materials Science and Engineering Chongqing UniversityChongqing 400044China

LZ91 Mg-li alloy plates with three types of initial texture were rolled by 70%reduction at both room temperature and 200℃to explore the rolling texture formation ofα-Mg *** results showed that the rolling texture is largely affected by the initial *** the samples exhibited two main texture components as RD-split double peaks texture and TD-split double peaks texture after large strain *** intensity of the two texture components was strongly influenced by the initial orientation and rolling *** twinning altered the large-split non-basal orientation to a near basal one at low rolling *** basal orientation induced by twinning is unstable,which finally transmitted to the RD-split *** strong TD-split texture formed due to slip-induced orientation transition from its initial *** competition between prismatic and basal slip determined the intensity and tilt angle of the TD-split *** increasing the rolling temperature,the TD-split texture component was enhanced in all three *** of extension twinning behavior and the promotion of prismatic slip at elevated temperature are the main reasons for the difference in hot and cold rolling texture.

关键词： Magnesium-lithium alloys Rolling texture Extension twinning Slip competition

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{1012}twin–twin intersection-induced lattice rotation and dynamic recrystallization in Mg–6Al–3Sn–2Zn alloy

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Journal of Magnesium and Alloys 2024年第4期12卷 1529-1539页

作者： Bin-Jiang Lv Sen Wang Fu-Hao Gao Ning Cui Yi-Nan li Tie-Wei Xu feng guo School of Mechanical and Automotive Engineering Qingdao University of Technology266520China Key Lab of industrial Fluid Energy Conservation and Pollution Control Qingdao University of Technology266520China

This study investigated the formation mechanism of new grains due to twin–twin intersections in a coarse-grained Mg–6Al–3Sn–2Zn alloy during different strain rates of an isothermal *** results of electron backscattered diffraction investigations showed that the activated twins were primarily{1012}tension twins,and 60°boundaries formed due to twin–twin intersections under different strain *** twin variants with 60°boundaries transformed into new grains through lattice rotations at a low strain rate(0.01 s^(−1)).At a high strain rate(10 s^(−1)),the regions surrounded by subgrain boundaries through high-density dislocation arrangement and the 60°boundaries transformed into new grains via dynamic recrystallization.

关键词： Mg alloy Twin-twin intersection Lattice rotation Dynamic recrystallization

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Left bundle branch area pacing combined with implantable cardioverter-defibrillator treatment for heart failure after myocardial infarction

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Journal of Geriatric Cardiology 2024年第5期21卷 577-582页

作者： Bing-Chen guo Jian XU Yan-Zong liU guo-Qing DU Bo YU Shu-feng li Wen-Juan DU Department of Cardiology the 2nd Affiliated Hospital of Harbin Medical UniversityHarbinChina The Key Laboratory of Myocardial Ischemia Chinese Ministry of EducationHarbinChina Department of Ultrasonography Guangdong Provincial People's HospitalGuangzhouGuangdongChina

Left bundle branch area pacing(LBBAP)has emerged as a new physiological pacing *** studies have confirmed the feasibility and efficacy of LBBAP for cardiac resynchronization therapy(CRT)in heart failure(HF)patients with left bundle branch block(LBBB)and a narrower QRS duration(QRSd)to have a higher percentage of super responders,and lower pacing thresholds than biventricular pacing(BiVP).

关键词： pacing branch bundle

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Layered niobium carbide enabling excellent kinetics and cycling stability of li-Mg-B-H hydrogen storage material Layered niobium carbide enabling excellent kinetics

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Rare Metals 2024年第3期43卷 1153-1166页

作者： li-Wen Lu Hui Luo Guang-Xu li Yun li Xin-Hua Wang Cun-Ke Huang Zhi-QiangLan Wen-Zheng Zhou Jin guo Mohammad Ismail Hai-Zhen liu Guangxi Novel Battery Materials Research Center of Engineering Technology Guangxi Colleges and Universities Key Laboratory of Blue Energy and Systems IntegrationSchool of Physical Science and TechnologyGuangxi UniversityNanning530004China State Key Laboratory of Featured Metal Materials and life-Cycle Safety for Composite Structures Nanning530004China School of Mechanical and Electrical Engineering Quzhou College of TechnologyQuzhou324000China Department of Materials Science and Engineering Zhejiang UniversityHangzhou310027China Faculty of Ocean Engineering Technology and Informatics Universiti Malaysia Terengganu21030Kuala NerusTerengganuMalaysia Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Nankai UniversityTianjin300071China

The li-Mg-B-H composite(2liBH_(4)+MgH_(2))has a high capacity of 11.4 wt%as a hydrogen storage ***,the slow kinetics and poor cycling stability severely restrict its practical *** this work,a layered Nb_(2)C MXene was first synthesized and then introduced to tailor the kinetics and cycling stability of the li-Mg-B-H *** milled 2liH+MgB_(2)composites were initially hydrogenated to obtain the 2liBH_(4)+MgH_(2)*** 2liBH_(4)+MgH_(2)+5wt%Nb_(2)C can release 9.0 wt%H_(2)in 30 min at 400℃,while it is only 2.7 wt%for the undoped 2liBH_(4)+MgH_(2).The dehydrogenation activation energies of MgH_(2)and liBH_(4)are 123 and 154 kJ·mol^(-1)respectively for the 5 wt%Nb_(2)C-doped composite,lower than the undoped composite(164 and 165 kJ·mol^(-1)).The 2liBH_(4)+MgH_(2)+5 wt%Nb_(2)C possesses excellent cycling stability,with the reversible capacity only slightly reduced from 9.4 wt%for the 1st cycle to 9.3 wt%for the 20th ***_(2)C keeps stable in the composite and acts as an efficient catalyst for the li-Mg-B-H *** is believed that both the layered structure and the active Nb element contribu te to the enhanced hydrogen storage performances of the li-Mg-B-H *** work confirms that the Nb_(2)C MXene with layered stru cture has a significant enhancing impact on the li-Mg-B-H hydrogen storage materials,which is different from the bulk NbC.

关键词： Hydrogen storage lithium borohydride Magnesium hydride Nb_(2)C MXene

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