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Human neural stem cell-derived extracellular vesicles protect against ischemic stroke by activating the PI3K/AKT/mTOR pathway

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Neural Regeneration Research 2025年第11期20卷 3245-3258页

作者： Jiayi Wang Mengke Zhao dong Fu Meina Wang Chao Han Zhongyue Lv Liang Wang jing Liu Stem Cell Clinical Research Center The First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning ProvinceChina Dalian Innovation Institute of Stem Cell and Precision Medicine DalianLiaoning ProvinceChina Institute(College)of Integrative Medicine Dalian Medical UniversityDalianLiaoning ProvinceChina

Human neural stem cell-derived extracellular vesicles exhibit analogous functions to their parental cells,and can thus be used as substitutes for stem cells in stem cell therapy,thereby mitigating the risks of stem cell therapy and advancing the frontiers of stem cell-derived *** lays a foundation for the development of potentially potent new treatment modalities for ischemic ***,the precise mechanisms underlying the efficacy and safety of human neural stem cell-derived extracellular vesicles remain unclear,presenting challenges for clinical *** promote the translation of therapy based on human neural stem cell-derived extracellular vesicles from the bench to the bedside,we conducted a comprehensive preclinical study to evaluate the efficacy and safety of human neural stem cell-derived extracellular vesicles in the treatment of ischemic *** found that administration of human neural stem cell-derived extracellular vesicles to an ischemic stroke rat model reduced the volume of cerebral infarction and promoted functional recovery by alleviating neuronal *** human neural stem cell-derived extracellular vesicles reduced neuronal apoptosis by enhancing phosphorylation of phosphoinositide 3-kinase,mammalian target of rapamycin,and protein kinase B,and these effects were reversed by treatment with a phosphoinositide 3-kinase *** findings suggest that human neural stem cell-derived extracellular vesicles play a neuroprotective role in ischemic stroke through activation of phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin signaling ***,we showed that human neural stem cell-derived extracellular vesicles have a good in vivo safety ***,human neural stem cell-derived extracellular vesicles are a promising potential agent for the treatment of ischemic stroke.

关键词： behavior exosome extracellular vesicles ischemic stroke mammalian target of rapamycin(mTOR) middle cerebral artery occlusion neural stem cells neuronal apoptosis phosphoinositide 3-kinase(PI3K) protein kinase B(AKT)

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自动气象站虚拟培训平台技术研究

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机床与液压 2020年第6期48卷 155-161页

作者：荆国栋邹立尧杨睿崔颖中国气象局北京100081

针对自动气象站实训教学设备不足、可培训场景受限、设备故障重现难度高等问题,设计了一套以虚拟仿真技术为基础,以Unity3D引擎为工具的自动气象站虚拟培训平台。并对该平台的功能、架构以及开发流程中所涉及的关键技术进行了介绍。应... 详细信息

针对自动气象站实训教学设备不足、可培训场景受限、设备故障重现难度高等问题,设计了一套以虚拟仿真技术为基础,以Unity3D引擎为工具的自动气象站虚拟培训平台。并对该平台的功能、架构以及开发流程中所涉及的关键技术进行了介绍。应用结果表明:该平台实现了自动气象站的培训、考核等一系列功能,对于提高气象站培训效果具有极高的推动作用。

关键词：装备保障虚拟现实自动气象站虚拟培训平台

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Multi-source and multi-temporal remote sensing image classification for flood disaster monitoring

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Global Geology 2025年

作者： LI Zhu JIA Zhenyang dong jing LIU Zhenghong College of Earth Sciences Jilin University Dandong No.2 High School

Flood disasters can have a serious impact on people's production and lives, and can cause huge ***-sourceremotesensingdata,thisstudyestablished decision tree classification rules through multi-source and multi-temporal feature fusion, classified ground objects before the disaster and extracted flood information in the disaster area based on optical images during the disaster, so as to achieve rapid acquisition of the disaster situation of each disaster bearing *** the case of Qianliang Lake, which suffered from flooding in 2020, the results show that decision tree classification algorithms based on multi-temporal features can effectively integrate multi-temporal and multispectral information to overcome the shortcomings of single-temporal image classification and achieve ground-truth object classification.

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Pure Java Implementation of BSP

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Advances in Manufacturing 2000年第S1期4卷 71-77页

作者： MENG Rui, LI guo-ping dong jing-yi,Wei-qin School of Computer Engineering and Science, Shanghai University, Shanghai 200072, China School of Computer Engineering and Science Shanghai University Shanghai 200072 China

With the wide acceptance of the computing concept of cluster-based or cluster-of-clusters computing, network-based high performance computing is gaining increasing popularity among parallel computing community. Current parallel environments such as MPI (Message Passing Interface) or BSP (Bulk Synchronous Parallel) can not apply readily to heterogeneous computing platform. In order to exploit the maximum performance potential that a heterogeneous environment brings, we have made some experiments on implementing BSP in pure Java, a fully platform-independent language. The experimental results show that implementation of parallel libraries in Java is feasible and the performance is moderately acceptable. The paper describes our experiences in implementation of BSP in pure Java. Implementation and efficiency issues such as data transport, network communication, support thread, barrier synchronization and dynamic class loading mechanism are discussed in detail.

关键词： BSP pure Java parallel computing

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Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li dongqing Sun Shaliu Fu Lei Gu Xin Shao Qinqin Wang Xin dong Bin Duan Feiyang Xing Jun Wu Minmin Xiao Fangqing Zhao jing-dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

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磺化酞菁铝修饰氨基功能化磁性材料及其光敏化降解双酚A

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无机化学学报 2019年第8期35卷 1379-1386页

作者：郭冬菁胡美琴沈昊宇张建孙洁许宜铭浙江大学宁波理工学院宁波315100 中国科学院宁波材料技术与工程研究所宁波315201 浙江大学化学系杭州310027

采用溶剂热法制备氨基功能化Fe3O4磁性材料(NH2@nFe3O4),通过浸渍法将磺化酞菁铝(AlPcS)负载于NH2@nFe3O4。材料的傅立叶红外、漫反射、X射线衍射、扫描电镜、透射电镜、振动磁强计等表征表明:AlPcS主要通过静电作用与NH2@nFe3O4结合,Al... 详细信息

采用溶剂热法制备氨基功能化Fe3O4磁性材料(NH2@nFe3O4),通过浸渍法将磺化酞菁铝(AlPcS)负载于NH2@nFe3O4。材料的傅立叶红外、漫反射、X射线衍射、扫描电镜、透射电镜、振动磁强计等表征表明:AlPcS主要通过静电作用与NH2@nFe3O4结合,AlPcS-NH2@nFe3O4平均粒径为127 nm,饱和磁化强度为75.3 emu·g^-1。在可见光和空气作用下,该功能化磁性材料对降解弱碱性水溶液中环境内分泌干扰物双酚A(BPA)具有较高的光敏化活性。随着AlPcS负载量的增加活性呈先升高后下降的趋势,负载量为3.4%(质量分数)的复合材料性能最佳,反应60 min后,20.0 mg·L^-1 BPA降解率为96%;循环使用10次,BPA降解率仍保持93%以上。通过NaN3猝灭实验探讨了反应机理,证实1O2是光敏化过程中的主要活性物种。

关键词：磁载光催化剂酞菁双酚A 可见光降解

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Applications of in-situ solid-state nuclear magnetic resonance in methanol to olefins reaction

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Science China Chemistry 2025年第1期68卷 134-151页

作者： jing Niu Shutao Xu Yingxu Wei Zhongmin Liu National Engineering Research Center of Lower-Carbon Catalysis Technology Dalian Institute of Chemical PhysicsChinese Academy of Sciences State Key Laboratory of Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences University of Chinese Academy of Sciences

The methanol-to-olefins（MTO） reaction offers an alternative pathway for the production of low-carbon olefins from non-oil feedstocks. Fundamental research has been impeded by a lack of comprehensive understanding of its underlying mechanism,despite the significant progress made in industry. In-situ solid-state nuclear magnetic resonance（ss NMR） spectroscopy has emerged as a pivotal tool, offering crucial insights into key species under real-time operando conditions. Furthermore, the host–guest interaction between zeolites or surface species residing on zeolites and the reactant/active intermediates is revealed by the combination of in-situ13C MAS NMR and 2D correlation spectroscopy. Moreover, recent technological advancements in hyperpolarization（HP） methods, including HP129Xe NMR and dynamic nuclear polarization（DNP）, have significantly improved the sensitivity of ss NMR, enabling detailed structural and kinetic analysis as well as the detection of trace species. In this feature article, we summarized recent advancements in（in-situ） ss NMR spectroscopy applied to MTO reaction processes,encompassing mechanistic investigations at various stages and the intricate host–guest interactions. These theoretical insights into the dynamic evolution of MTO reactions lay a solid foundation for the optimization of catalytic processes and the development of efficient catalysts, thereby advancing the techniques towards more sustainable and economical production route for olefins.

关键词： MTO zeolites in-situ ssNMR reactive intermediates reaction mechanism

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MAGNETIC AND FERROMAGNETIC RESONANCE STUDY OF Ni-Zn-Cu FERRITE SYSTEM

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Chinese Science Bulletin 1989年第13期34卷 1071-1075页

作者：李国栋井宁李德新郭淑娇王会宗苏彦欣张雅琴 Institute of Physics Academia Sinica Beijing University of Science and Technology of China Heifei Beijing Institute of Radio Measurements

In recent years, the millimeter wave technique has been developed rapidly owing to the requirement of microwave remote sensor, high resolution radar, missile-guide and radio astronomy. And these requirments have prompted the study of gyromagnetic materials and devices used in millimeter wave. For gyromagnetic devices used in nonresonant region, the high saturation magnetization and narrow ferromag-

关键词： Ni-Zn-Cu ferrites microwave ferrites ferromagnotic resonance of ferrites magnetic properties of ferrites

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交锁髓内针和加压钢板对胫骨中远段骨折疗效的对比

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中国实用医药 2010年第27期5卷 24-25页

作者：齐诺郭晶东吉林省伊通满族自治县第一人民医院 130700

目的探讨交锁髓内针和加压钢板对胫骨中远段骨折疗效差异。方法回顾分析胫骨中远段闭合骨折及Ⅰ型和Ⅱ型骨折共28例的临床资料,将其术后疗效进行对比,利用SPSS12.0软件对两组数据进行统计学分析。结果交锁髓内针组愈合13例,愈合率100%,... 详细信息

目的探讨交锁髓内针和加压钢板对胫骨中远段骨折疗效差异。方法回顾分析胫骨中远段闭合骨折及Ⅰ型和Ⅱ型骨折共28例的临床资料,将其术后疗效进行对比,利用SPSS12.0软件对两组数据进行统计学分析。结果交锁髓内针组愈合13例,愈合率100%,平均愈合时间为20周(17～32周),膝关节活动度受限1例,踝关节活动度受限2例,跪姿膝前痛(VAS Scores on Kneeling)平均值4.5(0～10),蹲坐姿膝前痛(VAS Scores on Squatting)平均值2.8(0～9.2)。Jonher-Wruh评分:优8例,良3例,中2例,优良率84.61%。加压钢板组愈合15例,愈合率100%,平均愈合时间为19周(14～28周),膝关节活动受限2例,踝关节活动受限3例,跪姿膝前痛平均值0.7(0～49),蹲坐姿膝前疼痛平均值1.9(0～50)。Jonher-Wruh评分:优9例,良3例,中3例,优良率80%。统计学显示:两组愈合时间无统计学差异P>0.05(P=0.23),跪姿膝前痛平均值有统计学差异P0.05。结论对于胫骨中远段的闭合骨折和Ⅰ型和Ⅱ型骨折,交锁髓内针内固定和加压钢板内固定两种治疗方式的术后近期疗效无明显差异。

关键词：胫骨中远段骨折髓内针加压钢板视觉模拟评分法

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胫骨骨折髓内针置入点对术后膝前痛发生的影响

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中国实用医药 2010年第26期5卷 45-46页

作者：齐诺郭晶东吉林省伊通满族自治县第一人民医院 130700

目的探讨胫骨骨折髓内针不同置入点对术后膝前痛发生率的影响。方法回顾分析胫骨骨折髓内针固定患者158例的临床资料,根据髓内针置入点不同分为两组,对比两组术后膝前痛发生率、跪姿疼痛评分和蹲坐姿疼痛评分。利用SPSS12.0软件对两组... 详细信息

目的探讨胫骨骨折髓内针不同置入点对术后膝前痛发生率的影响。方法回顾分析胫骨骨折髓内针固定患者158例的临床资料,根据髓内针置入点不同分为两组,对比两组术后膝前痛发生率、跪姿疼痛评分和蹲坐姿疼痛评分。利用SPSS12.0软件对两组数据进行统计学分析。结果本组患者158例,术后骨不连5例,术后感染2例,骨筋膜室综合征1例,无术后髌韧带断裂及髓内针断裂病例。术后愈合时间平均21.4周。经髌韧带入路组:术后AKP发生率为51.39%(37例),跪姿疼痛评价平均值为7.2;蹲坐姿疼痛评价平均值为5.8。髌韧带旁入路组:术后AKP发生率为48.84%,跪姿疼痛评价平均值为5.5;蹲坐姿疼痛评价平均值为5.5。统计学显示:两组术后AKP发生率无明显差异;跪姿疼痛平均值有统计学显著差异P0.05。结论髌韧带旁入路置入髓内针并不能减少术后膝前痛的发生率,但可有效缓解膝前痛的症状。

关键词：胫骨骨折髓内针膝前痛经髌韧带入路髌韧带旁入路

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