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Tungsten 2025年第1期 183-194页

作者： Xin-Ran Sun Hao-Ming Yuan guo-da zhang Chao Wang Shu-Juan Sun Peng-Fei Shi Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers School of Chemistry and Chemical Engineering Linyi University

The combination of photodynamic therapy（PDT） and chemodynamic therapy（CDT） in tumor treatment has attracted considerable ***,tumor hypoxia and glutathione（GSH） overproduction in the tumor tissue restricted the progress of their ***,a Mn-porphyrinic metal-organic framework（Mn-TCPP） was constructed by the one-pot method and further used for immobilizing glucose oxidase（GOx） to obtain GOx@*** would rapidly exhaust endogenous glucose into hydrogen peroxide（H2O2） and gluconic acid,thus shutting off the energy supply of tumor cells for starvation ***-TCPP catalyzed H2O2to produce oxygen,regulating the hypoxic tumor microenvironment and in turn improving1O2generation under laser ***,Mn-TCPP can reduce reactive oxygen species consumption owing to the redox reaction between Mn3+and GSH,thus greatly enhancing ***,benefiting from GOx-mediated starvation therapy,Mn2+produced by Mn3+reduction can react with sufficient intracellular H2O2to generate ·OH with high cytotoxicity through a Fenton-like *** treatment by GOx@Mn-TCPP under laser irradiation in vitro,the cell viability of 4T1 and A549 tumor cells reached to 20%,reflecting GOx@Mn-TCPP could give full play to the advantages of PDT/CDT/starvation *** results in vivo demonstrated that GOx@Mn-TCPP mediated synergistic cascade therapy could significantly inhibit tumor growth and improve the therapeutic effect.

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ImSpiRE: image feature-aided spatial resolution enhancement method

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Science China Life Sciences 2025年第1期 272-283页

作者： Yuwei Hua Yizhi zhang Zhenming guo Shan Bian Yong zhang State Key Laboratory of Cardiovascular Diseases and Medical Innovation Center Institute for Regenerative MedicineDepartment of NeurosurgeryShanghai East HospitalShanghai Key Laboratory of Signaling and Disease ResearchFrontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji University

The resolution of most spatially resolved transcriptomic technologies usually cannot attain the single-cell level, limiting their applications in biological discoveries. Here, we introduce ImSpiRE, an image feature-aided spatial resolution enhancement method for in situ capturing spatial transcriptome. Taking the information stored in histological images, ImSpiRE solves an optimal transport problem to redistribute the expression profiles of spots to construct new transcriptional profiles with enhanced resolution, together with extending the gene expression profiles into unmeasured regions. Applications to multiple datasets confirm that ImSpiRE can enhance spatial resolution to the subspot level while contributing to the discovery of tissue domains, signaling communication patterns, and spatiotemporal characterization.

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“乡下人”的是与非——沈从文的身份认同研究

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西安建筑科技大学学报（社会科学版） 2017年第6期36卷 89-94页

作者：郭大章西南大学文学院重庆400715

沈从文一辈子都以"乡下人"自居,但沈从文却出生于湘西凤凰的一个名门望族,且沈从文的创作带有极其深刻的内涵和"民族重造"的理想,这便与其"乡下人"身份产生了很大的矛盾。由此,沈从文其实并非传统意义上的"乡下人",他的这种自称,隐含了... 详细信息

沈从文一辈子都以"乡下人"自居,但沈从文却出生于湘西凤凰的一个名门望族,且沈从文的创作带有极其深刻的内涵和"民族重造"的理想,这便与其"乡下人"身份产生了很大的矛盾。由此,沈从文其实并非传统意义上的"乡下人",他的这种自称,隐含了来自偏远湘西的沈从文的自卑心理,以及沈从文想以此来保持自己独立的价值评判尺度等原因。因而,沈从文"乡下人"身份的内涵也变得丰富起来:除带有明确少数民族含义和现代意识之外,还兼具"知识分子"、"都市人"和"乡下人"等多重身份特征。

关键词：沈从文 “乡下人” 身份认同内涵

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司马文森“粤北散记”系列散文论

石家庄学院学报 2023年第2期25卷 130-137页

作者：郭大章陕西师范大学文学院陕西西安710119

司马文森“粤北散记”系列散文以其丰富的内容和强烈的纪实特点,真实而生动地反映了粤北地区的抗战现实,具有浓郁的地方色彩;不仅激发了中国军民的抗战“斗志”,同时也引发了抗战“反思”,强调了对“人”的命运的关注,诠释了“文人”与... 详细信息

司马文森“粤北散记”系列散文以其丰富的内容和强烈的纪实特点,真实而生动地反映了粤北地区的抗战现实,具有浓郁的地方色彩;不仅激发了中国军民的抗战“斗志”,同时也引发了抗战“反思”,强调了对“人”的命运的关注,诠释了“文人”与“抗战”的关系,具有“文学”价值的同时,还具有珍贵的“史料”价值;不仅丰富了抗战文学的内容,清算了抗战文学的“二元对立”模式,同时也继承和发展了五四散文“人的文学”特征,在当时的抗战散文中具有特殊的地位,有着重要的文学史意义。

关键词：司马文森粤北散记特点意义

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韩少功小说中的宗教意识

太原学院学报（社会科学版） 2018年第1期19卷 59-64页

作者：郭大章西南大学文学院重庆400715

韩少功的小说中,隐藏着浓厚的宗教意识,既有佛教的生命轮回和救世于苦难的意识,也有基督教的博爱和牺牲以及批判和拯救意识,还有巫楚文化中的巫鬼气息和自然图腾崇拜等原始宗教意识,这些宗教意识对其小说创作产生了极大的影响,使其小说... 详细信息

韩少功的小说中,隐藏着浓厚的宗教意识,既有佛教的生命轮回和救世于苦难的意识,也有基督教的博爱和牺牲以及批判和拯救意识,还有巫楚文化中的巫鬼气息和自然图腾崇拜等原始宗教意识,这些宗教意识对其小说创作产生了极大的影响,使其小说完成了从世俗到宗教的蜕变和超越,形成了一种有思想深度的小说。

关键词：韩少功小说宗教意识作用

Sequence-activated chemiluminescence probes: programmable illumination for high-contrast in vivo sensing and imaging

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Science China Chemistry 2025年第01期 26-34页

作者： Yutao zhang Juan Li Wei-Hong Zhu Zhiqian guo Shanghai Key Laboratory of Functional Materials Chemistry Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Institute of Fine Chemicals School of Chemistry and Molecular Engineering East China University of Science and Technology State Key Laboratory of Bioreactor Engineering Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell MetabolismEast China University of Science & Technology

Sequence-activated chemiluminescence(CL) technique offers a unique approach to detecting specific biomolecules or cellular events with high sensitivity and spatial resolution. The fundamental principle behind sequence-activated CL probes involves tailoring highly-controllable CL signals in response to specific sequences or events of interest, thus enabling high-contrast signals under complex physiological conditions. This sequential activation could be triggered by enzymes, reactive oxygen species(ROS), biothiols or changes in the microenvironment. These unique sequence-activated CL probes bestow several advantages, including minimal background, deep-tissue penetration, and the ability of non-invasive or minimally invasive detection. The sequence-activated CL techniques represent a significant advancement in molecular imaging and diagnostics. In this mini-review, we focus on the latest developments in sequential CL probes, addressing the technical challenges and discussing the future trajectory by harnessing CL signaling and molecular recognition.

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Deciphering the role of ultra-low-loaded rhodium in NiFe-MIL-53 for superior oxygen evolution reaction

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Journal of Energy Chemistry 2025年第1期100卷 77-86页

作者： Jinzhi Jia Jinhua zhang Kailu guo Lanyue zhang Gening Du Hao You Junfeng Huang Mudong Tu Hua Li Yong Peng Wei Dou Cailing Xu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering School of Materials and Energy Lanzhou University College of Chemistry and Chemical Engineering Luoyang Normal University

Designing highly active and stable electrocatalysts of oxygen evolution reaction （OER） is one of the crucial *** this study,a novel OER electrocatalyst,NiFe-MIL-53 modified with ultra-low rhodium（Rh@NiFe-MIL-53）,is successfully prepared via the hydrothermal ***-situ Raman spectroscopy and electrochemical impedance spectroscopy reveal that the doped Rh accelerates the phase transformation of NiFe-MIL-53 and the in-situ formed Rh@NiFeOOH is the actual active *** importantly,the enhanced reversibility of electrochemical reconstruction between NiFeOOH and NiFe（OH）2after doping Rh is beneficial for improving the electrochemical stability of the catalyst.X-ray photoelectron spectroscopy spectra show the strong electronic interaction between single-atom Rh and Ni/Fe in Rh@***,theoretical calculations confirm that the integration of single-atom Rh into the NiFeOOH successfully reduces the band gap,regulates the d-band center （εd）,accelerates the charge transfer,and optimizes the adsorption behavior of oxygen-containing intermediates,thereby lowering the energy barrier of rate-determining ***,the optimized Rh@NiFe-MIL-53 exhibits excellent OER activity （240 mV） with a small Tafel slope of 48.2 mV dec-1and long-term durability (over1270 h at 10 m A cm-2and 110 h at 200 mA cm-2).This work presents a new perspective on designing highly efficient OER electrocatalysts.

关键词： NiFe-MIL-53 Rh Electrochemical reconstruction Catalytic mechanism Oxygen evolution reaction

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人性在世俗权力中迷失——刘震云小说论

齐齐哈尔师范高等专科学校学报 2009年第4期 50-51页

作者：郭大章重庆市巴蜀渝东中学重庆404600

刘震云的小说始终深深的关注着人性,通常把思考的目光聚焦在世俗权力下的人性上,展现那些常人难以察觉的人性在世俗权力下的被奴役和蹂躏,在悲观和绝望中寄予了作者深广的人文意图。

关键词：刘震云人性世俗权力迷失

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刘盛亚“卍字旗下”系列散文论

齐齐哈尔大学学报（哲学社会科学版） 2022年第7期 21-25页

作者：郭大章陕西师范大学文学院陕西西安710119

刘盛亚“卍字旗下”系列散文以纪实的手法,详细反映了20世纪30年代德国的社会现实,对希特勒政府进行着“暴露”和“讽刺”,宣扬着“人道主义”精神,并提倡和展现“战斗”的精神,以其罕见的题材丰富了“抗战文学”的内容,极大地激发了中... 详细信息

刘盛亚“卍字旗下”系列散文以纪实的手法,详细反映了20世纪30年代德国的社会现实,对希特勒政府进行着“暴露”和“讽刺”,宣扬着“人道主义”精神,并提倡和展现“战斗”的精神,以其罕见的题材丰富了“抗战文学”的内容,极大地激发了中国人民的抗日决心和信心,有利于抗日民族统一战线的建立,在宣扬“抗战”的众多散文中,形成了一道独特而美丽的“风景”。

关键词：刘盛亚 “卍字旗下”系列散文抗战文学

Viscosity and structure relationship with equimolar substitution of CaO with MgO in the CaO–MgO–Al_(2)O_(3)–SiO_(2)slag melts

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 70-79页

作者： Yong Hou Shuo zhang Jie dang Jia guo Hanghang Zhou Xuewei Lü College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Chongqing Key Laboratory of Vanadium-Titanium Metallurgy and New Materials Chongqing UniversityChongqing 400044China

Currently,the Al_(2)O_(3)content in the high-alumina slag systems within blast furnaces is generally limited to 16wt%–18.5wt%,making it challenging to overcome this *** most studies that concentrated on managing the MgO/Al_(2)O_(3)ratio or basicity,this paper explored the effect of equimolar substitution of MgO for CaO on the viscosity and structure of a high-alumina CaO-MgO-Al_(2)O_(3)-SiO_(2)slag system,providing theoretical guidance and data to facilitate the application of high-alumina *** results revealed that the viscosity first decreased and then increased with higher MgO substitution,reaching a minimum at 15mol%MgO *** transform infrared spectroscopy(FTIR)results found that the depths of the troughs representing[SiO_(4)]tetrahedra,[AlO_(4)]tetrahedra,and Si-O-Al bending became progressively deeper with increased MgO *** of the Raman spectra showed that the average number of bridging oxygens per Si atom and the X_(Q^(3))/X_(Q^(2))(X_(Q^(i))is the molar fraction of Q^(i) unit,and i is the number of bridging oxygens in a[SiO_(4)]tetrahedral unit)ratio increased from 2.30 and 1.02 to 2.52 and 2.14,respectively,indicating a progressive polymerization of the silicate structure.X-ray photoelectron spectroscopy(XPS)results highlighted that non-bridging oxygen content decreased from 77.97mol% to 63.41mol% with increasing MgO concentration,whereas bridging oxygen and free oxygen contents *** analysis demonstrated a gradual increase in the polymerization degree of the tetrahedral structure with the increase in MgO ***,bond strength is another important factor affecting the slag *** occurrence of a viscosity minimum can be attributed to the complex evolution of bond strengths of non-bridging oxygens generated during depolymerization of the[SiO_(4)]and[AlO_(4)]tetrahedral structures by CaO and MgO.

关键词： aluminosilicate viscosity structure spectroscopy