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Visualization and characterization of experimental hydraulic fractures interacting with karst fracture-cavity distributions

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第5期16卷 1667-1683页

作者： Hanzhi Yang Xin Chang Chunhe Yang Wuhao guo Lei wang guokai Zhao Yintong guo State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing UniversityChongqing400044China State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China

Karst fracture-cavity carbonate reservoirs,in which natural cavities are connected by natural fractures to form cavity clusters in many circumstances,have become significant fields of oil and gas exploration and *** fracturing is considered as the best method for exploiting carbonate reservoirs;however,previous studies primarily focused on the effects of individual types of geological formations,such as natural fractures or cavities,on fracture *** this study,true-triaxial physical simulation experiments were systematically performed under four types of stress difference conditions after the accurate prefabrication of four types of different fracture-cavity distributions in artificial ***,the interaction mechanism between the hydraulic fractures and fracture-cavity structures was systematically analyzed in combination with the stress distribution,cross-sectional morphology of the main propagation path,and three-dimensional visualization of the overall fracture *** was found that the propagation of hydraulic fractures near the cavity was inhibited by the stress concentration surrounding the *** contrast,a natural fracture with a smaller approach angle(0°and 30°)around the cavity can alleviate the stress concentration and significantly facilitate the connection with the *** addition,the hydraulic fracture crossed the natural fracture at the 45°approach angle and bypassed the cavity under higher stress difference conditions.A new stimulation effectiveness evaluation index was established based on the stimulated reservoir area(SRA),tortuosity of the hydraulic fractures(T),and connectivity index(CI)of the *** findings provide new insights into the fracturing design of carbonate reservoirs.

关键词： Karst fracture-cavity reservoir Fracturing experiment Fracture propagation Cross-sectional morphology Stimulation effectiveness

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Synthesis,Style Editing,and Animation of 3D Cartoon Face

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Tsinghua Science and Technology 2024年第2期29卷 506-516页

作者： Ming guo Feng Xu Shunfei wang Zhibo wang Ming Lu Xiufen Cui Xiao Ling School of Software and BNRist Tsinghua UniversityBeijing 100084China Department of Multimedia and Smart Guangdong OPPO Mobile Telecommunications Corp.Ltd.Dongguan 523860China Intel Labs IntelBeijing 100089China

As a popular kind of stylized face,cartoon faces have rich application *** is challenging to create personalized 3D cartoon faces directly from 2D real ***,in order to adapt to more application scenarios,automatic style editing,and animation of cartoon faces is also a crucial problem that is urgently needed to be solved in the industry,but has not yet had a perfect *** solve this problem,we first propose“3D face cartoonizer”,which can generate high-quality 3D cartoon faces with texture when fed into 2D facial *** contribute the first 3D cartoon face hybrid dataset and a new training strategy which first pretrains our network with low-quality triplets in a reconstruction-then-generation manner,and then finetunes it with high-quality triplets in an adversarial manner to fully leverage the hybrid ***,we implement style editing for 3D cartoon faces based on k-means,which can be easily achieved without retrain the neural *** addition,we propose a new cartoon faces'blendshape generation method,and based on this,realize the expression animation of 3D cartoon faces,enabling more practical *** dataset and code will be released for future research.

关键词： cartoon 3D face animation computer graphics

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Highly crystallization-induced emissive luminophores with mechanoluminescent features for two-photon harvesting fluorescence imaging and latent fingerprint identification

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Nano Research 2024年第7期17卷 6475-6482页

作者： Jian Lu Juan Gao Rui-Xuan Qian Shuai-Hua wang Fa-Kun Zheng guo-Cong guo Fujian Science and Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350108China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China

Fluorescence imaging can be employed in fields of medical treatment,astronomical exploration,and national defense *** fluorescence imaging often takes the single-photon techniques,which is vulnerable to background interference and ***,two-photon fluorescence imaging can achieve much higher-resolution fluorescence imaging for reducing scattering and deeper ***,by assembling the tetraphenylethylene backbones with nontoxic and non-noble K^(+)ions,compound 1([(Hdma)K(H_(2)ettc)]_(n),H_(4)ettc=4',4''',4''''',4'''''''-(ethene-1,1,2,2-tetrayl)tetrakis(([1,1'-biphenyl]-4-carboxylic acid)))with the crystallization-induced emissions exhibited charming fluorescence imaging under two-photon excitation microscopy(TPEM).Besides,luminescent powders based on compound 1 can achieve high-resolution fingerprint recognition,providing secure access control and identification for a novel authentication *** with the commercial fluorescent dyes coumarin-6,the as-synthesized compound 1 showed great solvent stability,indicating its durability against harsh ***,compound 1 shows mechanoluminescent properties for the perturbation of weak supramolecular interactions within ordered arrangements of the H_(2)ettc^(2−)*** novel compound has provided an important insight to the development of twophoton fluorescence imaging and advanced external-stimuli responsive materials.

关键词： crystallization-induced emission fluorescence imaging two-photon absorption fingerprint recognition mechanoluminescence

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Systematic analysis of DNA polymerases as therapeutic targets in pan-cancers

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BIOCELL 2024年第1期48卷 123-138页

作者： ZHENHUA LI HUILAI LV FAN ZHANG ZIMING ZHU QIANG guo MINGBO wang CHAO HUANG LIJUAN CHEN WENPAN ZHANG yun LI ZIQIANG TIAN Department of Thoracic Surgery Fourth Hospital of Hebei Medical UniversityShijiazhuang050011China Department of Thoracic Surgery The First Hospital of XingtaiXingtai054001China Department of Thoracic Surgery Affiliated Hospital of Hebei UniversityBaoding050017China Shanghai OrigiMed Co. Ltd.Shanghai200000China Department of Thoracic Surgery The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen518107China

Introduction:DNA polymerases are crucial for maintaining genome stability and influencing ***,the clinical implications of DNA polymerases in tumorigenesis and their potential as anti-cancer therapy targets are not well ***:We conducted a systematic analysis using TCGA Pan-Cancer Atlas data and Gene Set Cancer Analysis results to examine the expression profiles of 15 DNA polymerases(POLYs)and their clinical *** also evaluated the prognostic value of POLYs by analyzing their expression levels in relation to overall survival time(OS)using Kaplan-Meier survival ***,we investigated the correlations between POLY expression and immune cells,DNA damage repair(DDR)pathways,and *** sensitivity analysis was performed to assess the relationship between POLY expression and drug ***:Our analysis revealed that 14 out of 15 POLYs exhibited significantly distinct expression patterns between tumor and normal samples across most cancer types,except for DNA nucleotidylexotransferase(DNTT).Specifically,POLD1 and POLE showed elevated expression in almost all cancers,while POLQ exhibited high expression levels in all cancer *** POLYs showed heightened expression in specific cancer subtypes,while others exhibited low ***-Meier survival curves demonstrated significant prognostic value of POLYs in multiple cancers,including PAAD,KIRC,and *** analysis further validated these *** patterns of POLYs varied significantly among different cancer types and were associated with poorer survival *** correlations were observed between the expression of POLY members and immune cells,DDR pathways,and *** sensitivity analysis indicated an inverse relationship between POLY expression and drug ***:Our comprehensive study highlights the significant role of POLYs in cancer development and identifies them as promising prognostic and

关键词： DNA polymerases(POLYs) Prognostic biomarker The Cancer Genome Atlas(TCGA) Ubiquitination network

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C_(60) as a metal-free catalyst for lithium-oxygen batteries

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Nano Research 2024年第5期17卷 3982-3987页

作者： Xinxin Zhang Jiaming Tian Yu wang Shaohua guo Yafei Li Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials School of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023China College of Engineering and Applied Sciences Jiangsu Key Laboratory of Artificial Functional MaterialsNational Laboratory of Solid State MicrostructuresCollaborative Innovation Center of Advanced MicrostructuresFrontiers Science Center for Critical Earth Material CyclingNanjing UniversityNanjing 210023China

Carbon materials have shown significant potential as catalysts for lithium-oxygen batteries(LOBs).However,the intrinsic carbon sites are typically inert,necessitating extensive modifications and resulting in a limited density of active *** we present C_(60) as a metal-free cathode catalyst for LOBs,using density functional theory calculations and experimental *** lithiation reactions on the pristine carbon sites of C_(60) are energetically favorable due to its curvedπ-conjugation over the pentagon-hexagon *** kinetic analysis specifically reveals low energy barriers for Li_(2)O_(2) decomposition and Li diffusion on C_(60).Consequently,C_(60) exhibits significantly higher catalytic activity than typical carbon materials such as graphene and carbon *** electrochemical measurements validate the predictions,notably demonstrating that the intrinsic activity of C_(60) is comparable to that of noble metals.

关键词： lithium-oxygen batteries C_(60) density functional theory(DFT)calculations metal-free cathode

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MPI/OpenMP-Based Parallel Solver for Imprint Forming Simulation

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 461-483页

作者： Yang Li Jiangping Xu yun Liu Wen Zhong Fei wang School of Mechanical Engineering Jiangsu UniversityZhenjiang212016China School of Mechanical Engineering Wuhan Polytechnic UniversityWuhan430023China Shenyang Mint Company Limited Shenyang110092China

In this research,we present the pure open multi-processing(OpenMP),pure message passing interface(MPI),and hybrid MPI/OpenMP parallel solvers within the dynamic explicit central difference algorithm for the coining process to address the challenge of capturing fine relief features of approximately 50 *** such precision demands the utilization of at least 7 million tetrahedron elements,surpassing the capabilities of traditional serial programs previously *** mitigate data races when calculating internal forces,intermediate arrays are introduced within the OpenMP *** helps ensure proper synchronization and avoid conflicts during parallel ***,in the MPI implementation,the coins are partitioned into the desired number of *** division allows for efficient distribution of computational tasks across multiple *** simulation examples are conducted to compare the three solvers with serial programs,evaluating correctness,acceleration ratio,and parallel *** results reveal a relative error of approximately 0.3%in forming force among the parallel and serial solvers,while the predicted insufficient material zones align with experimental ***,speedup ratio and parallel efficiency are assessed for the coining process *** pureMPI parallel solver achieves a maximum acceleration of 9.5 on a single computer(utilizing 12 cores)and the hybrid solver exhibits a speedup ratio of 136 in a cluster(using 6 compute nodes and 12 cores per compute node),showing the strong scalability of the hybrid MPI/OpenMP programming *** approach effectively meets the simulation requirements for commemorative coins with intricate relief patterns.

关键词： Hybrid MPI/OpenMP parallel computing MPI OpenMP imprint forming

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Achieving high power factor in GaSb with intrinsically high mobility via Ge doping

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Rare Metals 2024年第10期43卷 5435-5441页

作者： Yan-Ci Yan guo-Wei wang Qi-Hong Xiong Xu Lu Peng Chen Wei Zou Deng-Feng Li Hong Wu yun Zhou Xiao-Yuan Zhou School of Science Chongqing University of Posts and Telecommunications College of Physics Chongqing University College of Ocean Science and Engineering Shanghai Maritime University

The thermoelectric power factor is as crucial as their overall thermoelectric ***-based compounds are deemed to achieve high power factor owing to their intrinsically high mobility compared to classical thermoelectric ***,the carrier concentration of pristine GaSb is considerably lower than the optimum value,which hinders its ability to attain high electrical *** this paper,we present the investigations on the thermoelectric performance of p-type *** experimental results reveal that Ge doping can effectively tune the carrier concentration.

关键词： Carrier concentration

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The impact of broad glutamine metabolism inhibition on the tumor microenvironment

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Genes & Diseases 2024年第3期11卷 2-4页

作者： Tianhe Li yun-Ta Chuang Tian-Li wang Departments of Pathology Oncologyand Gynecology and ObstetricsThe Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins University School of MedicineBaltimoreMD 21231USA

Glutamine is an importantα-amino acid that provides carbon and nitrogen sources for the biosynthesis of nucleotides,proteins,and *** also generates metabolites that fuel the tricarboxylic acid cycle and maintain intracellular redox *** cells have a heightened metabolic dependence on glutamine to support incessant tumor growth and mitigate tumor microenvironmental stresses including hypoxia,nutrient depletion.

关键词： metabolism tumor microenvironment

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Dual-functional microneedle with programmatic regulation of macrophage for autoimmune psoriasis treatment

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Nano Research 2024年第8期17卷 7436-7448页

作者： Ze Qiang Zhao Bo Zhi Chen Jia Li Gan yun Hao Feng Ling Liang Lingyun Yu Zi Yi wang Samin Abbaszadeh Mohammad-Ali Shahbazi Ruixing Yu Xin Dong guo State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China Beijing Laboratory of Biomedical Materials College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China China-Japan Friendship Hospital Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100029China Department of Dermatology China-Japan Friendship HospitalBeijing 100029China Department of Pharmaceutical Biomaterials School of PharmacyZanjan University of Medical SciencesZanjan 45139-56184Iran Department of Biomaterials and Biomedical Technology University Medical Center GroningenUniversity of GroningenAntonius Deusinglaan 19713 AV GroningenThe Netherlands W.J.Kolff Institute for Biomedical Engineering and Materials Science University of GroningenAntonius Deusinglaan 19713 AV GroningenThe Netherlands

Modulating the immune microenvironment to establish sustained positive feedback within immune pathways represents a promising avenue for the treatment of ***,the precise and efficient delivery of therapeutic systems to the subcutaneous basal layer to modulate immune disorders is a major challenge in the treatment of autoimmune *** this project,we introduce a dual-functional microneedle(DF-MN)designed to combine MNs with multiple release kinetics and immunotherapy,the programmed treatment is achieved through segmented design of the MN structure,realizing the unification of rapid and long-lasting treatment of autoimmune *** vivo imaging results showed that GelMA@M-CSF showed fluorescent signals after 5 days of delivery to subcutaneous tissues,whereas HA@IL-13 showed minimal fluorescent signals after 2 *** multistage release behavior of MNs and the diffusion mechanism of drugs were explained at the molecular level,in combination with coarse-grained molecular ***,DF-MN can successfully induce macrophage reprogramming in vitro and ameliorate overall symptoms in a psoriasis mice model,suggesting that it has the potential to be an effective strategy for the treatment of psoriasis and portends to be a transformative platform for the treatment of other autoimmune diseases.

关键词： microneedle psoriasis M2 macrophage immunoregulation

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A Secure Mutual Authentication Protocol Based on Visual Cryptography Technique for IoT-Cloud

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Chinese Journal of Electronics 2024年第1期33卷 43-57页

作者： Brou Bernard Ehui Chen CHEN Shirui wang Hua guo Jianwei LIU School of Cyber Sciences and Technology Beihang University State Key Laboratory of Software Development Environment Beihang University Sino-French Engineering School Beihang University Beihang Hangzhou Innovation Institute Yuhang

Because of the increasing number of threats in the IoT cloud, an advanced security mechanism is needed to guard data against hacking or attacks. A user authentication mechanism is also required to authenticate the user accessing the cloud services. The conventional cryptographic algorithms used to provide security mechanisms in cloud networks are often vulnerable to various cyber-attacks and inefficient against new attacks. Therefore,developing new solutions based on different mechanisms from traditional cryptography methods is required to protect data and users’ privacy from attacks. Different from the conventional cryptography method, we suggest a secure mutual authentication protocol based on the visual cryptography technique in this paper. We use visual cryptography to encrypt and decrypt the secret images. The mutual authentication is based on two secret images and *** user requests the ticket from the authentication server(AS) to obtain the permission for accessing the cloud services. Three shared secret keys are used for encrypting and decrypting the authentication process. We analyze the protocol using the Barrows-Abadi-Needham(BAN)-logic method and the results show that the protocol is robust and can protect the user against various attacks. Also, it can provide a secure mutual authentication mechanism.

关键词： Visualization Cloud computing Data privacy Protocols Biometrics (access control) Authentication Resists

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