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Intraorbital Granular Cell Tumor Involving in Medial Rectus and Optic Nerve

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Chinese Medical Journal 2017年第13期130卷 1627-1628页

作者： Guo-Yuan Yang Wei-Min He Department of Ophthalmology West China Hospital Sichuan University Chengdu Sichuan 610041 China

To the Editor： Here, we present a rare case whose medial rectus and optic nerve in the left eye are both affected by intraorbital granular cell tumor （GCT）. Macroscopic size of the mass was around 4.3 cm×2.2 cm ×... 详细信息

关键词： Granular Cell Tumor Involving Medial Rectus Optic Nerve

Challenges and Responses of Left-Behind Elderly and Children in Rural China Amid the New Population Development Stage

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China CDC weekly 2023年第27期5卷 609-613页

作者： Dianqi yuan Peisen yang Hanbing yang Huameng Tang Chao guo Institute of Population Research Peking UniversityBeijingChina APEC Health Science Academy Peking UniversityBeijingChina

The disparate economic growth in China has compelled numerous adults from rural areas to migrate to cities in search of more lucrative employment prospects(1).In the 7th National Census,it was reported that the floating population totaled 375,816,759,accounting for approximately 26.00%of the overall population.Such migratory patterns often result in leaving behind vulnerable groups,particularly children and older adults,in rural regions.Given the inadequately established care systems,these groups are particularly susceptible and have consistently been at the forefront of social security concerns in China(2).

关键词： Population Rural floating

Damage behavior of the KKV direct hit against fluid-filled submunition payload

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Defence Technology（防务技术） 2022年第11期18卷 2052-2064页

作者： yang Zan Hai-fu Wang yuan-feng Zheng Huan-guo guo State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China

The damage effects of fluid-filled submunition payload impacted by the kinetic kill vehicle(KKV)are investigated by simulations and ground-based experiments.Numerical simulations showed that the damage level and number of submunitions were significantly influenced by the diameter of the KKV compared with its length.Based on that,a high velocity penetrator formed by shaped charge explosion was used to simulate the direct hit experiment of a KKV impacting submunition payload.Experimental results demonstrated that the damage modes of submunitions mainly included the slight damage,perforation and total smash,showing a good agreement with the simulations.To understand the multiple damage modes of submunitions,the damage behavior of the submunitions in direct hit process were analyzed based on the AUTODYN-3D code.Numerical results presented that increased KKV diameter can increase the crater diameter and expand the damage volume,which will achieve a higher direct hit lethality.Further analysis indicated that there were other mechanical behaviors can enhance the damage to submunitions not lying in the KKV flight path,such as secondary debris kill,neighboring submunitions collision with each other,and high-speed fluid injection effect.

关键词： Kinetic kill vehicle Tactical ballistic missiles Submunition payload Direct hit Damage behavior

Weill-Marchesani-like syndrome caused by an FBN1 mutation with low-penetrance

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Chinese Medical Journal 2021年第11期134卷 1359-1361页

作者： Guo-Yuan Yang Xi Huang Bing-Jie Chen Zhu-Ping Xu Department of Ophthalmology West China HospitalSichuan UniversityChengduSichuan 610041China

Weill-Marchesani syndrome(WMS)is a rare connective tissue disorder characterized by brachydactyly,short stature,joint stiffness,cardiovascular abnormalities,and eye anomalies including microspherophakia,cataracts,ectopia lentis,myopia,and secondary glaucoma.Patients with incomplete WMS signs are diagnosed with Weill-Marchesani-like syndrome(WMS-like).To date,both autosomal dominant(AD)and autosomal recessive(AR)inheritance modes have been reported for WMS.Genetic heterogeneity inWMSsuggests a connection between these genes.AR and AD WMS cannot be distinguished clearly by clinical findings alone.[1]Furthermore,inter-familial as well as intra-familial clinical variability due to different fibrillin-1 gene(FBN1)mutations also exists.

关键词： clinical cardiovascular cataract

Advancement in stroke research

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Stroke & Vascular Neurology 2019年第2期4卷 61-62页

作者： Guo-Yuan Yang Neuroscience and Neuroengineering Center Med-X Research Institute and School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghaiChina

Stroke is the second most common cause of death in the world especially in the ageing population.1 Thrombolysis and intravascular embolectomy are the main treatment and populated rapidly.23 However,the benefi-ciary is still limited because the mechanistic studies are behind.The basic research on stroke is improved because of new devices,novel techniques and the development of other disciplines.4 The update of a broad range of topics related to stroke is a widely appreciated feature.In order to improve the understanding of cellular and molecular mechanisms of stroke,the 2nd Summit of Chinese Basic Science Research on Stroke 2018 has been held in Beijing,China.

关键词： population. death intravascular

Deposition of TiN/TiAlN multilayers by plasma-activated EB-PVD:tailored microstructure by jumping beam technology

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Rare Metals 2017年第8期36卷 651-658页

作者： Guo-Yuan Yang Hui Peng Hong-Bo guo Sheng-Kai Gong School of Materials Science and Engineering Beihang UniversityBeijing 100191China Beijing Key Laboratory for Advanced Functional Material and Thin Film Technology Beihang UniversityBeijing 100191China Key Laboratory of Aerospace Materials and Performance(Ministry of Education) Beihang UniversityBeijing 100191China

Plasma-activated electron beam-physical vapor deposition（EB-PVD）was used for depositing nitride multilayer coatings in this work.Different from the conventional coating methods,the multilayers were obtained by manipulating electron beam（EB）to jump between two different evaporation sources alternately with variable frequencies（jumping beam technology）.The plasma activation was generated by a hollow cathode plasma unit.The deposition process was demonstrated by means of tailoring TiN/TiAlN multilayers with different modulation periods（M1：26.5 nm,M2：80.0 nm,M3：6.0 nm,M4：4.0 nm）.The microstructure and hardness of the multilayer coatings were comparatively studied with TiN and TiAlN singlelayer coatings.The columnar structure of the coatings（TiN,TiAlN,M1,M2）is replaced by a glassy-like microstructure when the modulation period decreases to less than 10 nm（M3,M4）.Simultaneously,superlattice growth occurs.With the decrease of modulation period,both the hardness and the plastic deformation resistance（H^3/E^2,H-hardness and E-elastic modulus）increase.M4coating exhibits the maximum hardness of（49.6±2.7）GPa and the maximum plastic deformation resistance of^0.74 GPa.

关键词： Nano-multilayer coatings Superlattice Plasmaactivation TiN/TiAlN EB-PVD Hardness

Arterial stiffness and stroke:de-stiffening strategy,a therapeutic target for stroke

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Stroke & Vascular Neurology 2017年第2期2卷 65-72页

作者： Yajing Chen Fanxia Shen Jianrong Liu Guo-Yuan Yang Department of Neurology Ruijin Hospital and Ruijin Hospital NorthShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Neuroscience and Neuroengineering Center Med-X Research Institute and School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghaiChina

Stroke is the second leading cause of mortality and morbidity worldwide.Early intervention is of great importance in reducing disease burden.Since the conventional risk factors cannot fully account for the pathogenesis of stroke,it is extremely important to detect useful biomarkers of the vascular disorder for appropriate intervention.Arterial stiffness,a newly recognised reliable feature of arterial structure and function,is demonstrated to be associated with stroke onset and serve as an independent predictor of stroke incidence and poststroke functional outcomes.In this review article,different measurements of arterial stiffness,especially pressure wave velocity,were discussed.We explained the association between arterial stiffness and stroke occurrence by discussing the secondary haemodynamic changes.We reviewed clinical data that support the prediction role of arterial stiffness on stroke.Despite the lack of long-term randomised double-blind controlled therapeutic trials,it is high potential to reduce stroke prevalence through a significant reduction of arterial stiffness(which is called de-stiffening therapy).Pharmacological interventions or lifestyle modification that can influence blood pressure,arterial function or structure in either the short or long term are promising de-stiffening therapies.Here,we summarised different de-stiffening strategies including antihypertension drugs,antihyperlipidaemic agents,chemicals that target arterial remodelling and exercise training.Large and well-designed clinical trials on de-stiffening strategy are needed to testify the prevention effect for stroke.Novel techniques such as modern microscopic imaging and reliable animal models would facilitate the mechanistic analyses in pathophysiology,pharmacology and therapeutics.

关键词： therapeutic prevention stiffness

Aperture shape optimization in intensity-modulated radiation therapy planning

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Nuclear Science and Techniques 2023年第9期34卷 106-117页

作者： Li-yuan Zhang Zhi-guo Gui Peng-Cheng Zhang Jie yang Shanxi Provincial Key Laboratory for Biomedical Imaging and Big Data North University of ChinaTaiyuan 030051China School of Medicine Management Shanxi University of Chinese MedicineTaiyuan 030619China

The gradient element of the aperture gradient map is utilized directly to generate the aperture shape without modulation.This process can be likened to choosing the direction of negative gradient descent for the generic aperture shape optimiza-tion.The negative gradient descent direction is more suitable under local conditions and has a slow convergence rate.To overcome these limitations,this study introduced conjugate gradients into aperture shape optimization based on gradient modulation.First,the aperture gradient map of the current beam was obtained for the proposed aperture shape optimiza-tion method,and the gradients of the aperture gradient map were modulated using conjugate gradients to form a modulated gradient map.The aperture shape was generated based on the modulated gradient map.The proposed optimization method does not change the optimal solution of the original optimization problem,but changes the iterative search direction when generating the aperture shape.The performance of the proposed method was verified using cases of head and neck cancer,and prostate cancer.The optimization results indicate that the proposed optimization method better protects the organs at risk and rapidly reduces the objective function value by ensuring a similar dose distribution to the planning target volume.Compared to the contrasting methods,the normal tissue complication probability obtained by the proposed optimization method decreased by up to 4.61%,and the optimization time of the proposed method decreased by 5.26%on average for ten cancer cases.The effectiveness and acceleration of the proposed method were verified through comparative experiments.According to the comparative experiments,the results indicate that the proposed optimization method is more suitable for clinical applications.It is feasible for the aperture shape optimization involving the proposed method.

关键词： Aperture shape Column generation Conjugate gradient Gradient modulation Direct aperture optimization

Chinese Medicine as Supporting Therapy for Psoriasis:Past,Present,and Future

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Chinese Journal of Integrative Medicine 2023年第3期29卷 280-288页

作者： yang Xue-yuan CAI Wan-ling guo Chen-lu CHEN Qi-hua Department of Andrology The First Affiliated Hospital of Hunan University of Chinese MedicineChangsha(410007)China Post-graduate School Hunan University of Chinese MedicineChangsha(410208)China Department of Dermatology Shuguang HospitalShanghai University of Chinese MedicineShanghai(201203)China

Psoriasis is a chronic skin disease and an important health concern.Western medicine and therapies are the main treatment strategies for psoriasis vulgaris(PV);however,the overall prognosis of patients with PV is still poor.Therefore,PV prevention is especially crucial.Chinese medicine(CM)has a long history of treating psoriasis,and it has unique wisdom in different cognitive angles and treatment modes from modern medicine.In this review,we first summarized the herbs and ancient CM formulas that have therapeutic effects on PV.Second,the research status and obstacles to the current development of CM in modern medicine were reviewed.Finally,the future of CM in the context of precision medicine and integrated medicine was discussed.After a detailed reading of the abundant literature,we believe that CM,through thousands of years of continuous development and clinical practice,has achieved high effectiveness and safety for PV treatment,despite its surrounding controversy.Moreover,precise analyses and systematic research methods have provided new approaches for the modernization of CM in the future.The treatment of PV with CM is worth popularizing,and we hope it can benefit more patients.

关键词： Chinese medicine psoriasis vulgaris molecular mechanism network pharmacology Chinese herbal medicine