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Characterization of a pangolin SARS-CoV-2-related virus isolate that uses the human ACE2 receptor

Science China(life Sciences) 2024年第7期67卷 1502-1513页

作者： Luo-yuan Xia Xue-Feng Wang Xiao-Ming Cui Yi-Ming Zhang Zhen-Fei Wang En-Tao li Chang-Fa Fan Ke Song yuan-guo li Run-Ze Ye Fang-Xu li Dai-Yun Zhu Jie Zhang Zhuang-Zhuang Shi Ming-Zhu Zhang liang-Jing li Shi-Jing Shen Song Jin Ya-Wei Zhang Wei-Guang Fu lin Zhao Wen-Hao Wang Tie-Cheng Wang You-Chun Wang Jia-Fu Jiang Yan-ling Hu Na Jia Yu-Wei Gao Wu-Chun Cao Institute of EcoHealth School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012China Changchun Veterinary Research Institute Changchun 130122China State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing 100071China Division of Animal Model Research Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug ControlBeijing 102629China National Institutes for Food and Drug Control Beijing 102629China life Sciences Institute Guangxi Medical UniversityNanning 530020China College of life Sciences Shandong Normal UniversityJinan 250014China Research Unit of Discovery and Tracing of Natural Focus Diseases Chinese Academy of Medical SciencesBeijing 100071China

Various SARS-CoV-2-related coronaviruses have been increasingly identified in pangolins,showing a potential threat to *** we report the infectivity and pathogenicity of the SARS-CoV-2-related virus,PCoV-GX/P2V,which was isolated from a Malayan pangolin(Manis javanica).PCoV-GX/P2V could grow in human hepatoma,colorectal adenocarcinoma cells,and human primary nasal epithelial *** replicated more efficiently in cells expressing human angiotensin-converting enzyme 2(hACE2)as SARS-CoV-2 *** intranasal inoculation to the hACE2-transgenic mice,PCoV-GX/P2V not only replicated in nasal turbinate and lungs,but also caused interstitial pneumonia,characterized by infiltration of mixed inflammatory cells and multifocal alveolar *** population immunity established by SARS-CoV-2 infection and vaccination may not protect people from PCoV-GX/P2V *** findings further verify the hACE2 utility of PCoV-GX/P2V by in vivo experiments using authentic viruses and highlight the importance for intensive surveillance to prevent possible cross-species transmission.

关键词： pangolin SARS-CoV-2-related virus infectivity pathogenicity human cell lines human ACE2 receptor hACE2-transgenic mice

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基于BaGa_(4)Se_(7)晶体的中红外辐射源稳定性实验研究

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激光与红外 2024年第5期54卷 685-691页

作者：李楠李惟帆祁峰姚吉勇郭丽媛路远沈阳航空航天大学电子信息工程学院辽宁沈阳110136 辽宁省太赫兹成像感知重点实验室辽宁沈阳110169 中国科学院沈阳自动化所光电信息处理重点实验室辽宁沈阳110069 中国科学院机器人与智能制造创新研究院辽宁沈阳110169 中国科学院理化技术研究所北京100190

在实际应用中,光源的输出能量稳定性影响着光源在各种应用中的可靠性和性能,如激光治疗、光谱分析、光电对抗以及光成像等领域。本文首先对光学参量振荡器(OPO)系统从激光泵浦源、谐振腔结构和非线性晶体三个方面对输出能量稳定性进行... 详细信息

在实际应用中,光源的输出能量稳定性影响着光源在各种应用中的可靠性和性能,如激光治疗、光谱分析、光电对抗以及光成像等领域。本文首先对光学参量振荡器(OPO)系统从激光泵浦源、谐振腔结构和非线性晶体三个方面对输出能量稳定性进行分析。实验方面,使用BaGa_(4)Se_(7)(BGSe)晶体搭建脉冲激光泵浦的3~8μm中红外OPO辐射源,从激光泵浦源和OPO系统两部分对输出能量波动性进行了详细的测量和分析。当输入泵浦能量为30 mJ,正入射输出4.5μm波长时,平均能量为2.151 mJ,标准差为56.49μJ,计算RMS波动为2.62%。根据分析得出,随着激光增益的提高和腔损耗的减小,输出脉冲的波动减小。该研究为不同应用场景下BGSe晶体的红外辐射源的工作参数的选择提供了有益的指导。

关键词：中红外激光 BaGa 4Se 7 光参量振荡器稳定性方均根波动

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种子注入式太赫兹波参量产生源研究

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激光与红外 2024年第6期54卷 858-863页

作者：路远李惟帆祁峰姚吉勇郭丽媛李楠沈阳航空航天大学电子信息工程学院辽宁沈阳110136 辽宁省太赫兹成像感知重点实验室辽宁沈阳110169 中国科学院沈阳自动化所光电信息处理重点实验室辽宁沈阳110169 中国科学院机器人与智能制造创新研究院辽宁沈阳110169 中国科学院理化技术研究所北京100190

种子注入式太赫兹波参量产生源(is-TPG)基于非线性晶体中的受激电磁偶子散射,具有线宽窄、相干性好、室温运转、可调谐等优点。本文基于5%摩尔百分比氧化镁掺杂的同成分铌酸锂晶体(MgO:CLN),对连续/脉冲种子注入式太赫兹波参量产生源(is... 详细信息

种子注入式太赫兹波参量产生源(is-TPG)基于非线性晶体中的受激电磁偶子散射,具有线宽窄、相干性好、室温运转、可调谐等优点。本文基于5%摩尔百分比氧化镁掺杂的同成分铌酸锂晶体(MgO:CLN),对连续/脉冲种子注入式太赫兹波参量产生源(is/ips-TPG)调谐范围、输出能量、阈值等方面进行了研究。相比于is-TPG系统,ips-TPG系统调谐范围范围扩大约80%。is-TPG系统与ips-TPG系统3dB带宽分别为1THz与1.41THz,占各自调谐范围的51%和39%。ips-TPG系统相比is-TPG系统3dB带宽范围扩大了41%。在相近的平均功率密度下,由于ips-TPG具有更高的峰值功率密度降低了阈值,产生了更强的THz波输出,最大转换效率为1.01×10^(-5)。不同形式种子光的注入对太赫兹波参量辐射源有着显著的影响,实验结果表明ips-TPG系统的输出特性更为突出在实际应用中具有更高的价值。本文最后对其未来发展进行了分析和展望。

关键词：太赫兹参量辐射源种子注入非共线相位匹配受激电磁耦子

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Three-dimensional finite element analysis of hyperbaric oxygen therapy on the optic nerve from a damaged orbit

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Neural Regeneration Research 2011年第29期6卷 2290-2294页

作者： yuan guo Yanjun li Weiyi Chen Meiwen An Institute of Applied Mechanics and Biomedical Engineering Taiyuan University of Technology Taiyuan 030024 Shanxi Province China

A middle-aged male patient with a right orbital comminuted fracture underwent computer tomography scanning, and a three-dimensional finite element model of the eyes and relevant tissues was established. Optic nerve stress in a hyperbaric oxygen environment was simulated and analyzed by changing the elastic modulus and external pressure of the skull at the damage side. Results showed that stress maximized at the contact site of the optic nerve and the eyeball in the damaged and intact eye orbits. Optic nerve stress at the damaged orbit significantly increased; however, stress in the intact orbit only slightly changed with decreased elastic modulus of the skull while external pressure remained unchanged. Maximum optic nerve stress increased in the damaged and intact side, along with increased external pressure, while elastic modulus remained unchanged. These experimental findings suggested that the optic nerve was compressed under hyperbaric oxygen and optic nerve stress was greater in the damaged orbit than in the intact orbit.

关键词： computer tomography digital medicine eye orbit finite element model hyperbaric oxygen optic nerve neural regeneration

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A New Route for Synthesis of Entecavir

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Chinese Chemical Letters 2006年第7期17卷 907-910页

作者： li Wei guo yuan Jing XIAO li Ping YANG Department of chemistry East China Normal University Shanghai 200062

A new economical synthetic route of the key intermediate 6. The synthesis of a modified Mitsunobu reaction. of entecavir was presented, involving the preparation 6 was conveniendy achieved in good overall yield by a m... 详细信息

关键词： Entecavir new route synthesis.

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Accelerating Effect of Wetting-Drying Cycles on Steel Bar Corrosion in Concrete

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Journal of China University of Mining and Technology 2005年第3期15卷 197-202页

作者： li guo yuan Ying-shu li Fu-min School of Architecture and Civil Engineering China University of Mining and Technology Xuzhou Jiangsu 221008 China

Raining and sun-shining processes in natural climate were simulated by water spraying and infrared lightshining alternately as wetting-drying cycles in accelerated durability test. The accelerating effects of the wet-ting-drying cycles and the variation of corrosion current density and corrosion potential of steel bar in concrete undersuch conditions were studied. The result shows that the main reason leading to accelerating corrosion of steel bar inconcrete is the wetting-drying cycles, which can cause the increase of corrosion potential difference between the an-ode and cathode of steel bar corrosion cell and the decrease of concrete resistance. Corrosion rate of the steel bar inconcrete under four typical conditions, including wetting-drying cycle, long time submerging in water, long time ex-posure to indoor and outdoor environment were measured and compared. The test results indicate that the corrosionrates under the four typical conditions are in the order of spraying and infrared light shining cycles, outdoor environ-ment, indoor environment, and submerging in water, respectively.

关键词： wetting-drying cycle concrete steel bar corrosion rate

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Double-confined nanoheterostructure Sb/Sb_(2)S_(3)@Ti_(3)C_(2)T_(x)@C toward ultra-stable li-/Na-ion batteries

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Rare Metals 2024年第5期43卷 2067-2079页

作者： Dan Wang Qun Ma Huan He Zhi-yuan Wang Run-guo Zheng Hong-Yu Sun Yan-guo liu Chun-li liu School of Materials Science and Engineering Northeastern UniversityShenyang110819China School of Resources and Materials Northeastern University at QinhuangdaoQinhuangdao 066004China Key Laboratory of Dielectric and Electrolyte Functional Material Hebei Province Qinhuangdao 066004China Department of Physics and Oxide Research Center Hankuk University of Foreign StudiesYongin 17035Korea

Antimony-based materials with high capacities and moderate potentials are promising anodes for lithium-/-sodium-ion ***,their tremendous volume expansion and inferior conductivity lead to poor structural stability and sluggish reaction ***,a doubleconfined nanoheterostructure Sb/Sb_(2)S_(3)@Ti_(3)C_(2)T_(x)@C has been fabricated through a solvothermal method followed by low-temperature heat *** dual protection of“MXene”and“carbon”can better accommodate the volume expansion of Sb/Sb_(2)S_(3).The strong covalent bond(Ti-S,Ti-O-Sb,C-O-Sb)can firmly integrate Sb-based material with Ti_(3)C_(2)T_(x)and carbon,which significantly improves the structure *** addition,the carbon layer can restrain the oxidation of MXenes,and the nano-Sb/Sb_(2)S_(3)can facilitate electron/ion transport and suppress the restacking of *** heterogeneous interface between Sb and Sb_(2)S_(3)can further promote interfacial charge *** MXene-Sb/Sb_(2)S_(3)@C-1 with the optimal Sb content shows high specific capacities,comparable rate properties and ultra-stable cycling performances(250 m Ah·g^(-1)after 2500 cycles at 1 A·g^(-1)for sodium-ion batteries).Ex situ X-ray diffractometer(XRD)test reveals the storage mechanism including the conversion and alloying process of MXene-Sb/Sb_(2)S_(3)@*** voltammetry(CV)test results demonstrate that the pseudocapacitance behavior is dominant in MXene-Sb/Sb_(2)S_(3)@C-1,especially at large *** design paves the way for exploring high-performance alloy-based/conversion-type anode for energy storage devices.

关键词： Sb/Sb_(2)S_(3) MXene Carbon Anode lithium-ion batteries Sodium-ion batteries

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Hydrothermal Synthesis, Characterization and Magnetic Properties of Rare Earth Iron Garnets Sm_3Fe_5O_(12) and Eu_3Fe_5O_(12)

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Chemical Research in Chinese Universities 2011年第5期27卷 715-719页

作者： guo li yuan Hong-ming HUANG Ke-ke yuan lin liU Shao-kong FENG Shou-hua State Key Laboratory of Inorganic Synthesis ＆ Preparative Chemistry College of Chemistry Jilin University Changehun 130012 P. R. China

The rare earth iron garnets R3Fe5O12（R=Sm, Eu） were synthesized under mild hydrothermal conditions, and their crystal growth was found to be sensitive to alkalinity, reaction temperature and time. The as-prepared samples were characterized by powder X-ray diffraction（XRD）, scanning electron microscopy（SEM）, infrared spectra（IR） and Raman spectrum. The M vs. H loops and magnetic parameters have been traced with a vibrating sample magnetometer（VSM） and superconducting quantum interference devices（SQUIDs） magnetometer. We proposed the formation mechanisms and formulated a reasonable explanation for their growth habits. Different morphologic characteristics were observed by changing alkalinity in the reaction systems. The magnetic studies gave saturation magnetization（Ms） and Curie temperature（TC）. The magnetic behaviors of Sm3Fe5O12 and Eu3Fe5O12 in mild hydrothermal systems are comparable with those in high temperature solid state reactions.

关键词： Rare earth iron garnet Hydrothermal synthesis Magnetism

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Facile synthesis of hypercrosslinked resin via photochlorination of p-xylene and succedent alkylation polymerization

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Chinese Chemical Letters 2011年第9期22卷 1115-1118页

作者： ling ling Bai Yong Hao Zhou Xiu li Wang Si guo yuan Xian li Wu School of Chemical Engineering and Energy Zhengzhou University Zhengzhou 450001 China

A combination of photochlorination ofp-xylene and succedent Friedel-Crafts alkylation polymerization was firstly used in the preparation of the hypercrosslinked adsorptive resin. The data of GC-MS and GC showed that a series of chlorizates were produced when p-xylene was photochlorinated. Hypercrosslinked resins could be synthesized by copolymerization, self-polymerization of chlorizates or post crosslinking reaction. The chemical structure and micromorphology of the porous resins were characterized by BET, FF-IR, SEM and elementary analysis （EA）. The results showed that the novel adsorptive resins possess high BET surface near to 1038 m^2/g and large pore volumes range from 0.5 to 1.2 cm^3/g.

关键词： Hypercrosslinked resin Synthesis p-Xylene Photochlorination Polymerization

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PARALLEL IMPLEMENTATION AND OPTIMIZATION OF THE SEBVHOS ALGORITHM

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Journal of Electronics(China) 2011年第3期28卷 277-283页

作者： li Wen guo li yuan Hongxing Wei Yifang Guan Hua Deptartmen of Electronic Science and Technology University of Science and Technology of China Hefei 230027 China

In this paper, a parallel Surface Extraction from Binary Volumes with Higher-Order Smoothness (SEBVHOS) algorithm is proposed to accelerate the SEBVHOS execution. The original SEBVHOS algorithm is parallelized first, and then several performance optimization techniques which are loop optimization, cache optimization, false sharing optimization, synchronization overhead op-timization, and thread affinity optimization, are used to improve the implementation's performance on multi-core systems. The performance of the parallel SEBVHOS algorithm is analyzed on a dual-core system. The experimental results show that the parallel SEBVHOS algorithm achieves an average of 1.86x speedup. More importantly, our method does not come with additional aliasing artifacts, com-paring to the original SEBVHOS algorithm.

关键词： Multi-core Parallel algorithm Performance optimization 3D reconstruction

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