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Imprinted Human Serum Albumin with Antioxidant Activity

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Chemical Research in Chinese Universities 2011年第2期27卷 258-263页

作者： SHEN Na YAN Fei guo Yi LU Shao-wu GONG Ping-sheng XU Ya-wei YAN Gang-lin mu ying LUO Gui-min Key Laboratory of Molecular Enzymology and Engineering Ministry of Education College of Life Science Jilin University Changchun 130012 P. R. China State Key Laboratory of Industrial Control Technology Research Center for Analytical Instrumentation Institute of Cyber-Systems and Control Zhejiang University Hangzhou 310058 P. R. China

In order to create a new mimic of glutathione peroxidase（GPx）, bioimprinting was used to generate gluta-thione（GSH） binding site and chemical modification was used to incorporate catalytic group selenocystine（Sec）. Human serum albumin（HSA） and S-substituted dinitrophenyl glutathione（GSH-S-DNP） were chosen as the imprinted matrix and imprinting template, respectively, to generate a GSH-imprinted protein（GSH-HSA） by bioimprinting. Sec was incorporated into the GSH-HSA by chemical modification to give a new GPx mimic（Se-GSH-HSA）. Se-GSH-HSA displayed considerably higher GPx activity than non-printed HSA（Se-HSA）. The enzymic properties and kinetics of Se-GSH-HSA were studied. Moreover, Se-GSH-HSA was confirmed to have stronger antioxidant ability to protect mitochondria against oxidative damage with ferrous sulfate/ascorbate-induced mitochondria damage model, indicating that Se-GSH-HSA has potential application in medicine.

关键词： Antioxidant Enzyme mimic Glutathione peroxidase Molecular imprinting

The IAMAS-CNC Early Career Scientists Nobel Prize Online Interpretation Workshop

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Advances in Atmospheric Sciences 2022年第6期39卷 1012-1015页

作者： Jing LI Zhongjing JIANG Yueming DONG Lu ZHANG Tong ying Zhenyu ZHANG mu mu Department of Atmospheric and Oceanic Sciences School of PhysicsPeking UniversityBeijing 100871China Department of Atmospheric and Oceanic Sciences Fudan UniversityShanghai 200438China

*** The 2021 Nobel Prize for Physics was awarded to three scientists for their contribution to the physical understanding of complex systems(The Nobel Committee for Physics,2021).Two of the laureates,*** MANABE and *** HASSELMANN,are climate *** is the first time a climate scientist has won a Nobel Prize for physics and is thus a great encouragement to the entire climate science community,especially young *** the two winners'groundbreaking contributions that led to their award were achieved decades ago,young people may not be very familiar with these ***,to help young scientists better understand the scientific merit of the fundamental works and to inspire them in their future research careers,on 20 October 2021,the young scientist working group of The China National Committee of the International Association of Meteorology and Atmospheric Sciences(IAMAS-CNC)organized an online Nobel Prize interpretation *** 400 participants attended the online workshop,and more than 120000 parti-cipants watched the replay.

关键词： Nobel breaking young

A New Mathematical Model for Description of the Liquid Discrete Flow Within a Packed Bed

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Journal of Iron and Steel Research International 2008年第6期15卷 16-23页

作者： WANG Cheng-shan mu Xiao-jing ZHENG Shao-bo JIANG guo-chang XIAO Xing-guo College of Materials Science and Engineering Chongqing University Chongqing 400044 China College of Chemistry and Chemical Engineering Chongqing University Chongqing 400044 China State Enhance Laboratory of Ferro Metallurgy Shanghai University Shanghai 200072 China School of Materials and Metallurgy Northeastern University Shenyang 110004 Liaoning China

The molten liquid discrete flow inside a packed bed is a typical transport phenomenon in the blast furnace. As for the reported mathematical models presenting the liquid discrete flow within the packed bed, there are some barriers for their application to an engineering scale-up, or some imperfections in model descriptions. To overcome these deficiencies, the effects of the packed bed on the liquid discrete flow have been divided into resistance action and dispersal action, and appropriate descriptions have been given for the two aetions, respectively. Consequently, a new mathematical model has been built to present the liquid discrete flow inside a coke bed in the blast furnace. The mathematical model can predict the distribution of liquid flux and the liquid flowing range inside the packed bed at any time. The prediction of this model accords well with the experimental data. The model will be much better for the simulation of the ironmaking process, compared with the existent model.

关键词： mathematical model liquid discrete flow packed bed blast furnace ironmaking process

High-strength antiswelling adhesive achieves both hemostasis and wound healing

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Journal of Pharmaceutical Analysis 2024年第6期14卷 781-784页

作者： Xin Zhao Jinlong Luo ying Huang Lei mu Jueying Chen Zhen Liang Zhanhai Yin Dake Chu Yong Han Baolin guo State Key Laboratory for Mechanical Behavior of Materials Frontier Institute of Science and TechnologyXi'an Jiaotong UniversityXi'an710049China Department of Plastic Surgery Xijing HospitalAir Force Medical UniversityXi'an710032China Department of Orthopaedics The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an710061China Department of Gastroenterology The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an710061China Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of StomatologyXi'an Jiaotong UniversityXi'an710049China

Skin is one of the most vulnerable tissues,but there is a lack of injectable bioactive hydrogel dressings,which possess high strength,antiswelling capacity,and wet tissue adhesiveness,but also a rapid gelling process to enable rapid hemostasis,sutureless wound closure,and scarless healing of infected skin wounds[1e5].A new injectable,antibacterial,and multifunctional hydrogel dressings based on poly(citric acid-co-polyethylene glycol)-g-dopamine(PCPD)and amino-terminated Pluronic F127(APF)mi-celles loaded with astragaloside IV(AS)was developed for this pur-pose,as shown in Fig.1A[6].

关键词： healing wound stasis

Selective construction of molecular Solomon links and figure-eight knots by fine-tuning unsymmetrical ligands

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Science China Chemistry 2023年第10期66卷 2885-2891页

作者： Qiu-Shui mu Xiang Gao Zheng Cui Yue-Jian Lin guo-Xin Jin State Key Laboratory of Molecular Engineering of Polymers Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsDepartment of ChemistryFudan UniversityShanghai 200433China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

Using the strategy of ligand fine-tuning by steric hindrance, we successfully obtained Solomon links(4_(1)^(2)) and figure-eight knots(4_(1)) with half-sandwich organometallic unit and amino-acid embedded ligands. The two curved bidentate ligands exhibit subtle differences, whereas they result in totally distinct entanglement modes. An alcoholysis reaction with the ligands leads to the formation of a molecular tweezer. Notably, unsymmetrical ligands were utilized in the self-assembly process to explore the formation of directional molecules, and the reactions exhibited selectivity due to comprehensive π interactions and multiple hydrogen bonds. The topologies and behavior of the above structures were confirmed through single-crystal X-ray diffraction,nuclear magnetic resonance techniques and mass spectrometry.

关键词： interlocked molecule figure-eight knot solomon link supramolecular self-assembly

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A Statistical Examination on the Compensation between the Enthalpies and Entropies Obtained from the Calorimetric Methods

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Chinese Chemical Letters 2001年第2期12卷 167-170页

作者： Lei LIU Chao YANG Ting Wei mu Qing Xiang guo Department of Chemistry University of Science and Technology of ChinaHefei 230026 Department of Chemistry Columbia UniversityNew YorkNY 10027

The validity of the compensation between the enthalpies and entropies obtained from the calorimetric methods was statistically examined for the first time based on computer simulations. It turned out that several claimed enthalpy-entropy compensations in literature based upon the calorimetric measurements were statistically correct. Interestingly, a linear relationship between the slopes and correlation coefficients of the T DeltaS-DeltaH plots of different physical origin of the compensation behavior.

关键词： Calorimetry enthalpy-entropy compensation molecular recognition solvent reorganization statistics

On the Structure of the Arginine-carboxylate Salt Bridge:A Density Functional Theory Study

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Chinese Chemical Letters 2001年第3期12卷 219-222页

作者： Ting Wei mu Yong FENG Lei LIU Qing Xiang guo Department of Chemistry University of Science and Technology of ChinaHefei 230026

High level density functional theory (DFT) calculations are performed for the first time to answer the question whether the arginine-carboxylate salt bridge stays in a zwitterionic state or a neutral one. The results indicate that in the gas phase, the neutral form is more stable and hence proton transfer occurs from guanidinium to carboxylate. However, in an aqueous solution the zwitterionic form should be favored. The difference might he caused by the electrostatic interaction between the salt bridge and its molecular environment. Therefore, the solvation effect has to be considered in the modeling of proteins, whose stabilization depends heavily on the salt-bridges.

关键词： Arginine-carboxylate interaction salt bridge DFT proton transfer solvation effect

Bibliometric study of research and development for neglected diseases in the BRICS

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Infectious Diseases of Poverty 2016年第1期5卷 810-819页

作者： Jing Bai Wei Li Yang-mu Huang Yan guo School of Public Health Peking University Health Science CenterXueyuan Road 38Haidian DistrictBeijing 100191China Peking University Health Science Library Xueyuan Road 38Haidian DistrictBeijing 100191China

Background:Large numbers of people are suffering from a group of diseases that mainly affect developing countries,as there are no available or affordable products for prevention or *** and development(R&D)for these diseases is still a low priority on the health ***,Russia,India,China and South Africa(BRICS)are quickly growing economies and having more and more positive impact on global ***,their R&D capacity is believed to be enhanced through decades of investment in education and life science *** BRICS,as a group of emerging and developing countries,are expected to make greater contributions to solving the problem that mainly affects the entire developing countries ***,there has been little research to provide a macroscopic overview of BRICS’effort in R&D for neglected *** aim of this study is to investigate scientific production in BRICS countries in this area and their main research ***:Global relevant literature was searched without time limits through PubMed and high yield countries were identified using *** up to the end of 2013 from the BRICS was obtained and high frequency words were extracted and clustered using Bibliography Item Co-occurrence Mining System 2.0(BICOMS)and Graphical Clustering Toolkit 1.0(gCLUTO).Results:In total,32,47,51,31 and 44 high frequency words from Brazil,Russia,India,China and South Africa respectively were extracted for clustering *** clustering indicated that eight diseases were research hotspots in BRICS *** had the most extensive hotspots and Brazil came in *** other three countries shared common research foci:helminthiasis,Human Immunodeficiency Virus infection and Acquired Immune Deficiency Syndrome(HIV/AIDS)and ***:Developed countries still make the majority of contributions to R&D on neglected diseases,but BRICS countries are playing a growing *** of the“big three di

关键词： Neglected diseases Research and development BRICS Bibliometric analysis

Leaching behavior of zinc and copper from zinc refinery residue and filtration performance of pulp under the hydrothermal process

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International Journal of Minerals,Metallurgy and Materials 2019年第1期26卷 21-32页

作者： Lei Cao Ya-long Liao Gong-chu Shi Yu Zhang mu-yuan guo Faculty of Metallurgical and Energy Engineering Kunming University of Science and Technology

This study aims to investigate the leaching behavior and filtration performance of zinc refinery residue under hydrothermal conditions. The relationships between the structure and morphology of silicon in the leaching residue and the pulp filtration performance were explored by determining the pulp filtration speed, analyzing quantitatively the silicon content in the leachate, and characterizing the leaching residue structure. The results show that hydrothermal leaching induces the coagulation–hydrolysis of the silicon in solution, consequently altering the microstructure of the leaching residue, and that silicon oxygen tetrahedra([SiO_4]^(4-)) form the main skeleton structure of the residue. The results obtained also show that the leaching rates of zinc and copper are 98.1% and 98.7%, respectively, and that the filtration speed is 526.32 L/(m^2·h) under the conditions of sulfuric acid concentration of 140 g/L, leaching temperature of 160°C, leaching time of 3.0 h, oxygen partial pressure of 0.75 MPa, stirring speed of 600 r/min, and a liquid-to-solid ratio of 10 mL/g.

关键词： zinc refinery residue hydrothermal leaching filtration performance mesoporous structure