检索结果-南通市图书馆

结合逐步敲入策略与制剂工艺过程的肾宝片复杂成分辨识

在线全文

学校读者我要写书评

暂无评论

中草药 2021年第14期52卷 4162-4175页

作者：陆萌贾晓斌郭舒臣易欢段龙强耿炤封亮中国药科大学中药学院江苏南京211198 江西汇仁药业股份有限公司技术中心江西南昌330052

目的结合肾宝片处方22味药材组成及其制剂工艺过程,阐明肾宝片提取物(浸膏)的化学成分,为肾宝片质量控制提供依据。方法采用UPLC分别建立浸膏1与浸膏2的指纹图谱,将浸膏1、2成分与全浸膏对应,按照浸膏1、2逐步敲入的方式,验证全浸膏中... 详细信息

目的结合肾宝片处方22味药材组成及其制剂工艺过程,阐明肾宝片提取物(浸膏)的化学成分,为肾宝片质量控制提供依据。方法采用UPLC分别建立浸膏1与浸膏2的指纹图谱,将浸膏1、2成分与全浸膏对应,按照浸膏1、2逐步敲入的方式,验证全浸膏中的成分,并利用UPLC-Q-TOF-MS快速鉴定各浸膏中的成分。结果基于UPLC重点分析表征了全浸膏中朝藿定A、B、C及淫羊藿苷、松果菊苷、毛蕊花糖苷、补骨脂素、异补骨脂素等21个成分;利用UPLC-QTOF-MS从浸膏1中共鉴定了朝藿定A、人参皂苷Rg1、人参皂苷Ro等17个化合物,浸膏2中鉴定了松果菊苷、毛蕊花糖苷、甘草苷、大黄素等58个化合物,从全浸膏中共鉴定了宝藿苷I、人参皂苷Rb1、甘草酸、毛蕊花糖苷等82个化合物,涵盖了处方中22味药材,主要组分包括淫羊藿黄酮组分、人参皂苷组分、制何首乌蒽醌组分、黄芪皂苷组分、肉苁蓉苯乙醇苷组分与补骨脂香豆素组分。结论基于UPLC-Q-TOF-MS对肾宝片的化学成分进行了较为全面的分析,为其物质基础及制剂工艺过程的质量控制提供了实验依据。

关键词：逐步敲入策略制剂工艺过程肾宝片 UPLC UPLC-Q-TOF-MS 物质基础质量控制朝藿定淫羊藿苷松果菊苷毛蕊花糖苷补骨脂素人参皂苷甘草苷大黄素宝藿苷甘草酸

在线全文

学校读者我要写书评

暂无评论

几种除草剂对刺果藤等玉米田杂草的防除效果

农药 2015年第5期54卷 369-371页

作者：王品舒岳瑾郭书臣袁志强董杰乔岩张金良北京市植物保护站北京100029 北京市延庆县植物保护站北京102100

[目的]筛选可防除玉米田刺果藤并兼治其他杂草的除草剂。[方法]试验设9种除草剂处理,通过田间试验,评价各药剂的除草效果。[结果]55%硝磺·莠去津SC 783.75 g a.i./hm2和4%烟嘧磺隆OD 24 g a.i./hm2+38%莠去津SC 570 g a.i./hm2的防效较... 详细信息

[目的]筛选可防除玉米田刺果藤并兼治其他杂草的除草剂。[方法]试验设9种除草剂处理,通过田间试验,评价各药剂的除草效果。[结果]55%硝磺·莠去津SC 783.75 g a.i./hm2和4%烟嘧磺隆OD 24 g a.i./hm2+38%莠去津SC 570 g a.i./hm2的防效较好,用药较少,药后30 d,2种处理对刺果藤的鲜质量防效均在87%以上,对总杂草的鲜质量防效均在89%以上。[结论]上述2种处理适用于发生刺果藤的玉米田除草。

关键词：玉米刺果藤除草剂防除效果

基于UPLC-Q-TOF-MS代谢组学研究炙淫羊藿温肾助阳的炮制机制

在线全文

学校读者我要写书评

暂无评论

药学学报 2021年第10期56卷 2849-2857页

作者：王玲孙娥侯健徐金娣郭舒臣韦英杰贾晓斌南京中医药大学第三临床医学院江苏南京210028 江苏省中医药研究院江苏南京210028 中国药科大学中药学院江苏南京211198

采用代谢组学方法探究炙淫羊藿温肾助阳和炮制增效机制。建立氢化可的松诱导的大鼠肾阳虚证模型,基于UPLC-Q-TOF-MS(ultra-performance liquid chromatography with quadrupole time-of-flight tandem mass spectrometry)代谢组学方法,联合多元统计分析和单变量统计分析,筛选并鉴定血浆、尿液样品中与肾阳虚相关的潜在生物标志物,分析羊脂油组、淫羊藿生品组、淫羊藿加热品组、淫羊藿炙品组改善肾阳虚证的代谢调控机制。结果显示,氢化可的松诱导的肾阳虚大鼠血浆、尿液代谢呈现明显的轨迹变化,在血浆和尿液中鉴定出15种与肾阳虚相关的生物标志物,涉及5条代谢通路,分别为甘油磷脂代谢、鞘脂代谢、硫代谢、乙醛酸和二羧酸代谢、半胱氨酸和蛋氨酸代谢。炙淫羊藿温肾助阳的代谢通路涉及甘油磷脂代谢、半胱氨酸和蛋氨酸代谢,而炙淫羊藿两个炮制因素“加热”“羊脂油”分别通过调节甘油磷脂代谢、半胱氨酸和蛋氨酸代谢来增强其温肾助阳的作用,进而阐明了炙淫羊藿的炮制增效机制。本文涉及的动物实验符合伦理学标准,并且已获得江苏省中医药研究院动物伦理委员会批准(批准号:AEWC-20200702-119)。

关键词：炙淫羊藿炮制机制代谢组学肾阳虚证 UPLC-Q-TOF-MS 代谢通路

Underground laboratories · Deep underground observation ·Scientific questions—Insights from observations of multi-physic fields in deep underground labs

在线全文

学校读者我要写书评

暂无评论

Science China Earth Sciences 2025年

作者： Huiqi REN Yun WANG Chang chen Guangyu FU Longqing QIU Lianghui guo chengliang XIE Yongsheng HE Heping SUN Jiwen TENG Institute of Defense Engineering Academy of Military Sciences State Kay Laboratory of Geological Processes and Mineral Resources Key Laboratory of Intraplate Volcanoes and Earthquakes Ministry of Education China University of Geosciences (Beijing) Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences Innovation Academy for Precision Measurement Science and Technology Chinese Academy of Sciences Institute of Geology and Geophysics Chinese Academy of Sciences

This paper presents a comprehensive review on recent development and research conducted in domestic and international underground laboratories. We first introduce the differences in three environments—surface, mountain tunnel cavities and underground coal mine tunnels—by examining cosmic ray background, ambient noises related to gravity and seismic measurement, and electromagnetic noises in magnetic and magnetotelluric measurements. We highlight potential misuse of the term Underground Lab or Deep Underground Lab when describing observations in different physical fields. We introduce unique features of underground coal mine tunnels in China, such as large spaces, ultra-quiet conditions, and ultra-clean environments. When comparing with mountain tunnel cavities and borehole observations, coal mine tunnel observations have superior long-term stability and high precision. Through observations and comparisons of multi-physic fields at surface and the deep underground, we find that the higher SNR seismic observations conducted in deep underground tunnels in coal mines are beneficial to improve velocity tomography of the solid earth. The gravity observation with a Superconducting Quantum Interference Device(SQUID) makes it possibly to capture slow earthquake, which has not been observed previously in the Chinese mainland. SQUID magnetic observations can detect fluctuations as weak as femto-Tesla(fT), enabling us to explore the attenuation of Schumann Resonance down to the solid Earth. This opens opportunities to investigate the connections between the Earth's magnetic field and the interactions within the human brain and heart. To improve the precision of quantum measurement,we should consider the possible effects of weak magnetic disturbances in deep underground environments. Finally, we discuss the importance of deep underground laboratories, observing facilities and techniques deployed in these laboratories, and their possible connection with respect to “deep space” an

关键词：

Deliberate design of MOF-based pre-catalyst rationalizing the structural reconstruction toward efficient oxygen evolution reaction

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2025年

作者： Yunhui chen Meng Tian Zhongqi Zhang Guangzhao Wang Yan guo Jing Wu Dawei Qi Zhenhua Yan Xiangyu Liu Xi Liu State Key Laboratory of High-efficiency Coal Utilization and Green Chemical Engineering College of Chemistry and Chemical EngineeringNingxia University Key Laboratory of Extraordinary Bond Engineering and Advanced Materials Technology of Chongqing School of Electronic Information Engineering Yangtze Normal University Frontiers Science Center for New Organic Matter Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) State Key Laboratory of Advanced Chemical Power Sources College of Chemistry Nankai University School of Chemistry and Chemical Engineering In-situ Center for Physical Sciences Frontiers Science Center for Transformative Molecules Shanghai Jiao Tong University

Metal-organic frameworks （MOFs）,that have emerged as promising electrocatalysts in oxygen evolution reaction （OER）,usually undergo structural reconstruction to form metal hydroxides as active ***,it remains a great challenge to design and synthesize ideal MOF-based pre-catalysts for properly cognizing and utilizing the reconstruction process toward efficient OER ***,the well-defined MOF-808 is post-modified by 2-hydroxyphosphonoacetic acid （HPAA） to form a micro-adsorber that enables to capture of metal ions ***3+and Ni2+ions are synergistically anchored into the microadsorber,developing a Fe/Ni-containing pre-catalyst that can be dynamically electrooxidized to be an active and stable dual-site electrocatalyst denoted by R-MOF-HPAA@FeNi with abundant metal *** a result,R-MOF-HPAA@FeNi exhibits an excellent OER performance with a low overpotential of 272 mV and Tafel slope of 35.9 m V dec-1,as well as long-term stability over 300 h at 10 m A *** and theoretical calculations suggest the resulting catalyst mainly follows a lattice oxygen mechanism （LOM） of dual-metal-site mechanism （DMSM）.Owing to the chelating role of HPAA,the post-synthesized MOF-HPAA behaves as a trap to uniformly and firmly adhere Fe3+and Ni2+ions,leading to a functionalized MOF-based pre-catalyst which can be structurally evolved into atomic level-distributed OER electrocatalysts.

关键词：

不同年份老香黄定量分析及其化学模式识别研究

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

分析测试学报 2021年第1期40卷 10-18页

作者：郭舒臣郑玉忠郭瑞曾鑫海梁惠芬陈奕东杨应楷董婷霞王怀友詹华强深圳市可食用及药用资源研究重点实验室香港科技大学深圳研究院广东深圳518057 香港科技大学生命科学部暨中药研发中心中国香港999077 中国药科大学中药学院江苏南京211198 韩山师范学院食品工程与生物科技学院广东潮州521041 广东济公保健食品有限公司广东潮安515638

建立了一种联合化学标志物定量分析和化学模式识别技术快速判别不同年份老香黄的方法,并筛选其差异性化学标志物。采用超高效液相色谱-串联质谱(UPLC-MS/MS)建立了对21种与老香黄相关的化学标志物及其内标物山柰酚-3-O-芸香糖苷的检测方... 详细信息

建立了一种联合化学标志物定量分析和化学模式识别技术快速判别不同年份老香黄的方法,并筛选其差异性化学标志物。采用超高效液相色谱-串联质谱(UPLC-MS/MS)建立了对21种与老香黄相关的化学标志物及其内标物山柰酚-3-O-芸香糖苷的检测方法,该方法的线性关系良好,灵敏度高,专属性强,可用于对不同年份老香黄的区别分析。根据检出的不同年份老香黄的15个化学标志物含量,结合主成分分析(PCA)、聚类分析(HCA)、正交偏最小二乘法判别分析(OPLS-DA)法进行分析,可快速判别不同年份的老香黄,并筛选出6个差异性化学标志物。结果表明,贡献最大的差异化学标志物为5,7-二甲氧基香豆素,其中0年含量为(47.465±1.987)μg/g,3年含量为(17.069±0.542)μg/g,5年含量为(11.073±1.862)μg/g,8年含量为(41.905±2.240)μg/g,10年含量为(21.079±2.270)μg/g,15年含量为(43.267±2.432)μg/g,20年含量为(51.711±1.439)μg/g,该标志物的含量在一定程度上体现了不同年份的老香黄,可用于区分老香黄的贮藏年份。为了验证方法的可靠性,进行盲样适用性能力测试,测定结果所得年份和厂家提供的保持一致。该研究给市面上老香黄的质量控制及其品质鉴定提供了快速可靠的方法。

关键词：老香黄超高效液相色谱-串联质谱(UPLC-MS/MS) 模式识别化学标志物质量控制

在线全文

学校读者我要写书评

暂无评论

RCA在医疗设备维修管理中的应用

中国医疗设备 2016年第7期31卷 141-142,145页

作者：王明刚毛英军郭姝宸陈磊解放军第401医院医学工程科山东青岛266071

本文通过分析医疗设备故障发生情况,以根本原因分析法(RCA)为基础,运用失效模式与影响分析(FMEA)方法分析设备故障情况,并且使用鱼骨图工具进一步探讨可能导致设备发生故障的远端因子,以发现导致医疗设备故障的潜在因子,针对原因制定纠... 详细信息

本文通过分析医疗设备故障发生情况,以根本原因分析法(RCA)为基础,运用失效模式与影响分析(FMEA)方法分析设备故障情况,并且使用鱼骨图工具进一步探讨可能导致设备发生故障的远端因子,以发现导致医疗设备故障的潜在因子,针对原因制定纠正措施,并在后续行动中验证。将RCA应用于医疗设备维修管理,可以有效提高设备完好率。

关键词：医疗设备根本原因分析预防性维修电磁干扰

在线全文

学校读者我要写书评

暂无评论

医疗设备现场质量检测技术的探讨

中国医疗设备 2014年第6期29卷 128-130页

作者：王明刚毛英军陈燚郭姝宸陈磊中国人民解放军第四零一医院山东青岛266071

环境条件是影响质量检测结果的重要原因之一。有些医疗设备的现场质量检测环境条件与实验室环境条件差异较大,易对设备的质量检测造成影响。本文从检测仪器选型、检测程序的制定以及检测数据的处理等多方面探讨了医疗设备现场质量检测技... 详细信息

环境条件是影响质量检测结果的重要原因之一。有些医疗设备的现场质量检测环境条件与实验室环境条件差异较大,易对设备的质量检测造成影响。本文从检测仪器选型、检测程序的制定以及检测数据的处理等多方面探讨了医疗设备现场质量检测技术,旨在为克服环境差异对检测工作的影响提供参考。

关键词：医疗设备质量检测仪器选型现场环境数据处理

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin