检索结果-南通市图书馆

Molecular recognition of cyclophanes in water

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第5期35卷 32-44页

作者： Fang-yuan Chen Wen-Chao Geng Kang Cai Dong-sheng guo College of Chemistry State Key Laboratory of Elemento-Organic ChemistryKey Laboratory of Functional Polymer Materials(Ministry of Education)Frontiers Science Center for New Organic MatterCollaborative Innovation Center of Chemical Science and Engineering(Tianjin)Nankai UniversityTianjin 300071China College of Chemistry Nankai UniversityTianjin 300071China

Molecular recognition in water,the biological solvent,always receives significant research focus in supramolecular *** mechanisms of molecular recognition in water is key to comprehending biological processes at the molecular *** the past five decades,supramolecular chemists have developed a vast array of synthetic receptors with highly diverse structures and recognition *** them,cyclophanes represent an important family of macrocyclic receptors that have been extensively *** aromatic moieties in cyclophanes not only facilitate chemical modifications to impart water solubility but also enable forming hydrophobic cavities for guest inclusion in aqueous *** by Koga et al.,who reported the first inclusion complex of cyclophanes in water and solid state,numerous water-soluble cyclophanes,including derivatives of blue box,calixarenes,resorcinarenes,pillararenes,octopusarenes,biphenarenes,coronarenes,and naphthotubes,etc.,have been synthesized and subjected to investigation of the recognition capabilities in aqueous *** review provides an overview of cyclophane receptors designed to bind organic guests in *** categorize them into two classes based on the modifications made to their hydrophobic cavities:those with“exo-functionalized hydrophobic cavities”and those with“endo-functionalized hydrophobic cavities”.We introduce their distinctive features and discuss strategies to enhance recognition affinity and *** review aims to inspire the development of novel synthetic receptors with intriguing properties and foster practical applications of cyclophanes.

关键词： Biomimetic receptor Cyclophane Molecular recognition Hydrophobic effect High-affinity Macrocycles

Deep genome skimming reveals the hybrid origin of Pseudosasa gracilis (Poaceae: Bambusoideae)

在线全文

学校读者我要写书评

暂无评论

Plant Diversity 2024年第3期46卷 344-352页

作者： Xiang-Zhou Hu Cen guo sheng-yuan Qin De-Zhu Li Zhen-Hua guo Germplasm Bank of Wild Species Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China University of Chinese Academy of Sciences Beijing 100049China

Pseudosasa gracilis(Poaceae:Bambusoideae)is a temperate woody bamboo species endemic to Southcentral China with a narrow *** phylogenetic studies revealed an unexpected,isolated phylogenetic position of *** we conducted phylogenomic analysis by sampling populations of *** and its sympatric species *** and Sinosasa polytricha reflecting different genomic signals,by deep genome *** molecular evidence from chloroplast genes and genome-wide SNPs,we deciphered the phylogenetic relationships of *** plastid and nuclear data indicate that *** is more closely related to Sinosasa,which is discordant with the taxonomic *** further explore this molecular-morphological conflict,we screened 411“perfect-copy”syntenic genes to reconstruct phylogenies using both the concatenation and coalescent *** observed extensive discordance between gene trees and the putative species tree.A significant hybridization event was detected based on 411 genes from the D subgenome,showing *** was a hybrid descendant between Sinosasa longiligulata and ***,with 63.56%and 36.44%inheritance probabilities of each ***,introgression events were detected in the C subgenome between *** and *** in the same distribution *** findings suggest that sympatric hybridization and introgression play a crucial role in the origin of *** providing an empirical example of bamboo of hybrid origin using comprehensive analyses based on genomic data from different inheritance systems and morphological characters,our study represents a step forward in understanding of reticulate evolution of bamboos.

关键词： Phylogenomics Hybridization Introgression Pseudosasa gracilis Pseudosasa Sinosasa

A hiddenly high hepatitis C virus related liver disease burden among Chinese patients with non-liver disease complaints: A hospital based study from 2013 to 2017

在线全文

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2018年第2期11卷 171-176页

作者： Hua-Ping Huang guo-sheng yuan Yu-Chen Zhou Cheng-Guang Hu Jun-Wei Liu Shuai yuan Yu-Rong Qiu Yi-Ping Li Yong-yuan Zhang yuan-Ping Zhou Department of Infectious Diseases and Hepatology Unit Nanfang HospitalSouthern Medical University Department of Respiratory Diseases The First Affiliated Hospital of Hainan Medical University Department of Hepatobiliary Surgery Nanfang HospitalSouthern Medical University Laboratory Medicine Center Nanfang HospitalSouthern Medical University Institute of Human Virology and Key Laboratory of Tropical Disease Control of Ministry of Education Zhongshan School of MedicineSun Yat-sen University HBVtech

Objective: To determine the frequency of anti-HCV antibody positivity in patients with nonliver disease complaints, to explore whether anti-HCV positive patients had been properly advised and visited hepatologists for further assessments, and to investigate their clinical characteristics as well as the HCV treatment ***: A hospital based survey of nonliver disease patients with anti-HCV positive and their attending physicians was conducted to determine: *** the patients adequately advised of the implication of anti-HCV positive finding; *** what extent the patients were aware of potential chronic liver disease associated with HCV infection and whether they sought for further assessments and care of ***: A total of 295 294 non-liver disease patients were tested for anti-HCV antibody, and 2 778 of them were found to be positive(0.94%).However, only 45.10%(1 253/2 778) of the anti-HCV antibody(+) patients were referred to hepatologists and received HCV RNA *** addition, 34.10%(312/915) and 1.42%(13/915) of them had already advanced to cirrhosis and hepatocellular carcinoma(HCC), *** analysis showed that the patients who declined antiviral therapy were older, with lower education and lower income, possessed poorer knowledge on the risk of chronic hepatitis C, and had more severe liver ***, 65% of the surveyed physicians did not know the genotype-guided treatment duration suggested by the ***, 22% of the surveyed physicians did not know the standard assays for the diagnosis of HCV ***: Our findings highlight the challenge and hidden enormous burden of chronic HCV infection among patients with non-liver disease complaints in China.

关键词： China HCV Hepatitis C antibody Diagnosis Treatment status Survey

P-and SV-wave dispersion and attenuation in saturated microcracked porous rock with aligned penny-shaped fractures

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Petroleum Science 2024年第1期21卷 143-161页

作者： sheng-Qing Li Wen-Hao Wang yuan-Da Su Jun-Xin guo Xiao-Ming Tang School of Geosciences China University of Petroleum(East China)Qingdao 266580ShandongChina Laoshan National Laboratory Qingdao 266071ShangdongChina Guangdong Provincial Key Laboratory of Geophysical High-resolution Imaging Technology Southern University of Science and TechnologyShenzhen 518055GuangdongChina Department of Earth and Space Sciences Southern University of Science and TechnologyShenzhen 518055GuangdongChina

P-and SV-wave dispersion and attenuation have been extensively investigated in saturated poroelastic media with aligned ***,there are few existing models that incorporate the multiple wave attenuation mechanisms from the microscopic scale to the macroscopic ***,in this work,we developed a unified model to incorporate the wave attenuation mechanisms at different scales,which includes the microscopic squirt flow between the microcracks and pores,the mesoscopic wave-induced fluid flow between fractures and background(FB-WIFF),and the macroscopic Biot's global flow and elastic scattering(ES)from the *** Tang's modified Biot's theory and the mixed-boundary conditions,we derived the exact frequency-dependent solutions of the scattering problem for a single penny-shaped fracture with oblique incident P-and *** then developed theoretical models for a set of aligned fractures and randomly oriented fractures using the Foldy *** results indicated that microcrack squirt flow considerably influences the dispersion and attenuation of P-and SV-wave *** coupling effects of microcrack squirt flow with the FB-WIFF and ES of fractures cause much higher velocity dispersion and attenuation for P waves than for SV *** oriented fractures substantially reduce the attenuation caused by the FB-WIFF and ES,particularly for the ES attenuation of SV *** a comparison with existing models in the limiting cases and previous experimental measurements,we validated our model.

关键词： Aligned fractures P-and SV-wave Dispersion and attenuation Microcracked porous background FB-WIFF Elastic scattering Squirt flow

Early detection of multiple endocrine neoplasia type 1: A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第26期30卷 3247-3252页

作者： Jie-Hao yuan Su Luo Ding-guo Zhang Li-sheng Wang Department of Gastroenterology Shenzhen People’s Hospital(The Second Clinical Medical CollegeJinan University)Shenzhen 518020Guangdong ProvinceChina

BACKGROUND Multiple endocrine neoplasias(MENs)are a group of hereditary diseases invol-ving multiple endocrine glands,and their prevalence is *** type 1(MEN1)has diverse clinical manifestations,mainly involving the parathyroid glands,gastrointestinal tract,pancreas and pituitary gland,making it easy to miss the clinical *** SUMMARY We present the case of a patient in whom MEN1 was detected early.A middle-aged male with recurrent abdominal pain and diarrhea was admitted to the *** tests at admission revealed hypercalcemia and hypophosphatemia,and emission computed tomography of the parathyroid glands revealed a hy-perfunctioning parathyroid *** findings suggested a duodenal bulge and *** endoscopy revealed a hypoechoic lesion in the duodenal *** blood tests revealed elevated levels of serum *** was performed,and pathological analysis of the surgical specimens revealed a parathyroid adenoma after parathyroidectomy and a neuroendocrine tumor after duodenal *** time from onset to the definitive diagnosis of MEN1 was only approximately 1 *** For patients who present with gastrointestinal symptoms accompanied by hyper-calcemia and hypophosphatemia,clinicians need to be alert to the possibility of MEN1.

关键词： Multiple endocrine neoplasia type 1 Gastrointestinal symptoms Hypercal-cemia Early detection Case report

p38 Signaling Mediates Naringin-Induced Osteogenic Differentiation of Porcine Metanephric Mesenchymal Cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2024年第9期30卷 818-825页

作者： JI Peng-cheng XIE yuan-sheng guo Wen-kai FU Bo CHEN Xiang-mei Chinese PLA Medical School Beijing100853China Department of Nephrology First Medical Center of Chinese PLA General HospitalChinese PLA Institute of NephrologyState Key Laboratory of Kidney DiseasesNational Clinical Research Center for Kidney DiseasesBeijing Key Laboratory of Kidney DiseasesBeijing100853China School of Medicine Nankai UniversityTianjin300071China

Objective:To explore the potential of metanephric mesenchymal cells(MMCs)for osteogenesis and naringin’s ability to enhance this process and its molecular ***:Porcine MMCs at 70 days of gestation were used as tool cells,cultured in osteogenic induction medium,identified by immunocytochemistry *** potential of porcine MMCs and naringin’s ability to enhance this process was tested by detecting changes in cell viability,alkaline phosphatase(ALP)activity,the expression of runt-related transcription factor 2(Runx2),osteopontin(OPN)and osteocalcin(OCN),and the formation of mineralized nodules,and the application of the p38 signaling pathway inhibitor SB203580 vitiated the osteogenesis-promoting effect of ***:Immunocytochemical staining showed that the cells were Vimentin and Six2(+),E-cadherin and CK-18(−).Naringin can activate the p38 signaling pathway to enhance the osteogenesis of porcine MMCs by increasing cell viability,ALP activity,the expressions of Runx2,OPN and OCN,and the formation of mineralized nodules(P<0.05).The application of p38 signaling pathway inhibitor SB203580 vitiated the osteogenesis-promoting effect of naringin,manifested by decreased ALP activity,the expressions of Runx2,OPN and OCN,and the formation of mineralized nodules(P<0.05).Conclusion:Naringin,the active ingredient of Chinese herbal medicine Rhizoma Drynariae for nourishing Shen(Kidney)and strengthening bone,enhances the osteogenic differentiation of renal MMCs through the p38 signaling pathway.

关键词： metanephric mesenchymal cells naringin osteogenesis differentiation

Dynamic Analysis of A Deepwater Drilling Riser with A New Hang-off System

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China Ocean Engineering 2024年第1期38卷 29-41页

作者： LI Yan-wei LIU Xiu-quan WANG Jin-long CHEN guo-ming CHANG yuan-jiang sheng Lei-xiang Centre for Offshore Engineering and Safety Technology China University of PetroleumQingdao 266580China National Engineering Laboratory of Offshore Geophysical and Exploration Equipment China University of PetroleumQingdao 266580China China CNOOC Research Institute Co. Ltd.Beijing 100028China

The safety of risers in hang-off states is a vital challenge in offshore oil and gas engineering.A new hang-off system installed on top of risers is proposed for improving the security of *** approach leads to a challenging problem:coupling the dynamics of risers with a new hang-off system combined with multiple structures and complex *** accurately analyze the dynamic responses of the coupled system,a coupled dynamic model is established based on the Euler-Bernoulli beam-column theory and penalty function method.A comprehensive analysis method is proposed for coupled dynamic analysis by combining the finite element method and the Newmarkβ*** analysis program is also developed in MATLAB for dynamic *** simulation results show that the dynamic performances of the risers at the top part are significantly improved by the new hang-off system,especially the novel design,which includes the centralizer and articulation *** bending moment and lateral deformation of the risers at the top part decrease,while the hang-off joint experiences a great bending moment at the bottom of the lateral restraint area which requires particular attention in design and *** platform navigation speed range under the safety limits of risers expands with the new hang-off system in use.

关键词： deepwater drilling riser new hang-off system dynamic analysis finite element method penalty function method

Effect of post rolling stress on phase transformation behavior of microalloyed dual phase steel

在线全文

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2024年第3期31卷 688-699页

作者： Wen-quan Sun sheng-yi Yong Tie-heng yuan Ting-song Yang An-rui He Chao Liu Rui-chun guo National Engineering Research Center for Advanced Rolling and Intelligent Manufacturing University of Science and Technology BeijingBeijing 100083China

The slow phase transformation of microalloyed dual phase steel makes the nonuniform stress and temperature fields during the post rolling cooling process have a significant impact on the phase transformation *** the relatively slow phase transformation of DP780 steel within the microalloyed dual phase steel series,the influence of stress on the phase transformation behavior of DP780 steel was *** quantify the nonuniform thermal and stress conditions in the steel coil,a thermo-mechanical coupled finite element model of the hot-rolled strip cooling process was *** on the simulation data,DP780 steel was chosen as the research material,and Gleeble 3500 thermal simulation equipment was used for experimental *** thermal expansion curves were analyzed through regression to establish the dynamic model of DP780 steel phase transformation under ***,metallographic analysis was conducted to determine phase transformation type and grain size of DP780 *** results confirmed that the stress promotes the occurrence of semi-diffusion-type bainite ***,an appropriate level of stress facilitates the growth of bainitic grains,while the increased stress inhibits the growth of ferritic grains.

关键词： Microalloyed dual phase steel Stress Bainitic transformation Grain Finite element method

Reliability-based life-cycle cost seismic design optimization of coastal bridge piers with nonuniform corrosion using different materials

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Earthquake Engineering and Engineering Vibration 2024年第1期23卷 209-225页

作者： Wu Xiangtong yuan Wenting guo Anxin Key Lab of Smart Prevention and Mitigation of Civil Engineering Disasters of the Ministry of Industry and Information Technology Harbin Institute of TechnologyHarbin 150090China Key Lab of Structures Dynamic Behavior and Control of the Ministry of Education Harbin Institute of TechnologyHarbin 150090China Institute of Transportation Inner Mongolia UniversityHohhot 010070China

Reinforcement corrosion is the main cause of performance deterioration of reinforced concrete(RC)*** research has been performed to investigate the life-cycle cost(LCC)of coastal bridge piers with nonuniform corrosion using different *** this study,a reliability-based design optimization(RBDO)procedure is improved for the design of coastal bridge piers using six groups of commonly used materials,i.e.,normal performance concrete(NPC)with black steel(BS)rebar,high strength steel(HSS)rebar,epoxy coated(EC)rebar,and stainless steel(SS)rebar(named NPC-BS,NPC-HSS,NPC-EC,and NPC-SS,respectively),NPC with BS with silane soakage on the pier surface(named NPC-Silane),and high-performance concrete(HPC)with BS rebar(named HPC-BS).First,the RBDO procedure is improved for the design optimization of coastal bridge piers,and a bridge is selected to illustrate the ***,reliability analysis of the pier designed with each group of materials is carried out to obtain the time-dependent reliability in terms of the ultimate and serviceability ***,the repair time of the pier is predicted based on the time-dependent reliability ***,the time-dependent LCCs for the pier are obtained for the selection of the optimal design.

关键词： reliability-based design optimization(RBDO) life-cycle cost(LCC) nonuniform corrosion coastal bridge pier repair