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机械研究与应用 2005年第3期18卷 68-68,73页

作者：郭仁生佛山职业技术学院广东佛山528000

在实验和分析的基础上,对工作在稳定状态下的转轴,提出一种简化可行的疲劳强度校核方法。

关键词：稳定状态转轴疲劳强度简化校核

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对心直动从动体盘形凸轮压力角的校核

机械设计 1985年第1期 53-56页

作者：郭仁生武汉无线电工业学校

本文给出了对心直动从动件盘形凸轮最大压力角及其在凸轮廓线上位置的计算公式,这无论对使用作图法校核凸轮压力角,或是采用计算机辅助设计凸轮,都提供了方便。

关键词：压力角直动凸轮廓线盘形凸轮从动件校核

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《机械设计基础》精品课程建设实践与探索

湖南工业职业技术学院学报 2007年第2期7卷 137-139,143页

作者：郭仁生佛山职业技术学院广东佛山528000

本文从制造业发展和技术应用与高技能人才培养目标的定位出发,对高职《机械设计基础》精品课程建设的课堂教学、实践环节、教材建设、教研科研、产学研合作和考核评价等方面进行了多年的实践和探索,以期将精品课程建设提高到新水平。

关键词：机械设计基础课程建设实践探索

Plasmonic tandem heterojunctions enable high-efficiency charge transfer for broad spectrum photocatalytic hydrogen production

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Journal of Energy Chemistry 2025年第1期100卷 710-720页

作者： Wenxuan Chen Xiu-Qing Qiao guo Hui Bojing Sun Dongfang Hou Meidi Wang Xueqian Wu Tao Wu Dong-sheng Li College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials China Three Gorges University Hubei Three Gorges Laboratory College of Chemistry and Materials Science and Guangdong Provincial Key Laboratory of Supramolecular Coordination Chemistry Jinan University

Rational engineering of semiconductor photocatalysts for efficient hydrogen production is of great significance but still challenging,primarily due to the limitations in charge transfer ***,a fascinating plasmonic tandem heterojunction with the hc-CdS/Mo2C@C heterostructure is aimfully prepared for effectively promoting the charge separation kinetics of the CdS photocatalyst via the synergistic strategy of phase junction,Schottky junction,and photothermal *** difference in atomic configuration between cubic-CdS （c-CdS） and hexagonal-CdS （h-CdS） leads to effective charge separation through a typical Ⅱ charge transfer mechanism,and plasmonic Schottky junction further extracts the electrons in the hc-CdS phase junction to realize gradient charge ***,the photothermal effect of Mo2C@C helps to expand the light absorption,accelerate charge transfer kinetics,and reduce the hydrogen evolution energy *** carbon layer provides a fast channel for charge transfer and protects the photocatalyst from *** a result,the optimized hc-CMC photocatalyst exhibits a significantly high photocatalytic H2production activity of 28.63 mmol/g/h and apparent quantum efficiency of 61.8%,surpassing most of the reported *** study provides a feasible strategy to enhance the charge transfer kinetics and photocatalytic activity of CdS by constructing plasmonic tandem heterogeneous junctions.

关键词： Heterojunctions LSPR Photocatalyst Phase junction Schottky junction Photothermal effect

Transforming growth factor-beta 1 enhances discharge activity of cortical neurons

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Neural Regeneration Research 2025年第2期20卷 548-556页

作者： Zhihui ren Tian Li Xueer Liu Zelin Zhang Xiaoxuan Chen Weiqiang Chen Kangsheng Li Jiangtao sheng Department of Microbiology and Immunology Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular ImmunopathologyShantou University Medical CollegeShantouGuangdong ProvinceChina Department of Neurosurgery First Affiliated Hospital of Shantou University Medical CollegeShantouGuangdong ProvinceChina

Transforming growth factor-beta 1(TGF-β1)has been extensively studied for its pleiotropic effects on central nervous system *** neuroprotective or neurotoxic effects of TGF-β1 in specific brain areas may depend on the pathological process and cell types ***-gated sodium channels(VGSCs)are essential ion channels for the generation of action potentials in neurons,and are involved in various neuroexcitation-related ***,the effects of TGF-β1 on the functional properties of VGSCs and firing properties in cortical neurons remain *** this study,we investigated the effects of TGF-β1 on VGSC function and firing properties in primary cortical neurons from *** found that TGF-β1 increased VGSC current density in a dose-and time-dependent manner,which was attributable to the upregulation of Nav1.3 *** VGSC current density and Nav1.3 expression were significantly abolished by preincubation with inhibitors of mitogen-activated protein kinase kinase(PD98059),p38 mitogen-activated protein kinase(SB203580),and Jun NH2-terminal kinase 1/2 inhibitor(SP600125).Interestingly,TGF-β1 significantly increased the firing threshold of action potentials but did not change their firing rate in cortical *** findings suggest that TGF-β1 can increase Nav1.3 expression through activation of the ERK1/2-JNK-MAPK pathway,which leads to a decrease in the firing threshold of action potentials in cortical neurons under pathological ***,this contributes to the occurrence and progression of neuroexcitatory-related diseases of the central nervous system.

关键词： central nervous system cortical neurons ERK firing properties JNK Nav1.3 p38 transforming growth factor-beta 1 traumatic brain injury voltage-gated sodium currents

Exosomes:the next-generation therapeutic platform for ischemic stroke

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Neural Regeneration Research 2025年第5期20卷 1221-1235页

作者： Wenjing Yin Hongyin Ma Yang Qu Jiaxin ren Yingying Sun Zhen-Ni guo Yi Yang Stroke Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional ***,there is an urgent need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological *** have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain *** physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic *** rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages *** in technology have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction ***,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified *** optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic stroke mesenchymal stem cells microglia neuroprotection stents

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网上评教系统对教学质量监控的作用

电脑知识与技术 2010年第1期6卷 159-160页

作者：李江萍郭仁生佛山职业技术学院电子信息系计算机教研室广东佛山528237 佛山职业技术学院教学督导室广东佛山528237

学生评教是当前我国高等院校普遍采用的一种教学质量管理和监控手段,学生评教的基本目的是通过系统采集教师的教学信息,让教师及时了解教学情况,促进教师不断改进教学,达到提高教学质量的目的。

关键词：学生评教影响质量监控

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巨大纵隔肿瘤的影像诊断及临床意义

实用放射学杂志 2000年第10期16卷 597-599页

作者：郭盛仁沈均康陆之安钱铭辉苏州医学院附属第二医院!江苏苏州215004

目的 :探讨巨大纵隔肿瘤的影像学诊断标准及影像学检查的效能。方法 :从透视胸片、B超、CT及SPECT四个方面分析了 15例病例。结果 :(1)X线纵隔七分区法定位 10例定性正确。 (2 )CT对纵隔肿瘤和它与临近组织的关系显示最好。 (3)B超能清... 详细信息

目的 :探讨巨大纵隔肿瘤的影像学诊断标准及影像学检查的效能。方法 :从透视胸片、B超、CT及SPECT四个方面分析了 15例病例。结果 :(1)X线纵隔七分区法定位 10例定性正确。 (2 )CT对纵隔肿瘤和它与临近组织的关系显示最好。 (3)B超能清晰分辨实性和囊性肿瘤。 (4)SPECT可助于鉴别肿瘤的良恶性。结论 :巨大纵隔肿瘤的影像学诊断标准为 (1)在侧位胸片上以 7分区法定位 ,肿瘤占据部位超过 1个分区以上。 (2 )肿瘤的平均直径在 6cm以上。

关键词：纵隔肿瘤影像诊断

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屏气不佳患者胸部螺旋CT扫描方法探讨

中国CT和MRI杂志 2012年第3期10卷 102-104页

作者：易壁星蔡武郭盛仁苏州大学附属第二医院XCT室江苏苏州215004

目的探讨屏气不佳患者胸部螺旋CT扫描的最佳方案。方法临床检查中出现屏气不佳的患者300例,采用GE公司单排/双排螺旋CT进行胸部扫描。扫描技术包括从肺底扫描至肺尖、充分吸氧、根据屏气持续时间调整相关扫描参数、缩短扫描时间、连续... 详细信息

目的探讨屏气不佳患者胸部螺旋CT扫描的最佳方案。方法临床检查中出现屏气不佳的患者300例,采用GE公司单排/双排螺旋CT进行胸部扫描。扫描技术包括从肺底扫描至肺尖、充分吸氧、根据屏气持续时间调整相关扫描参数、缩短扫描时间、连续扫描及标准重建。由2位高年资的影像科医生对其图像质量进行评价。结果采用上述扫描方法,282例患者能在单次屏气中完成整个肺部扫描,图像质量好;18例患者在扫描后期屏气效果不佳,但对肺上部的图像质量影响不大,图像质量可。结论根据屏气持续时间调整相关扫描参数和从肺底开始向肺尖扫描的检查方法,可减少屏气不佳患者呼吸运动伪影的影响,具有较高的临床实用价值。

关键词：屏气不佳螺旋CT 扫描方法

Relationship between parenting stress and behavioral and emotional problems in preschool children: A mediation effect analysis

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World Journal of Psychiatry 2025年第1期15卷 128-136页

作者： Zhi-Wei Fu Yue-Jing Li Ran Yu Rui-Qing guo Li-Xia Gao sheng-Xia Zhao Department of Children's Health Shijiazhuang Maternity and Child Healthcare HospitalShijiazhuang 050000Hebei ProvinceChina

BACKGROUND Emotional reactions,such as anxiety,irritability,and aggressive behavior,have attracted clinical attention as behavioral and emotional problems in preschool-age *** To investigate the current status of family rearing,parental stress,and behavioral and emotional problems of preschool children and to analyze the mediating effect of the current status of family rearing on parental stress and behavioral/emo-tional *** We use convenience sampling to select 258 preschool children in the physical examination center of our hospital from October 2021 to September *** children and their parents were evaluated using a questionnaire ***'s correlation was used to analyze the correlation between child behavioral and emotional problems and parental stress and family rearing,and the structural equation model was constructed to test the mediating *** The score for behavioral/emotional problems of 258 preschool children was(27.54±3.63),the score for parental stress was(87.64±11.34),and the score for parental family rearing was(31.54±5.24).There was a positive correlation between the behavioral and emotional problems of the children and the“hostile/mandatory”parenting style;meanwhile,showed a negative correlation with the“support/participation”parenting style(all Prents in parental stress and children's behavior problems was 29.89%.CONCLUSION Parental family upbringing has a mediating effect between parental stress and behavioral and emotional problems of *** paying attention to the behavioral and emotional problems of preschool-age children,clinical medical staff should provide correct and reasonable parenting advice to their parents to promote the mental health of preschool-age children.

关键词： Preschool children Parenting stress Children's behavioral and emotional problems Family rearing Mediating effect