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Expression of Livin and vascular endothelial growth factor in different clinical stages of human esophageal carcinoma

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World Journal of Gastroenterology 2008年第37期14卷 5749-5754页

作者： Li Chen guo-sheng ren Fan Li Shan-Quan Sun Department of Thoracic Surgery the First AffiliatedHospital of Chongqing Medical University Chongqing 400016China Department of General Surgery theFirst Affiliated Hospital of Chongqing Medical UniversityChongqing 400016 China Anatomy institution of Chongqing MedicalUniversity Chongqing 400016 China

AIM： To investigate the role of Livin and vascular endothelial growth factor （VEGF） in human esophageal carcinoma, and analyze its relationship to clinical stages.METHODS： Expression of Livin in fresh esophageal cancer tissues was detected by immunohistochemistry （IHC）, Western blotting and reverse transcriptasepolyrnerase chain reaction （RT-PCR）, and VEGF by Western blotting and RT-PCR. All statistical analyses were performed by SPSS version 11.0. RESULTS： Livin positivity was also significantly correlated with tumor stages, increasing with tumor progression. Expression of Livin and VEGF increased with the process of esophageal carcinoma. In the fourth clinical stage, expression of Livin and VEGF was the most significant. Expression of Livin was positively correlated with VEGF. CONCLUSION： Over-expression of Livin and VEGF contributes to the pathogenesis of esophageal carcinoma.

关键词： Esophageal carcinoma Livin Vascular endothelial growth factor

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Bilateral chylothorax following left supraclavicular lymph node dissection for breast cancer: one case report and literature review

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Chinese Journal of Cancer 2014年第6期33卷 317-320页

作者： De-Juan Yang guo-sheng ren Xiao-Yi Wang Department of Breast and Endocrine Surgery The First Affiliated Hospital of Chongqing Medical University

Chylothorax is a rare complication of neck dissection, and bilateral chylothorax is even rarer. However, both are potentially serious and sometimes life-threatening, especially those that are associated with left neck dissection for head and neck neoplasms. We report one case of bilateral chylothorax following left supraclavicular dissection for breast cancer. This case was treated successfully with a new conservative management approach.

关键词：乳腺癌淋巴结乳糜锁骨复习文献头颈部肿瘤并发症

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Effects of recombinant human growth hormone on enterocutaneous fistula patients

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World Journal of Gastroenterology 2008年第44期14卷 6858-6862页

作者： guo-sheng Gu Jian-An ren Ning Li Jie-Shou Li The Research Institute of General Surgery Clinical School (Jinling Hospital) School of Medicine Nanjing University Nanjing 210002 Jiangsu Province China

AIM： To explore the effects of recombinant human growth hormone （rhGH） on intestinal mucosal epithelial cell proliferation and nutritional status in patients with enterocutaneous fistula. METHODS： Eight patients with enterocutaneous fistulas received recombinant human growth hormone （10 ug/d） for 7 d. Image analysis and immunohistochemical techniques were used to analyse the expression of proliferating cell nuclear antigen （PCNA） in intestinal mucosal epithelial cells in biopsy samples from the patients who had undergone an endoscopic biopsy through the fistula at day 0, 4 and 7. Body weights, nitrogen excretion, serum levels of total proteins, albumin, prealbumin, transferrin and fibronectin were measured at day 0, 4 and 7. RESULTS： Significant improvements occurred in the expression of PCNA in the intestinal mucosal epithelial cells at day 4 and 7 compared to day 0 （24.93 ± 3.41%, 30.46 ± 5.24% vs 12.92 ± 4.20%, p 〈 0.01）. These changes were accompanied by the significant improvement of villus height （500.54 ± 53.79 um, 459.03 ± 88.98um vs 210.94 ± 49.16 um, P 〈 0.01）, serum levels of total proteins （70.52 ± 5.13 g/L, 74.89 ± 5.16 g/L vs 63.51 ± 2.47 g/L, P 〈 0.01）, albumin （39.44 ± 1.18 g/L, 42.39 ± 1.68 g/L vs 35.74 ± 1.75 g/L, P 〈 0.01） and fibronectin （236.3 4- 16.5 mg/L, 275.8± 16.9 mg/L vs 172.5 ± 21.4 mg/L, P 〈 0.01） at day 4 and 7, and prealbumin （286.38 ± 65.61 mg/L vs 180.88 ± 48.28 mg/L, P 〈 0.05）, transferrin （2.61 ± 0.12 g/L vs 2.41 ±0.14 g/L, P 〈 0.05） at day 7. Nitrogen excretion was significantly decreased at day 7 （3.40 ± 1.65 g/d vs 7.25 ± 3.92 g/d, P 〈 0.05）. No change was observed in the body weight. CONCLUSION： Recombinant human growth hormone could promote intestinal mucosal epithelial cell proliferation and protein synthesis in patients with enterocutaneous fistula.

关键词： Recombinant human growth hormone Enterocutaneous fistula Intestinal Epithelial cell Proliferating cell nuclear antigen

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Aberrant promoter CpG methylation and its translational applications in breast cancer

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Chinese Journal of Cancer 2013年第1期32卷 12-20页

作者： Ting-Xiu Xiang Ying Yuan Li-Li Li Zhao-Hui Wang Liang-Ying Dan Yan Chen guo-sheng ren Qian Tao Molecular Oncology and Epigenetics Laboratory The First Affiliated Hospital of Chongqing Medical University Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences(CAS)-CUHK Cancer Epigenetics Laboratory Department of Clinical OncologySir YK Pao Center for Cancer and Li Ka Shing Institute of Health SciencesThe Chinese University of Hong Kong Hong Kong and CUHK Shenzhen Research Institute

Breast cancer is a complex disease driven by multiple factors including both genetic and epigenetic *** studies revealed that abnormal gene expression induced by epigenetic changes,including aberrant promoter methylation and histone modification,plays a critical role in human breast *** of tumor suppressor genes(TSGs) by promoter CpG methylation facilitates cells growth and survival advantages and further results in tumor initiation and progression,thus directly contributing to breast ***,aberrant promoter methylation of TSGs,which can be reversed by pharmacological reagents,occurs at the early stage of tumorigenesis and therefore may serve as a potential tumor marker for early diagnosis and therapeutic targeting of breast *** this review,we summarize the epigenetic changes of multiple TSGs involved in breast pathogenesis and their potential clinical applications as tumor markers for early detection and treatment of breast cancer.

关键词：临床应用乳腺癌甲基化 CpG 异常子区肿瘤抑制基因肿瘤标志物

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