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Artificial neural network-based method for discriminating Compton scattering events in high-purity germaniumγ-ray spectrometer

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Nuclear Science and Techniques 2024年第2期35卷 64-84页

作者： Chun-Di Fan guo-Qiang Zeng Hao-Wen Deng Lei Yan Jian Yang Chuan-Hao Hu Song qing Yang Hou College of Nuclear Technology and Automation Engineering Chengdu University of TechnologyChengdu 610059China

To detect radioactive substances with low activity levels,an anticoincidence detector and a high-purity germanium(HPGe)detector are typically used simultaneously to suppress Compton scattering background,thereby resulting in an extremely low detection limit and improving the measurement ***,the complex and expensive hardware required does not facilitate the application or promotion of this ***,a method is proposed in this study to discriminate the digital waveform of pulse signals output using an HPGe detector,whereby Compton scattering background is suppressed and a low minimum detectable activity(MDA)is achieved without using an expensive and complex anticoincidence detector and *** electric-field-strength and energy-deposition distributions of the detector are simulated to determine the relationship between pulse shape and energy-deposition location,as well as the characteristics of energy-deposition distributions for fulland partial-energy deposition *** relationship is used to develop a pulse-shape-discrimination algorithm based on an artificial neural network for pulse-feature *** accurately determine the relationship between the deposited energy of gamma(γ)rays in the detector and the deposition location,we extract four shape parameters from the pulse signals output by the *** learning is used to input the four shape parameters into the ***,the pulse signals are identified and classified to discriminate between partial-and full-energy deposition *** partial-energy deposition events are removed to suppress Compton *** proposed method effectively decreases the MDA of an HPGeγ-energy dispersive *** results show that the Compton suppression factors for energy spectra obtained from measurements on ^(152)Eu,^(137)Cs,and ^(60)Co radioactive sources are 1.13(344 keV),1.11(662 keV),and 1.08(1332 keV),respectively,and that the corresponding MDAs are 1.4%,5.

关键词： High-purity germaniumγ-ray spectrometer Pulse-shape discrimination Compton scattering Artificial neural network Minimum detectable activity

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NF-κB in biology and targeted therapy:new insights and translational implications

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1322-1358页

作者： qing guo Yizi Jin Xinyu Chen Xiaomin Ye Xin Shen Mingxi Lin Cheng Zeng Teng Zhou Jian Zhang Department of Medical Oncology Fudan University Shanghai Cancer CenterNo.270Dong'an RoadShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghaiChina State Key Laboratory of Oncogenes and Related Genes Renj-Med-X Stem Cell Research CenterShanghai Cancer Institute&Department of UrologyRen Ji HospitalSchool of Medicine and School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghai 200127PR China Department of Cardiology the First Affiliated Hospital of Sun Yat-Sen University58 Zhongshan 2nd RoadGuangzhou 510080China Department of Neurology Rujin HospitalShanghai JiaoTong University Schoolof MedicineShanghaiChina

NF-κB signaling has been discovered for nearly 40 ***,NF-κB signaling was identified as a pivotal pathway in mediating inflammatory ***,with extensive and in-depth investigations,researchers have discovered that its role can be expanded to a variety of signaling mechanisms,biological processes,human diseases,and treatment *** this review,we first scrutinize the research process of NF-κB signaling,and summarize the composition,activation,and regulatory mechanism of NF-κB *** investigate the interaction of NF-κB signaling with other important pathways,including PI3K/AKT,MAPK,JAK-STAT,TGF-β,Wnt,Notch,Hedgehog,and TLR *** physiological and pathological states of NF-κB signaling,as well as its intricate involvement in inflammation,immune regulation,and tumor microenvironment,are also ***,we illustrate how NF-κB signaling is involved in a variety of human diseases,including cancers,inflammatory and autoimmune diseases,cardiovascular diseases,metabolic diseases,neurological diseases,and ***,we discuss the therapeutic approaches targeting NF-κB signaling,including IKK inhibitors,monoclonal antibodies,proteasome inhibitors,nuclear translocation inhibitors,DNA binding inhibitors,TKls,non-coding RNAs,immunotherapy,and ***,we provide an outlook for research in the field of NF-κB *** hope to present a stereoscopic,comprehensive NF-κB signaling that will inform future research and clinical practice.

关键词： PI3K/AKT diseases involvement

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A lithium–tin fluoride anode enabled by ionic/electronic conductive paths for garnet-based solid-state lithium metal batteries

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Rare Metals 2024年第2期43卷 575-587页

作者： Lei Zhang Qian-Kun Meng Xiang-Ping Feng Ming Shen Yu-qing Zhang Quan-Chao Zhuang Run-guo Zheng Zhi-Yuan Wang Yan-Hua Cui Hong-Yu Sun Yan-guo Liu School of Materials Science and Engineering Northeastern UniversityShenyang110819China School of Resources and Materials Northeastern University at QinhuangdaoQinhuangdao066004China School of Materials and Physics China University of Mining&TechnologyXuzhou221116China Institute of Electronic Engineering China Academy of Engineering PhysicsMianyang621900China

The high energy density and stability of solid-state lithium metal batteries(SSLMBs)have garnered great ***-type oxides,especially Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12)(LLZTO),with high ionic conductivity,wide electrochemical window,and stability to Li metal anode,are promising solid-state electrolyte(SSEs)materials for ***,Li/LLZTO interface issues including high interface resistance,inhomogeneous Li deposition,and Li dendrite growth have hindered the practical application of ***,a multi-functional Li–SnF_(2) composite anode with Li,LiF,and Li-Sn alloy was specifically designed and *** composite anode improves the wettability to LLZTO,constructing an intimate contact interface between it and ***,ionic/electronic conductive paths in situ formed at the interface can effectively uniform Li deposition and suppress Li *** solid-state symmetric cell exhibits low interface resistance(11Ω·cm^(2)) and high critical current density(1.3 mA·cm^(−2))at 25℃.The full SSLMB based on LiFePO_(4) or LiNi_(0.5)Co_(0.2)Mn_(0.3)O_(2) cathode also shows stable cycling performance and high rate *** work provides a new composite anode strategy for achieving high-energy density and high-safety SSLMBs.

关键词： Solid-state lithium metal batteries(SSLMBs) Lithium-tin fluoride anode Ionic/electronic conductive Interface resistance Lithium dendrite

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Resveratrol inhibits pancreatic cancer proliferation and metastasis by depleting senescent tumor-associated fibroblasts

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 3980-3993页

作者： He Jiang guo-Tai Wang Zheng Wang qing-Yong Ma Zhen-Hua Ma Department of Hepatobiliary Surgery The First Affiliated HospitalXi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Hepatobiliary Surgery Affiliated Hospital of Shaanxi University of Chinese MedicineXianyang 712000Shaanxi ProvinceChina

BACKGROUND Pancreatic cancer,a formidable gastrointestinal neoplasm,is characterized by its insidious onset,rapid progression,and resistance to treatment,which often lead to a grim *** the complex pathogenesis of pancreatic cancer is well recognized,recent attention has focused on the oncogenic roles of senescent tumor-associated ***,their precise role in pancreatic cancer remains *** is a natural polyphenol known for its multifaceted biological actions,including antioxidative and neuroprotective properties,as well as its potential to inhibit tumor proliferation and *** current investigation builds on prior research and reveals the remarkable ability of resveratrol to inhibit pancreatic cancer proliferation and *** To explore the potential of resveratrol in inhibiting pancreatic cancer by targeting senescent tumor-associated *** Immunofluorescence staining of pancreatic cancer tissues revealed prominent coexpression ofα-SMA and ***-1 expression was determined using *** were treated with the senescence-inducing factors known as ***-term growth assays confirmed that 3CKs significantly decreased the CAF growth *** blotting was conducted to assess the expression levels of p16 and *** was performed to assess LaminB1 *** real-time polymerase chain reaction was used to measure the levels of several senescence-associated secretory phenotype factors,including IL-4,IL-6,IL-8,IL-13,MMP-2,MMP-9,CXCL1,and CXCL12.A scratch assay was used to assess the migratory capacity of the cells,whereas Transwell assays were used to evaluate their invasive *** Specifically,we identified the presence of senescent tumor-associated fibroblasts within pancreatic cancer tissues,linking their abundance to cancer ***,Resveratrol effectively eradicated these fibroblasts and hindered their senescence,which co

关键词： Resveratrol Pancreatic Cancer Proliferation Metastasis Senescent Fibroblasts

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Seasonal response of nitrogen exchange fluxes to crab disturbance at sediment-water interface in coastal tidal wetlands

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Water Science and Engineering 2024年第2期17卷 129-138页

作者： guo-fen Hua Shang-qing Liu Xiang-dong Liu Jin-li Li Yue Fang Wen-ting Xie Xiang Xu College of Water Conservancy and Hydroelectric Power Hohai UniversityNanjing 210098China College of Renewable Energy Hohai UniversityNanjing 210098China

Coastal wetlands are hotspots for nitrogen(N)cycling,and crab burrowing is known to transform N in intertidal marsh ***,the underlying mechanisms remain *** study conducted field experiments and used indoor control test devices to investigate the seasonal response of nitrogen to crab disturbance at the sediment-water interface in coastal tidal flat *** results showed that crab disturbance exhibited significant seasonality with large seasonal differences in cave density and *** to crab disturbance,nitrogen fuxes at the sediment-water interface were much greater in the box with crabs than in the box without *** summer,NH-N showed a positive flux from the sediment to the overlying water,but NO2-N and NOg-N showed positive fluxes from the sediment to the overlying water only in early *** winter,NH-N showed a positive flux from the sediment to the overlying water,but NO-N and NO,-N both exhibited positive and negative *** results indicated that the presence of crab burrows can cause the aerobic layer to move downward by approximately 8-15 cm in summer and directly promote nitrification at the sediment surface.

关键词： Coastal tidal flat wetland Crab disturbance Nitrogen flux Nitrification Denitrification Sediment-water interface

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Preparation and Reinforcement Adaptability of Jute Fiber Reinforced Magnesium Phosphate Cement Based Composite Materials

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Journal of Wuhan University of Technology(Materials Science) 2024年第4期39卷 999-1009页

作者：刘芯州郭远臣 WANG Rui XIANG Kai WANG Xue YE qing College of Civil Engineering Chongqing Three Gorges UniversityChongqing 404100China

To improve the brittleness characteristics of magnesium phosphate cement-based materials(MPC)and to promote its promotion and application in the field of structural reinforcement and repair,this study aimed to increase the toughness of MPC by adding jute fiber,explore the effects of different amounts of jute fiber on the working and mechanical properties of MPC,and prepare jute fiber reinforced magnesium phosphate cement-based materials(JFRMPC)to reinforce damaged *** improvement effect of beam performance before and after reinforcement was compared,and the strengthening and toughening mechanisms of jute fiber on MPC were explored through microscopic *** experimental results show that,as the content of jute fiber(JF)increases,the fluidity and setting time of MPC decrease continuously;When the content of jute fiber is 0.8%,the compressive strength,flexural strength,and bonding strength of MPC at 28 days reach their maximum values,which are increased by 18.0%,20.5%,and 22.6%compared to those of M0,*** beam strengthened with JFRMPC can withstand greater deformation,with a deflection of 2.3 times that of the unreinforced beam at *** strain of the steel bar is greatly reduced,and the initial crack and failure loads of the reinforced beam are increased by 192.1%and 16.1%,respectively,compared to those of the unreinforced *** JF added to the MPC matrix dissipates energy through tensile fracture and debonding pull-out,slowing down stress concentration and inhibiting the free development of cracks in the matrix,enabling JFRMPC to exhibit higher strength and better *** JF does not cause the hydration of MPC to generate new compounds but reduces the amount of hydration products generated.

关键词： magnesium phosphate cement jute fiber reinforcement of damaged beam flexural behavior

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Self-Adaptive and Electric Field-Driven Protective Layer with Anchored Lithium Deposition Enable Stable Lithium Metal Anode

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Energy & Environmental Materials 2024年第3期7卷 32-40页

作者： Ting Chen Luchao Yue guoqiang Shu qing Yang Dong Wang Ruoyang Wang Xianyan Qiao Yan Sun Benhe Zhong Zhenguo Wu Xiaodong guo Department of Chemical Engineering Sichuan UniversityChengdu 610065China School of Mechanical Engineering Chengdu UniversityChengdu 610106China

Lithium metal battery has great development potential because of its lowest electrochemical potential and highest theoretical ***,the uneven deposition of Li^(+)flux in the process of deposition and stripping induces the vigorous growth of lithium dendrites,which results in severely battery performance degradation and serious safety ***,the tetragonal BaTiO3 polarized by high voltage corona was used to build an artificial protective layer with uniform positive polarization direction,which enables uniform Li^(+)*** contrast to traditional strategies of using protective layer,which can guide the uniform deposition of lithium *** ferroelectric protective layer can accurately anchor the Li^(+)and achieve bottom deposition of lithium due to the automatic adjustment of the electric ***,the huge volume changes caused by Li^(+)migration change of the lithium metal anode during charging and discharging is functioned to excite the piezoelectric effect of the protective layer,and achieve seamless dynamic tuning of lithium deposition/*** dynamic effect can accurately anchor and capture Li^(+).Finally,the layer-modified Li anode enables reversible Li plating/stripping over 1500 h at 1 mA cm^(-2)and 50℃in symmetric *** addition,the assembled Li-S full cell exhibits over 300 cycles with N/P≈*** work provides a new perspective on the uniform Li^(+)flux at the Li-anode interface of the artificial protective layer.

关键词： dense plating/stripping process electric field ferroelectric materials lithium metal batteries solid electrolyte interphase

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Patterns of Emergent Nonlinear Waves in an Initial Discontinuity Problem of the Bad Jaulent-Miodek Equation

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Acta Mathematicae Applicatae Sinica 2024年

作者： Ya-qing LIU Bo-ling guo Deng-shan WANG School of Applied Science Beijing Information Science and Technology University Institute of Applied Physics and Computational Mathematics Beijing Laboratory of Mathematics and Complex Systems (Ministry of Education) School of Mathematical Sciences Beijing Normal University

By means of the Whitham modulation theory, this paper studies the discontinuous initial value problem of the bad Jaulent-Miodek(JM) equation, which is compared with the good JM equation. The linear stability of the good and bad JM equations is analyzed to show the difference between the two equations. Also the physical significance of the JM equations is discussed by considering the reduction of the Euler's *** the zero-, one-, two-phase periodic solutions and the corresponding Whitham equations in the framework of the bad JM equation are derived by finite-gap integration approach. The degeneration of the one-phase periodic solution along with the genus-one Whitham equation are analyzed by taking the two sides limits of the modulus m of the Jacobi elliptic functions. The basic rarefaction wave patterns and dispersive shock wave patterns are proposed analytically and graphically, and then the complete classification of solutions and the all possible waveforms evolving from discontinuous initial values in the bad JM equation are established. In the results, various patterns of emergent nonlinear waves that appear to be new and are being detected for the first time.

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Deterministic wave prediction model for irregular long-crested waves with Recurrent Neural Network

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Journal of Ocean Engineering and Science 2024年第3期9卷 251-263页

作者： Yue Liu Xiantao Zhang Gang Chen qing Dong Xiaoxian guo Xinliang Tian Wenyue Lu Tao Peng State Key Laboratory of Ocean Engineering Shanghai Jiao Tong University(SJTU)Shanghai 200240China SJTU Yazhou Bay Institute of Deepsea Technology SanyaHainan572000China

Real-time predicting of stochastic waves is crucial in marine *** this paper,a deep learning wave prediction(Deep-WP)model based on the‘probabilistic’strategy is designed for the short-term prediction of stochastic *** Deep-WP model employs the long short-term memory(LSTM)unit to collect pertinent information from the wave elevation time *** irregular long-crested waves generated in the deepwater offshore basin at Shanghai Jiao Tong University are used to validate and optimize the Deep-WP *** the prediction duration is 1.92s,2.56s,and,3.84s,respectively,the predicted results are almost identical with the ground *** the prediction duration is increased to 7.68s or 15.36s,the Deep-WP model’s error increases,but it still maintains a high level of accuracy during the first few *** introduction of covariates will improve the Deep-WP model’s performance,with the absolute position and timestamp being particularly advantageous for wave ***,the Deep-WP model is applicable to predict waves with different energy *** proposed Deep-WP model shows a feasible ability to predict nonlinear stochastic waves in real-time.

关键词： Real-time wave prediction Probability LSTM Covariate

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FLOWERING LOCUS T(FT)in Photosensitive Type Chrysanthemum Accelerates Flowering in Arabidopsis

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Phyton-International Journal of Experimental Botany 2024年第4期93卷 819-830页

作者： Fenglan Wang Zhenyuan Cai Zhimei Li Shilong Zhang Honghui Luo qing Wu Hanhan Xia Yanhong guo College of Horticulture and Landscape Architecture Zhongkai University of Agriculture and EngineeringGuangzhou510225China

FLOWERING LOCUS T(FT)is an important factor for integrating flowering signals through the photoperiod pathway,which significantly promotes *** chrysanthemum varieties are short-day plants,sensitive to the photoperiod,which limits their ornamental and annual production *** this study,we aim to analyze the nutrients and flowering-related genes of chrysanthemums with different photoperiod types and to clone and verify the function of the flowering-related gene *** found that the formation of floral buds requires the accumulation of starch while consuming soluble sugars and the expression patterns of flowering-related genes GIGANTEA(GI),CONSTANS(CO),and FT in ***‘Zilian’and ***‘Zihongtuogui’had a certain synchronization during floral buds differentiation according to our quantitative validation,and the expression levels of CmGI,CmCO and CmFT in ***‘Zihongtuogui’were higher than those in ***.‘Zilian’in the later stage of *** was cloned from photosensitive ***‘Zihongtuogui’and polypeptide alignment and phylogenetic analysis showed that CmFT was clustered in FT-like *** further functional verification,we obtained two Arabidopsis transgenic *** results showed that CmFT transgenic ft mutant lines can significantly accelerate flowering in ***,we can initially confirm that CmFT plays an important role in promoting flowering,which may be the key reason for the photosensitivity of ***‘Zihongtuogui’.Overall,the results of this study are of great importance in revealing the flowering mechanism of different photoperiod types of chrysanthemums.

关键词： Chrysanthemum morifolium flowering-related genes CmFT photoperiod pathway heterologous expression

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