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Deletion of a 1,049 bp sequence from the 5′UTR upstream of the SiHEC3 gene induces a seed non-shattering mutation in sesame

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Journal of Integrative Agriculture 2024年第8期23卷 2589-2604页

作者： Ming Ju Guiting Li Qiuzhen Tian Hengchun Cao qin Ma Yinghui Duan Hui guo Zhanyou Zhang Yingying Huang Huili Wang Haiyang Zhang Hongmei Miao The Shennong Laboratory Zhengzhou 450002China Henan Sesame Research Center Henan Academy of Agricultural SciencesZhengzhou 450002China Key Laboratory of Specific Oilseed Crops Genomics of Henan Province Henan Sesame Research CenterHenan Academy of Agricultural SciencesZhengzhou 450002China

Sesame is a labor intensive crop with limited mechanized harvesting mainly due to the seed shattering(SS)*** this study,we performed a genetic analysis of the seed-shattering resistance(SR)trait with a SR sesame mutant *** the SS type,the parenchyma cells in the abscission zone of the 12M07 mutant are arranged loosely but adhere to the seed *** analysis of six generations derived from 12M07(SR)×Xiangcheng Dazibai(SS)showed that the SR trait is recessive and controlled by a single gene *** mapping of the F2population with 888,619 variants(single-nucleotide polymorphisms(SNPs)and insertion-deletion(InDels))and 31,884 structural variations(SVs)determined that only SV12002 in the 5′upstream region of gene Sindi0765000(named SiHEC3)in Chr.3 was significantly associated with the SR ***3 encodes the bHLH transcription factor.A 1,049 bp deletion occurred in the 5′UTR of Sihec3 in ***3 is mainly expressed in developing placental tissues,with the expression peaking in capsules at 45 days after pollination.A dual-luciferase reporter assay in tobacco confirmed that the promoter activity of Sihec3 was reduced because of the deletion of the 1,049 bp promoter ***–protein interaction network analysis showed that HEC3 is co-expressed with nine key proteins,such as SHATTERPROOF1(SHP1)and SEEDSTICK(STK)which participate in the secondary wall biosynthesis of the abscission layer in *** findings of this study show the important function of Sihec3corresponding with the SR trait and supply the genetic information for breeding new varieties that are amenable to mechanized harvesting in sesame and other crops.

关键词： sesame(Sesamum indicum L.) association mapping seed shattering structure variation bHLH transcription factor

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Unveiling size-fluorescence correlation of organic nanoparticles and its use in nanoparticle size determination

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Aggregate 2024年第1期5卷 331-336页

作者： Wu-Jie guo Shixiang Ma Hui Wang Lu Qiao Lei Chen Chenyu Hong Bin Liu Xiaoyan Zheng Hui-qing Peng State Key Laboratory of Chemical Resource Engineering Beijing Advanced Innovation Center for Soft Matter Science and EngineeringBeijing University of Chemical TechnologyBeijingChina Key Laboratory of Cluster Science of Ministry of Education Beijing Key Laboratory of Photoelectronic/Electro-photonic Conversion MaterialsKey Laboratory of Medicinal Molecule Science and Pharmaceutics Engineering of Ministry of Industry and Information TechnologySchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijingChina

Quantitatively establishing the correlation between nanoparticle size and fluorescence is essential for understanding the behavior and functionality of fluorescent nanoparticles(FNPs).However,such exploration focusing on organic FNPs has not been achieved to ***,we employ the use of supramolecular polymeric FNPs prepared from tetraphenylethylene-based bis-ureidopyrimidinone monomers(bis-UPys)to relate the size to the fluorescence of organic *** an equal concentration of bis-UPys,a logarithmic relationship between them is built with a correlation coefficient higher than *** calculations indicate that variations in fluorescence intensity among FNPs of different sizes are attributed to the distinct molecular packing environments at the surface and within the interior of the *** leads to different nonradiative decay rates of the embedded and exposed bis-UPys and thereby changes the overall fluorescence quantum yield of nanoparticles due to their different specific surface *** established fluorescence intensity-size correlation possesses fine universality and reliability,and it is successfully utilized to estimate the sizes of other nanoparticles,including those in highly diluted dispersions of *** work paves a new way for the simple and real-time determination of nanoparticle sizes and offers an attractive paradigm to optimize nanoparticle functionalities by the size effect.

关键词： aggregation-induced emission fluorescence detection fluorescent nanoparticle nanoparticle size supramolecular polymer

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Human immunodeficiency virus-associated dementia complex with positive 14-3-3 protein in cerebrospinal fluid:A case report

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World Journal of Clinical Cases 2024年第12期12卷 2065-2073页

作者： Yun-Sen He Xiao-Hong qin Min Feng qin-Jiang Huang Meng-Jun Zhang Li-Li guo Ming-Bin Bao Ye Tao Hong-Yuan Dai Bo Wu Department of Neurosurgery Sichuan Lansheng Brain Hospital&Shanghai Lansheng Brain Hospital Investment Co.Ltd.Chengdu 610036Sichuan ProvinceChina Department of Psychiatry Sichuan Provincial Center for Mental HealthChengdu 610072Sichuan ProvinceChina Department of Geriatrics Municipal People’s Hospital in LuzhouLuzhou 646000Sichuan ProvinceChina Department of Neurosurgery Wenjiang District People’s Hospital of ChengduChengdu 611100Sichuan ProvinceChina Department of Neurosurgery Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of China ChengduChengdu 610072Sichuan ProvinceChina Department of Neurology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072Sichuan ProvinceChina

BACKGROUND Human immunodeficiency virus(HIV)-associated dementia(HAD)is a subcortical form of dementia characterized by memory deficits and psychomotor ***,HAD often presents with symptoms similar to those of Creutzfeldt-Jakob disease(CJD),particularly in patients with acquired immune deficiency syndrome(AIDS).CASE SUMMARY We report the case of a 54-year-old male who exhibited cognitive dysfunction and secondary behavioral changes following HIV infection and suspected prion *** patient was diagnosed with HIV during hospitalization and his cerebrospinal fluid tested positive for 14-3-3 *** electroencephalogram showed a borderline-abnormal periodic triphasic wave ***-enhanced magnetic resonance imaging revealed moderate encephalatrophy and ***,symptomatic treatment and administration of amantadine were pursued for presumed CJD,but the patient’s condition continued to *** contrast,the patient’s condition improved following anti-HIV *** individual is also the only patient with this prognosis to have survived over 4 ***,the diagnosis was revised to *** In the diagnostic process of rapidly progressive dementia,it is crucial to rule out as many potential causes as possible and to consider an autopsy to diminish diagnostic *** 14-3-3 protein should not be regarded as the definitive marker for *** laboratory screening for infectious diseases is essential to enhance diagnostic precision,especially in AIDS patients with potential ***,a trial of diagnostic treatment may be considered when additional testing is not feasible.

关键词： HIV-associated dementia Cognitive dysfunction Creutzfeld-Jakob disease Rapidly progressive dementia Case report

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Evolution of template-assisted two-dimensional porphyrin chiral grating structure by directed self-assembly using chiral second harmonic generation microscopy

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Chinese Chemical Letters 2024年第10期35卷 196-200页

作者： Changhui Yu Peng Shang Huihui Hu Yuening Zhang Xujin qin Linyu Han Caihe Liu Xiaohan Liu Minghua Liu Yuan guo Zhen Zhang Beijing National Laboratory for Molecular Sciences State Key Laboratory of Molecular Reaction Dynamics Institute of Chemistry Chinese Academy of Sciences University of Chinese Academy of Sciences Beijing National Laboratory for Molecular Science CAS Key Laboratory of Colloid Interface and Chemical Thermodynamics Institute of Chemistry Chinese Academy of Sciences

Directed self-assembly has been used to create micro-nano scale patterns, including chiral periodic structures of organic molecules, for potential applications in optics, photonics, metamaterials, and medical and sensing technologies. This study presents a straightforward approach for fabricating large-scale chiral grating porphyrin assemblies through template-assisted techniques. The solution of tetrakis(4-sulfonatophenyl)porphyrin(TPPS) was induced by chiral amino acids(L/D-arginine and L/D-serine) to selfassemble into highly ordered chiral grating structures with the assistance of sodium dodecyl sulfate(SDS).The structures show precise line widths(5.5 μm) and gaps(18 μm). Using in situ optical microscopy and second harmonic generation(SHG) microscopy, the chiral characteristics and dynamic evolution of the template-assisted self-assembly are investigated. It is found that the chirality of amino acids induced TPPS self-assembled into chiral structures and the liquid contraction interface significantly enhanced the chirality of the assemblies. This study is significant for understanding the mechanism of chiral evolution and designing novel micro-nano materials with predetermined chiral properties.

关键词： Chiral assembly Chiral evolution Micro-nano structure Porphyrin Second harmonic generation microscopy Template-assisted self-assembly

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Ten ring-B aromatized ergosterols from Aspergillus spectabilis

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Chinese Journal of Natural Medicines 2024年第7期22卷 654-662页

作者： WEI Mengsha SUN Weiguang LIU Linlin LI Yongqi LI Lanqin LI qin CHEN Yu guo Jieru GU Lianghu ZHU Hucheng CHEN Chunmei ZHANG Yonghui Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation School of PharmacyTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Tongji Hospital Affiliated to Tongji Medical College Huazhong University of Science and TechnologyWuhan 430030China

Spectasterols F−O(1−10),ten interesting ergosterols with an aromatized B ring,were obtained from Aspergillus *** structures and absolute configurations were determined using a combination of high-resolution electrospray ionization mass spectrometry(HR-ESI-MS),nuclear magnetic resonance(NMR)spectroscopy,single-crystal X-ray diffraction analyses,and electronic circular dichroism(ECD)***,these aromatic ergosterols feature versatile side ***,compound aromatic ergosterols featured versatile side chains,and compound 4 is an unusual C23 ergosterol characterized by a shorter side chain due to oxidative cleavage between C-23 and *** compounds were evaluated for their neuroprotective activities,with compound 8 showing a dose-dependent ability to reduce apoptosis and protect mitochondrial function in glutamate-induced SH-SY5Y cells.

关键词： Steroids Aspergillus spectabilis Aromatic ergosterols Neuroprotective activities Structure elucidation

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Pseudorabies virus manipulates mitochondrial tryptophanyl-tRNA synthetase 2 for viral replication

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Virologica Sinica 2024年第3期39卷 403-413页

作者： Xiu-qing Li Meng-Pan Cai Ming-Yang Wang Bo-Wen Shi guo-Yu Yang Jiang Wang Bei-Bei Chu Sheng-Li Ming College of Veterinary Medicine Henan Agricultural UniversityZhengzhou 450046China Key Laboratory of Animal Biochemistry and Nutrition Ministry of Agriculture and Rural AffairsZhengzhou 450046China Key Laboratory of Veterinary Biotechnology of Henan Province Henan Agricultural UniversityZhengzhou 450046China Longhu Advanced Immunization Laboratory Zhengzhou 450046China International Joint Research Center of National Animal Immunology Henan Agricultural UniversityZhengzhou 450046China Ministry of Education Key Laboratory for Animal Pathogens and Biosafety Zhengzhou 450046China School of Basic Medicine Chongqing Medical UniversityChongqing 400016China

The pseudorabies virus(PRV)is identified as a double-helical DNA virus responsible for causing Aujeszky's disease,which results in considerable economic impacts *** enzyme tryptophanyl-tRNA synthetase 2(WARS2),a mitochondrial protein involved in protein synthesis,is recognized for its broad expression and vital role in the translation *** findings of our study showed an increase in both mRNA and protein levels of WARS2 following PRV infection in both cell cultures and animal *** WARS2 expression via RNA interference in PK-15 cells led to a reduction in PRV infection rates,whereas enhancing WARS2 expression resulted in increased infection ***,the activation of WARS2 in response to PRV was found to be reliant on the cGAS/STING/TBK1/IRF3 signaling pathway and the interferon-alpha receptor-1,highlighting its regulation via the type I interferon signaling *** analysis revealed that reducing WARS2 levels hindered PRV's ability to promote protein and lipid *** research provides novel evidence that WARS2 facilitates PRV infection through its management of protein and lipid levels,presenting new avenues for developing preventative and therapeutic measures against PRV infections.

关键词： Pseudorabies virus WARS2 Innate immunity Protein synthesis Lipid synthesis

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Metal-N_(4)model single‐atom catalyst with electroneutral quadri‐pyridine macrocyclic ligand for CO_(2)electroreduction

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Carbon Energy 2024年第8期6卷 122-133页

作者： Jian‐Zhao Peng Yin‐Long Li Yao‐Ti Cheng Fu‐Zhi Li Bo Cao qing Wang Xian Yue guo‐Tao Lai Yang‐Gang Wang Jun Gu Department of Chemistry Southern University of Science and TechnologyShenzhenGuangdongChina Institute for Catalysis Hokkaido UniversitySapporoJapan

Metal–N–C single‐atom catalysts,mostly prepared from pyrolysis of metalorganic precursors,are widely used in heterogeneous *** metal sites with diverse local structures coexist in this type of material and it is challenging to characterize the local structure,a reliable structure–property relationship is difficult to *** macrocyclic complexes adsorbed on carbon support are well‐defined models to mimic the singleatom ***–N_(4)site with four electroneutral pyridine‐type ligands embedded in a graphene layer is the most commonly proposed structure of the active site of single‐atom catalysts,but its molecular counterpart has not been *** this work,we synthesized the conjugated macrocyclic complexes with a metal center(Co,Fe,or Ni)coordinated with four electroneutral pyridinic ligands as model catalysts for CO_(2)*** comparison,the complexes with anionic quadri‐pyridine macrocyclic ligand were also *** Co complex with the electroneutral ligand expressed a turnover frequency of CO formation more than an order of magnitude higher than that of the Co complex with the anionic *** ab initio molecular dynamics simulations based on the well‐defined structures of the model catalysts indicate that the Co complex with the electroneutral ligand possesses a stronger ability to mediate electron transfer from carbon to CO_(2).

关键词： ab initio molecular dynamics CO_(2)reduction electrocatalysis model catalyst single‐atom catalyst

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Effects of dense planting patterns on photosynthetic traits of different vertical layers and yield of wheat under different nitrogen rates

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The Crop Journal 2024年第2期12卷 594-604页

作者： Cuicun Wang Ke Zhang qing Liu Xiufeng Zhang Zhikuan Shi Xue Wang Caili guo Qiang Cao Yongchao Tian Yan Zhu Xiaojun Liu Weixing Cao National Engineering and Technology Center for Information Agriculture Nanjing Agricultural UniversityNanjing 210095JiangsuChina MOE Engineering Research Center of Smart Agricultural Nanjing Agricultural UniversityNanjing 210095JiangsuChina MARA Key Laboratory for Crop System Analysis and Decision Making Nanjing Agricultural UniversityNanjing 210095JiangsuChina Jiangsu Key Laboratory for Information Agriculture Nanjing Agricultural UniversityNanjing 210095JiangsuChina Institute of Smart Agriculture Nanjing Agricultural UniversityNanjing 210095JiangsuChina

A two-year field experiment was conducted to measure the effects of densification methods on photosynthesis and yield of densely planted ***-plant and inter-row distances were used to define ratefixed pattern(RR)and row-fixed pattern(RS)density ***,four nitrogen(N)rates(0,144,192,and 240 kg N ha-1,termed N0,N144,N192,and N240)were applied with three densities(225,292.5,and 360×10^(4)plants ha^(-1),termed D225,D292.5,and D360).The wheat canopy was clipped into three equal vertical layers(top,middle,and bottom layers),and their chlorophyll density(Ch D)and photosynthetically active radiation interception(FIPAR)were *** showed that the response of Ch D and FIPAR to N rate,density,and pattern varied with different layers.N rate,density,and pattern had significant interaction effects on Ch *** maximum values of whole-canopy Ch D in the two seasons appeared in N240 combined with D292.5 and D360 under RR,*** two growing seasons,FIPAR values of RR were higher than those of RS by 29.37%for the top layer and 5.68%for the middle layer,while lower than those of RS by 20.62%for the bottom layer on *** a low N supply(N0),grain yield was not significantly affected by density for both *** N240,increasing density significantly increased yield under RR,but D360 of RS significantly decreased yield by 3.72%and 9.00%versus D225 in two seasons,*** an appropriate and sufficient N application,RR increased the yield of densely planted wheat more than ***,the maximum yield in two seasons appeared in the combination of D360 with N144 or N192 rather than of D225 with N240 under both patterns,suggesting that dense planting combined with an appropriate N-reduction application is feasible to increase photosynthesis capacity and yield.

关键词： Chlorophyll density Densification method Nitrogen Photosynthetically active radiation interception Wheat

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原貌、定位与意义:中国境内第一座广播电台的出版史料研究

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现代传播（中国传媒大学学报） 2024年第3期46卷 59-67页

作者：高国庆秦霄湖州师范学院人文学院浙江传媒学院播音主持艺术学院

奥斯邦(***)是中国境内第一座广播电台开播的关键人物,大量中外近代出版物记载了奥斯邦入华创办电台的始末。结合中国境内、港、澳和其他境外出版史料,以及中外学术出版物的互证,还原奥斯邦及其电台的历史原貌,探讨历史定位,阐释历史意... 详细信息

奥斯邦(***)是中国境内第一座广播电台开播的关键人物,大量中外近代出版物记载了奥斯邦入华创办电台的始末。结合中国境内、港、澳和其他境外出版史料,以及中外学术出版物的互证,还原奥斯邦及其电台的历史原貌,探讨历史定位,阐释历史意义。出版史料互证包括史料互证、史料与学术出版互证、学术出版互证三个方面。出版史料互证对构建中国广播开端史具有重要意义。从补充境外史料、拓展研究维度、更新研究视角三个方面延展出版史料研究,是构建广播史新研究空间的必然方向。中国广播史研究仍旧可以从更为广泛的出版史料中进行挖掘。

关键词：奥斯邦出版史料技术史全球化广播史

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5S-Heudelotinone alleviates experimental colitis by shaping the immune system and enhancing the intestinal barrier in a gut microbiota-dependent manner

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2153-2176页

作者： qing Meng Jianshuang guo Ke Lv Yang Liu Jin Zhang Mingyue Li Xirui Cheng Shenghua Chen Xiaoguang Huo Quan Zhang Yue Chen Jing Li State Key Laboratory of Medicinal Chemical Biology College of PharmacyNankai UniversityTianjin 300353China College of Chemistry and Frontiers Science Center for New Organic Matter Haihe Laboratory of Sustainable Chemical TransformationsNankai UniversityTianjin 300071China Accendatech Company Ltd.Tianjin 300193China

Aberrant changes in the gut microbiota are implicated in many diseases,including inflammatory bowel disease(IBD).Gut microbes produce diverse metabolites that can shape the immune system and impact the intestinal barrier integrity,indicating that microbe-mediated modulation may be a promising strategy for preventing and treating *** fecal microbiota transplantation and probiotic supplementation are well-established IBD therapies,novel chemical agents that are safe and exert strong effects on the gut microbiota are urgently ***,we report the total synthesis of heudelotinone and the discovery of 5S-heudelotinone(an enantiomer)as a potent agent against experimental colitis that acts by modulating the gut microbiota.5S-Heudelotinone alters the diversity and composition of the gut microbiota and increases the concentration of short-chain fatty acids(SCFAs);thus,it regulates the intestinal immune system by reducing proinflammatory immune cell numbers,and maintains intestinal mucosal integrity by modulating tight junctions(TJs).Moreover,5S-heudelotinone(2)ameliorates colitis-associated colorectal cancer(CAC)in an azoxymethane(AOM)/dextran sulfate sodium(DSS)-induced in situ carcinoma ***,these findings reveal the potential of a novel natural product,namely,5S-heudelotinone,to control intestinal inflammation and highlight that this product is a safe and effective candidate for the treatment of IBD and CAC.

关键词： 5S-heudelotinone Total synthesis Inflammatory bowel disease Gut microbiota Short-chain fatty acids Immune system Intestinal barrier Drug discovery

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