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聚集体(英文) 2023年第2期4卷 300-308页

作者： guo-qiang zhang Weiwei Feng Zhiyuan Gao Gao-Lan zhang Xinying Wu Yating Xiao Xun Li Lei Zheng Dan Ding Jianshuang guo Bo Situ Frontiers Science Center for Cell Responses State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Bioactive MaterialsMinistry of Educationand College of Life SciencesNankai UniversityTianjinChina Department of Laboratory Medicine Nanfang HospitalSouthern Medical UniversityGuangzhouChina Department of Pharmacology and Molecular Sciences Johns Hopkins University School of MedicineBaltimoreMarylandUSA School of Molecular Medicine Hangzhou Institute for Advanced StudyUCASHangzhouChina School of Chemical Engineering University of Chinese academy of scienceBeijingChina

Detection and imaging of α-L-fucosidase(AFU)is of great value to understand its roles in hepatocellular carcinoma(HCC)and tumor early diagnosis,but ideal assays are still lacking.Herein,a near-infrared(NIR)fluorescent biosensor(α-Fuc-DCM)was elaborately designed and synthesized for rapid and ratiometric detection of AFU activity in cells and HCC tumor mouse models.In the presence of AFU,this biosensor shows an enhancement in NIR emission in a ratiometric manner,which significantly improves the detection accuracy with the limit of detection as low as 4.8 mU/mL.Taking advantage of these merits,the activity of AFU in lysosomes could be visualized using ratiometric and NIR dual modality in living cells.Furthermore,its remarkable application for monitoring of endogenous AFU activity in HCC tumor-bearing mouse model is also demonstrated with bright fluorescence signal,which indicated that the biosensor could clearly monitor the liver tumor in the early stage.Importantly,the α-Fuc-DCM probe can be utilized to detect the AFU in serum from HCC patients.This strategy offers a promising biosensor system for early diagnosis of HCC and studying the roles of AFU in cancers.

关键词： cell and tumor imaging NIR fluorescent nanoprobe α-L-fucosidase

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Universal production of functionalized 2D nanomaterials via integrating glucose-assisted mechanochemical exfoliation and cosolvent-intensified sonication exfoliation

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Nano Research 2023年第4期16卷 5033-5041页

作者： Zhi-guo Wang Hui-Yuan Shen Ruo-Lin Yu Jie-Feng Gao guo-qiang zhang Chun Xu Jun Lei Ji-Guang Du Jia-Zhuang Xu Zhong-Ming Li College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002China College of Physics Sichuan UniversityChengdu 610065China

Two-dimensional(2D)nanomaterials have aroused immense attention in extensive applications due to their intriguing physical and chemical properties.However,there is a formidable challenge to prepare few-layered and functionalized 2D nanomaterials in an effective and universal way.Herein,we developed an integrated strategy of glucose-assisted mechanochemical exfoliation and cosolvent-intensified sonication exfoliation to effectively exfoliate and functionalize 2D materials.Taking exfoliation of boron nitride(BN)as an example,the production yield and functionalization ratio of BN nanosheets(BNNSs)reached 47.5%and 25.8 wt.%,188%and 16%higher than that of BNNSs without sonication exfoliation,respectively.The introduction of glucose not only augmented the friction force between adjacent BN layers to promote the efficiency of ball-milling-driven exfoliation supported by density functional theory calculation,but also reacted with active edges of BNNSs for functionalization.Afterwards,cosolventintensified sonication exfoliation strongly stabilized exfoliated BNNSs,obviously boosting the exfoliation yield.This proposed method is universal for preparing various 2D nanomaterials like molybdenum disulfide,tungsten disulfide,and graphene nanosheets.The thin plate structure and high functionalization ratio enabled the release of property superiorities of 2D nanomaterials.Our work offers a promising prototype to realize mass production of functionalized 2D nanomaterials.

关键词： two-dimensional materials glucose cosolvent exfoliation functionalization

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Populating ^(229m)Th via two-photon electronic bridge mechanism

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Nuclear Science and Techniques 2021年第6期32卷 45-53页

作者： Neng-qiang Cai guo-qiang zhang Chang-Bo Fu Yu-Gang Ma Shanghai Tech University Shanghai 201210China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China

The isomer ^(229m)Th is the most promising candidate for clocks based on the nuclear transition because it has the lowest excitation energy of only 8.10±0.17 eV.Various experiments and theories have focused on methods of triggering the transition between the ground state and isomeric state,among which the electronic bridge(EB)is one of the most efficient.In this paper,we propose a new electronic bridge mechanism via two-photon excitation based on quantum optics for a two-level nuclear quantum system.The long-lived 7 s1/2 electronic shell state of^(229m)Th^(3+),with a lifetime of approximately 0.6 s,is chosen as the initial state and the atomic shells(7 s-10 s)could be achieved as virtual states in a two-photon process.When the virtual states return to the initial state 7 s1/2,there is a chance of triggering the nucleus 229Th^(3+),to its isomeric state ^(229m)Th ^(3+),via EB.Two lasers at moderate intensity((10^(10)-10^(14))W/m^(2)),with photon energies near the optical range,are expected to populate the isomer at a saturated rate of approximately 10^(9) s^(-1),which is much higher than that due to other mechanisms.We believe that this twophoton EB scheme can help in the development of nuclear clocks and deserves verification via a series of experiments with ordinary lasers in laboratories.

关键词： Electronic bridge ^(229)mTh Nuclear clocks Two-photon excitation

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International Journal of Minerals,Metallurgy and Materials 2019年第11期26卷 1450-1456页

作者： Ying Yan guo-qiang zhang Li-jia Chen Xiao-wu Li Department of Materials Physics and Chemistry School of Materials Science and Engineeringand Key Laboratory for Anisotropy and Texture of MaterialsMinistry of EducationNortheastern UniversityShenyang 110819China School of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China

To explore the specimen size effect of mechanical behavior of ultrafine-grained(UFG)materials with different structures,UFG Al sheets processed by equal channel angular pressing(ECAP)were selected as target materials and the dependency of tensile behavior on sheet thickness(t)was systematically investigated.The strength and ductility of ECAPed UFG Al sheets were improved synchronously as t increased from 0.2 to 0.7 mm,and then no apparent change occurred when t reached to 0.7 and 1.0 mm.The corresponding microstructure evolved from dislocation networks in equiaxed grains into the walls and subgrains and finally into the dominated cells in elongated grains or subgrains.Meanwhile,dense shear lines(SLs)and shear bands(SBs)were clearly observed and microvoids and cracks were initiated along SBs with the increase of t.These observations indicated that the plastic deformation of UFG Al sheets was jointly controlled by shear banding,dislocation sliding,and grain-boundary sliding.Furthermore,the propagation of SBs became difficult as t increased.Finally,the obtained results were discussed and compared with those of annealed UFG Al and UFG Cu.

关键词： ultrafine-grained pure Al specimen size effect strength ductility

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Comparison of microstructure and heat treatment distortion of gear steels with and without Nb addition

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Journal of Iron and Steel Research(International) 2021年第4期28卷 488-495页

作者： guo-qiang zhang Xiao-fei He Qian-zhen zhang Wen-jun Wang Mao-qiu Wang Institute of Special Steel Central Iron and Steel Research InstituteBeijing 100081China NGC Group Nanjing 211102JiangsuChina Technical Center CITIC Metal GroupBeijing 100027China

In order to research the effect of microalloying Nb,the microstructure and heat treatment distortion of case carburizing steels with and without Nb addition are compared.Results show that a uniform and fine prior austenite grain size was obtained for the steel with the addition of 0.03 wt.%Nb even after being carburized at 980℃for 37 h,resulting in a very deep hardened layer of about 4 mm.Nb is an effective microalloying element to hinder austenite grain growth of gears during high-temperature carburizing.Theoretical calculation and experimental observation of NbC precipitates indicate that fine NbC precipitates have not evidently dissolved at 980℃,and thus they can act as grain refiners due to pinning effect.Heat treatment distortion of Nb-added steel is much lower than that of the steel without Nb addition.It may be contributed to its fine and uniform grain size,which presumably influences stress during martensitic transformation.

关键词： Case hardening steel High-temperature carburizing Grain size Heat treatment distortion Microstructure

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Inhibitory Effects of Simvastatin on Oxidized Low-Density Lipoprotein-lnduced Endoplasmic Reticulum Stress and Apoptosis in Vascular Endothelial Cells

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Chinese Medical Journal 2018年第8期131卷 950-955页

作者： guo-qiang zhang Yong-Kang Tao Yong-Ping Bai Sheng-Tao Yan Shui-Ping Zhao Department of Emergency China-Japan Friendship Hospital Beijing 100029 China Department of Geriatric Medicine Xiangya Hospital Central South University Changsha Hunan 410008 China Department of Cardiology The Second Xiangya Hospital Central South University Changsha Hunan 410011 China

Background：Oxidized low-density lipoprotein （ox-LDL）-induced oxidative stress and endothelial apoptosis are essential for atherosclerosis. Our previous study has shown that ox-LDL-induced apoptosis is mediated by the protein kinase RNA-like endoplasmic reticulum kinase （PERK）/eukaryotic translation initiation factor 2α-subunit （eIF2α）/CCAAT/enhancer-binding protein homologous protein （CHOP） endoplasmic reticulum （ER） stress pathway in endothelial cells. Statins are cholesterol-lowering drugs that exert pleiotropic effects including suppression of oxidative stress. This study aimed to explore the roles of simvastatin on ox-LDL-induced ER stress and apoptosis in endothelial cells.Methods：Human umbilical vein endothelial cells （HUVECs） were treated with simvastatin （0.1, 0.5, or 2.5 μmol/L） or DEVD-CHO （selective inhibitor of caspase-3, 100 μmol/L） for 1 h before the addition of ox-LDL （100 μg/ml） and then incubated for 24 h, and untreated cells were used as a control group. Apoptosis, expression of PERK, phosphorylation of eIF2α, CHOP mRNA level, and caspase-3 activity were measured. Comparisons among multiple groups were performed with one-way analysis of variance （ANOVA） followed by post hoc pairwise comparisons using Tukey’s tests. A value of P 〈 0.05 was considered statistically significant.Results：Exposure of HUVECs to ox-LDL resulted in a significant increase in apoptosis （31.9% vs. 4.9%, P 〈 0.05）. Simvastatin （0.1, 0.5, and 2.5 μmol/L） led to a suppression of ox-LDL-induced apoptosis （28.0%, 24.7%, and 13.8%, F = 15.039, all P 〈 0.05, compared with control group）. Ox-LDL significantly increased the expression of PERK （499.5%, P 〈 0.05） and phosphorylation of eIF2α （451.6%, P 〈 0.05）, if both of which in the control groups were considered as 100%. Simvastatin treatment （0.1, 0.5, and 2.5 μmol/L） blunted ox-LDL-induced expression of PERK （407.8%, 339.1%, and 187.5%, F = 10.121, all P 〈 0.05, compared with control group） and phosphorylation of eIF2α （407.8%, 339.1%, 187.5%, F = 11.430, all P 〈 0.05, compared w

关键词： Apoptosis Endoplasmic Reticulum Stress Endothelial Cells Oxidized Low-Density Lipoprotein Simvastatin

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Variation of the uniaxial tensile behavior of ultrafine-grained pure aluminum after cyclic pre-deformation

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International Journal of Minerals,Metallurgy and Materials 2018年第6期25卷 663-671页

作者： Ying Yan Li-jia Chen guo-qiang zhang Dong Han Xiao-wu Li Department of Materials Physics and Chemistry School of Materials Science and Engineering and Key Laboratory for Anisotropy and Texture of Materials of Ministry of Education Northeastern University School of Materials Science and Engineering Shenyang University of Technology

To explore the influence of cyclic pre-deformation on the mechanical behavior of ultrafine-grained（UFG）materials with a high stacking fault energy（SFE）,UFG Al processed by equal-channel angular pressing（ECAP）was selected as a target material and its tensile behavior at different pre-cyclic levels D（D=N_i/N_f,where N_i and N_f are the applied cycles and fatigue life at a constant stress amplitude of 50 MPa,respectively）along with the corresponding microstructures and deformation features were systematically studied.The cyclic pre-deformation treatment on the ECAPed UFG Al led to a decrease in flow stress,and a stress quasi-plateau stage was observed after yielding for all of the different-state UFG Al samples.The yield strengths_（YS）,ultimate tensile strengths_（UTS）,and uniform straineexhibited a strong dependence on D when D≤20%;however,when D was in the range from 20%to 50%,no obvious change in mechanical properties was observed.The micro-mechanism for the effect of cyclic pre-deformation on the tensile properties of the ECAPed UFG Al was revealed and compared with that of ECAPed UFG Cu through the observations of deformation features and microstructures.

关键词： ultrafine-grained aluminum cyclic pre-deformation tensile property microstructure deformation mechanism

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Dermoscopy of papular elastorrhexis

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Chinese Medical Journal 2021年第12期134卷 1503-1504页

作者： Jia-Qing Zhao Zhe Xu Bin Wang Yan-Jia Li guo-qiang zhang Department of Dermatology The First Hospital of Hebei Medical UniversityShijiazhuangHebei 050031China Department of Dermatology Beijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China

To the Editor:Papular elastorrhexis(PE)is a rare acquired elastic tissue disease.Its etiology and pathogenesis remain unknown.PE is predisposed to the trunk and limbs and clinically presented as multiple asymptomatic,3-to 5-mm non-follicular flesh-colored papules on children and adolescents,mainly in women.It presents only cutaneous involvement,and most of the patients are asymptomatic and often misdiagnosed and untreated.Herein,we present a case of PE and describe its dermoscopic features that have not been previously reported.

关键词： involvement limbs pathogenesis

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Development of gated fiber detectors for laser-induced strong electromagnetic pulse environments

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Nuclear Science and Techniques 2021年第6期32卷 36-44页

作者： Po Hu Zhi-guo Ma Kai Zhao guo-qiang zhang De-Qing Fang Bao-Ren Wei Chang-Bo Fu Yu-Gang Ma Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China School of Physical Science and Technology Shanghai Tech UniversityShanghai 201210China School of Nuclear Sciences and Technology University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China

With the development of laser technologies,nuclear reactions can happen in high-temperature plasma environments induced by lasers and have attracted a lot of attention from different physical disciplines.However,studies on nuclear reactions in plasma are still limited by detecting technologies.This is mainly due to the fact that extremely high electromagnetic pulses(EMPs)can also be induced when high-intensity lasers hit targets to induce plasma,and then cause dysfunction of many types of traditional detectors.Therefore,new particle detecting technologies are highly needed.In this paper,we report a recently developed gated fiber detector which can be used in harsh EMP environments.In this prototype detector,scintillating photons are coupled by fiber and then transferred to a gated photomultiplier tube which is located far away from the EMP source and shielded well.With those measures,the EMPs can be avoided which may result that the device has the capability to identify a single event of nuclear reaction products generated in laser-induced plasma from noise EMP backgrounds.This new type of detector can be widely used as a time-of-flight(TOF)detector in high-intensity laser nuclear physics experiments for detecting neutrons,photons,and other charged particles.

关键词： Gated fiber detector Radiation detection High-intensity laser Strong electromagnetic pulses

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All-optical signal processing for linearity enhancement of Mach–Zehnder modulators

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Chinese Science Bulletin 2014年第22期59卷 2655-2660页

作者： Xiao-Ping Zheng guo-qiang zhang Shangyuan Li Han-Yi zhang Bing-Kun Zhou Tsinghua National Laboratory for Information Science and Technology Department of Electronic Engineering Tsinghua University

This paper presents the fundamental principles and recent advances in the field of linearity enhancement of Mach–Zehnder modulators in microwave photonic systems using all-optical signal processing.A review of the fu... 详细信息

关键词：光信号处理线性度调制器马赫子系统原理微波

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