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Intestinal microcirculation dysfunction in sepsis: pathophysiology, clinical monitoring, and therapeutic interventions

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World Journal of Emergency Medicine 2022年第5期13卷 343-348页

作者： A-ling Tang Mei-jia Shen Guo-Qiang Zhang Graduate School Beijing University of Chinese MedicineBeijing 100029China Graduate School Peking Union Medical CollegeBeijing 100730China Department of Emergency China-Japan Friendship HospitalBeijing 100029China

BACKGROUND:Intestinal microcirculation dysfunction is an important factor that causes poor prognosis in sepsis patients and is an important pathophysiological basis for the occurrence and development of sepsis.DATA RESOURCES:PubMed,Web of Science,and China National Knowledge Infrastructure(CNKI)were searched from inception to August 1,2021.The search was limited to the English language only.Two reviewers independently identified studies related to intestinal microcirculation dysfunction in sepsis.Exclusion criteria were duplicate articles according to multiple search criteria.RESULTS:Fifty articles were included,and most of them were animal studies.These studies reported pathogenesis,including endothelial dysfunction,leukocyte recruitment and adhesion,microthrombus formation,microcirculation hypoperfusion,and redistribution of intestinal wall blood flow.The monitoring methods of intestinal microcirculation were also diverse,including handheld microscopes,intravital microscopy(IVM),laser Doppler blood flow instruments,laser speckle contrast imaging,tissue refl ectance spectrophotometry,biochemical markers of intestinal ischemia,and histopathological examination.In view of the related pathogenesis of intestinal microcirculation disorder in sepsis,existing studies also have diff erent opinions on its treatment.CONCLUSIONS:Limited by monitoring,there are few clinical studies on intestinal microcirculation dysfunction in sepsis.Related research mainly focuses on basic research,but some progress has also been made.Therefore,this review may provide a reference for future research on intestinal microcirculation dysfunction in sepsis.

关键词： Sepsis Microcirculation Intestinal barrier Intestinal ischemia Review

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Dissipation-induced nonreciprocal magnon blockade in a magnon-based hybrid system

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Science China(Physics,Mechanics & Astronomy) 2022年第6期65卷 44-52页

作者： Yimin Wang Wei Xiong Zhiyong Xu Guo-Qiang Zhang Jian-qiang You Communications Engineering College Army Engineering University of PLANanjing 210007China Department of Physics Wenzhou UniversityWenzhou 325035China Interdisciplinary Center of Quantum Information State Key Laboratory of Modern Optical Instrumentationand Zhejiang Province Key Laboratory of Quantum Technology and DeviceSchool of PhysicsZhejiang UniversityHangzhou 310027China

We propose an experimentally realizable nonreciprocal magnonic device at the single-magnon level by exploiting magnon block-ade in a magnon-based hybrid system.The coherent qubit-magnon coupling,mediated by virtual photons in a microwave cavity,leads to the energy-level anharmonicity of the composite modes.In contrast,the corresponding dissipative counterpart,induced by traveling microwaves in a waveguide,yields inhomogeneous broadenings of the energy levels.As a result,the cooperative effects of these two kinds of interactions give rise to the emergence of the direction-dependent magnon blockade.We show that this can be demonstrated by studying the equal-time second-order correlation function of the magnon mode.Our study opens an avenue to engineer nonreciprocal magnonic devices in the quantum regime involving only a small number of magnons.

关键词： nonreciprocal magnon blockade non-classical statistics dissipative coupling hybrid system

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Populating ^(229m)Th via two-photon electronic bridge mechanism

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Nuclear Science and Techniques 2021年第6期32卷 45-53页

作者： Neng-qiang Cai Guo-Qiang Zhang Chang-Bo Fu Yu-Gang Ma Shanghai Tech University Shanghai 201210China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China

The isomer ^(229m)Th is the most promising candidate for clocks based on the nuclear transition because it has the lowest excitation energy of only 8.10±0.17 eV.Various experiments and theories have focused on methods of triggering the transition between the ground state and isomeric state,among which the electronic bridge(EB)is one of the most efficient.In this paper,we propose a new electronic bridge mechanism via two-photon excitation based on quantum optics for a two-level nuclear quantum system.The long-lived 7 s1/2 electronic shell state of^(229m)Th^(3+),with a lifetime of approximately 0.6 s,is chosen as the initial state and the atomic shells(7 s-10 s)could be achieved as virtual states in a two-photon process.When the virtual states return to the initial state 7 s1/2,there is a chance of triggering the nucleus 229Th^(3+),to its isomeric state ^(229m)Th ^(3+),via EB.Two lasers at moderate intensity((10^(10)-10^(14))W/m^(2)),with photon energies near the optical range,are expected to populate the isomer at a saturated rate of approximately 10^(9) s^(-1),which is much higher than that due to other mechanisms.We believe that this twophoton EB scheme can help in the development of nuclear clocks and deserves verification via a series of experiments with ordinary lasers in laboratories.

关键词： Electronic bridge ^(229)mTh Nuclear clocks Two-photon excitation

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Quantum simulation of Hofstadter butterfly with synthetic gauge fields on two-dimensional superconducting-qubit lattices

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Frontiers of physics 2023年第6期18卷 283-290页

作者： Wei Feng Dexi Shao Guo-Qiang Zhang Qi-Ping Su Jun-Xiang zhang Chui-Ping Yang School of Physics Hangzhou Normal UniversityHangzhou 311121China School of Physics Zhejiang UniversityHangzhou 310027China

Motivated by recent realizations of two-dimensional(2D)superconducting-qubit lattices,we propose a protocol to simulate Hofstadter butterfly with synthetic gauge fields in superconducting circuits.Based on the existing 2D superconducting-qubit lattices,we construct a generalized Hofstadter model on zigzag lattices,which has a fractal energy spectrum similar to the original Hofstadter butterfly.By periodically modulating the resonant frequencies of qubits,we engineer a synthetic gauge field to mimic the generalized Hofstadter Hamiltonian.A spectroscopic method is used to demonstrate the Hofstadter butterfly from the time evolutions of experimental observables.We numerically simulate the dynamics of the system with realistic parameters,and the results show a butterfly spectrum clearly.Our proposal provides a promising way to realize the Hofstadter butterfly on the latest 2D superconducting-qubit lattices and will stimulate the quantum simulation of novel properties induced by magnetic fields in superconducting circuits.

关键词： quantum simulation superconducting circuits superconducting qubit quantum computation

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Preface:special topic on rechargeable battery technology

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Science China Chemistry 2024年第1期67卷 1-3页

作者： Yu-guo guo qiang zhang Jun Chen Li-Jun Wan CAS Key Laboratory of Molecular Nanostructure and Nanotechnology CAS Research/Education Center for Excellence in Molecular SciencesBeijing National Laboratory for Molecular Sciences(BNLMS)Institute of ChemistryChinese Academy of Sciences(CAS)Beijing 100190China University of Chinese Academy of Sciences Beijing 100049China Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China Frontiers Science Center for New Organic Matter Renewable Energy Conversion and Storage Center(RECAST)Haihe Laboratory of Sustainable Chemical TransformationsKey Laboratory of Advanced Energy Materials Chemistry(Ministry of Education)College of ChemistryNankai UniversityTianjin 300071China

Rechargeable batteries play a major role in the transition from fossil energy to renewable energy and are considered the key-enabling decarbonization technology for several industries,including electronics,transportat... 详细信息

关键词： battery artificial technology

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A novel transperineal approach for surgical resection of presacral tumors with an arc-shaped incision in front of the apex of the coccyx(with video)

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Gastroenterology Report 2022年第1期10卷 603-605页

作者： Guo-Qiang Zhang Gang-Cheng Wang Zhi zhang Liang-Liang Ding You-Cai Wang Yin-Jun Liu Department of General Surgery Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer HospitalZhengzhouHenanP.R.China

Introduction Presacral cystic tumors are rare and are composed of many types of tumors located in the presacral space[1].The mainstay of treatment is total excision without preoperative biopsy[2].In recent years,the number of patients with presacral cystic tumors who have been treated in the Affiliated Cancer Hospital of Zhengzhou University has increased.In particular,>25%of patients have presented with residual presacral cystic walls with perineal refractory sinuses due to the failure of presacral tumor operations in other hospitals.We studied the surgical records of patients with failed primary procedures and suggested that inadequate surgical exposure due to a lack of proper surgical approach was the main reason.Therefore.

关键词： presacral surgical shaped

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Development of a wide-range and fast-response digitizing pulse signal acquisition and processing system for neutron flux monitoring on EAST

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Nuclear Science and Techniques 2022年第3期33卷 126-136页

作者： Li Yang Hong-Rui Cao Jin-Long Zhao Zi-Han zhang qiang Li guo-Bin Wu Yong-qiang zhang guo-qiang Zhong Li-Qun Hu Zi-Jun zhang Institute of Plasma Physics Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China University of Science and Technology of China Hefei 230026China Hefei University of Technology Hefei 230009China

The neutron count rate fluctuation reaches six orders of magnitude between the ohmic plasma scenario and high power of auxiliary heating on an experimental advanced superconducting tokamak(EAST).The measurement result of neutron flux monitoring(NFM)is a significant feedback parameter related to the acquisition of radiation protection-related information and rapid fluctuations in neutron emission induced by plasma magnetohydrodynamic activity.Therefore,a wide range and high time resolution are required for the NFM system on EAST.To satisfy these requirements,a digital pulse signal acquisition and processing system with a wide dynamic range and fast response time was developed.The present study was conducted using a field-programmable gate array(FPGA)and peripheral component interconnect extension for instrument express(PXIe)platform.The digital dual measurement modes,which are composed of the pulse-counting mode and AC coupled square integral's Campbelling mode,were designed to expand the measurement range of the signal acquisition and processing system.The time resolution of the signal acquisition and processing system was improved from 10 to 1 ms owing to utilizing highspeed analog-to-digital converters(ADCs),a high-speed PXIe communication with a direct memory access(DMA)mode,and online data preprocessing technology of FPGA.The signal acquisition and processing system was tested experimentally in the EAST radiation field.The test results showed that the time resolution of NFM was improved to 1 ms,and the dynamic range of the neutron counts rate was expanded to more than 10^(6) counts per second.The Campbelling mode was calibrated using a multipoint average linear fitting method;subsequently,the fitting coefficient reached 0.9911.Therefore,the newly developed pulse signal acquisition and processing system ensures that the NFM system meets the requirements of high-parameter experiments conducted on EAST more effectively.

关键词： EAST Neutron flux monitoring High time resolution Wide range Pulse signal acquisition and processing system

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The relationship between amyloid-beta and brain capillary endothelial cells in Alzheimer's disease

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Neural Regeneration Research 2022年第11期17卷 2355-2363页

作者： Yan-Li zhang Juan Wang Zhi-Na zhang qiang Su Jun-Hong guo Department of Neurology First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Neurology Sixth Hospital of Shanxi Medical University(General Hospital of Tisco)TaiyuanShanxi ProvinceChina School of Public Health Shanxi Medical UniversityTaiyuanShanxi ProvinceChina

Neurovascular dysfunction,as an integral part of Alzheimer's disease,may have an important influence on the onset and progression of chronic neurodegenerative processes.The bloodbrain barrier(BBB)pathway is one of the main pathways that mediates the clearance of amyloidbeta(Aβ)in the brain parenchyma.A large number of studies have shown that receptors and ATPbinding cassette transporte rs expressed on endothelial cells play an important role in Aβtransport across the BBB,but the specific mechanism is not clear.In this review,we summarize the possible mechanisms of Aβproduction and clearance,and in particular the relationship between Aβand brain capillary endothelial cells.Aβis produced by abnormal cleavage of the amyloid precursor protein via amyloidogenic processing under pathological conditions.Dys regulation of Aβclearance is considered to be the main reason for the massive accumulation of Aβin the brain parenchyma.Several pathways mediating Aβclearance from the brain into the periphery have been identified,including the BBB pathway,the blood-cerebros pinal fluid barrier and arachnoid granule pathway,and the lymphoidrelated pathway.Brain ca pilla ry endothelial cells are the key components of Aβclearance mediated by BBB.Receptors(such as LRP1,RAGE,and FcRn)and ATP-binding cassette transporters(such as P-gp,ABCA1,and ABCC1)expressed on endothelial cells play a critical role in Aβtranscytosis across the BBB.The toxic effects of Aβcan induce dysregulation of receptor and transpo rter expression on endothelial cells.Excessive Aβexerts potent detrimental cerebrovascular effects by promoting oxidative stress,inducing chronic inflammation,and impairing endothelial structure and functions.All of these are main causes for the reduction in Aβclearance across the BBB and the accumulation of Aβin the brain parenchyma.Therefo re,studies on the intera ctions between Aβand brain capillary endothelial cells,including their receptors and transporters,studies on inhibition of the toxic effects of Aβon endothelial cells,and stud

关键词： Alzheimer's disease amyloid beta Aβclearance blood-brain barrier cerebral amyloid angiopathy dementia endothelial cells oxidative stress review therapeutics transcytosis

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Interface-dominated mechanical behavior in advanced metal matrix composites

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Nano Materials Science 2020年第1期2卷 66-71页

作者： qiang guo Yifan Han Di zhang State Key Lab of Metal Matrix Composites Shanghai Jiao Tong University800 Dongchuan RoadShanghai200240China

Metal matrix composites(MMCs)incorporate a reinforcing or functional secondary phase into a metal matrix to achieve specific properties.Of the parameters which may affect the mechanical behavior of MMCs,the structure and properties of the reinforcement/matrix interface play a crucial role.This article reviews recent developments in measuring the interfacial properties in advanced MMCs,with an emphasis on the use of micro-/nano-mechanical testing approaches.It is shown that,with the novel in situ and ex situ experimental capability,researchers can now obtain some of the critical interfacial properties as well as the effects of reinforcement/matrix interfaces on the composites’deformation and failure mechanisms that were unattainable previously by conventional methodologies.Moreover,the micro-/nano-mechanical testing platform allows for both fundamental and applied research on the composites’mechanical performance under service conditions,which is considered a promising and emerging research direction.

关键词： Metal matrix composites Interface Mechanical behavior Nanostructure Strengthening

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A NIR ratiometric fluorescent biosensor for sensitive detection and imaging of α-L-fucosidase in living cells and HCC tumor-bearing mice

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聚集体(英文) 2023年第2期4卷 300-308页

作者： Guo-Qiang Zhang Weiwei Feng Zhiyuan Gao Gao-Lan zhang Xinying Wu Yating Xiao Xun Li Lei Zheng Dan Ding Jianshuang guo Bo Situ Frontiers Science Center for Cell Responses State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Bioactive MaterialsMinistry of Educationand College of Life SciencesNankai UniversityTianjinChina Department of Laboratory Medicine Nanfang HospitalSouthern Medical UniversityGuangzhouChina Department of Pharmacology and Molecular Sciences Johns Hopkins University School of MedicineBaltimoreMarylandUSA School of Molecular Medicine Hangzhou Institute for Advanced StudyUCASHangzhouChina School of Chemical Engineering University of Chinese academy of scienceBeijingChina

Detection and imaging of α-L-fucosidase(AFU)is of great value to understand its roles in hepatocellular carcinoma(HCC)and tumor early diagnosis,but ideal assays are still lacking.Herein,a near-infrared(NIR)fluorescent biosensor(α-Fuc-DCM)was elaborately designed and synthesized for rapid and ratiometric detection of AFU activity in cells and HCC tumor mouse models.In the presence of AFU,this biosensor shows an enhancement in NIR emission in a ratiometric manner,which significantly improves the detection accuracy with the limit of detection as low as 4.8 mU/mL.Taking advantage of these merits,the activity of AFU in lysosomes could be visualized using ratiometric and NIR dual modality in living cells.Furthermore,its remarkable application for monitoring of endogenous AFU activity in HCC tumor-bearing mouse model is also demonstrated with bright fluorescence signal,which indicated that the biosensor could clearly monitor the liver tumor in the early stage.Importantly,the α-Fuc-DCM probe can be utilized to detect the AFU in serum from HCC patients.This strategy offers a promising biosensor system for early diagnosis of HCC and studying the roles of AFU in cancers.

关键词： cell and tumor imaging NIR fluorescent nanoprobe α-L-fucosidase

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