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Gentiopicroside Alleviates Atherosclerosis by Suppressing Reactive Oxygen Species-Dependent NLRP3 Inflammasome Activation in Vascular Endothelial Cells via SIRT1/Nrf2 Pathway

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Chinese Journal of Integrative Medicine 2025年第2期31卷 118-130页

作者： LI Zhu-qing ZHANG Feng LI Qi WANG Li SUN Xiao-qiang LI Chao YIN Xue-mei LIU Chun-lei WANG Yan-xin DU Xiao-yu LU cheng-zhi Department of Cardiology Tianjin First Central HospitalTianjin300192China The First Central Clinical School Tianjin Medical UniversityTianjin300070China Department of Cardiology The First College of Clinical Medical ScienceChina Three Gorges University&Yichang Central People’s HospitalYichangHubei Province443003China School of Medicine Nankai UniversityTianjin300071China

Objective:To evaluate the protective effects of gentiopicroside(GPS)against reactive oxygen species(ROS)-induced NOD-like receptor family,pyrin domain containing 3(NLRP3)inflammasome activation in endothelial cells,aiming to reduce ***:Eight-week-old male ApoE-deficient mice were randomly divided into 2 groups(n=10 per group):the vehicle group and the GPS treatment *** groups were fed a high-fat diet for 16 ***(40 mg/kg per day)was administered by oral gavage to the GPS group,while the vehicle group received an equivalent volume of the vehicle *** the end of the treatment,blood and aortic tissues were collected for assessments of atherosclerosis,lipid profiles,oxidative stress,and molecular expressions related to NLRP3 inflammasome activation,ROS production,and ***,in vitro experiments on human aortic endothelial cells treated with oxidized low-density lipoprotein(ox-LDL)were conducted to evaluate the effects of GPS on NLRP3 inflammasome activation,pyroptosis,apoptosis,and ROS production,specifically examining the role of the sirtuin 1(SIRT1)/nuclear factor erythroid 2-related factor 2(Nrf2)***1 and Nrf2 inhibitors were used to confirm the pathway's ***:GPS treatment significantly reduced atherosclerotic lesions in the en face aorta(P<0.01),as well as in the thoracic and abdominal aortic regions,and markedly decreased sinus lesions within the aortic root(P<0.05 or P<0.01).Additionally,GPS reduced oxidative stress markers and proinflammatory cytokines,including interleukin(IL)-1βand IL-18,in lesion areas(P<0.05,P<0.01).In vitro,GPS inhibited ox-LDL-induced NLRP3 activation,as evidenced by reduced NLRP3(P<0.01),apoptosis-associated speck-like protein containing a CARD,cleaved-caspase-1,and cleavedgasdermin D expressions(all P<0.01).GPS also decreased ROS production,apoptosis,and pyroptosis,with the beneficial effects being significantly reversed by SIRT1 or Nrf2 ***:GPS exe

关键词： endothelial dysfunction gentiopicroside NLRP3 inflammasome SIRT1 nuclear factor erythroid 2-related factor 2 Chinese medicine

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“Zero‑Strain” NiNb_(2)O_(6) Fibers for All‑Climate Lithium Storage

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Nano-Micro Letters 2025年第1期17卷 348-360页

作者： Yan Zhao qiang Yuan Liting Yang Guisheng Liang Yifeng cheng Limin Wu Chunfu Lin Renchao Che College of Physics Donghua UniversityShanghai 201620People’s Republic of China School of Materials Science and Engineering Institute of Materials for Energy and EnvironmentQingdao UniversityQingdao 266071People’s Republic of China Laboratory of Advanced Materials Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsAcademy for Engineering&TechnologyFudan UniversityShanghai 200438People’s Republic of China Zhejiang Laboratory Hangzhou 311100People’s Republic of China Inner Mongolia University Hohhot 010021People’s Republic of China

Niobates are promising all-climate Li^(+)-storage anode material due to their fast charge transport,large specific capacities,and resistance to electrolyte ***,their moderate unit-cellvolume expansion(generally 5%–10%)during Li^(+)storage causes unsatisfactory long-term ***,“zero-strain”NiNb_(2)O_(6) fibers are explored as a new anode material with comprehensively good electrochemical *** Li^(+)storage,the expansion of electrochemical inactive NiO_(6) octahedra almost fully offsets the shrinkage of active NbO_(6) octahedra through reversible O *** superior volume-accommodation capability of the NiO_(6) layers guarantees the“zero-strain”behavior of NiNb_(2)O_(6) in a broad temperature range(0.53%//0.51%//0.74%at 25//−10//60℃),leading to the excellent cyclability of the NiNb_(2)O_(6) fibers(92.8%//99.2%//91.1%capacity retention after 1000//2000//1000 cycles at 10C and 25//−10//60℃).This NiNb_(2)O_(6) material further exhibits a large reversible capacity(300//184//318 mAh g−1 at 0.1C and 25//−10//60℃)and outstanding rate performance(10 to 0.5C capacity percentage of 64.3%//50.0%//65.4%at 25//−10//60℃).Therefore,the NiNb_(2)O_(6) fibers are especially suitable for large-capacity,fast-charging,long-life,and all-climate lithium-ion batteries.

关键词： NiNb_(2)O_(6)porous fiber “Zero-strain”mechanism Electrochemical property Harsh-temperature operation Operando characterization

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Bioinspired smart dual-layer hydrogels system with synchronous solar and thermal radiation modulation for energy-saving all-season temperature regulation

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Journal of Energy Chemistry 2025年第2期101卷 175-190页

作者： Meng-Chen Huang Chao-Hua Xue Zhongxue Bai Jun cheng Yong-Gang Wu Chao-Qun Ma Li Wan Long Xie Hui-Di Wang Bing-Ying Liu Xiao-Jing guo College of Bioresources Chemical and Materials Engineering Shaanxi University of Science & Technology School of Manufacture Science and Engineering Key Laboratory of Testing Technology for Manufacturing Process Ministry of Education Southwest University of Science and Technology School of Life Science and Engineering Southwest University of Science and Technology Northwest Institute for Nonferrous Metal Research Shaanxi Key Laboratory of Biomedical Metal Materials

All-season thermal management with zero energy consumption and emissions is more crucial to global decarbonization over traditional energy-intensive cooling/heating ***,the static single thermal management for cooling or heating fails to self-regulate the temperature in dynamic seasonal temperature ***,inspired by the dual-temperature regulation function of the fur color changes on the backs and abdomens of penguins,a smart thermal management composite hydrogel(PNA@H-PM Gel) system was subtly created though an "on-demand" dual-layer structure design *** PNA@H-PM Gel system features synchronous solar and thermal radiation modulation as well as tunable phase transition temperatures to meet the variable seasonal thermal requirements and energy-saving demands via self-adaptive radiative cooling and solar heating ***,this system demonstrates superb modulations of both the solar reflectance(ΔR=0.74) and thermal emissivity(ΔE=0.52) in response to ambient temperature changes,highlighting efficient temperature regulation with average radiative cooling and solar heating effects of 9.6℃ in summer and 6.1℃ in winter,***,compared to standard building baselines,the PNA@H-PM Gel presents a more substantial energy-saving cooling/heating potentials for energy-efficient buildings across various regions and *** novel solution,inspired by penguins in the real world,will offer a fresh approach for producing intelligent,energy-saving thermal management materials,and serve for temperature regulation under dynamic climate conditions and even throughout all seasons.

关键词： Energy-saving Radiative cooling Self-adaptive thermal management Spectral modulation Thermochromic hydrogel

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Investigations of inelastic cross sections of H_(2)O molecule by He^(2+) and C^(6+) projectiles with energy range around the Bragg peak

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Nuclear Science and Techniques 2025年第2期36卷 141-154页

作者： guo-Zhuang Li cheng-Ye Sun Rui cheng Yan-Shi Zhang Liang-Wen Chen Sheng Zhang Xin-Xia Li Lei Yang School of Nuclear Science and Technology University of South ChinaHengyang 421001China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Interdisciplinary Center for Fundamental and Frontier Sciences Nanjing University of Science and TechnologyJiangyin 214443China Center for Basic Teaching and Experiment Nanjing University of Science and TechnologyJiangyin 214443China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China

Inelastic collisions are the dominant cause of energy loss in *** the energy range around the Bragg peak,single ionization(SI)and single-electron capture(SC)are the primary inelastic collisions that lead to energy *** study employs the classical trajectory Monte Carlo method to study the SI and SC processes of H_(2)O molecules using He^(2+) and C^(6+) projectiles in the energy range of 10 keV/u to 10 MeV/*** total cross sections,single differential cross sections,impact parameter dependence of SI and SC,and fragmentation cross sections were *** illustrate that the cross section for SI is the highest when the projectile energy is close to the Bragg peak *** the projectile energy is below the Bragg peak energy,the ionized electrons in the forward direction dominate,and the removal of electrons can be associated with large impact *** the projectile energy increases,the emission angle of the electrons gradually transitions from small angles(60°~120°)to large angles(60°~120°),and the removal of electrons is associated with small impact *** energy distributions of the ionized electron are similar when the projectile energy is equal to,below or above the Bragg peak *** fragmentation cross sections after SI and SC in the energy range around the Bragg peak were also estimated.

关键词： Classical trajectory Monte Carlo Heavy ion-water molecule collision Inelastic cross sections

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Biomaterial-based strategies:a new era in spinal cord injury treatment

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Neural Regeneration Research 2025年第12期20卷 3476-3500页

作者： Shihong Zhu Sijun Diao Xiaoyin Liu Zhujun Zhang Fujun Liu Wei Chen Xiyue Lu Huiyang Luo Xu cheng qiang Liao Zhongyu Li Jing Chen Department of Neurosurgery West China HospitalWest China Medical SchoolSichuan UniversityChengduSichuan ProvinceChina National Engineering Research Center for Biomaterials College of Biomedical EngineeringSichuan UniversityChengduSichuan ProvinceChina Department of Ophthalmology State Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Anesthesiology West China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Pharmacy West China HospitalWest China Medical SchoolSichuan UniversityChengduSichuan ProvinceChina

Enhancing neurological recovery and improving the prognosis of spinal cord injury have gained research attention *** cord injury is associated with a complex molecular and cellular *** complexity has prompted researchers to elucidate the underlying pathophysiological mechanisms and changes and to identify effective treatment *** approaches for spinal cord injury repair include surgery,oral or intravenous medications,and administration of neurotrophic factors;however,the efficacy of these approaches remains inconclusive,and serious adverse reactions continue to be a *** advancements in tissue engineering and regenerative medicine,emerging strategies for spinal cord injury repair now involve nanoparticle-based nanodelivery systems,scaffolds,and functional recovery techniques that incorporate biomaterials,bioengineering,stem cell,and growth factors as well as three-dimensional *** biomaterial scaffolds should not only provide structural support for neuron migration,adhesion,proliferation,and differentiation but also mimic the mechanical properties of natural spinal cord ***,these scaffolds should facilitate axon growth and neurogenesis by offering adjustable topography and a range of physical and biochemical *** three-dimensionally interconnected porous structure and appropriate physicochemical properties enabled by three-dimensional biomimetic printing technology can maximize the potential of biomaterials used for treating spinal cord ***,correct selection and application of scaffolds,coupled with successful clinical translation,represent promising clinical objectives to enhance the treatment efficacy for and prognosis of spinal cord *** review elucidates the key mechanisms underlying the occurrence of spinal cord injury and regeneration post-injury,including neuroinflammation,oxidative stress,axon regeneration,and *** review also briefly dis

关键词： biomaterials growth factors nanoparticles neural regeneration scaffolds spinal cord injury stem cells therapy strategies tissue engineering

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Subgenome asymmetry of gibberellins-related genes plays important roles in regulating rapid growth of bamboos

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Plant Diversity 2025年第1期47卷 68-81页

作者： Ling Mao Cen guo Liang-Zhong Niu Yu-Jiao Wang Guihua Jin Yi-Zhou Yang Ke-cheng Qian Yang Yang Xuemei Zhang Peng-Fei Ma De-Zhu Li Zhen-Hua guo Germplasm Bank of Wild Species&Yunnan Key Laboratory of Crop Wild Relatives Omics Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Plant Diversity and Specialty Crops Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China Center for Integrative Conservation&Yunnan Key Laboratory for the Conservation of Tropical Rainforests and Asian Elephants Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglunMenglaYunnan 666303China Yunnan Key Laboratory of Dai and Yi Medicines Yunnan University of Chinese MedicineKunmingYunnan 650500China

Rapid growth is an innovative trait of woody bamboos that has been widely ***,the genetic basis and evolution of this trait are poorly *** advantage of genomic resources of 11 representative bamboos at different ploidal levels,we integrated morphological,physiological,and transcriptomic datasets to investigate rapid *** particular,these bamboos include two large-sized and a small-sized woody species,compared with a diploid herbaceous *** results showed that gibberellin A1 was important for the rapid shoot growth of the world's largest bamboo,Dendrocalamus sinicus,and indicated that two gibberellins(GAs)-related genes,KAO and SLRL1,were key to the rapid shoot growth and culm size in woody *** expression of GAs-related genes exhibited significant subgenome asymmetry with subgenomes A and C demonstrating expression dominance in the large-sized woody bamboos while the generally submissive subgenomes B and D dominating in the small-sized *** subgenome asymmetry was found to be correlated with the subgenome-specific gene structure,particularly UTRs and core *** study provides novel insights into the molecular mechanism and evolution of rapid shoot growth following allopolyploidization in woody bamboos,particularly via subgenome *** findings are helpful for understanding of how polyploidization in general and subgenome asymmetry in particular contributed to the origin of innovative traits in plants.

关键词： Allopolyploids GAs DEGs Culm sizes Rapid shoot growth Woody bamboos

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Fluorescence sensor based on IFE between AEP@UCNPs and oxTMB for the determination of Cd^(2+)in paddy rice combined with HRP enzyme inhibition mechanism

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Food Science and Human Wellness 2025年第1期14卷 154-160页

作者： Haizhen Ding Shuai Hou Siqi Zhao Liping guo Ao Sun Qiuhui Hu Leiqing Pan qiang Liu Chao Ding Collaborative Innovation Center for Modern Grain Circulation and Safety Key Laboratory of Grains and Oils Quality Control and ProcessingCollege of Food Science and EngineeringNanjing University of Finance and EconomicsNanjing 210023China College of Food Science and Technology Nanjing Agricultural UniversityNanjing 210095China

Cadmium ion(Cd^(2+))detection technology plays a prominent role in food safety and human ***,we designed and constructed an 2-aminoethyl dihydrogen phosphate(AEP)@upconversion nanoparticles(UCNPs)fluorescence sensor for quantitative detection of Cd^(2+)in paddy rice based on inner filter effect(IFE)combined with enzyme inhibition *** AEP modification UCNPs can offer a stable fluorescence donor at 658 nm and be quenched by the oxidized tetramethylbenzidine(oxTMB)catalyzed by horseradish peroxidase(HRP)*** addition of Cd^(2+),the fluorescence of AEP@UCNPs fluorescence sensor was weaken due to the IFE between AEP@UCNPs and *** addition of Cd^(2+),HRP enzyme activity was inhibited by Cd^(2+),leading to the decreased oxTMB,resulting in the enhance upconversion fluorescence *** a result,the fluorescence intensity signal at 658 nm of the IFE-based AEP@UCNPs fluorescence sensor increased linearly with the increase in Cd^(2+)in a wide range from 0.5μmol/L to 6μmol/L and the limit of detection(LOD)was 24.6 n mol/*** addition,our proposed IFE-based AEP@UCNPs fluorescence sensor can achieve Cd^(2+)detection in paddy rice in 30 min.

关键词： Paddy rice Cd^(2+) Enzyme inhibition Upconversion nanoparticles(UCNPs) Inner filter effect(IFE)

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Design and fabrication of (Hf0.25Zr0.25Ta0.25Nb0.2)C-SiC ceramics with improved microwave absorbing properties via PDC route

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JOURNAL OF ADVANCED CERAMICS 2025年第1期14卷 49-58页

作者： Du, Bin Wang, Saidi guo, Linwei Ouyang, Yimin cheng, Hanwei cheng, Yajuan Zhang, Tao Guangzhou Univ Sch Phys & Mat Sci Guangzhou 510006 Peoples R China

The development of advanced and efficient microwave-absorbing materials through the precise regulation of dielectric loss and impedance matching remains a significant challenge. In this study, (Hf 0.25 Zr 0.25 Ta 0.25 Nb 0.25 )C-SiC (HEC-SiC) biphasic ceramic powders were synthesized via a single-source- precursor route. The SiC content was systematically controlled by adjusting the amount of methyltrimethoxysilane. The resulting polymer-derived HEC-SiC composite exhibited a unique microstructure, with nanosized SiC particles uniformly distributed throughout the HEC matrix. As a result, the HEC-SiC-2 composite, containing approximately 21.21 wt% SiC, achieved a minimum reflection loss value (RLmin) of -54.28 dB at 12.39 GHz with a thickness of 3.14 mm. The superior microwave attenuation capability is attributed to optimized impedance matching, enhanced interfacial polarization between the HEC matrix and nanosized SiC, and dipole polarization induced by defects within HEC. This study offers a novel strategy for the fabrication of high-entropy ceramic-SiC biphasic composites with excellent microwave absorbing properties, paving the way for their application in electromagnetic interference shielding and stealth technologies.

关键词： polymer-derived ceramics high-entropy ceramics microwave absorbing properties SiC

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Efficient gene disruption in polyploid genome by Cas9–Trex2 fusion protein

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Journal of Integrative Plant Biology 2025年第1期67卷 7-10页

作者： Wenbo Pan Chunlei Gao De Niu Jinghua cheng Jiao Zhang Xiying Yan qiang Long Yao Yao Zhu Wenjing Sun Qi Xie Yuehui He Xing Wang Deng Huawei Zhang Jian Li State Key Laboratory of Wheat Improvement Shandong Laboratory of Advanced Agricultural Sciences in WeifangPeking University Institute of Advanced Agricultural SciencesWeifang 261325China Guangdong Provincial Key Laboratory of Biotechnology for Plant Development Ministry of Education&Guangdong Provincial Key Laboratory of Laser Life ScienceSchool of Life SciencesSouth China Normal UniversityGuangzhou 510631China Shenzhen Tidy field System Biotechnology Co. LtdShenzhen 518107China State Key Laboratory of Plant Genomics Institute of Genetics and Developmental BiologyThe Innovative Academy of Seed DesignChinese Academy of SciencesBeijing 100101China

Despite significant advancements in the efficiency of the CRISPR/Cas9 genome editing system over the past decade,performing gene disruption in polyploid crops such as common wheat(Triticum aestivum L.)remains challeng... 详细信息

关键词： CRISPR/Cas9 crops trait

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BIBR1532 inhibits proliferation and metastasis of esophageal squamous cancer cells by inducing telomere dysregulation

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 214-225页

作者： Qin Wang Qing-Rong Li Lei Xu Zi-Chun Yuan Xiao Liu Mao-Ju Tang Man Luo Xiao-Wu Zhong qiang Ma Xiao-Lan guo Department of Clinical Laboratory Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina School of Laboratory Medicine&Translational Medicine Research Center North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina

BACKGROUND Esophageal squamous cell carcinoma(ESCC)is a malignant tumor with high morbidity and mortality,and easy to develop resistance to chemotherapeutic *** are DNA-protein complexes located at the termini of chro-mosomes in eukaryotic cells,which are unreplaceable in maintaining the stability and integrity of ***,an RNA-dependent DNA polymerase,play vital role in telomere length maintain,targeting telomerase is a promising therapeutic strategy for ***150 and KYSE410 cells were cultured and exposed to various concentrations of *** viability was assessed at 48 hours and 72 hours to determine the IC50 *** effects of BIBR1532 on ESCC cell proliferation,migration,and cellular senescence were evaluated using the cell counting kit-8 assay,plate colony formation assay,scratch assay,transwell assay,andβ-galactosidase staining,*** blotting was performed to detect the expression of RESULTS The IC50 values for KYSE150 and KYSE410 cells after 48 hours of BIBR1532 exposure were 48.53μM and 39.59μM,*** values decreased to 37.22μM and 22.71μM,respectively,following a longer exposure of 72 ***1532 exhibited dose-dependent effects on KYSE150 and KYSE410 cells,including decreased hTERT expression,inhibition of proliferation and metastasis,and induction of cellular ***,BIBR1532 upregulated the expression of the DDR protein,γ-H2AX,and activated the ataxia telangiectasia and Rad3-related protein(ATR)/check point kinase 1(CHK-1)and ataxia-telangiectasia mutated gene(ATM)/CHK2 ***1532 downregulated the expression of telomere-binding proteins,including telomeric-repeat binding factor 1(TRF1),TRF2,protection of telomeres 1,and TIN2-interacting protein *** a nude mouse xenograft model,BIBR1532 significantly suppressed tumor growth,reduced hTERT expression,and increasedγ-H2AX protein *** and eosin staining of various organs,including the heart,liver,s

关键词： Esophageal squamous cell carcinoma BIBR1532 Human telomerase reverse transcriptase DNA damage response Telomere-binding proteins

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