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成人重型血友病A患者凝血因子Ⅷ药代动力学研究

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中国实验血液学杂志 2024年第5期32卷 1509-1517页

作者：张颖郭志芳王晶晶卢文亮郝瑾瑜王欣潘芝娟郭艳茹郭新蕾孙佳佳姜波李治郭志萍北京大学第一医院太原医院(太原市中心医院)血液科山西太原030006

目的:检测成人重型血友病A患者的凝血因子Ⅷ(FⅧ)药代动力学(PK)参数,对PK参数可能的影响因素进行相关性研究,并对患者进行PK指导下的个体化预防治疗。方法:对23例FⅧ抑制物阴性的成人重型血友病A患者的FⅧPK参数进行检测,分析患者年龄... 详细信息

目的:检测成人重型血友病A患者的凝血因子Ⅷ(FⅧ)药代动力学(PK)参数,对PK参数可能的影响因素进行相关性研究,并对患者进行PK指导下的个体化预防治疗。方法:对23例FⅧ抑制物阴性的成人重型血友病A患者的FⅧPK参数进行检测,分析患者年龄、血管性血友病因子抗原(vWF:Ag)水平、血型、体重和体重指数(BMI)、FⅧ基因突变对于FⅧPK参数的影响,并根据PK参数推荐个体化预防方案。结果:FⅧ平均半衰期(t_(1/2))为20.6±9.3(11.47-30.12)h。t_(1/2)随着年龄增长(r=0.580)和vWF:Ag水平升高(r=0.814)呈延长趋势。平均药时曲线下面积(AUC)为913±399(328-1878)IU·h/dl,与年龄(r=0.557)和vWF:Ag水平(r=0.784)呈正相关。平均驻留时间(MRT)为24.7±12.4(13.2-62.2)h,与年龄(r=0.664)和vWF:Ag水平(r=0.868)呈正相关。FⅧ平均回收率(IVR)为2.59±0.888(1.5-4.29)(IU/dl)/(IU/kg),平均清除率(CL)为3±1.58(0.97-7.18)ml/(kg·h),IVR和CL与年龄及vWF:Ag均无明显相关性。PK指导的个体化给药模式下,15例患者为超低剂量、6例为小剂量、2例为中剂量预防方案。结论:成人重型血友病A患者FⅧ半衰期个体差异较大,患者年龄越大,vWF:Ag水平越高,FⅧ半衰期越长。需要根据FⅧPK参数进行个体化给药,以优化预防治疗模式。

关键词：重型血友病A 凝血因子Ⅷ 成人药代动力学半衰期

Resonance Light Scattering Imaging Determination of Heparin

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Chinese Chemical Letters 2006年第1期17卷 53-56页

作者： Hong ping guo Cheng zhi HUANG Jian LING College of Chemistry and Chemical Engineering Southwest University Chongqing 400715

A laser-induced resonance light scattering （RLS） imaging method to determine heparin is described based on the high light scattering emission power of the aggregation species of heparin with α, β, γ, δ-tetra（4-trimethylaminoniumphenyl）prophyrin （TAPP） in solution, By imaging the light scattering signals of the aggregation species, we proposed the method to determine the heparin with a detection range of 0.02 - 0.6μg/mL and the detection limit （30） of 1.3 ng/mL.

关键词： Heparin α β γ δ-tetra(4-trimethylaminonium phenyl)prophyrin (TAPP) resonance light scattering (RLS) imaging.

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Cell Research 2001年第1期11卷 74-80页

作者： YANG zhi XING guo YONG AN, zhi ping ZHU (Shanghai Institute of Plant Physiology, Chinese Academy of Sciences, Shanghai 200032, China) (Department of Biology, Henan University, Kaifeng 475001, China) 1Shanghai Institute of Plant Physiology Chinese Academy of Sciences Shanghai 200032 China 2Department of Biology Henan University Kaifeng 475001 China 1Shanghai Institute of Plant Physiology Chinese Academy of Sciences Shanghai 200032 China

Bicoid is one of the important Drosophila maternal genes involved in the control of embryo polarity and larvae segmentation. To clone and characterize the rice bicoid-related genes, one cDNA clone, Rb24 (EMBL accession number: AJ2771380), was isolated by screening of rice unmature seed cDNA library. Sequence analysis indicates that Rb24 contains a putative amino acid sequence, which is homologous to unique 8 amino acids sequence within Drosophila bicoid homeodomain (50% identity, 75% similarity) and involves a lys-9 in putative helix 3. Northern blot analysis of rice RNA has shown that this sequence is expressed in a tissue-specific manner. The transcript was detected strongly in young panicles, but less in young leaves and roots. This results are further confirmed with paraffin section in situ hybridization. The signal is intensive in rice globular embryo and located at the apical tip of the embryo, then, along with the development of embryo, the signal is getting reduced and transfers into both sides of embryo. The existence of bicoid-related sequence in rice embryo and the similarity of polar distribution of bicoid and Rb24 mRNA in early embryo development may implicates a conserved maternal regulation mechanism of body axis presents in Drosophila and in rice.

关键词： Rice bicoid-related DNA polar distribution embryogenesis.

Satellite RFI mitigation on FAST

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Research in Astronomy and Astrophysics 2021年第1期21卷 178-184页

作者： Yu Wang Hai-Yan Zhang Hao Hu Shi-Jie Huang Wei-Wei Zhu guo-ping zhi Tao Zhang Zhan-Chun Fan Li Yang University of Chinese Academy of Sciences Beijing 100049China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China CAS Key Laboratory of FAST National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Beijing Institute of Spacecraft System Engineering Beijing 100094China

As the most sensitive single-dish radio telescope,the Five-hundred Aperture Spherical radio Telescope(FAST)is very susceptive to radio frequency interference(RFI)from active radio ***,due to the rapid development of space applications and research,satellite interference has become one of the main RFI sources for FAST,particularly at the L ***,we have developed several measures to mitigate satellite *** the one hand,an antenna with 4.5-meter diameter has been constructed and installed at the FAST site to detect the satellite interference in the frequency band between 1 to 5 ***,we have developed a satellite RFI database based on the FAST sky coverage,the observing frequency bands,and known satellite *** combining the satellite RFI monitoring antenna and the database,we have established a satellite RFI mitigation *** this system,we can not only track satellites to collect their characteristics and update the database but also help the observer to program the observing plan by predicting satellite *** the practical observation of FAST at the L band,the feasibility of this system to mitigate satellite RFI has been *** particular,the system effectively avoids strong satellite interference from entering the main beam of the telescope and causing receiver saturation.

关键词： telescopes:FAST satellite radio frequency interference mitigation

Discrete Approximation and Convergence Analysis for a Class of Decision-Dependent Two-Stage Stochastic Linear Programs

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Journal of the Operations Research Society of China 2024年第3期12卷 649-679页

作者： Jie Jiang zhi-ping Chen College of Mathematics and Statistics Chongqing UniversityChongqing401331China School of Mathematics and Statistics Xi’an Jiaotong UniversityXi’an710049ShaanxiChina Center for Optimization Technique and Quantitative Finance Xi’an International Academy for Mathematics and Mathematical TechnologyXi’an710049ShaanxiChina

Customary stochastic programming with recourse assumes that the probability distribution of random parameters is independent of decision *** studies demonstrated that stochastic programming models with endogenous uncertainty can better reflect many real-world activities and applications accompanying with decision-dependent *** this paper,we concentrate on a class of decision-dependent two-stage stochastic programs(DTSPs)and investigate their discrete *** develop the discrete approximation methods for DTSPs,we first derive the quantitative stability results for *** on the stability conclusion,we examine two discretization schemes when the support set of random variables is bounded,and give the rates of convergence for the optimal value and optimal solution set of the discrete approximation problem to those of the original *** we extend the proposed approaches to the general situation with an unbounded support set by using the truncating *** an illustration of our discretization schemes,we reformulate the discretization problems under specific structures of the decision-dependent ***,an application and numerical results are presented to demonstrate our theoretical results.

关键词： Stochastic programming Decision-dependence Discrete approximation Stability Convergence rate

Two-dimensional conjugated coordination polymer monolayer as anode material for lithium-ion batteries:A DFT study

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Chinese Chemical Letters 2024年第6期35卷 180-184页

作者： Xin-Tong Zhao Jin-zhi guo Wen-Liang Li Jing-ping Zhang Xing-Long Wu MOE Key Laboratory for UV Light-Emitting Materials and Technology Northeast Normal UniversityChangchun 130024China Faculty of Chemistry Northeast Normal UniversityChangchun 130024China Key Laboratory of Organo-Pharmaceutical Chemistry of Jiangxi Province Gannan Normal UniversityGanzhou 341000China

Nowadays,lithium-ion batteries(LIBs)play a crucial role in modern society in the aspect of portable electronic devices and large-scale smart ***,the current performance of lithium-ion batteries has been unable to meet the growing expectations of society and scientific ***,we have synthetically investigated availability of 2D Ni-TABQ monolayer as anode based on DFT for LIBs *** findings have demonstrated that 2D Ni-TABQ monolayer is a semiconductor with a small band gap of 0.2 eV,which suggest that the electronic property of 2D Ni-TABQ monolayer would take place an evident shift from semiconductor property to metallic property after Li ***,we checked the stability of 2D Ni-TABQ monolayer and investigated the viability of exfoliation from bulk multilayer Ni-TABQ to form 2D Ni-TABQ monolayer in the light of exfoliation energy and binding *** continuously studied electrochemical properties of 2D Ni-TABQ monolayer with respect of theoretical specific capacity,Li-ion diffusion barriers and open-circuit *** the charging process,2D Ni-TABQ monolayer can achieve a high specific capacity of 722 m Ah/g with an open-circuit voltage range from 1.12 V to 0.22 *** aforementioned results make the 2D Ni-TABQ monolayer a promising anode for LIBs.

关键词： The first principles Density functional theory Lithium-ion battery Anode material Two-dimensional material

Earth-abundant Zn-dipyrrin chromophores for efficient CO2 photoreduction

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National Science Review 2024年第6期11卷 214-222页

作者： Song guo Fu-Gui Zeng Xiao-Di Li Kai-Kai Chen ping Wang Tong-Bu Lu zhi-Ming Zhang Institute for New Energy Materials and Low Carbon Technologies School of Materials Science& Engineering Tianjin University of Technology

The development of strong sensitizing and Earth-abundant antenna molecules is highly desirable for CO2reduction through artificial photosynthesis. Herein, a library of Zn–dipyrrin complexes（Z-1-Z-6） are rationally designed via precisely controlling their molecular configuration to optimize strong sensitizing Earth-abundant photosensitizers. Upon visible-light excitation, their special geometry enables intramolecular charge transfer to induce a charge-transfer state, which was first demonstrated to accept electrons from electron donors. The resulting long-lived reduced photosensitizer was confirmed to trigger consecutive intermolecular electron transfers for boosting CO2-to-CO conversion. Remarkably, the Earth-abundant catalytic system with Z-6 and Fe-catalyst exhibits outstanding performance with a turnover number of >20 000 and 29.7% quantum yield, representing excellent catalytic performance among the molecular catalytic systems and highly superior to that of noble-metal photosensitizer Ir（ppy）2（bpy）+under similar conditions. Experimental and theoretical investigations comprehensively unveil the structure–activity relationship, opening up a new horizon for the development of Earth-abundant strong sensitizing chromophores for boosting artificial photosynthesis.

关键词： Zn complex photocatalysis CO2 reduction charge transfer photosensitizer

Sex differences in the association between the muscle quality index and the incidence of depression: A cross-sectional study

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World Journal of Psychiatry 2024年第9期14卷 1335-1345页

作者： Gui-ping Huang Li-ping Mai zhi-Jie Zheng Xi-Pei Wang guo-Dong He Institute of Medical Research Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080Guangdong ProvinceChina

BACKGROUND Depression presents significant challenges to mental health *** phy-sical activity is highly beneficial to mental and physical health,relatively few stu-dies have conducted on the relationship between *** To investigate the association between muscle quality index(MQI)and incidence of *** The data used in this cross-sectional study were obtained from the 2011-2014 National Health and Nutritional Examination Survey,which included informa-tion on MQI,depression,and confounding *** logistic regre-ssion models were employed,while taking into account the complex multi-stage sampling design.A restricted cubic spline model was utilized to investigate the non-linear relationship between the MQI and ***,subgroup analyses were performed to identify influential *** The prevalence of depression in this population was 8.44%.With the adjusted model,the MQI was associated with depression in females(odds ratio=0.68,95%confidence interval:0.49-0.95)but not in males(odds ratio=1.08,95%confidence interval:0.77-1.52).Restricted cubic spline adjustment of all covariates showed a significant negative non-linear relationship between depression and the MQI in *** observed trend indicated an 80%decrease in the risk of depression for each unit increase in MQI,until a value of ***,when the MQI exceeded 2.2,the prevalence of depression increased by 20%for every unit increase in the *** analyses further confirmed that the MQI was negatively associated with *** The MQI was inversely correlated with depression in females but not males,suggesting that females with a higher MQI might decrease the risk of depression.

关键词： Sex differences Muscle quality index Depression National Health and Nutrition Examination Survey Population-based study

A Local Tb Theorem for Square Functions and Parabolic Layer Potentials

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Acta Mathematica Sinica,English Series 2024年第8期40卷 1941-1966页

作者： zhi Dan WANG guo Ming ZHANG School of Physical and Mathematical Sciences Nanjing Tech UniversityNanjing 211816P.R.China Frontiers Science Center for Nonlinear Expectations Ministry of EductionResearch Center for Mathematics and Interdisciplinary SciencesShandong UniversityQingdao266237P.R.China

In this paper,we give a locally parabolic version of Tb theorem for a class of vector-valued operators with off-diagonal decay in L^(2) and certain quasi-orthogonality on a subspace of L^(2),in which the testing functions themselves are also *** an application,we establish the boundedness of layer potentials related to parabolic operators in divergence form,defined in the upper half-space Rn+2+:={(x,t,λ)∈R^(n+1)×(0,∞)},with uniformly complex elliptic,L^(∞),t,λ-independent coefficients,and satisfying the De Giorgi/Nash estimates.

关键词： Local Tb theorems Calderon-Littlewood-Paley family Parabolic layer potentials Carleson measure estimates