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Improved preparation of(1S,3',4'S,5'S,6'R)-5-chloro-6-[(4-ethylphenyl)methyl]-3',4',5',6'-tetrahydro-6'-(hydroxymethyl)-spiro[isobenzofuran-l(3H),2'-[2H]pyran]-3',4',5'-triol

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Chinese Chemical Letters 2013年第2期24卷 131-133页

作者： Yong-Hai Liu Ting-Ming Fu Chun-Yan Ou Wen-Ling Fan guo-ping peng School of Pharmacy Nanjing University of Chinese Medicine

Received 9 November 2012 Received in revised form 23 November 2012 Accepted 3 December 2012 Available online 29 January 2013

关键词： Type 2 diabetesSodiurn glucose co-transporter 2InhibitorPreparation

A new pteridinedione from Whitmania pigra

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Chinese Chemical Letters 2010年第5期21卷 603-605页

作者： Yun Feng Zheng,Cun Yu Li,guo ping peng,Hong Yang Li College of Pharmacy,Nanjing University of Chinese Medicine,Nanjing 210046,China College of Pharmacy Nanjing University of Chinese Medicine Nanjing 210046 China

A new compound,6-methylsulfinylthieno[3,2-g]-2,4(1H,3H)-pteridinedione,was isolated from the water extract of Whitmania pigra *** structure was elucidated on the basis of NMR and ESIMS spectra.

关键词： Whitmania pigra Heterocycle 6-Methylsulfinylthieno[3,2-g]-2,4(1H,3H)-pteridinedione

Alzheimer’s disease early diagnostic and staging biomarkers revealed by large-scale cerebrospinal fluid and serum proteomic profiling

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The Innovation 2024年第1期5卷 118-126页

作者： Qing-Qing Tao Xue Cai Yan-Yan Xue Weigang Ge Liang Yue Xiao-Yan Li Rong-Rong Lin guo-ping peng Wenhao Jiang Sainan Li Kun-Mu Zheng Bin Jiang Jian-ping Jia Tiannan guo Zhi-Ying Wu Department of Neurology and Research Center of Neurology in the Second Affiliated Hospital and Key Laboratory of Medical Neurobiology of Zhejiang Province Zhejiang University School of MedicineHangzhou 310009China Liangzhu Laboratory Zhejiang UniversityHangzhou 311100China Westlake Laboratory of Life Sciences and Biomedicine Key Laboratory of Structural Biology of Zhejiang ProvinceSchool of Life SciencesWestlake UniversityHangzhou 310024China Institute of Basic Medical Sciences Westlake Institute for Advanced StudyHangzho 310024China Department of Neurology First Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Department of Neurology First Affiliated HospitalSchool of MedicineXiamen UniversityXiamen 361009China Innovation Center for Neurological Disorders and Department of Neurology Xuanwu HospitalCapital Medical UniversityNational Clinical Research Center for Geriatric DiseasesBeijing 100053China MOE Frontier Science Center for Brain Science and Brain-machine Integration School of Brain Science and Brain MedicineZhejiang UniversityHangzhou 310058China CAS Center for Excellence in Brain Science and Intelligence Technology Shanghai 200031China

Amyloid-b,tau pathology,and biomarkers of neurodegeneration make up the core diagnostic biomarkers of Alzheimer disease(AD).However,these proteins represent only a fraction of the complex biological processes underlying AD,and individuals with other brain diseases in which AD pathology is a comorbidity also test positive for these diagnostic *** ADspecific early diagnostic and disease staging biomarkers are *** this study,we performed tandem mass tag proteomic analysis of paired cerebrospinal fluid(CSF)and serum samples in a discovery cohort comprising 98 *** biomarkers were validated by parallel reaction monitoring–based targeted proteomic assays in an independent multicenter cohort comprising 288 *** quantified 3,238 CSF and 1,702 serum proteins in the discovery cohort,identifying 171 and 860 CSF proteins and 37 and 323 serum proteins as potential early diagnostic and staging biomarkers,*** the validation cohort,58 and 21 CSF proteins,as well as 12 and 18 serum proteins,were verified as early diagnostic and staging biomarkers,*** 19-protein CSF and an 8-protein serum biomarker panels were built by machine learning to accurately classify mild cognitive impairment(MCI)due to AD from normal cognition with areas under the curve of 0.984 and 0.881,*** 19-protein CSF biomarker panel also effectively discriminated patients with MCI due to AD from patients with other neurodegenerative ***,we identified 21 CSF and 18 serum stage-associated proteins re-flecting AD *** findings provide a foundation for developing bloodbased tests for AD screening and staging in clinical practice.

关键词： cerebrospinal Alzheimer fluid

Sleep quality of spousal caregivers is associated with neuropsychiatric symptoms and living ability of patients with Alzheimer disease

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Chinese Medical Journal 2019年第12期132卷 1490-1493页

作者： Yi Chen Jun-Yang Wang Xiao-Yan Liu Fan-Xia Meng Ai-ping Li guo-ping peng Department of Neurology First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310003China

Alzheimer disease (AD) is the most common neurodegenerative disorder, accounting for the majority of cases of dementia. The global prevalence of AD is rising, representing an increasing challenge for older individuals and their families.[1] Seven out of every ten patients with AD receive informal care at home, relying on co-resident family members, especially spouses.[2] However, cultural differences exist in the effects of the disorder. For example, Chinese caregivers of patients with dementia had higher scores on measures of depression and caregiver burden compared with caregivers of patients with dementia in Western societies.[3] It is important to consider that AD not only affects the patient but also their caregivers, particularly spousal caregivers who spend more than half their time with the patient.[4] As AD progresses, patients become increasingly dependent on caregivers. Meanwhile, there is an increasingly heavy caregiver burden, characterized as the physical, psychological, or emotional, social, and financial problems experienced by family members who care for impaired older adults.[5] Additionally, it is frequently reported that sleep disturbance symptoms are associated with health consequences among AD caregivers.[6]

关键词： Sleep quality spousal caregivers neuropsychiatric symptoms

Bioactive constituents of oleanane-type triterpene saponins from the roots of Glycyrrhiza glabra

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Bioactive constituents of oleanane-type triterpene saponins ...

Synergistic effect of bonding heterogeneity and phonon localization in introducing excellent thermoelectric properties in layered heteroanionic NdZnSbO material

中国化学会第十届全国天然有机化学学术会议

作者： Yun-Feng Zheng Juan-Hua Wei Yu-ping Tang guo-ping peng School of Pharmacy Nanjing University of Chinese Medicine Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization

＜正＞Three new oleanane-type triterpene saponins,named licorice-saponin M3（1）,licorice-saponin N4（2）and licorice-saponin O4（3）,an artificial product（4）,as well as five known triterpene glucuronides（5-9）,were isolated from the roots of Glycyrrhiza glabra L..Their structures were established using 1D and 2D NMR spectroscopy,mass spectrometry and by comparison with

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Journal of Energy Chemistry 2025年第1期100卷 259-272页

作者： Da Wan Shuwei Tang Shulin Bai Xiaodong Li peng Ai Wanrong guo Tuo Zheng College of Materials Science and Engineering Liaoning Technical University Faculty of Chemistry Northeast Normal University

Layered rare-earth metal oxides, harnessing the dual properties of oxides and two-dimensional layered materials, exhibit remarkable thermal stability and quantum confinement effects. Therefore, this work adopts the first-principles calculation combined with the Boltzmann transport theory to predict the thermoelectric properties of NdZnSbO compound. The coexistence of weak interlayer van der Waals interactions, robust intralayer ionic bonding, and partial covalent bonding leads to remarkable bonding heterogeneity, which engenders pronounced phonon scattering and imposes constraints on thermal transport along the out-of-plane direction. The weakened chemical bonds induced by the antibonding states, together with the rattling-like behavior of the Zn atom, culminate in the profound anharmonicity in the layered NdZnSbO compound. The weakening bond and heavy element contribute to the softness of phonon modes, which significantly diminishes the phonon group velocity. The redistribution-dominated four-phonon scattering process spans a large optical gap, which effectively reduces the lattice thermal conductivity. The NdZnSbO compound exhibits direct semiconductor characteristic with a bandgap of 0.73 e V by adopting the Heyd-Scuseria-Ernzerhof(HSE06) functional in combination with spin–orbit coupling(SOC) effect. The multi-valley feature of NdZnSbO compound augur favorably for band degeneracy, thus amplifying the power factor. Consequently, an optimal figure-of-merit(ZT) of 3.40 at 900 K is achieved for the n-type NdZnSbO compound. The present study delves deeply insights into the origins for the low thermal conductivity of NdZnSbO compound and proposes an optimization scheme to enhance overall thermoelectric performance.

关键词： Bond strength (chemical)

CaH2-promoted activity of Ni-carbonate interface for CO2 methanation

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Journal of Energy Chemistry 2025年第1期100卷 522-532页

作者： Jin-peng Wang guo-Cui Mao Hui-Lin Jiang Bao-Xia Dong Yun-Lei Teng School of Chemistry and Chemical Engineering Yangzhou University

Transition metal-carbonate interfaces often act as active sites in heterogeneous catalytic *** interface between transition metal and metal carbonate exhibits a dynamic equilibrium during the CO2hydrogenation reaction,involving surface carbonate hydrogenation and ***,there have been few reports on engineering the activity of the interface between transition metal and alkaline earth metal carbonate for catalytic *** work demonstrated that the incorporation of CaH2in Ni/CaCO3enhances the CO2methanation activity of the *** CO2conversion for Ni/CaH2-CaCO3reached 68.5%at 400°C,which was much higher than that of the Ni/CaCO3（31.6%） and Ni/CaH2-CaO （42.4%） ***,the Ni/CaH2-CaCO3catalysts remained stable during the stability test for 24 h at 400°C and 8 *** research revealed that CaH2played a crucial role in promoting the activity of the Ni-carbonate interface for ***2could modify the electronic structure of Ni and tune the structural properties of CaCO3to generate medium basic sites （OH groups）,which are favorable for the activation of H2and ***-situ Fourier transform infrared spectroscopy （FTIR） analysis combined with density functional theory calculations demonstrated that CO2activation occurs at the hydroxyl group （OH） on the CaH2-modified Ni-carbonate surface,leading to the formation of CO3H****,our study has confirmed that CO2methanation over the Ni/CaH2-CaCO3catalysts proceeds via the formate pathway.

关键词： CO 2 methanation Metal hydride Ni catalysts Carbonate Metal-carbonate interface

A Mn-porphyrinic metal–organic framework immobilizing glucose oxidase for combined photodynamic/chemodynamic/starvation therapy

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Tungsten 2025年第1期7卷 183-194页

作者： Xin-Ran Sun Hao-Ming Yuan guo-Da Zhang Chao Wang Shu-Juan Sun peng-Fei Shi Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers School of Chemistry and Chemical Engineering Linyi University

The combination of photodynamic therapy（PDT） and chemodynamic therapy（CDT） in tumor treatment has attracted considerable ***,tumor hypoxia and glutathione（GSH） overproduction in the tumor tissue restricted the progress of their ***,a Mn-porphyrinic metal-organic framework（Mn-TCPP） was constructed by the one-pot method and further used for immobilizing glucose oxidase（GOx） to obtain GOx@*** would rapidly exhaust endogenous glucose into hydrogen peroxide（H2O2） and gluconic acid,thus shutting off the energy supply of tumor cells for starvation ***-TCPP catalyzed H2O2to produce oxygen,regulating the hypoxic tumor microenvironment and in turn improving1O2generation under laser ***,Mn-TCPP can reduce reactive oxygen species consumption owing to the redox reaction between Mn3+and GSH,thus greatly enhancing ***,benefiting from GOx-mediated starvation therapy,Mn2+produced by Mn3+reduction can react with sufficient intracellular H2O2to generate ·OH with high cytotoxicity through a Fenton-like *** treatment by GOx@Mn-TCPP under laser irradiation in vitro,the cell viability of 4T1 and A549 tumor cells reached to 20%,reflecting GOx@Mn-TCPP could give full play to the advantages of PDT/CDT/starvation *** results in vivo demonstrated that GOx@Mn-TCPP mediated synergistic cascade therapy could significantly inhibit tumor growth and improve the therapeutic effect.

关键词： Chemodynamic therapy Immobilizing enzyme Metal–organic frameworks Photodynamic therapy Starvation therapy

国内外港口工程深度基准面及码头面高程计算方法对比

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水运工程 2016年第10期 68-74,79页

作者：杨国平张鹏周剑中交水运规划设计院有限公司北京100007

全面总结了我国深度基准面的历史演变过程和基本算法,介绍世界各国深度基准面的分类和使用进展。同时,针对国内外港口工程码头面高程计算方法的差异,从计算原理、组合因素、资料分析等方面对比国内外计算标准的差异,对码头面高程计算中... 详细信息

全面总结了我国深度基准面的历史演变过程和基本算法,介绍世界各国深度基准面的分类和使用进展。同时,针对国内外港口工程码头面高程计算方法的差异,从计算原理、组合因素、资料分析等方面对比国内外计算标准的差异,对码头面高程计算中设计水位的定义和统计方法等进行细化分解,清晰了国内外标准使用中的异同,为准确运用国内外标准提供了有益的指导。

关键词：深度基准面码头面高程高程计算港口工程