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PARP1-DNA co-condensation:the driver of broken DNA repair

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2351-2353页

作者： Xiang Wei Fangfang Zhou long zhang Life Sciences Institute The Second Affiliated Hospital of the Zhejiang University School of MedicineThe MOE Key Laboratory of Biosystems Homeostasis&Protection and Zhejiang Provincial Key Laboratory for Cancer Molecular Cell BiologyZhejiang UniversityHangzhouChina The First Affiliated Hospital the Institutes of Biology and Medical SciencesSuzhou Medical CollegeSoochow UniversitySuzhouJiangsu 215123China

A recent study published by Simon Alberti1 in Cell has revealed that DNA double-strand break(DSB)sites that prevent the disjunction of broken DNA ends are formed through poly(ADPribose)(PAR)polymerase 1(PARP1)-DNA co-condensation.1(Fig.1).Here,a comprehensive and novel model was provided for the ordered assembly of PARP1-DNA condensates,which can rationally make clear broken DNA end synapses and how repair effectors are recruited to repair DSB.

关键词： PARP1 repair rational

Matching Rota-Baxter Systems and Gröbner-Shirshov Bases

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Algebra Colloquium 2024年第3期31卷 389-406页

作者： Yi zhang Shuangjian guo School of Mathematics and Statistics Nanjing University of Information Science and Technology Nanjing 210044China School of Mathematics and Statistics Guizhou University of Finance and Economics Guiyang 550025China

Motivated by the concept of matching Rota-Baxter algebras arising from polarized associative Yang-Baxter equations and Volterra integral equations,we introduce the notion of a matching Rota-Baxter system,which generalizes the Rota-Baxter system proposed by *** show that this notion is also related to Yang-Baxter pairs and to matching pre-Lie *** then modify the definition of matching Rota-Baxter systems by adding a curvature term,and make a connection with matching pre-Lie algebras and with compatible associative ***,we study matching Rota-Baxter systems on a dendriform algebra and show how they induce matching quadri-algebra ***,we give a linear basis of free matching Rota-Baxter system by Grobner-Shirshov bases methods.

关键词： Rota-Baxter systems curved matching Rota-Baxter systems Gröbner-Shirshov bases

Ultrahigh strength and uniform corrosion in Zn-Li alloys through ultrahigh pressure supersaturated solid solution treatment for biodegradable orthopedic applications

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Rare Metals 2024年第10期43卷 5284-5304页

作者： Wan-Ying Li Yi-long Dai Wen-Hao Cai Si-Han Lin Lin guo De-Chuang zhang Yuncang Li Cuie Wen School of Materials Science and Engineering Xiangtan University Department of Prosthodontics Shanghai Ninth People′s HospitalShanghai Jiao Tong University Key Laboratory of Low Dimensional Materials&Application Technology Ministry of EducationXiangtan University School of Engineering RMIT UniversityMelbourne

Zn-Li alloys are considered promising candidate materials for biodegradable orthopedic implant applications due to their high mechanical performance and good ***,the presence of a large number of second-phase particles in this class of Zn alloys can lead to severe localized degradation due to micro-galvanic corrosion,which is detrimental to the mechanical integrity of the alloys during tissue healing in the human *** this study we report ultrahigh strength,uniform corrosion,good cytocompatibility,and effective antibacterial ability in Zn-x Li（x=0.3,0.5,0.7;wt%） alloys achieved through supersaturated solid solution treatment （SSST） at 375℃ under ultrahigh pressure of 3 GPa.A high concentration of β-LiZn4phases coexisted with the-Zn matrix in the as-cast Zn-x Li alloys,whereas almost all the Li dissolved into the-Zn matrix of SSST *** yield strength was 437 MPa for SSST Zn-0.3Li,592 MPa for SSST Zn-0.5 Li and 686 MPa for SSST *** SSST Zn-Li alloys showed uniform degradation with remarkably reduced degradation rates compared to their as-cast *** 25% concentration extracts of the Zn-x Li alloys demonstrated no cytotoxicity toward MC3T3-E1 cells,and the alloys exhibited effective antibacterial ability agains methicillin-resistant staphylococcus aureus.

关键词： Corrosion behavior Mechanical property Supersaturated solid solution treatment (SSST) Ultrahigh pressure Zn-Li alloy

Deficiency of betaine-homocysteine methyltransferase activates glucose-6-phosphate dehydrogenase(G6PD)by decreasing arginine methylation of G6PD in hepatocellular carcinogenesis

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Science China(Life Sciences) 2024年第8期67卷 1648-1665页

作者： Jie Gao Xiaoyi Shi Yaohui Sun Xudong Liu Feng zhang Chengcheng Shi Xiao Yu Zhiping Yan long Liu Shizhe Yu Jiacheng zhang Xiaodan zhang Shuijun zhang Wenzhi guo Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Henan Diagnosis&Treatment League for Hepatopathy The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Henan Innovative Research Group for Hepatobiliary&Pancreatic Surgery and Digestive Organ Transplantation Zhengzhou 450052China Henan Organ Transplantation Quality Control Centre Zhengzhou 450052China Henan Engineering Technology Research Center for Organ Transplantation Zhengzhou 450052China Department of Pharmacy The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of General Surgery Huashan HospitalFudan University Shanghai 200040China Cancer Metastasis Institute Fudan UniversityShanghai 200040China

Betaine-homocysteine methyltransferase(BHMT)regulates protein methylation and is correlated with tumorigenesis;however,the effects and regulation of BHMT in hepatocarcinogenesis remain largely ***,we determined the clinical significance of BHMT in the occurrence and progression of hepatocellular carcinoma(HCC)using tissue samples from 198 *** was to be frequently found(86.6%)expressed at relatively low levels in HCC tissues and was positively correlated with the overall survival of patients with *** overexpression effectively suppressed several malignant phenotypes in hepatoma cells in vitro and in vivo,whereas complete knockout of Bhmt(Bhmt^(−/−))produced the opposite *** combined proteomics,metabolomics,and molecular biological strategies and detected that Bhmt^(−/−)promoted hepatocarcinogenesis and tumor progression by enhancing the activity of glucose-6-phosphate dehydrogenase(G6PD)and PPP metabolism in DEN-induced HCC mouse and subcutaneous tumor-bearing *** contrast,restoration of Bhmt with an AAV8-Bhmt injection or pharmacological inhibition of G6PD attenuated ***,coimmunoprecipitation identified monomethylated modifications of the G6PD,and BHMT regulated the methylation of *** sequence analysis,generation and application of specific antibodies,and site-directed mutagenesis indicated G6PD methylation at the arginine residue ***,we established bidirectionally regulated BHMT cellular models combined with methylation-deficient G6PD mutants to demonstrate that BHMT potentiated arginine methylation of G6PD,thereby inhibiting G6PD activity,which in turn suppressed *** together,this study reveals a new methylation-regulatory mechanism in hepatocarcinogenesis owing to BHMT deficiency,suggesting a potential therapeutic strategy for HCC treatment.

关键词： HCC BHMT arginine methylation G6PD PPP metabolism

Unraveling magnetic properties and martensitic transformation in Mn-rich Ni-Mn-Sn alloys:first-principles calculations and experiments

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Rare Metals 2024年第4期43卷 1769-1785页

作者： Yu zhang Jing Bai Ke-Liang guo Jia-Xin Xu Jiang-long Gu Nicola Morley Qui-Zhi Gao Yu-Dong zhang Claude Esling Xiang Zhao Liang Zuo Key Laboratory for Anisotropy and Texture of Materials(Ministry of Education) School of Material Science and EngineeringNortheastern UniversityShenyang110819China Key Laboratory of Dielectric and Electrolyte Functional Material Hebei Province School of Resources and MaterialsNortheastern University at QinhuangdaoQinhuangdao066004China Department of Material Science and Engineering University of SheffieldSheffieldS13JDUK State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao066004China Laboratoire d’Étude des Microstructures Et de Mécanique des Matériaux University of Lorraine57045MetzFrance

We have investigated the phase stability,magnetic properties,and martensitic transformation thermodynamics/kinetics of the Ni_(24-x)Mn_(18+x+y)Sn_(6-y)(x,y=0,1,2)system by combining the first-principles calculations and *** calculation results show that the optimized lattice parameters are consistent with the experimental ***,we obtain the relation equation for the austenite formation energy(E_(form-A))and Mn content(X_(Mn)):E_(form-A)=507.358X_(Mn)-274.126,as well as for the six-layer modulated(6M)martensite formation energy(E_(form-6M))and Ni content(X_(Ni)):E_(form-6M)=-728.484X_(Ni)+*** ternary phase diagram of the total magnetic moment was *** excess Mn will reduce the total magnetic moment of 6M(Mag6M)and non-modulated(NM)(MagNM)martensites,with the following equations relating the total magnetic moment and Mn content:Mag_(6M)=-15.905X_(Mn)+7.902and Mag_(NM)=-14.781X_(Mn)+7.411,while the effect on austenite is *** variation of total magnetic moment is mainly dominated by the Mn atomic magnetic *** 3d electrons of Mn_(Sn)(Mn at Sn sublattice)play an important role in magnetic properties from the perspective of the electronic density of *** on the thermodynamics of martensitic transformation,the alloys will likely undergo austenite?6M?NM transformation *** the thermodynamic and kinetic results,the martensitic transformation temperature decreases with x increasing and increases with y *** results are expected to provide reference for predicting the phase stability and magnetic properties of NiMn-Sn alloys.

关键词： Ni-Mn-Sn First-principles calculations Martensitic transformation Magnetic property Kinetics

Slowly rotating charges from Weyl double copy for Kerr black hole with Chern-Simons correction

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Communications in Theoretical Physics 2024年第8期76卷 139-146页

作者： Yi-Ran Liu Jing-Rui zhang Yun-long zhang School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUCASHangzhou 310024China CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100149China National Astronomy Observatories Chinese Academy of ScienceBeijing 100101China International Center for Theoretical Physics Asia-Pacific Beijing/HangzhouChina

The Weyl double copy builds the relation between gauge theory and gravity theory, in particular the correspondence between gauge solutions and gravity solutions. In this paper, we obtain the slowly rotating charge solutions from the Weyl double copy for the Kerr black hole with small Chern-Simons correction. Based on the Weyl double copy relation, for the Petrov type D solution in Chern-Simons modified gravity, we find the additional correction to the electromagnetic field strength tensor of the rotating charge. For the Petrov type I solution, we find that the additional electromagnetic field strength tensors have external sources, while the total sources vanish at the leading order.

关键词： Chern-Simons modified gravity Weyl double copy Kerr black hole

Interface Engineering of Titanium Nitride Nanotube Composites for Excellent Microwave Absorption at Elevated Temperature

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Nano-Micro Letters 2024年第9期16卷 147-160页

作者： Cuiping Li Dan Li Shuai zhang long Ma Lei zhang Jingwei zhang Chunhong Gong College of Chemistry and Molecular Sciences Henan UniversityKaifeng 475004People’s Republic of China National and Local Joint Engineering Research Center for Applied Technology of Hybrid Nanomaterials Henan UniversityKaifeng 475004People’s Republic of China

Currently,the microwave absorbers usually suffer dreadful electromagnetic wave absorption(EMWA)performance damping at elevated temperature due to impedance mismatching induced by increased conduction ***,the development of high-performance EMWA materials with good impedance matching and strong loss ability in wide temperature spectrum has emerged as a top ***,due to the high melting point,good electrical conductivity,excellent environmental stability,EM coupling effect,and abundant interfaces of titanium nitride(TiN)nanotubes,they were designed based on the controlling kinetic diffusion procedure and Ostwald ripening *** from boosted heterogeneous interfaces between TiN nanotubes and polydimethylsiloxane(PDMS),enhanced polarization loss relaxations were created,which could not only improve the depletion efficiency of EMWA,but also contribute to the optimized impedance matching at elevated ***,the TiN nanotubes/PDMS composite showed excellent EMWA performances at varied temperature(298-573 K),while achieved an effective absorption bandwidth(EAB)value of 3.23 GHz and a minimum reflection loss(RLmin)value of−44.15 dB at 423 *** study not only clarifies the relationship between dielectric loss capacity(conduction loss and polarization loss)and temperature,but also breaks new ground for EM absorbers in wide temperature spectrum based on interface engineering.

关键词： TiN nanotubes Interface engineering Polarization loss Impedance matching Electromagnetic wave absorption performance

Characterization and Monitoring of Transient Enamine Radical Intermediates in Photoredox/Chiral Primary Amine Synergistic Catalytic Cycle

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CCS Chemistry 2024年第10期6卷 2420-2426页

作者： Shixue zhang Liang Cheng Jian-Qing Qi Zongbin Jia long zhang Lei Jiao Xingwei guo Sanzhong Luo Center of Basic Molecular Science(CBMS) Department of ChemistryTsinghua UniversityBeijing 100084

Enamine-derived radicals are crucial intermediates in singly occupied molecular orbital(SOMO)***,observing them directly is elusive and remains a long-standing ***,an advanced time-resolved electron paramagnetic resonance technique was employed to characterize and monitor the key intermediates in photoredox transformations by primary aminocatalysis on a microsecond *** transient enamine radical cation,generated by single electron transfer(SET),and the deprotonated form ofα-imino radical intermediates were directly observed for the first time,both spectroscopically and *** reactions with styrene,enamine radical cation was found to be faster thanα-imino radical by one order of *** revealed the subtle role of deprotonation associated with secondary enamine radical cation in the photoredox transformations by primary aminocatalysis.

关键词： aminocatalysis radical chemistry electron paramagnetic resonance direct observation time-resolved technique

Physics-based seismic analysis of ancient wood structure:fault-to-structure simulation

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Earthquake Engineering and Engineering Vibration 2024年第3期23卷 727-740页

作者： Ba Zhenning Fu Jisai Wang Fangbo Liang Jianwen zhang Bin zhang long State Key Laboratory of Hydraulic Engineering Intelligent Construction and Operation (Tianjin University)Tianjin 300350China School of Civil Engineering Tianjin UniversityTianjin 300350China Administrative Office of the Summer Palace Beijing 100091China School of Architecture Tianjin UniversityTianjin 300072China

Based on the domain reduction method,this study employs an SEM-FEM hybrid workflow which integrates the advantages of the spectral element method(SEM)for flexible and highly efficient simulation of seismic wave propagation in a three-dimensional(3D)regional-scale geophysics model and the finite element method(FEM)for fine simulation of structural response including soil-structure interaction,and performs a physics-based simulation from initial fault rupture on an ancient wood *** verification of the hybrid workflow,a large-scale model of an ancient wood structure in the Beijing area,The Tower of Buddhist Incense,is established and its responses under the 1665 Tongxian earthquake and the 1730 Yiheyuan earthquake are *** results from the simulated ground motion and seismic response of the wood structure under the two earthquakes demonstrate that this hybrid workflow can be employed to efficiently provide insight into the relationships between geophysical parameters and the structural response,and is of great significance toward accurate input for seismic simulation of structures under specific site and fault conditions.

关键词： spectral element method finite element method fault-to-structure simulation physical model domain reduction method