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西昌学院学报（社会科学版） 2005年第4期17卷 125-129页

作者：游上郭松林福建师范大学地理科学学院福建福州350007

大学本科旅游专业人才是我国旅游行业中高级人才的生力军,做好本科旅游专业人才培养工作有着重要的历史和现实意义。本文通过对现有平面型模式旅游本科人才培养的现状及问题的探讨,提出高校旅游本科教育的立体化模式,以期对我国旅游本... 详细信息

大学本科旅游专业人才是我国旅游行业中高级人才的生力军,做好本科旅游专业人才培养工作有着重要的历史和现实意义。本文通过对现有平面型模式旅游本科人才培养的现状及问题的探讨,提出高校旅游本科教育的立体化模式,以期对我国旅游本科教育改革提供某种参考。

关键词：旅游本科教育平面型教育模式立体化教育模式

Constraints on holographic QCD phase transitions from PTA observations

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Science China(Physics,Mechanics & Astronomy) 2025年第1期68卷 67-74页

作者： song He Li Li Sai Wang Shao-Jiang Wang Center for Theoretical Physics and College of Physics Jilin UniversityChangchun 130012China School of Physical Science and Technology Ningbo UniversityNingbo 315211China CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences(UCAS)Hangzhou 310024China Theoretical Physics Division Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China School of Physical Sciences University of Chinese Academy of Sciences(UCAS)Beijing 100049China Max Planck Institute for Gravitational Physics(Albert Einstein Institute) Am Muhlenberg 1Golm 14476Germany

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition,yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT)left *** specific baryon chemical poten-tial,the first-order QCD phase transition agrees with the observational constraint of baryon ***,therefore,provides a scenario for phase transition gravitational waves(GWs)within the standard model of particle *** these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA)observations,the duration of this FoPT can be well constrained,and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

嗜水气单胞菌在欧洲鳗鲡体内的免疫组织化学定位与病理观察

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华中农业大学学报 2011年第4期30卷 494-499页

作者：郭松林冯建军熊静关瑞章集美大学水产学院/鳗鲡现代产业技术教育部工程研究中心厦门361021

采用从鳗鲡分离的嗜水气单胞菌进行人工感染试验,以探讨感染后不同时期嗜水气单胞菌在欧洲鳗鲡肝脏、肾脏和肠道内的定位和由此引起的组织病理学变化。将细菌分2次对鳗鲡进行肌肉注射。第1次采用每克体质量10^3-10^7cfu的不同剂量注射... 详细信息

采用从鳗鲡分离的嗜水气单胞菌进行人工感染试验,以探讨感染后不同时期嗜水气单胞菌在欧洲鳗鲡肝脏、肾脏和肠道内的定位和由此引起的组织病理学变化。将细菌分2次对鳗鲡进行肌肉注射。第1次采用每克体质量10^3-10^7cfu的不同剂量注射以确定该菌的半数致死量,结果表明其半数致死量为5×10^4cfu/g。第2次以每尾鱼1×10^7cfu的剂量注射欧洲鳗鲡,此后分别在注射后6、24、48 h采集鳗鲡的肝脏、肾脏、肠道进行组织病理学和免疫组织化学定位研究。结果表明：3个时期的临床症状和病理变化存在一定的差别,鳗鲡早期无明显病理变化,而后期主要表现为败血症症状;鳗鲡肾脏组织的病理变化较其他脏器明显,主要表现为肾小管上皮细胞肿胀和肾小球坏死脱落;鳗鲡肝脏则主要表现为严重充血,肠道偶见肠粘膜脱落。免疫组织化学定位结果表明,感染细菌主要分布在鳗鲡肾脏内,肝脏和肠道也有感染细菌分布。

关键词：欧洲鳗鲡嗜水气单胞菌人工感染病理变化免疫组织化学定位

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鱼类病原菌外膜蛋白及其免疫原性研究进展

水生生物学报 2011年第1期35卷 163-169页

作者：熊静关瑞章郭松林黄文树中国科学院水生生物研究所武汉430072 集美大学水产学院厦门361021 中国科学院研究生院北京100049 鳗鲡现代产业技术教育部工程研究中心厦门361021

细菌性疾病是水产养殖病害中最常见且危害甚为严重的一类疾病[1]。长期以来,一直用于鱼类细菌性疾病防治的西药类药物,由于会导致病原菌产生耐药性,在鱼体内产生药物残留危害人类健康等副作用而被限制使用[2]。因此,为了选择更加安全有... 详细信息

细菌性疾病是水产养殖病害中最常见且危害甚为严重的一类疾病[1]。长期以来,一直用于鱼类细菌性疾病防治的西药类药物,由于会导致病原菌产生耐药性,在鱼体内产生药物残留危害人类健康等副作用而被限制使用[2]。因此,为了选择更加安全有效的防治方法,疫苗免疫逐步得到了人们的重视。

关键词：鱼类病原菌外膜蛋白免疫原性免疫保护作用交叉免疫保护作用

TRIPLET combined with microwave ablation:A novel treatment for advanced hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 10-12页

作者： Fei-Yu Zhao guo-Wei Si Nian-song Qian Department of Thoracic Oncology Respiratory and Critical Care MedicineThe Eighth Medical Center of People’s Liberation Army General HospitalBeijing 100853China Department of Gastroenterology Fourth Medical CentreGeneral Hospital of the People's Liberation ArmyBeijing 100142China Senior Department of Thoracic Oncology Respiratory and Critical Care MedicineThe Eighth Medical Center of People’s Liberation Army General HospitalBeijing 100091China

This editorial comments on a study by Zuo et *** focus is on the efficacy of he-patic arterial infusion chemotherapy combined with camrelizumab and apatinib(the TRIPLET regimen),alongside microwave ablation therapy,in treating advanced hepatocellular carcinoma(HCC).The potential application of this combination therapy for patients with advanced HCC is evaluated.

关键词： Microwave ablation Hepatic arterial infusion chemotherapy Apatinib Camrelizumab Hepatocellular carcinoma

Oxygen atmosphere enhances ball milling remediation of petroleum-contaminated soil and reuse as adsorptive/catalytic materials for wastewater treatment

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Journal of Environmental Sciences 2025年第1期147卷 652-664页

作者： Pingting Gao Simin song Mingxin Wang Meng Yao Jinjuan Xue School of Environmental Science and Engineering Changzhou UniversityChangzhou 213164China Jiangsu Petrochemical Safety and Environmental Protection Engineering Research Center Changzhou 213164China

Ball milling is an environmentally friendly technology for the remediation of petroleumcontaminated soil(PCS),but the cleanup of organic pollutants requires a long time,and the post-remediation soil needs an economically viable disposal/reuse strategy due to its vast *** present paper develops a ball milling process under oxygen atmosphere to enhance PCS remediation and reuse the obtained carbonized soil(BCS-O)as wastewater treatment *** total petroleum hydrocarbon removal rates by ball milling under vacuum,air,and oxygen atmospheres are 39.83%,55.21%,and 93.84%,*** Langmuir and pseudo second-order models satisfactorily describe the adsorption capacity and behavior of BCS-O for transition *** Cu^(2+),Ni^(2+),and Mn^(2+)adsorbed onto BCS-O were mainly bound to metal carbonates and metal ***,BCS-O can effectively activate persulfate(PDS)oxidation to degrade aniline,while BCS-O loaded with transition metal(BCS-O-Me)shows better activation efficiency and ***-O and BCS-O-Me activated PDS oxidation systems are dominated by^(1)O_(2)oxidation and electron *** main active sites are oxygen-containing functional groups,vacancy defects,and graphitized *** oxygen-containing functional groups and vacancy defects primarily activate PDS to generate^(1)O_(2)and attack *** carbon promotes aniline degradation by accelerating electron *** paper develops an innovative strategy to simultaneously realize efficient remediation of PCS and sequential reuse of the postremediation soil.

关键词： Petroleum-contaminated soil Ball milling Oxygen atmosphere Pyrolysis Resource utilization

Tuning support morphology to control alloy over PtCo/γ-Al_(2)O_(3) for the preferential oxidation of CO

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燃料化学学报(中英文) 2025年第1期53卷 96-105页

作者： song Lichuan ZHONG Liding SHEN Jia LOU Yake guo Yun WANG Li State Key Laboratory of Green Chemical Engineering and Industrial Catalysis Research Institute of Industrial CatalysisSchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China

The preferential oxidation of CO(CO-PROX)reaction is a cost-effective method for eliminating trace amounts of CO from the fuel ***-based catalysts have been extensively studied for COPROX,with their activity influenced by the morphology of the *** synthesis was employed to produce different morphologies ofγ-Al_(2)O_(3):flower-likeγ-Al_(2)O_(3)(f)exposing(110)crystal faces,sheet-likeγ-Al_(2)O_(3)(s)revealing(100)crystal faces,and rod-likeγ-Al_(2)O_(3)(r)displaying(111)crystal faces,followed by loading PtCo *** exposed crystal faces of the support impact the alloying degree of the PtCo nanoparticles,and an increase in the alloying degree correlates with enhanced catalyst ***_(3)Co intermetallic compounds were identified onγ-Al_(2)O_(3)(f)exposing(110)crystal faces,and PtCo/γ-Al_(2)O_(3)(f)showed high catalytic activity in the CO-PROX reaction,achieving 100%CO conversion across a broad temperature range of 50−225°*** contrast,only partial alloying of PtCo was observed onγ-Al_(2)O_(3)(s).Furthermore,no alloying between Pt and Co occurred in PtCo/γ-Al_(2)O_(3)(r),resulting in a reaction rate at 50°C that was merely 11%of that of PtCo/γ-Al_(2)O_(3)(f).The formation of Pt3Co intermetallic compounds led to a more oxidized state of Pt,which significantly diminished the adsorption of CO on Pt and augmented the active oxygen species,thereby facilitating the selective oxidation of CO.

关键词： PtCo catalysts γ-Al_(2)O_(3) support morphology CO-PROX

CAF-derived exosome-miR-3124-5p promotes malignant biological processes in NSCLC via the TOLLIP/TLR4-MyD88-NF-κB pathway

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Oncology Research 2025年第1期33卷 133-148页

作者： TAO SUN QINGHUA song HUA LIU Department of Respiratory and Critical Care Medicine Affiliated Hospital of Nantong UniversityMedical School of Nantong UniversityNantong226001China Department of Emergency The People’s Hospital of RugaoNantong226500China Department of Haematology The People’s Hospital of RugaoNantong226500China

Background:Lung cancer is a life-threatening disease that occurs worldwide,but is especially common in *** crucial role of the tumour microenvironment(TME)in non-small cell lung cancer(NSCLC)has attracted recent ***-associated fibroblasts(CAFs)are the main factors that contribute to the TME function,and CAF exosomes are closely linked to ***:The expression levels of miR-3124-5p and Toll-interacting protein(TOLLIP)were analysed by bioinformatics prediction combined with RT-qPCR/Western Blot *** were isolated and identified from clinical NSCLC *** electron microscopy and Western Blot were used to identify exosomes from these *** in proliferation(CCK-8 and clone formation),migration(wound healing),and invasion(transwell)of NSCLC cells were *** Luciferase reporter test was applied to clarify the binding of miR-3124-5p to *** TOLLIP/TLR4/MyD88/NF-κB pathway proteins were determined using Western blot ***:MiR-3124-5p is overexpressed in clinical tissues and cells of ***-3124-5p was dramatically enriched in CAF-derived *** experiments revealed that CAFs delivered miR-3124-5p into NSCLC cells via exosomes,stimulating cancer cell ***-3124-5p acted as a sponge to negatively regulate TOLLIP expression,which activated the TLR4/MyD88/NF-κB axis to promote the occurrence and development of *** salvage tests were performed to determine whether CAF-exosome-derived miR-3124-5p plays a pro-cancer role in NSCLC by affecting the TOLLIP signalling ***:These results provide an interesting direction for the diagnosis and therapy of NSCLC.

关键词： Non-small cell lung cancer(NSCLC) Cancer-associated fibroblasts(CAFs) Exosomes miR-3124-5p Toll-interacting protein(TOLLIP)

A Power Battery Fault Diagnosis Method Based on Long-Short Term Memory-Back Propagation

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Energy Engineering 2025年第2期122卷 709-731页

作者： Yuheng Yin Jiahao song Minghui Yang School of Automation Harbin University of Science and TechnologyHarbin150080China

The lithium battery is an essential component of electric cars;prompt and accurate problem detection is vital in guaranteeing electric cars’safe and dependable functioning and addressing the limitations of Back Propagation(BP)neural networks in terms of vanishing gradients and inability to effectively capture dependencies in time series,and the limitations of Long-Short Term Memory(LSTM)neural network models in terms of risk of overfitting.A method based on LSTM-BP is put forward for power battery fault diagnosis to improve the accuracy of lithium battery fault ***,a lithium battery model is constructed based on the second-order RC equivalent circuit and the electro-thermal coupling model,and various lithium battery failures are simulated to examine the fault ***,the lithium battery charging and discharging experiments collect,clean,and process the battery *** constructing a neural network LSTM-BP model,we verified the superiority and accuracy of the LSTM-BP neural network model by comparing the LSTM model and BP model vertically and by comparing the Recurrent Neural Network(RNN)model,the Gated Recurrent Unit(GRU)model,and the Residual Neural Network(ResNet)model of a more advanced architecture ***,the lithium battery fault diagnosis process is summarized through the threshold quantitative criteria,and different faults are diagnosed and *** show that the LSTM-BP neural network not only overcomes the limitations of the LSTMneural network and BP neural network but also improves the ability to process sequence data and reduces the risk of overfitting.

关键词： Lithium battery fault diagnosis BP neural network LSTM neural network