检索结果-南通市图书馆

Agricultural Sciences in China 2009年第1期8卷 68-75页

作者： QIAN guo-liang hu Bai-shi JIANG Ying-hua LIU Feng-quan Department of Plant Pathology College of Plant Protection Nanjing Agricultural University~Key Laboratory of Monitoring and Managementof Crop Diseases and Pest Insects Ministry of Agriculture Nanjing 210095 P.R.China

Strain OH11, a Gram-negative, nonspore forming, rod-shaped bacterium with powerful antagonistic activity, was isolated from rhizosphere of green pepper in Jiangsu Academy of Agricultural Sciences of China and characterized to determine its taxonomic position. 16S rRNA gene sequence analysis revealed that strain OH11 belongs to the Gammaproteobacteria and had the highest degree of sequence similarity to Lysobacter enzymogenes strain C3 （AY074793）（99%）, Lysobacter enzymogenes strain N4-7 （U89965）（99%）, Lysobacter antibioticus strain （AB019582）（97%）, and Lysobacter gummosus strain （AB16136）（97%）. Chemotaxonomic data revealed that strain OHI 1 possesses a quinine system with Q-8 as the predominant compound and C15：0 iso, C17：1 iso ω9c as the predominant iso-branched fatty acids, all of which corroborated the assignment of strain OH11 to the genus Lysobacter. Results of DNA-DNA hybridization and physiological and biochemical tests clearly showed that strain OH11 was classified as Lysobacter enzymogenes. Strain OH11 could produce protease, chitinase, and β-1,3-glucanase. It showed strong in vitro antifungal activity against Rhizoctonia solani, Sclerotinia scletotiorum, and several other phytopathogenic fungi. This is the first report of identification and characterization of Lysobacter enzymogenes as a biological control agent of plant diseases in China.

关键词： Lysobacter enzymogenes identification characterization biological control

Prevalence of and risk factors for aspirin resistance in elderly patients with coronary artery disease

在线全文

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2013年第1期10卷 21-27页

作者： Xian-Feng Liu Jian Cao Li Fan Lin Liu Jian Li guo-liang hu Yi-Xin hu Xiao-Li Li First Geriatric Cardiology Division of South Building Chinese PLA General Hospital 28 Fuxing Road Beijing 100853 China

Objective To assess the prevalence of and related risk factors for aspirin resistance in elderly patients with coronary artery disease (CAD). Methods Two hundred and forty-six elderly patients (75.9 ±7.4 years) with CAD who received daily aspirin therapy (≥75 mg) over one month were recruited. The effect of aspirin was assessed using light transmission aggregometry (LTA) and thrombelastography platelet mapping assay (TEG). Aspirin resistance was defined as ≥20% arachidonic acid (AA)-induced aggregation and ≥70% adenosine diphosphate (ADP)-induced aggregation in the LTA assay. An aspirin semi-responder was defined as meeting one (but not both) of the criteria described above. Based on the results of TEG, aspirin resistance was defined as ≥50% aggregation induced by AA. Results As determined by LTA, 23 (9.3%) of the elderly CAD patients were resistant to aspirin therapy; 91 (37.0%) were semi-responders. As determined by TEG, 61 patients (24.8%) were aspirin resistant. Of the 61 patients who were aspirin resistant by TEG, 19 were aspirin resistant according to LTA results. Twenty-four of 91 semi-responders by LTA were aspirin resistant by TEG. Multivariate logistic regression analysis revealed that elevated fasting serum glucose level (Odds ratio: 1.517; 95% CI: 1.176–1.957; P = 0.001) was a significant risk factor for aspirin resistance as determined by TEG. Conclusions A significant number of elderly patients with CAD are resistant to aspirin therapy. Fasting blood glucose level is closely associatedwith aspirin resistance in elderlyCAD patients.

关键词： Aspirin resistance Coronary artery disease Risk factors

Establishing a predictive model for aspirin resistance in elderly Chinese patients with chronic cardiovascular disease

在线全文

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2016年第5期13卷 458-464页

作者： Jian CAO Wei-Jun HAO Ling-Gen GAO Tian-Meng CHEN Lin LIU Yu-Fa SUN guo-liang hu Yi-Xin hu Li FAN Department of Geriatric Cardiology Chinese PLA General Hospital Beijing China Health Division of Guard Bureau General Staff Department of Chinese PLA Beijing China

Background Resistance to anti-platelet therapy is detrimental to patients. Our aim was to establish a predictive model for aspirin resistance to identify high-risk patients and to propose appropriate intervention. Methods Elderly patients （n = 1130） with stable chronic coronary heart disease who were taking aspirin （75 mg） for 〉 2 months were included. Details of their basic characteristics, laboratory test results, and medications were collected. Logistic regression analysis was performed to establish a predictive model for aspirin resistance. Risk score was finally established according to coefficient B and type of variables in logistic regression. The Hosmer-Lemeshow （HL） test and receiver operating characteristic curves were performed to respectively test the calibration and discrimination of the model. Results Seven risk factors were included in our risk score. They were serum creatinine （〉 110 μmol/L, score of 1）; fasting blood glucose （〉 7.0 mmol/L, score of 1）; hyperlipidemia （score of 1）; number of coronary arteries （2 branches, score of 2; 〉 3 branches, score of 4）; body mass index （20-25 kg/m2, score of 2; 〉 25 kg/m2, score of 4）; percutaneous coronary intervention （score of 2）; and smoking （score of 3）. The HL test showed P ≥ 0.05 and area under the receiver operating characteristic curve ≥ 0.70. Conclusions We explored and quantified the risk factors for aspirin resistance. Our predictive model showed good calibration and discriminative power and therefore a good foundation for the further study of patients undergoing anti-platelet therapy.

关键词： Aspirin resistance Cardiovascular disease Predictive model Risk score

High prevalence of aspirin resistance in elderly patients with cardiovascular disease and metabolic syndrome

在线全文

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2016年第6期13卷 531-536页

作者： Lin LIU Ying-hui GAO Jian CAO hua-Xin ZHANG Li FAN guo-liang hu Yi-Xin hu Xiao-Li LI Xiao ZOU Jian-hua LI Nanlou Respiratory Disease Department Chinese PLA General Hospital Beijing China Peking University Hepatology Institute Peking University People's Hospital Peking University Beijing China Nanlou Clinical Lab Chinese PLA General Hospital Beijing China Department of Clinical Laboratory of South Building Chinese PLA General Hospital Beijing China Clinical Department of South Building Chinese PLA General Hospital Beijing China

Background Metabolic syndrome is known to be a prothrombotic state. We undertook this study to examine a hypothesis that aspirin resistance may be associated with metabolic syndrome, and to assess other potential determinants of aspirin resistance in patients with cardiovascular disease （CVD）. Methods A total of 469 elderly patients with CVD were recruited. One hundred and seventy-two patients with metabolic syndrome and 297 without metabolic syndrome （control group） received daily aspirin therapy （〉 75 mg） over one month. Platelet aggregation was measured by light transmission aggregometry （LTA）. Aspirin resistance was defined as 〉 20% arachidonic acid （AA）- and 〉 70% adenosine diphosphate （ADP）-induced aggregation according to LTA. Aspirin semi-responders were defined as meeting one （but not both） of these criteria. Results By LTA, 38 of 469 （8.1%） patients were aspirin resistant. The prevalence of aspirin resistance was higher in the metabolic syndrome group compared with the control group [11.6 % vs. 6.6%, odds ratio （OR） = 2.039; 95% confidence interval （CI）： 1.047-3.973]. In the multivariate logistic regression analysis, metabolic syndrome （OR = 4.951, 95% CI： 1.440-17.019, P = 0.011） was a significant risk factor for aspirin resistance. Conclusions A significant number of patients with CVD and metabolic syndrome are resistant to aspirin therapy. This might further increase the risk of cardiovascular morbidity and mortality in these patients.

关键词： Aspirin resistance Cardiovascular disease Metabolic syndrome

Salubrinal protects against tunicamycin and hypoxia induced cardiomyocyte apoptosis via the PERK-eIF2a signaling pathway

在线全文

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2012年第3期9卷 258-268页

作者： Chun-Lei Liu Xin Li guo-liang hu Rui-Jun Li Yun-Yun He Wu Zhong Song Li Kun-Lun He Li-Li Wang Department of Cardiology Chinese PLA General Hospital28 Fuxing RoadBeijing 100853China Medical School of Nankai University 74 Weijin RoadTianjin 300074China Pharmacy Institute of Military Medical Sciences 27 Taiping RoadBeijing 100850China

Objectives This study examined the protective effect of salubrinal and the mechanism underlying this protection against tunicamycin （TM）- and hypoxia-induced apoptosis in rat cardiomyocytes. Methods Neonatal rat cardiomyocytes were cultured from the ventricles of l-day-old Wistar rats. Cells were exposed to different concentrations of salubrinal （10, 20, and 40 gmol/L） for 30 min followed by TM treatment or hypoxia for 36 h. Apoptosis was measured by a multiparameter HCS （high content screening） apoptosis assay, TUNEL assay and flow cytometry. The phosphorylation of eukaryotic translation initiation factor 2 subunit alpha （eIF2c0 and the expression of cleaved caspase-12 were determined by Western blotting. C/EBP homologous protein （CHOP） was detected by immunocytochemistry. Results HCS, TUNEL assays and flow cytometry showed that salubrinal protected cardiomyocytes against apoptosis induced by TM or hypoxia. Western blotting showed that salubrinal protected cardiomyocytes against apoptosis by inducing eIF2ct phosphorylation and down-regulating the expression of the endoplasmic reticulum stress-mediated apoptotic proteins, CHOP and cleaved caspase-12. Conclusions Our study suggests that salubrinal protects rat cardiomyocytes against TM- or hypoxia-associated apoptosis via a mechanism involving the inhibition of ER stress-mediated apoptosis.

关键词： Endoplasmic reticulum stress Rat cardiomyocytes Apoptosis Salubrinal Cell protection

Effect of Nb-V microalloying on the hot deformation behavior of medium Mn steels

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 360-368页

作者： Yumeng Wang Qinyi guo Bin hu Haiwen Luo School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China

The influence of Nb-V microalloying on the hot deformation behavior and microstructures of medium Mn steel(MMS)was investigated by uniaxial hot compression *** establishing the constitutive equations for simulating the measured flow curves,we successfully constructed deformation activation energy(Q)maps and processing maps for identifying the region of flow *** concluded the following consequences of Nb-V alloying for MMS.(i)The critical strain increases and the increment diminishes with the increasing deformation temperature,suggesting that NbC precipitates more efficiently retard dynamic recrystallization(DRX)in MMS compared with solute Nb.(ii)The deformation activation energy of MMS is significantly increased and even higher than that of some reported high Mn steels,suggesting that its ability to retard DRX is greater than that of the high Mn content.(iii)The hot workability of MMS is improved by narrowing the hot processing window for the unstable flow stress,in which fine recrystallized and coarse unrecrystallized grains are present.

关键词： medium manganese steel niobium-vanadium microalloying flow behavior dynamic recrystallization hot workability

带锥齿蜗轮蜗杆传动式消防水炮结构设计及流场仿真（英文）

在线全文

学校读者我要写书评

暂无评论

机床与液压 2016年第6期44卷 57-61,81页

作者： Ming XU Xiao-yu ZHANG guo-liang hu Gang LI School of Mechatronics Engineering East China Jiaotong University Nanchang 330013 China

A fire water monitor driven by worm gear with bevel gear was designed based on the theoretical calcula-tions. The classification and features of fire water monitor were elaborated, and the design of whole structure andkey components of fire water monitor were discussed. Moreover, the jet characteristics and the influence factors onthe jet performances were also investigated in details. The simulation results approximately agree with the expecta-tion effect, which reflects the rationality of the design. The relevant analysis can provide some guidance for thedesign and optimization of fire water monitor.

关键词： Fire water monitor, Structure design, Flow field simulation

Domain generalization with semi-supervised learning for people-centric activity recognition

在线全文

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2025年第1期68卷 171-188页

作者： Jing LIU Wei Zhu Di LI Xing hu liang SONG Academy for Engineering & Technology Fudan University Shanghai East-bund Research Institute on Networking Systems of AI School of Optoelectronic Information and Computer Engineering University of Shanghai for Science & Technology

People-centric activity recognition is one of the most critical technologies in a wide range of real-world applications,including intelligent transportation systems, healthcare services, and brain-computer interfaces. Large-scale data collection and annotation make the application of machine learning algorithms prohibitively expensive when adapting to new tasks. One way of circumventing this limitation is to train the model in a semi-supervised learning manner that utilizes a percentage of unlabeled data to reduce the labeling burden in prediction tasks. Despite their appeal, these models often assume that labeled and unlabeled data come from similar distributions, which leads to the domain shift problem caused by the presence of distribution gaps. To address these limitations, we propose herein a novel method for people-centric activity recognition,called domain generalization with semi-supervised learning(DGSSL), that effectively enhances the representation learning and domain alignment capabilities of a model. We first design a new autoregressive discriminator for adversarial training between unlabeled and labeled source domains, extracting domain-specific features to reduce the distribution gaps. Second, we introduce two reconstruction tasks to capture the task-specific features to avoid losing information related to representation learning while maintaining task-specific consistency. Finally, benefiting from the collaborative optimization of these two tasks, the model can accurately predict both the domain and category labels of the source domains for the classification task. We conduct extensive experiments on three real-world sensing datasets. The experimental results show that DGSSL surpasses the three state-of-the-art methods with better performance and generalization.

关键词： activity recognition deep learning domain generalization semi-supervised learning adversarial training

同方期刊数据库

Optimization Strategies of Na_(3)V_(2)(PO_(4))_(3) Cathode Materials for Sodium‑Ion Batteries

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第2期17卷 204-251页

作者： Jiawen hu Xinwei Li Qianqian liang Li Xu Changsheng Ding Yu Liu Yanfeng Gao School of Materials Science and Engineering Shanghai UniversityShanghai 200444People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China

Na_(3)V_(2)(PO_(4))_(3)(NVP)has garnered great attentions as a prospective cathode material for sodium-ion batteries(SIBs)by virtue of its decent theoretical capacity,superior ion conductivity and high structural ***,the inherently poor electronic conductivity and sluggish sodium-ion diffusion kinetics of NVP material give rise to inferior rate performance and unsatisfactory energy density,which strictly confine its further application in ***,it is of significance to boost the sodium storage performance of NVP cathode *** to now,many methods have been developed to optimize the electrochemical performance of NVP cathode *** this review,the latest advances in optimization strategies for improving the electrochemical performance of NVP cathode material are well summarized and discussed,including carbon coating or modification,foreign-ion doping or substitution and nanostructure and morphology *** foreign-ion doping or substitution is highlighted,involving Na,V,and PO_(4)^(3−)sites,which include single-site doping,multiple-site doping,single-ion doping,multiple-ion doping and so ***,the challenges and prospects of high-performance NVP cathode material are also put *** is believed that this review can provide a useful reference for designing and developing high-performance NVP cathode material toward the large-scale application in SIBs.

关键词： Sodium-ion batteries Na_(3)V_(2)(PO_(4))_(3) Cathode materials Electrochemical performance Optimization strategies

振动空泡近弹性壁面的可视化实验研究(英文)

在线全文

学校读者我要写书评

暂无评论

机床与液压 2015年第6期43卷 38-42页

作者：徐明胡国良华东交通大学机电工程学院南昌330013

研究了振动空泡与明胶弹性壁面及管道的相互作用机理,其中振动空泡由一个60 V的低压电路产生,实验时采用高速相机记录振动空泡的形状变化及弹性壁面的膨胀与收缩过程,并且高速相机的帧率分别设为12 500 f/s和15 000 f/s。实验观察到了... 详细信息

研究了振动空泡与明胶弹性壁面及管道的相互作用机理,其中振动空泡由一个60 V的低压电路产生,实验时采用高速相机记录振动空泡的形状变化及弹性壁面的膨胀与收缩过程,并且高速相机的帧率分别设为12 500 f/s和15 000 f/s。实验观察到了空泡分裂及二次空化现象,结果表明:振动空泡的动力学行为明显受到了弹性壁面的影响。

关键词：振动空泡弹性壁面弹性管道