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The effects of diabetes on male fertility and epigenetic regulation during spermatogenesis

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Asian Journal of Andrology 2015年第6期17卷 948-953,I0008-I0009页

作者： guo-lian ding Ye Liu Miao-E Liu Jie-Xue Pan Meng-Xi guo Jian-Zhong Sheng He-Feng Huang International Peace Maternity and Child Health Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200030 China The Key Laboratory of Reproductive Genetics Ministry of Education (Zhejiang University) Hangzhou 310058 China Department of Pathology and Pathophysiology School of MedicineZhejiang University Hangzhou 310058 China

The effects of diabetes mellitus include long-term damages, dysfunctions, and failures of various organs. An important complication of diabetes is the disturbance in the male reproductive system. Glucose metabolism is an important event in spermatogenesis. Moreover, glucose metabolism is also important for maintaining basic cell activity, as well as specific functions, such as motility and fertilization ability in mature sperm. Diabetic disease and experimentally induced diabetes both demonstrated that either type 1 diabetes or type 2 diabetes could have detrimental effects on male fertility, especially on sperm quality, such as sperm motility, sperm DNA integrity, and ingredients of seminal plasma. Epigenetic modifications are essential during spermatogenesis. The epigenetic regulation represents chromatin modifications including DNA methylation, histone modifications, remodeling of nucleosomes and the higher-order chromatin reorganization and noncoding RNAs. If spermatogenesis is affected during the critical developmental window, embryonic gonadal development, and germline differentiation, environmentally-induced epigenetic modifications may become permanent in the germ line epigenome and have a potential impact on subsequent generations through epigenetic transgenerational inheritance. Diabetes may influence the epigenetic modification during sperm spermatogenesis and that these epigenetic dysregulation may be inherited through the male germ line and passed onto more than one generation, which in turn may increase the risk of diabetes in offspring.

关键词： diabetes epigenetic regulation sperm spermatogenesis

Secure control and filtering for industrial metaverse

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Frontiers of Information Technology & Electronic Engineering 2024年第2期25卷 179-181页

作者： Qing-Long HAN Derui ding Xiaohua GE School of Science Computing and Engineering TechnologiesSwinburne University of TechnologyMelbourneVIC 3122Australia Department of Control Science and Engineering University of Shanghai for Science and TechnologyShanghai 200093China

Metaverse can be regarded as a socialized and virtualized cyberspace parallel yet interactive to the real world.Benefiting from the rapid development of cloud computing and digital twins,metaverse is transforming traditional control and filtering para‐digms of industrial automation systems into cyberphysical social systems.Under this scenario,future industrial automation systems could be an integration of real-world ones and virtual twins combined with great computational power within a certain temporal and spatial range.

关键词： interactive filtering Secure

Mental health and insomnia problems in healthcare workers after the COVID-19 pandemic:A multicenter cross-sectional study

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World Journal of Psychiatry 2024年第5期14卷 704-714页

作者： Wei ding Min-Zhong Wang Xian-Wei Zeng Zhen-Hua Liu Yao Meng Hui-Ting Hu Yuan Zhang Yu-Guang Guan Fan-Gang Meng Jian-guo Zhang Shu Wang Department of Public Health Liaocheng People’s HospitalLiaocheng 252000Shandong ProvinceChina Department of Neurology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Department of Neurosurgery Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina Sleep Medicine Center Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Department of Neurology The First Affiliated Hospital of Shandong First Medical UniversityJinan 250014Shandong ProvinceChina Department of Neurology Heze Mudan People’s HospitalHeze 274000Shandong ProvinceChina Neonatal Center Beijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China Department of Neurosurgery SanBo Brain HospitalCapital Medical UniversityBeijing 100093China Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China

BACKGROUND Healthcare workers(HCWs)are at increased risk of contracting coronavirus disease 2019(COVID-19)as well as worsening mental health problems and insomnia.These problems can persist for a long period,even after the pandemic.However,less is known about this topic.AIM To analyze mental health,insomnia problems,and their influencing factors in HCWs after the COVID-19 pandemic.METHODS This multicenter cross-sectional,hospital-based study was conducted from June 1,2023 to June 30,2023,which was a half-year after the end of the COVID-19 emergency.Region-stratified population-based cluster sampling was applied at the provincial level for Chinese HCWs.Symptoms such as anxiety,depression,and insomnia were evaluated by the Generalized Anxiety Disorder-7,Patient Health Questionnaire-9,and Insomnia Severity Index.Factors influencing the symptoms were identified by multivariable logistic regression.RESULTS A total of 2000 participants were invited,for a response rate of 70.6%.A total of 1412 HCWs[618(43.8%)doctors,583(41.3%)nurses and 211(14.9%)nonfrontline],254(18.0%),231(16.4%),and 289(20.5%)had symptoms of anxiety,depression,and insomnia,respectively;severe symptoms were found in 58(4.1%),49(3.5%),and 111(7.9%)of the participants.Nurses,female sex,and hospitalization for COVID-19 were risk factors for anxiety,depression,and insomnia symptoms;moreover,death from family or friends was a risk factor for insomnia symptoms.During the COVID-19 outbreak,most[1086(76.9%)]of the participating HCWs received psychological interventions,while nearly all[994(70.4%)]of them had received public psychological education.Only 102(7.2%)of the HCWs received individual counseling from COVID-19.CONCLUSION Although the mental health and sleep problems of HCWs were relieved after the COVID-19 pandemic,they still faced challenges and greater risks than did the general population.Identifying risk factors would help in providing targeted interventions.In addition,although a major proportion of HCWs have received public psychological educatio

关键词： COVID-19 Mental health Psychological symptoms Insomnia Sleep disorders Cross-sectional study Epidemiological study

The gene encoding flavonol synthase contributes to lesion mimic in wheat

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The Crop Journal 2024年第3期12卷 814-825页

作者： Tingting Dong Hongchun Xiong Huijun guo Yongdun Xie Linshu Zhao Jiayu Gu Huiyuan Li Shirong Zhao Yuping ding Xiyun Song Luxiang Liu College of Life Sciences Key Laboratory of Major Crop Germplasm Innovation and Application in QingdaoQingdao Agricultural UniversityQingdao 266109ShandongChina State Key Laboratory of Crop Gene Resources and Breeding/National Engineering Laboratory of Crop Molecular Breeding/CAEA Research and Development Centre on Nuclear Technology Applications for Irradiation Mutation Breeding Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China

Lesion mimic often exhibits leaf disease-like symptoms even in the absence of pathogen infection,and is characterized by a hypersensitive-response(HR)that closely linked to plant disease resistance.Despite this,only a few lesion mimic genes have been identified in wheat.In this investigation,a lesion mimic wheat mutant named je0297 was discovered,showing no alteration in yield components when compared to the wild type(WT).Segregation ratio analysis of the F_(2)individuals resulting from the cross between the WT and the mutant revealed that the lesion mimic was governed by a single recessive gene in je0297.Using Bulked segregant analysis(BSA)and exome capture sequencing,we mapped the lesion mimic gene designated as lm6 to chromosome 6BL.Further gene fine mapping using 3315 F_(2)individuals delimited the lm6 within a 1.18 Mb region.Within this region,we identified 16 high-confidence genes,with only two displaying mutations in je0297.Notably,one of the two genes,responsible for encoding flavonol synthase,exhibited altered expression levels.Subsequent phenotype analysis of TILLING mutants confirmed that the gene encoding flavonol synthase was indeed the causal gene for lm6.Transcriptome sequencing analysis revealed that the DEGs between the WT and mutant were significantly enriched in KEGG pathways related to flavonoid biosynthesis,including flavone and flavonol biosynthesis,isoflavonoid biosynthesis,and flavonoid biosynthesis pathways.Furthermore,more than 30 pathogen infection-related(PR)genes exhibited upregulation in the mutant.Corresponding to this expression pattern,the flavonoid content in je0297 showed a significant decrease in the 4^(th)leaf,accompanied by a notable accumulation of reactive oxygen,which likely contributed to the development of lesion mimic in the mutant.This investigation enhances our comprehension of cell death signaling pathways and provides a valuable gene resource for the breeding of disease-resistant wheat.

关键词： Lesion mimic mutant Wheat Gene mapping Flavonol synthase gene Flavonoid

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Development of porphyrin-based fluorescent sensors and sensor arrays for saccharide recognition

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Chinese Chemical Letters 2024年第2期35卷 16-23页

作者： Yubin ding Jiaxin Wang Ruinan Wang Yongshu Xie Department of Chemistry College of SciencesNanjing Agricultural UniversityNanjing 210095China Shanghai Key Laboratory of Functional Materials Chemistry Key Laboratory for Advanced Materials and Institute of Fine ChemicalsSchool of Chemistry and Molecular EngineeringEast China University of Science & TechnologyShanghai 200237China

Saccharide sensing is a very meaningful research topic as saccharides are involved in many biological activities.However,it is challenging to design molecular sensors for saccharides because this family of compounds is hydromimetic in aqueous solutions and shares a similar chemical structure.In this review,research progress in the development of porphyrin-based saccharide sensors is described with representative examples.We focus on using porphyrin as the signal reporter because porphyrins exhibit unique advantages in high chemical stability,long emission wavelength,and multiple structural modification strategies.Reported literature results have been classified into mainly two sections according to the general working principles of the porphyrin sensor molecules.In the first section,recognition unit,design strategy and sensing performance of traditional porphyrin-based selective saccharide sensors are discussed.While in the second section,development of porphyrin-based sensor arrays for pattern recognition of saccharides has been summarized.Looking through the design strategy and sensing performance of reported achievements,it is reasonable to anticipate a bright future for designing practical porphyrin-based saccharide sensors.

关键词： Porphyrin Saccharide Fluorescent sensing Selective sensing Pattern recognition

Optical system for extremely large spectroscopic survey telescope

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 158-174页

作者： ding-qiang Su Hua Bai Xiangyan Yuan Xiangqun Cui Key Laboratory of the Ministry of Education School of Astronomy and Space ScienceNanjing UniversityNanjing 210023China Nanjing Institute of Astronomical Optics and Technology(NIAOT) Chinese Academy of SciencesNanjing 210042China University of Chinese Academy of Sciences Nanjing 211135China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 101408China

This article presents research work on a spectroscopic survey telescope.Our idea is as follows:for such a telescope,a pure reflecting optical system is designed,which should have an aperture and a field of view(FOV)both as large as possible and excellent image quality,and then a strip lensm(lens-prism)atmospheric dispersion corrector(S-ADC)is added,only for correcting the atmospheric dispersion.Given the fund limitation and the simplicity of scaling up,some 12-m telescopes are designed as examples.Su,Korsch,and Meinel put forward the four-mirror Nasmyth systems I and II,which are used in this paper.FOVs of 1.5°,2°,and 2.5°are selected.For all systems,the image qualities are excellent.Because the S-ADC relaxes the optical glass size restriction,this 12-m telescope with a FOV of 2.5°can be magnified in proportion to a 16-m telescope.Its etendue(from Frenchétendue)and focal surface will now be the largest in the world.In such a telescope,a pure reflecting optical system can also be obtained.A subsequent coudésystem is designed with excellent image quality.

关键词： telescopes spectroscopic survey

Compliance motion control of the hydraulic dual-arm manipulator with adaptive mass estimation of unknown object

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Frontiers of Mechanical Engineering 2024年第1期19卷 35-52页

作者： Bolin SUN Min CHENG Ruqi ding Bing XU State Key Laboratory of Mechanical Transmissions Chongqing UniversityChongqing 400044China Key Laboratory of Conveyance and Equipment(Ministry of Education) East China Jiaotong UniversityNanchang 330013China State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou 310027China

Given the limited operating ability of a single robotic arm,dual-arm collaborative operations have become increasingly prominent.Compared with the electrically driven dual-arm manipulator,due to the unknown heavy load,difficulty in measuring contact forces,and control complexity during the closed-chain object transportation task,the hydraulic dual-arm manipulator(HDM)faces more difficulty in accurately tracking the desired motion trajectory,which may cause object deformation or even breakage.To overcome this problem,a compliance motion control method is proposed in this paper for the HDM.The mass parameter of the unknown object is obtained by using an adaptive method based on velocity error.Due to the difficulty in obtaining the actual internal force of the object,the pressure signal from the pressure sensor of the hydraulic system is used to estimate the contact force at the end-effector(EE)of two hydraulic manipulators(HMs).Further,the estimated contact force is used to calculate the actual internal force on the object.Then,a compliance motion controller is designed for HDM closed-chain collaboration.The position and internal force errors of the object are reduced by the feedback of the position,velocity,and internal force errors of the object to achieve the effect of the compliance motion of the HDM,i.e.,to reduce the motion error and internal force of the object.The required velocity and force at the EE of the two HMs,including the position and internal force errors of the object,are inputted into separate position controllers.In addition,the position controllers of the two individual HMs are designed to enable precise motion control by using the virtual decomposition control method.Finally,comparative experiments are carried out on a hydraulic dual-arm test bench.The proposed method is validated by the experimental results,which demonstrate improved object position accuracy and reduced internal force.

关键词： hydraulic dual-arm manipulator compliance motion control unknown object adaptive mass estimation nonlinear control

A review on g-C_(3)N_(4)decorated with silver for photocatalytic energy conversion

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Chinese Chemical Letters 2024年第2期35卷 187-196页

作者： Ziyu Pan Wufan ding Hanchun Chen Haodong Ji Eco-environment and Resource Efficiency Research Laboratory School of Environment and EnergyPeking University Shenzhen Graduate SchoolShenzhen 518055China

Artificial photocatalytic energy conversion is considered as the most potential strategy for solving the increasingly serious energy crisis and environmental pollution problems by directly capturing solar energy.Therefore,high efficiency photocatalyst has drawn significant research attention in recent years.Due to the excellent electronic,optical,structural,and physicochemical performances,silver-based g-C_(3)N_(4)have become promising photocatalysts.This review emphasizes the recent progresses and challenges on g-C_(3)N_(4)decorated with silver for photocatalytic energy conversion.The extensive use of g-C_(3)N_(4)decorated with silver in diverse photocatalytic reactions,including hydrogen evolution,pollutant degradation and carbon dioxide reduction,is also fully introduced.In addition,we propose the perspectives of g-C_(3)N_(4)decorated with silver on photocatalytic applications.We hope that this review will shed some light on the photocatalytic energy conversion of g-C_(3)N_(4)decorated with silver.

关键词： g-C_(3)N_(4) Silver-modified g-C_(3)N_(4) Photocatalytic energy conversion H_(2)evolution Pollutant degradation CO_(2)reduction

Numerical analysis of geosynthetic-reinforced embankment performance under moving loads

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 682-696页

作者： Xuanming ding Jinqiao Zhao Qiang Ou Jianfei Liu College of Civil Engineering Chongqing UniversityChongqing400045China Key Laboratory of New Technology for Construction of Cities in Mountain Area Chongqing UniversityChongqing400045China China United Engineering Corporation Limited Hangzhou310052China

The performance of geosynthetic-reinforced embankments under traffic moving loads is always a hotspot in the geotechnical engineering field.A three-dimensional(3D)model of a geosynthetic-reinforced embankment without drainage consolidation was established using the finite element software ABAQUS.In this model,the traffic loads were simulated by two moving loads of rectangular pattern,and their amplitude,range,and moving speed were realized by a Fortran subroutine.The embankment fill was simulated by an equivalent linear viscoelastic model,which can reflect its viscoelasticity.The geogrid was simulated by the truss element,and the geocell was simulated by the membrane element.Infinite elements were utilized to weaken the boundary effect caused by the model geometry at the boundaries.Validation of the established numerical model was conducted by comparing the predicted deformations in the cross-section of the geosynthetic-reinforced embankment with those from the existing literature.On this basis,the dynamic stress and strain distribution in the pavement structure layer of the geosynthetic-reinforced embankment under a moving load was also analyzed.Finally,a parametric study was conducted to examine the influences of the different types of reinforcement,overload,and the moving load velocity on the geosynthetic-reinforced embankment.

关键词： Geosynthetic-reinforced layer Numerical model Moving load Embankment Deformation Stress