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Protein post-translational modifications after spinal cord injury

Neural Regeneration Research 2021年第10期16卷 1935-1943页

作者： Shuang Zhu Bing-Sheng Yang Si-Jing li Ge Tong Jian-Ye Tan guo-Feng Wu lin li guo-li chen Qian chen li-Jun lin Department of Joint and Orthopedics Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Medical Ultrasonics Guangdong Province Key Laboratory of Hepatology ResearchThe Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Orthopedics Affiliated Hospital of Putian UniversityPutianFujian ProvinceChina Cell and Molecular Biology Laboratory Department of OrthopaedicsAlpert Medical School of Brown University/Rhode Island HospitalProvidenceRIUSA

Deficits in intrinsic neuronal capacities in the spinal cord,a lack of growth support,and suppression of axonal outgrowth by inhibitory molecules mean that spinal cord injury almost always has devastating *** such,one of the primary targets for the treatment of spinal cord injury is to develop strategies to antagonize extrinsic or intrinsic axonal growth-inhibitory factors or enhance the factors that support axonal *** these factors,a series of individual protein level disorders have been identified during the generation of axons following spinal cord ***,an increasing number of studies have indicated that post-translational modifications of these proteins have important implications for axonal *** researchers have discovered a variety of post-translational modifications after spinal cord injury,such as tyrosination,acetylation,and *** this review,we reviewed the post-translational modifications for axonal growth,functional recovery,and neuropathic pain after spinal cord injury,a better understanding of which may elucidate the dynamic change of spinal cord injury-related molecules and facilitate the development of a new therapeutic strategy for spinal cord injury.

关键词： extracellular matrix function impairment glial scar nerve regeneration neuropathic pain post-translational modification spinal cord injury therapeutic target

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The Cysteine Pairs in CLV2 are Not Necessary for Sensing the CLV3 Peptide in Shoot and Root Meristems

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Journal of Integrative Plant Biology 2010年第9期52卷 774-781页

作者： Xiufen Song Peng guo chen li Chun-Ming liu Key Laboratory of Photosynthesis and Environmental Molecular Physiology Institute of Botany Chinese Academy of Sciences Beijing 100093 China

Receptor-like proteins （RLPs） are involved in both plant defense and developmental processes. Previous genetic and biochemical studies show that the leucine-rich repeat （LRR） receptor-like protein CLAVATA2 （CLV2） functions together with CLAVATA1 （CLV1） and CORYNE （CRN） in Arabidopsis to limit the stem cell number in shoot apical meristem, while in root it acts with CRN to trigger a premature differentiation of the stem cells after sensing the exogenously applied peptides of CLV3p, CLE19p or CLE40p. It has been proposed that disulfide bonds might be formed through two cysteine pairs in the extracellular LRR domains of CLV1 and CLV2 to stabilize the receptor complex. Here we tested the hypothesis by replacing these cysteines with alanines and showed that depletions of one or both of the cysteine pairs do not hamper the function of CLV2 in SAM maintenance. In vitro peptide assay also showed that removal of the cysteine pairs did not affect the perception of CLV3 peptides in roots. These observations allow us to conclude that the formation of disulfide bonds is not needed for the function of CLV2.

关键词： CYSTEINE proteinases PEPTIDES PROTEINS ARABIDOPSIS STEM cells

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Decarburization Thermodynamics of High-Carbon Ferromanganese Powders During Gas-Solid Fluidization Process

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Journal of Iron and Steel Research International 2012年第5期19卷 1-8页

作者： guo li-na chen Jin ZHANG Meng liANG Min College of Materials Science and Engineering Taiyuan University of Technology Taiyuan 030024 Shanxi China

Thermodynamic conditions of reactions between high-carbon ferromanganese powders and gas decarbonizers like O2, CO2 and water vapor were studied by thermodynamic calculation. In O2, CO2 and water vapor atmosphere, high-carbon ferromanganese powders were decarburized in a fluidized bed. When the temperature is respectively higher than 273, 1 226 and 1 312 K, the gas-solid decarburization reaction will occur between ferromanganese carbide on the surface of the high-carbon ferromanganese powders and different gas decarbonizers. Since metal manganese is easy to be oxidized by O2, CO2 or water vapor, the decarburization reaction will transfer into a solid-solid phase reaction of ferromanganese carbide and ferromanganese oxide, promoting external diffusion of carbon to achieve a further decarburization of high-carbon ferromanganese powders.

关键词： gas-solid fluidization high carbon ferromanganese powders gas decarbonizer solid-phase decarburization

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Strain rate response of a Zr-based composite fabricated by Bridgman solidification

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International Journal of Minerals,Metallurgy and Materials 2010年第2期17卷 214-219页

作者： Jun-wei Qiao Yong Zhang Ji-heng li guo-liang chen State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing Beijing 100083 China

Zr58.5Ti14.3Nb5.2Cu6.1Ni4.9Be11.0 bulk metallic glass matrix composites,containingβ-Zr dendrites,were fabricated by Bridgman solidification at the withdrawal velocity of 1.0 mm/s through a temperature gradient of～45 K/*** to the increasing compressive strain rates,the monotonic increasing and decreasing were obtained for the maximum strength and the fracture strain,*** results show that high strain rate may induce the insufficient time for the interaction between shear bands and the crystalline phase,and early fracture occurs as a *** fractographs are consistent with the mechanical properties,and the failure mode of the present Zr-based composites is in agreement with the frame of the ellipse criterion.

关键词： bulk metallic glass composites Bridgman solidification mechanical properties

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Superplastic behaviour and microstructure evolution of a fine-grained TA15 titanium alloy

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Rare Metals 2009年第5期28卷 523-527页

作者： ZHAO Zhanglong guo Hongzhen chen li YAO Zekun School of Material Science and Engineering Northwestern Polytechnical University Xi ＇an 710072 China

The fine-grained microstructure of TA15 titanium alloy was prepared through two-step forging technology combined with high and low temperatures, and a transnormal superplastic elongation of more than 2000% was obtained. The superplastic behaviour and microstructure evolution were systematically researched at different temperatures and strain rates through superplastic tensile test. The results indicate that the fine-grained TA15 alloy exhibits superplasticity at temperatures of 760-980°C and initial strain rates from 1.1 × 10^-2 to 5.5 × 10^-5 s^-1. The optimal superplastic conditions are 940°C and 3.3 × 10^-4 s^-1, in which the average elongation is 2526% and the maximum elongation is 2743%. During superplastic deformation, dynamic recovery and recrystallization occur obviously, and the corporate effect of strain hardening and recrystallization softening decides the superplastic ability directly.

关键词： titanium alloys superplasticity microstructure elongation

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Analysis of Phospholipids in Crucian Carp(Carassius auratus) Muscle by Offline HPLC-MALDI-TOF MS

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Chemical Research in Chinese Universities 2011年第3期27卷 371-374页

作者： li guo-chen WANG Yan-hong WU Ren-an WANG Shi-cheng Inspection and Testing Center of Agro-product Safety and Environment Quality Institute of Applied EcologyChinese Academy of SciencesShenyang 110016P.R.China National Chromatographic Research&Analysis Center Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023P.R.China

The interest in the analysis of phospholipids(PLs), especially phosphatidylcholine(PC), has been increasing due to the importance of them in biochemistry as well as in industry. A method was reported based on the offline combination of MALDI-TOF MS and normal-phase HPLC for analyzing PLs extracted from crucian carp. Total PLs of crucian carp were extracted and then separated by HPLC before the collected subfractions were analyzed by MALDI-TOF MS. The mass spectra obtained show peaks of H+, Na+ and K+ adducts of PC molecules. It is shown that the prior separation of PLs by HPLC is highly necessary to remove the signal suppressing and to avoid the possible overlapping. With this method, 9 possible PC molecules in crucian carp and the corresponding fatty acid compositions were given from the well-resolved mass spectra.

关键词： Phospholipid Phosphatidylcholine Phosphatidylethanolamine Sphingomyelin HPLC MALDI Crucian Carp

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Synthesis and Structure of A Novel Quasi-Two Dimensional Organic-inorganic Hybrid Coordination Polymer:{[Cu(en)_2][Ag_2I_4]}_n

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Chinese Journal of Structural Chemistry 2006年第2期25卷 149-152页

作者： SUN ling-guo li Hao-Hong chen Zhi-Rong HUANG Chang-Cang ZHAO Bin li Jun-Qian College of Chemistry and Chemical Engineering Fuzhou University Fuzhou Fujian 350002 China

A novel coordination polymer {[Cu（en）2][Ag2I4]}, （en = ethylenediamine） was synthesized by the reaction of NaAgI2 and Cu（en）2（NO3）2·2H2O at room temperature with pH = 6.0, and the structure was characterized by X-ray single-crystal diffraction. It crystallizes in monoclinic, space group C2/m, with a=10.646（2）, b = 13.304（3）, c = 6.8445（14） ,A°, β = 118.95（3）°, C4H16N4CuAg2I4, Mr = 907.10, V= 848.3（4） A°^3, Z= 2, Dc = 3.551 g/cm^3, F（000） = 806, μ（MoKa） = 10.787 mm^-1, the final R1 = 0.0256 and wR2 = 0.0654 for 900 observed reflections with I 〉 2σ（I）. According to structural analysis, the title compound consists of template cation [Cu（en）2]^2＋ and inorganic chain [Ag2I4]n^2-. The polymeric negative chain [Ag2I4]n^2- is built up from pairs of AgI4 tetrahedron by sharing one edge. Through N-H…I hydrogen-bonding interactions, the whole structure represents a quasi-two dimensional arrangement. Electrostatic attraction exists between organic cations and inorganic chains, leading to a so-called organic-inorganic hybrid structure.

关键词： coordination polymer single-crystal diffraction template synthesis iodide

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Degradation of furan tebufenozide in laboratory and field trials

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Science China Chemistry 2010年第8期53卷 1818-1824页

作者： guo Cong,li DaHui,chen JinHui,guo BaoYuan,WANG Huili & li JianZhong Research Center for Eco-Environmental Sciences,Chinese Academy of Sciences,Beijing 100085,China 1. Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China

Furan tebufenozide is a newly developed insect growth regulator and has been applied as a pesticide in agriculture in *** degradation under both laboratory and field conditions was investigated,and the degradation kinetics was fitted by simple first order kinetics (SFO) model and first order double exponential (FOD) *** studies were conducted with or without light in five simulated media (sterilized deionized water,river water,soil solution,sterilized soil and natural soil).No dissipations of furan tebufenozide were observed in sterilized aqueous and soil media under light prevented conditions,whereas degradation occurred under all the other conditions in the *** from SFO and FOD models,DT50 in the dark and light laboratory conditions was in the range of 39.7-82.5 and 1.1-8.0 days,*** results indicated that microbes and light were the main factors for the degradation of the pesticide in the *** field trials,derived from the SFO model,DT50 and DT90 were 30.3 and 100.5 days,while derived from the FOD model,DT50 and DT90 were 28.9 and 274.9 days,*** with laboratory experiments,field trials were influenced by multiple ***,the SFO model could not fit experimental data as well as the FOD model did in field trials.

关键词： uran tebufenozide dissipation soil water degradation kinetics

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The experimental studies on the carbon and nitrogen budgets of Pseudeuphausia sinica

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Acta Oceanologica Sinica 2003年第2期22卷 265-272页

作者： guo Donghui, li Shaqjing, chen Feng, Wang Guizhong, chen Gang Department of Oceanography,Institute of Subtropic Ocean,Xiamen University,Xiamen 361005,China Xiamen Univ Dept Oceanog Inst Subtrop Ocean Xiamen 361005 Peoples R China

The carbon and nitrogen budgets were estimated on the adult females, juveniles and post-furcilia larvae of Pseudeuphausia sinica fed on newly hatching nauplii of Artemia salina in the laboratory. It was found that the ingestion rate was linearly related to the food concentration, suggesting high feeding potential. The linear correlation could be established between the respirating rate (carbon consumption rate) and carbon ingestion rate, as well as carbon assimilation rate. The regression coefficients (*** dynamic action coefficients) were in the range from 9% to 16% (ingested C) or 10% to 17% (assimilated C) respectively, with lower in the post-furcilia larvae. There also existed a linear correlation equation between estimated total nitrogen excretion rate and the rates of nitrogen ingestion and assimilation separately, except for the juveniles. The defecation rates increased with the increase of the ingestion rate; as a result, assimilation efficiency was not related to the ingestion rate, ranging from 0.84 to 0.95. The results inducated that the nitrogen content in food particles was a key factor limiting the growth of P. sinica. The critical ingestion rate was 10 μgN·mg-1 body dry weight per day. Assimilated N was lost mostly by excretion, following allocated to somatic growth. The nitrogen loss by moult only accounted for a minor part. As for carbon budget, respiration and somatic growth also accounted for most of assimilation, but varied with ingestion rates. Moult loss was minor. Estimated reproductive growth (C&N) in the adult females accounted for somewhat higher percent of assimilation than the moult growth. The net growth efficiency (K2) increased with the increase of the ingestion rates, but decreased slightly for juvenile and post-furcilia larvae after the rates up to a certain value.

关键词： Pseudeuphausia. sinica carbon and nitrogen budgets Xiamen harbour

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Stereoselective Synthesis of α-Aminonitril on Glucose Templates

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有机化学 2003年第Z1期23卷 90-92页

作者： ZHANG Peng-Fei GU Yi-Xin guo Jun-li chen Min Department of Chemistry Hangzhou Teachers College Zhejiang 310036 Department of Chemistry Hangzhou Teachers College Zhejiang 310036 Department of Chemistry Hangzhou Teachers College Zhejiang 310036 Department of Chemistry Hangzhou Teachers College Zhejiang 310036

　　Both proteinogenic and non proteinogenic α-amino acids are of particular interest as constituents of peptide factors, peptidomimetics and antibiotics for the construction of modern selective drugs. [1] Furthemore, α-amino acid derivatives are interesting building units for chiral-pool syntheses of enantiomerically pure natural products. [2] Numerous efforts in modern organic synthesis are centered on the synthesis of enantiomerically pure α-amino acids. [3] During the past three decades efficient methods of asymmetric synthesis of α-amino acids have been developed; most of them are based on electrophilic transformations of organometallic intermediates. [4] Using the concept that the chirality of the carbohydrates can be exploited for diastereoselective reactions, Kunz and his cooperator had developed a Strecker synthesis with glycosyl amines as chiral auxiliaries. [5] ……

关键词： asymmetric synthesis organic synthesis natural products methods of

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