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Frontiers of physics 2015年第2期10卷 57-66页

作者： Quan-Xing guo lei zhang Yong zhang School of Physics and Engineering Sun Yat-Sen University Guangzhou 510275 China

Because of the many potential medical applications of nanoparticles, considerable research has been conducted on the interactions between nanoparticles and biomembranes. We employed coarse- grained molecular dynamics simulations to study the infiltration of lipid-wrapping C60 and polyhy- droxylated single-walled nanotubes. Diffusion coefficients and scaling factors are adopted to quantify the diffusivity of the biomembranes, and the rupture tension is used to measure the lateral strength of the lipid bilayer. According to our simulations, all wrapped nanoparticles, except those wrapped by dipalmitoyl-glycero-phosphoglycerol, can be inserted into the bilayers. Our simulations also re- veal that the bilayers remain in free diffusion after the nanoparticle insertions while their diffusion coefficient can be altered significantly. The polyhydroxylated single-walled nanotubes lead to signif- icant changes to the lateral strength of biomembranes and this effect depends on the quantity of the inserted nanoparticles. The simulations demonstrate the feasibility of using these methods to deliver nanopartieles while some suggestions are given for choosing the appropriate lipids for wrappiug. The results also suggest that the functionalized nanopartieles could be applied in strengthening or weakening the lateral strength of biomembranes for specific purposes.

关键词： lipid bilayer carbon nanoparticle molecular dynamics

Structures,kinematics,thermochronology and tectonic evolution of the Ramba gneiss dome in the northern Himalaya

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Progress in Natural Science:Materials International 2008年第7期18卷 851-860页

作者： lei guo,Jinjiang zhang,Bo zhang The Key Laboratory of Orogenic Belts and Crustal Evolution,Ministry of Education,China School of Earth and Space Sciences,Peking University,Beijing 100871,China The Key Laboratory of Orogenic Belts and Crustal Evolution Ministry of Education China School of Earth and Space Sciences Peking University Beijing 100871 China

The Ramba gneiss dome,one of the north Himalayan gneiss domes,is composed of three tectono-lithologic units separated by an upper and a lower detachment ***-grade metamorphic Tethyan Himalayan sedimentary sequence formed the upper unit above the brittle upper detachment *** gneiss and a leucogranite pluton made up the lower unit beneath the ductile lower detach- ment *** middle-grade garnet-,staurolite-and andalusite-schist constituted the middle unit between the two faults,which may be that the basal part of the upper unit experienced detachment *** Ramba dome underwent three episodes of deformation in its tectonic *** first episode was a top-down-to-north-northwest sliding possibly related to the activity of the south Tibetan detachment system(STDS).The second episode was the dominant deformation related to a east–west extension,which resulted in a unique top-down-to-east kinematics and the major tectonic features of the *** third episode was a collapse sliding toward the outsides of the *** Ramba gneiss dome is possibly a result of the east–west extension and magmatic *** lower detachment fault is probably the main detachment fault separating the sedimentary sequence from the crystalline basement during the east–west extension in the dominant deformation *** diapir of the leucogranite pluton formed the doming shape of the Ramba gneiss *** pluton intruded in the core of the dome in a late stage of the dominant deformation,and its Ar–Ar cooling ages are about 6 *** indicates that the dominant deformation of the dome happened at the same time of the east–west extension represented by the north–south trending rifts throughout the northern Himalaya and southern ***,the formation of the Ramba gneiss dome should be related to this east–west extension.

关键词： Ramba gneiss dome North Himalayan gneiss domes East–west extension

Laparoscopic ligation of proximal splenic artery aneurysm with splenic function preservation

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World Journal of Gastroenterology 2014年第16期20卷 4835-4838页

作者： Yun-Hai Wei Jie-Wei Xu Hua-Ping Shen guo-lei zhang Harsha Ajoodhea Ren-Chao zhang Yi-Ping Mou Department of General Surgery the Central Hospital of Huzhou Department of General Surgery Sir Run Run Shaw HospitalSchool of MedicineZhejiang University

Splenic artery aneurysm is one of the most common visceral aneurysms,and patients with this type of aneurysm often present without ***,when rupture occurs,it can be a catastrophic *** most of these aneurysms can be treated with percutaneous embolization,some located in uncommon parts of the splenic artery may make this approach *** present a patient with an aneurysm in the proximal splenic artery,close to the celiac trunk,which was treated by laparoscopic ligation only,without resection of the aneurysm,and with long-term preservation of splenic function.

关键词： Laparoscopy Splenic artery Aneurysm Laparoscopic ligation Splenic function preservation

Isolation and characterization of resistance and defense gene analogs in cotton (Gossypium barbadense L.)

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Science China Life Sciences 2006年第6期49卷 530-542页

作者： GAO Yulong,guo Wangzhen,WANG lei & zhang Tianzhen National Key Laboratory of Crop Genetics and Germplasm Enhancement,Nanjing Agricultural University,Nanjing 210095,China 1. National Key Laboratory of Crop Genetics and Germplasm Enhancement Nanjing Agricultural University Nanjing 210095 China

Plant disease resistance gene (R gene) and defense response gene encode some con-served motifs. In the present work,a PCR strategy was used to clone resistance gene analogs (RGAs) and defense gene analogs (DGAs) from Sea-island cotton variety Hai7124 using oligonucleotide primers based on the nucleotide-binding site (NBS) and serine/threonine kinase (STK) in the R-gene and pathogenesis-related proteins of class 2 (PR2) of defense response gene. 79 NBS sequences,21 STK sequences and 11 DGAs were cloned from disease-resistance cotton. Phylogenic analysis of 79 NBS-RGAs and NBS-RGAs nucleotide sequences of cotton already deposited in GenBank identified one new sub-cluster. The deduced amino acid sequences of NBS-RGAs and STK-RGAs were divided into two distinct groups respectively: Toll/Interleukin-1 receptor (TIR) group and non-TIR group,A group and B group. The expression of RGAs and DGAs having consecutive open reading frame (ORF) was also investigated and it was found that 6 NBS-RGAs and 1 STK-RGA were induced,and 1 DGA was up-regulated by infection of Verticillium dahliae strain VD8. 4 TIR-NBS-RGAs and 4 non-TIR-NBS-RGAs were arbitrarily used as probes for Southern-blotting. There existed 2-10 blotted bands. In addition,since three non-TIR-NBS-RGAs have the same hybridization pattern,we conjecture that these three RGAs form a cluster distribution in the genome.

关键词： cotton resistance gene analogs (RGAs) defense gene analogs (DGAs).

Effect of Molecular Structure on the Performance of Polyacrylic Acid Superplasticizer

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Journal of Wuhan University of Technology(Materials Science) 2007年第2期22卷 245-249页

作者：张荣国雷家珩 Department of Applied Chemistry Wuhan University of Technology

The effects of structure parameters, such as molecular structure, segment kinds, molecular weight, and organic functional groups, on the performance of polyacrylic acid superplasticizer were discussed. According to the differences of chain sections, functional groups, eic, polyacrylic acid superplasticizer could be divided into A, B, C three parts. Among them, A chain section included sulfonic acid groups, B chain section carboxyl groups, C chain section polyester. Polyacrylic acid superplasticizers with different matching of A, B, C chain sections, different length of C chain section and different molecular weights were synthesized by acrylic acid, polyethylene glycol, sodium methyl allylsulfonate; the relation between the molecular structure and perfolxnance was also studied. The expetimental results indicate that the water-reduction ratio increases obviously with the increment of the proportion of sodium methyl allylsulfonate chain section in the molecular; the slump retention increases greatly with the increment of the proportion of acrylic acid chain section; the dispersion of cement particles increases with the increment of the chain length of polyethylene glycol; when the molecular weight is in the range of 5000, the dispersion and slump retentibity increase with the increment of the average molecular weight of polymers.

关键词： polyacrylic acid superplasticizer cement concrete structure and performance anion surface-active agent molecule structural design

Treatment of abdominal compartment syndrome in severe acute pancreatitis patients with traditional Chinese medicine

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World Journal of Gastroenterology 2008年第22期14卷 3574-3578页

作者： Min-Jie zhang guo-lei zhang Wen-Bin Yuan Jun Ni Li-Feng Huang Department of General surgery Affiliated Central Hospital of Huzhou Normal College Huzhou 313000 Zhejiang Province China Research Center of Biomedicine and Health Hangzhou Normal University Hangzhou 310000 Zhejiang Province China

AIM: To investigate the therapeutic effect of traditional Chinese traditional medicines Da Cheng Qi Decoction (Timely-Purging and Yin-Preserving Decoction) and Glauber's salt combined with conservative measures on abdominal compartment syndrome (ACS) in severe acute pancreatitis (SAP) patients. METHODS: Eighty consecutive SAP patients, admitted for routine non-operative conservative treatment, were randomly divided into study group and control group (40 patients in each group). Patients in the study group received Da Cheng Qi Decoction enema for 2 h and external use of Glauber's salt, once a day for 7 d. Patients in the control group received normal saline (NS) enema. Routine non-operative conservative treatments included non-per os nutrition (NPON), gastrointestinal decompression, life support, total parenteral nutrition (TPN), continuous peripancreatic vascular pharmaceutical infusion and drug therapy. Intra-cystic pressure (ICP) of the two groups was measured during treatment. The effectiveness and outcomes of treatment were observed and APACHE Ⅱ scores were applied in analysis. RESULTS: On days 4 and 5 of treatment, the ICP was lower in the study group than in the control group(P < 0.05). On days 3-5 of treatment, acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ) scores for the study and control groups were significantly different (P < 0.05). Both the effectiveness and outcome of the treatment with Da Cheng Qi Decoction on abdominalgia, burbulence relief time, ascites quantity, cyst formation rate and hospitalization time were quite different between the two groups (P < 0.05). The mortality rate for the two groups had no significant difference. CONCLUSION: Da Cheng Qi Decoction enema and external use of Glauber's salt combined with routine non-operative conservative treatment can decrease the intra-abdominal pressure (IAP) of SAP patients and have preventive and therapeutic effects on abdominal compartment syndrome of SAP.

关键词： Da Cheng Qi Decoction Glauber's salt traditional Chinese medicine Severe acute pancreatitis Abdominal compartment syndrome

Short-term Earthquake Prediction in the Sichuan-Yunnan Region Using the Method of Modulated Earthquakes

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Earthquake Research in China 2011年第1期25卷 101-110页

作者： Wang Cuizhi Cao Jingquan guo Hongli zhang lei Xue Na Earthquake Administration of Tianjin Municipality Tianjin 300201 China

By scanning modulated or un-modulated earthquakes spatio-temporally in the region of Sichuan-Yunnan,short-term non-stationary seismic precursory patterns were extracted with significant difference and the characteristic of non-stationary short-term seismic anomalies were analyzed as well as prediction efficiency of modulated small earthquakes before a strong earthquake. Besides,small earthquake modulation ratios near the region of the epicenter were calculated and sorted by time. The results indicated that there were significant effects using the modulated earthquake method to predict earthquakes greater than MS6. 0 in a short time. Before the MS8. 0 Wenchuan earthquake,there were obvious short-term precursory seismicity gap patterns of modulated small earthquakes.

关键词： Modulated earthquake Non-steady-state Modulation ratio Short-term earthquake prediction

Molecular mapping of Verticillium wilt resistance QTL clustered on chromosomes D7 and D9 in upland cotton

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Science China(Life Sciences) 2009年第9期52卷 872-884页

作者： JIANG Feng,ZHAO Jun,ZHOU lei,guo WangZhen & zhang TianZhen National Key Laboratory of Crop Genetics & Germplasm Enhancement,Cotton Research Institute,Nanjing Agricultural University,Nanjing 210095,China National Key Laboratory of Crop Genetics & Germplasm Enhancement Cotton Research Institute Nanjing Agricultural University Nanjing 210095 China

Verticillium wilt is a destructive disease with international consequences for cotton production. Breeding broad-spectrum resistant cultivars is considered to be one of the most effective means for reducing crop losses. A resistant cotton cultivar,60182,was crossed with a susceptible cultivar,Jun-mian 1,to identify markers for Verticillium resistance genes and validate the mode of its inheritance. Genetic segregation analysis for Verticillium wilt resistance was evaluated based upon infected leaf percentage in the seedling stage using major gene-polygene mixed inheritance models and joint analysis of P1,P2,F1,B1,B2 and F2 populations obtained from the cultivar cross. We found that resistance of upland cotton cultivar 60182 to isolates BP2,VD8 and T9,and their isoconcentration mixture was controlled by two major genes with additive-dominance-epistatic effects,and the inheritance of the major gene was dominant. Furthermore,a genetic linkage map was constructed using F2 segregating population and resistance phenotypic data were obtained using F2:3 families inoculated with different isolates and detected in different developmental stages. The genetic linkage map with 139 loci was comprised of 31 linkage groups covering 1165 cM,with an average distance of 8.38 cM between two markers,or 25.89% of the cotton genome length. From 60182,we found 4 QTL on chromosome D7 and 4 QTL on D9 for BP2,5 QTL on D7 and 9 QTL on D9 for VD8,4 QTL on D7 and 5 QTL on D9 for T9 and 3 QTL on D7 and 7 QTL on D7 for mixed pathogens. The QTL mapping results revealed that QTL clusters with high contribution rates were screened simultaneously on chromosomes D9 and D7 by multiple interval mapping (CIM),whether from resistance phenotypic data from different developmental stages or for different isolates. The result is consistent with the genetic model of two major genes in 60182 and suggests broad-spectrum resistance to both defoliating isolates of V. dahliae and nondefoliating isolates. The markers

关键词： upland cotton Verticillium wilt genetic model QTL mapping

Effects of the extrusion parameters on microstructure,texture and room temperature mechanical properties of extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 136-146页

作者： Chenjin zhang Guangyu Yang lei Xiao Zhiyong Kan Jing guo Qiang Li Wanqi Jie State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China College of Materials Science and Engineering Fuzhou UniversityFuzhou 350108China College of Chemistry and Environmental Science Qujing Normal UniversityQujing 655011China

Microstructure,texture,and mechanical properties of the extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy were investigated at different extrusion temperatures(260 and 320℃),extrusion ratios(10:1,15:1,and 30:1),and extrusion speeds(3 and 6 mm/s).The experimental results exhibited that the grain sizes after extrusion were much finer than that of the homogenized alloy,and the second phase showed streamline distribution along the extrusion direction(ED).With extrusion temperature increased from 260 to 320℃,the microstructure,texture,and mechanical properties of alloys changed *** dynamic recrystallization(DRX)degree and grain sizes enhanced as the extrusion ratio increased from 10:1 to 30:1,and the strength gradually decreased but elongation(EL)*** the extrusion speed increased from 3 to 6 mm/s,the grain sizes and DRX degree increased significantly,and the samples presented the typical-rare-earth(RE)*** alloy extruded at 260℃ with extrusion ratio of 10:1 and extrusion speed of 3 mm/s showed the tensile yield strength(TYS)of 213 MPa and EL of 30.6%.After quantitatively analyzing the contribution of strengthening mechanisms,it was found that the grain boundary strengthening and dislocation strengthening played major roles among strengthening *** results provide some guidelines for enlarging the industrial application of extruded Mg-RE alloy.

关键词： Mg-rare earth alloys extrusion temperature extrusion ratio extrusion speed strengthening mechanisms

儿童攻击和同伴关系的相关:20年研究的元分析

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心理科学 2003年第5期26卷 843-846页

作者：郭伯良张雷香港中文大学

用多水平分析技术对近 2 0年关于儿童攻击和同伴关系相关的研究结果进行的元分析显示 ,现有研究中关于攻击和同伴关系相关结果的变异程度比较大 ,总体来说攻击和同伴接受之间有负向相关关系 ,和同伴拒绝之间有正向相关关系。

关键词：儿童攻击行为同伴关系元分析方法多水平模型环境变量