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Simulation of gas-solid flow in sinter vertical cooling furnace

Journal of Iron and Steel Research International 2023年第11期30卷 2133-2142页

作者： Teng-fei Qi Hai-feng Li jun-jie Sun guo-jun chen Yong-jie Zhang School of Metallurgy Northeastern UniversityShenyang110819LiaoningChina Key Laboratory for Ecological Metallurgy of Multi-Metallic Mineral(Ministry of Education) Northeastern UniversityShenyang110819LiaoningChina Technology Center Shanghai Meishan Iron and Steel Co.Ltd.Nanjing210039JiangsuChina Central Research Institute Baosteel Co.Ltd.Shanghai201900China

The velocity distribution of sinter and gas in vertical cooling furnace(VCF)has an important influence on gas-solid heat *** on the slot model of single hopper in the VCF of Meishan Iron and Steel Co.,Ltd.,the velocity and particle size distribution of sinter and the velocity and pressure distribution of gas were studied using a computational fluid dynamics-discrete element method model to obtain the gas-solid flow rule in the *** results showed that the velocity of sinter near the wall and the edge of vent cowl was lower than that in the rest of the same ***,the rectangular section of the vertical cooling furnace can be divided into a quasi-static zone,a plug flow zone and a convergent flow zone according to the flow velocity of the *** average particle size and the void fraction of sinter bed were distributed in"W"and"V"shape along the width direction,*** distribution of gas velocity in the furnace cavity was uneven,and the high-velocity area gradually changed from the center to the edge of the furnace cavity with the rise of *** the ratio of edge to center gas flow from 2.7∶1 to 0.7∶1 could improve the gas velocity,but could not change the gas velocity *** gas velocity distribution was more affected by the average particle size distribution of the sinter *** was suggested that measures need be taken to adjust it to improve the gas velocity distribution in the VCF.

关键词： Sinter Vertical cooling furnace Average particle size Void fraction Velocity distribution Gas distribution mode

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Mitochondria as a therapeutic target in Alzheimer’s disease

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Genes & Diseases 2016年第3期3卷 220-227页

作者： Jian Wang guo-jun chen Department of Neurology The First Affiliated Hospital of Chongqing Medical UniversityChongqing Key Laboratory of Neurology1 Youyi RoadChongqing 400016China

Alzheimer’s disease(AD)remains the most common neurodegenerative disease characterized by b-amyloid protein(Ab)deposition and memory *** have shown that mitochondrial dysfunction plays a crucial role in AD,which involves oxidative stress-induced respiratory chain dysfunction,loss of mitochondrial biogenesis,defects of mitochondrial dynamics and mtDNA *** mitochondria might serve as drug therapy target for *** this article,we first briefly discussed mitochondrial theory in the development of AD,and then we summarized recent advances of mitochondrial abnormalities in AD pathology and introduced a series of drugs and techniques targeting *** think that maintaining mitochondrial function may provide a new way of thinking in the treatment of AD.

关键词： Alzheimer’s disease Antioxidant Biogenesis Dynamics Mitochondria mtDNA Therapy

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A peptide-based near-infrared fluorescence probe for dynamic monitoring senile plaques in Alzheimer＇s disease mouse model

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Science Bulletin 2017年第23期62卷 1593-1601页

作者： chen-Wei Wang Dou-Dou Nan Xin-Meng Wang zun-Ji Ke guo-jun chen Jiang-Ning Zhou CAS Key Laboratory of Brain Function and Disease School of Life Sciences University of Science and Technology of China Hefei 230026 China Department of Biochemistry Shanghai University of Traditional Chinese Medidne Shanghai 201203 China Department of Neurology The First Affiliated Hospital of Chongqing Medical University Chongqing Key Laboratory of Neurology Chongqing 400016 China

In vivo monitoring neuropathological changes in Alzheimer＇s disease （AD） animal model is critical for drug development. Here, by integrating blood-brain barrier penetrable peptide, we have developed a peptide probe which based on angiopep-2. Angiopep-based probe exhibited high binding affinity to Aβ aggregates and labeled senile plaques in vivo. Remarkably, the in vivo near-infrared imaging data revealed that fluorescence signals of this probe were nearly 3-fold higher in the brains of 16-monthold APP/PSI transgenic mice compared to C57 mice and exhibited linear correlation with the senile plaques load process in 4-, 8-, 16-month-old APP/PSI transgenic mice. Moreover, senile plaques load was detected in vivo as early as 4 months of age that even at the very beginning of plaques developed in APP/PS1 transgenic mice. Taken together, this novel peptide-based probe achieved dynamic monitoring senile plaques in APP/PS1 transgenic mice and have been ready to use in drug development in AD mouse model.

关键词： Alzlaelmer's diseaseSenile plaquesAmyloid-β LRP-1 Angiopep In vivo imaging AD animal model

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Percutaneous recanalization of total saphenous vein graft occlusion with excimer laser treatment

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Journal of Geriatric Cardiology 2020年第4期17卷 234-240页

作者： Yuan HAN Quan-Min JING Qian-cheng WANG Yan-Bin SU guo-jun chen Department of Cardiology State Key Laboratory of Organ Failure ResearchNan Fang HospitalSouthern Medical UniversityGuangzhouChina Department of Cardiology General Hospital of Northern Theater CommandShenyangChina

Patients presenting with recurrence of anginal symptoms after saphenous vein bypass surgery pose an increasingly frequent *** general,approximately 40%to 50%of saphenous vein graft(SVG)will become diseased or occluded within the first ten years after surgery.[1]Because adverse clinical outcomes,such as high restenosis rates and distal embolization,have been reported,percutaneous coronary intervention(PCI)for SVG is not recommended as a first-line strategy.[2]Distal embolization occurs in 2%–17%of patients despite advances in therapy,including the utilization of embolic protection device(EPD),which may lead to increased mortality at both short follow-up and midterm follow-up.[3]However,these patients often associated with inappropriate anatomic characteristics of native vessel intervention including calcification,tortuosity,abundant plaque burden,and complex chronic total occlusion(CTO)***,repeat coronary bypass surgery is an option but is technically more demanding and is associated with a higher ***,it can sometimes result in SVG stenosis being the only intervention *** is why the recanalization of SVG lesions,especially totally occluded lesions,remains one of the most challenging procedures in interventional cardiology.

关键词： Excimer laser Percutaneous coronary intervention Saphenous vein graft

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Stereoselective Synthesis of α-Aminonitril on Glucose Templates

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有机化学 2003年第Z1期23卷 90-92页

作者： ZHANG Peng-Fei GU Yi-Xin guo jun-Li chen Min Department of Chemistry Hangzhou Teachers College Zhejiang 310036 Department of Chemistry Hangzhou Teachers College Zhejiang 310036 Department of Chemistry Hangzhou Teachers College Zhejiang 310036 Department of Chemistry Hangzhou Teachers College Zhejiang 310036

　　Both proteinogenic and non proteinogenic α-amino acids are of particular interest as constituents of peptide factors, peptidomimetics and antibiotics for the construction of modern selective drugs. [1] Furthemore, α-amino acid derivatives are interesting building units for chiral-pool syntheses of enantiomerically pure natural products. [2] Numerous efforts in modern organic synthesis are centered on the synthesis of enantiomerically pure α-amino acids. [3] During the past three decades efficient methods of asymmetric synthesis of α-amino acids have been developed; most of them are based on electrophilic transformations of organometallic intermediates. [4] Using the concept that the chirality of the carbohydrates can be exploited for diastereoselective reactions, Kunz and his cooperator had developed a Strecker synthesis with glycosyl amines as chiral auxiliaries. [5] ……

关键词： asymmetric synthesis organic synthesis natural products methods of

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The effect of NR4A1 on APP metabolism and tau phosphorylation

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Genes & Diseases 2018年第4期5卷 342-348页

作者： Li-Ge Zhao Ying Tang Jia-Ze Tan Jing-Wen Wang guo-jun chen Bing-Lin Zhu Department of Neurology The First Affiliated Hospital of Chongqing Medical UniversityChongqing Key Laboratory of Neurology1 Youyi RoadChongqing400016China

Alzheimer’s disease(AD)is characterized by senile plaques(SP)composed of b-amyloid protein(Ab)and neurofibrillary tangles(NFTs)composed of intracellular hyperphosphorylated ***,nuclear receptor subfamily 4 group A member 1(NR4A1)was implicated in synaptic plasticity,long-term memory formation,suggesting that it may play a role in the pathophysiology of ***,we showed that the expression of NR4A1 was significantly increased in the hippocampus of APP/PS1 transgenic *** addition,NR4A1 overexpression in HT22 cells up-regulated APP and BACE1 levels,down-regulated ADAM10 expression,and promoted amyloidogenesis as indicated by decreased a-CTF levels and elevated b-CTF ***,a raised level of phospho-tau(p-tau,S396)was accompanied by p-GSK3b(S9)expression reducing,but total tau,p-tau(S262 and T231),CDK5 and ERK remained unchanged in NR4A1-overexpressing ***,our results suggest that NR4A1 promotes the amyloidogenic processing of APP by regulating ADAM10 and BACE1 expression in HT22 cells;as well as NR4A1 accelerates tau hyperphosphorylation by GSK3b ***,NR4A1 may play an important role in the pathogenesis of AD.

关键词： Alzheimer’s disease(AD) ADAM10 BACE1 GSK3b NR4A1 tau

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Ubiquitination status does not affect Vps34 degradation

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Genes & Diseases 2020年第3期7卷 401-407页

作者： Jing Tang Fei Sun Xiao-Juan Deng Yuan-Lin Ma Kun-Yi Li Ying Tang guo-jun chen Department of Neurology The First Affiliated Hospital of Chongqing Medical UniversityChongqing Key Laboratory of Neurology1 Youyi RoadChongqing 400016China Department of Physiology Wayne State University School of MedicineDetroitMI48201USA

Vps34(vacuolar protein-sorting 34)plays important role in autophagy and endosomal *** processes are closely associated protein ubiquitination and *** have hypothesized that Vps34 ubiquitination status would also control its ***,we report that our results did not support this *** cells transiently transfected with ubiquitin(UB)constructs contained different lysine residues(Ks),Vps34 ubiquitination could occur regardless of the presence of any Ks in ***,Vps34 protein levels were not significantly altered in cells transiently transfected with these UB *** further found that Vps34 protein was altered by pharmacological manipulation of E2/E3 activity;yet this effect was not significantly affected by UB *** vivo experiments revealed that in APP/PS1 mice,an animal model of Alzheimer’s disease(AD),although ubiquitination of Vps34 was significantly reduced,Vps34 protein levels remained ***34 indeed was subjected to proteasomal or lysosomal degradation,as prolonged treatment of proteasomal inhibitor MG132 or lysosomal inhibitor chloroquine elevated Vps34 protein *** conclude that unlike most of other proteins,Vps34 ubiquitination is not closely associated with its degradation.

关键词： Alzheimer’s disease Degradation Ubiquitination UPS VPS34

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Increased risk of colorectal neoplasia in inflammatory bowel disease patients with post-inflammatory polyps:A systematic review and meta-analysis

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World Journal of Gastrointestinal Oncology 2022年第1期14卷 348-361页

作者： De-Gao He Xi-Jie chen Juan-Ni Huang jun-guo chen Min-Yi Lv Tian-Ze Huang Ping Lan Xiao-Sheng He Department of Colorectal Surgery The Sixth Affiliated HospitalSun Yat-sen UniversityGuangdong Institute of GastroenterologyGuangdong Provincial Key Laboratory of Colorectal and Pelvic Floor DiseasesGuangzhou 510655Guangdong ProvinceChina Department of Geriatrics the first Affiliated HospitalGuangzhou Medical UniversityGuangzhou 510120Guangdong ProvinceChina

BACKGROUND Inflammatory bowel disease(IBD)patients with post-inflammatory polyps(PIPs)may carry an increased risk of colorectal neoplasia(CRN)including dysplasia and *** guidelines recommend active colonoscopy follow-up for these ***,the evidence for guidelines is still *** addition,some recent high-quality reports present a different view,which challenges the current *** hypothesize that IBD patients with PIPs are at increased risk of *** To evaluate the risk of CRN in IBD patients with and without *** A systematic search of PubMed,Embase,Cochrane Library,and Web of Science was performed to identify studies that compared the risk of CRN in IBD patients with and without *** addition,we screened the reference lists and citation indices of the included *** assessment was performed using the Newcastle–Ottawa *** odds ratio(OR)was calculated using the random-effects model to explore the final pooled effect size of the included studies and determine whether PIPs increase the risk of *** analysis,subgroup analysis,and assessment of publication bias were performed to examine the sources of *** Twelve studies with 5819 IBD patients,including 1281(22.01%)with PIPs,were considered eligible for this *** found that IBD patients with PIPs were at an increased risk of CRN as compared to those without PIPs[OR 2.01;95%confidence interval(CI):1.43–2.83].The results were similar when colorectal cancer was used as the study endpoint(OR 2.57;95%CI:1.69–3.91).Furthermore,the risk of CRN was still increased(OR 1.80;95%CI:1.12–2.91)when restricted to ulcerative colitis *** was high among the included studies(I^(2)=75%).Subgroup analysis revealed that the high heterogeneity was due to the study *** analysis showed that the main statistical outcomes did not essentially change after excluding any one of the included *** significant pu

关键词： Colorectal neoplasia Inflammatory bowel disease Ulcerative colitis Postinflammatory polyps Pseudopolyps Meta-analysis

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A THREE-DIMENSIONAL TURBULENCE MODEL WITH ROTATIONAL VECTOR

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Chinese Journal of Aeronautics 1993年第1期 53-58页

作者： Zu guo-jun,chen Mao-zhang (Beijing University of Aeronautics and Astronautics,Beijing,China,100083)

The rotating terms in Reynolds stress equations (RSEs) are analyzed, and the appropriatemodellings to these terms are proposed in this paper. By means of the local equilibriumof turbulence production, dissipation and rotating terms, a nonisotropicthree-dimensional turbulence model which contains the rotational vector is proposed. Thismodel is appropriate to wild three-dimensional shear flows. It has been applied to the calculationsof two kinds of three dimensional turbulent boundary layers on rotating helicalblade and compressor rotor blade; the results are compared with experiments and the computationresults with C-S model, showing that the present model can improve the predictioncapability of near wall parameters to a certain extent. Moreover, this model is simpleand can be regarded as the extension of Bradshaw’s model in three dimensional flows.

关键词： A THREE-DIMENSIONAL TURBULENCE MODEL WITH ROTATIONAL VECTOR

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Nomogram for predicting overall survival time of patients with stageⅣcolorectal cancer

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Gastroenterology Report 2022年第1期10卷 575-584页

作者： Min-Yi Lv Xi-Jie chen jun-guo chen Bin Zhang Yan-Yun Lin Tian-Ze Huang De-Gao He Kai Wang Zeng-Jie Chi Jian-Cong Hu Xiao-Sheng He Department of Colorectal Surgery The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China Guangdong Institute of Gastroenterology GuangzhouGuangdongP.R.China Department of Colorectal Surgery Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor DiseasesThe Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China

Background Prognosis varies among stageⅣcolorectal cancer(CRC).Our study aimed to build a robust prognostic nomogram for predicting overall survival(OS)of patients with stageⅣCRC in order to provide evidence for individualized *** We collected the information of 16,283 patients with stageⅣCRC in the Surveillance,Epidemiology,and End Results(SEER)database and then randomized these patients in a ratio of 7:3 into a training cohort and an internal validation *** addition,501 patients in the Sixth Affiliated Hospital of Sun Yat-sen University(Guangzhou,China)database were selected and used as an external validation *** and multivariate Cox analyses were used to screen out significant variables for nomogram *** nomogram model was assessed using time-dependent receiveroperating characteristic curve(time-dependent ROC),concordance index(C-index),calibration curve,and decision curve *** curves were plotted using the Kaplan–Meier *** The C-index of the nomogram for OS in the training,internal validation,and external validation cohorts were 0.737,0.727,and 0.655,*** analysis and calibration curves pronounced robust discriminative ability of the ***,we divided the patients into a high-risk group and a low-risk group according to the *** Kaplan–Meier curves showed that the prediction of the nomogramwas consistent with the actual ***,model comparisons and decision curve analysis proved that the nomogram for predicting prognosis was significantly superior to the tumor-node-metastasis(TNM)staging *** We constructed a nomogram to predict OS of the stageⅣCRC and externally validate its generalization,which was superior to the TNM staging system.

关键词： stageⅣCRC nomogram overall survival prognosis SEER

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