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X-ray diagnosis of synchronous multiple primary carcinoma in the upper gastrointestinal tract

World Journal of Gastroenterology 2011年第14期17卷 1817-1824页

作者： Zhi-Hao yang Jian-Bo Gao Song-Wei Yue hua guo Xue-hua yang Department of Radiology The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052 Henan Province China

AIM:To analyze the radiological features of multiple primary carcinoma (MPC) in the upper gastrointestinal (GI) tract,study its biological characteristics and evaluate X-ray examination in its diagnosis. METHODS:Hypotonic double-contrast GI radiography was performed in 59 multiple primary carcinoma cases,pathologically proved by surgery or endoscopy biopsy. Radiological findings were analyzed. RESULTS:Of the 59 cases,esophageal MPC (EMPC) was seen in 24,esophageal and gastric MPC (EGMPC) in 27 and gastric MPC (GMPC) in 8. Of the 49 lesions found in 24 EMPC,hyperplastic type was seen in 23,medullary type in 9. The lesions were located at the upper (n = 17),middle (n = 19) or lower (n = 13) segment of the esophagus. In 27 EGMPC,the esophageal lesions were located at the middle (n = 16) or lower (n = 11) segment of the esophagus,while the gastric le-sions were located at the gastric cardia (n = 16),fundus (n = 1),body (n = 3) and antrum (n = 7). The esophageal lesions were mainly of the hyperplastic type (n = 12) or medullary type (n = 7),while the gastric lesions were mainly of the hyperplastic type (n = 18). A total of 119 lesions in the 59 patients with synchronous multiple carcinoma were proved by surgery or endoscopy biopsy,and preoperative upper radiographic examination detected 100 of them (84.03% sensitivity). Eighteen (52.94%) of the T1 lesions were found during preoperative diagnosis by radiographic examination. Moreover,only 3 (3.53%) of the T2-4 lesions were misdiagnosed. CONCLUSION:Hypotonic double-contrast upper gastrointestinal examination,providing accurate information about lesion morphology,location and size,can serve as a sensitive technique for the preoperative diagnosis of MPC.

关键词： Multiple primary carcinoma Upper gastrointestinal tract Radiography

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Molecular mechanisms of Baihedihuang decoction as a treatment for breast cancer related anxiety:A network pharmacology and molecular docking study

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World Journal of Clinical Cases 2022年第33期10卷 12104-12115页

作者： Zhong-Hui Li guo-hua yang Fang Wang Department of Oncology Wangjing HospitalChina Academy of Chinese Medical SciencesBeijing 100102China

BACKGROUND The therapeutic effects of a combination of Chinese medicines called Baihedihuang decoction(BD)have been clinically verified,although its molecular targets in breast cancer related anxiety remain *** To explore the molecular mechanisms of BD for breast cancer related anxiety *** We used the Traditional Chinese Medicine Systems Pharmacology database to screen the active ingredients and potential targets of BD,and constructed the"drug-ingredient-target"network map with the help of Cytoscape 3.8 ***,we used the Online Mendelian Inheritance in Man,DrugBank,and Gencards databases to collect the disease targets of breast cancer related anxiety,and used the STRING platform to perform protein interaction analysis and construct the protein-protein interaction *** platform was used for Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis of key *** docking technology was used to verify the drug component/target disease *** We screened 16 active ingredients of BD for breast cancer related anxiety,with 113 target *** are 931 disease targets of breast cancer related anxiety,and finally,43 key targets and 305 Kyoto Encyclopedia of Genes and Genomes pathways were *** main active ingredients of BD for breast cancer related anxiety are verbascoside,β-sitosterol,stigmasterol,catalpol,***2,TP53,HTR2A,ESR1,*** its key targets,and the main involved signaling pathways may include neuroactive ligand-receptor interaction pathway,5-hydroxytryptaminergic synapse,P53 signaling pathway,cGMP-PKG signaling pathway,the cAMP signaling pathway,***,molecular docking was performed with Vina software to validate the key active ingredients in BD with the selected key action *** molecular docking results showed that verbascoside,β-sitosterol,stigmasterol and CDK2 could stably bind and interact through amino acid residues SER249,ARG260,PRO228,ALA

关键词： Network pharmacology Molecular docking Baihedihuang decoction Breast cancer related anxiety Mechanism of action

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Design and Synthesis of a Novel Peptidomimetic Inhibitor of Caspase-3

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Chemical Research in Chinese Universities 2006年第2期22卷 225-228页

作者： ZHANG Jin-liang LIU Lin-hua guo yang-hong yang Jin-gang LI Wei ZHONG Da-fang WANG Ji-dong College of Life Science Jilin University Changchun 130021 P. R. China

Caspases, a family of cysteine proteases, comprise of highly homologous enzymes that play an important role in apoptotic cell death. Caspase-3 shows key functions in apoptosis, mediating apoptotic cascade from the intrinsic and extrinsic activation pathways. Therefore, caspase-3 is an attractive target for therapeutic intervention. For instance, inhibitors of caspase-3 have been described as promising cardioprotectants, neuroprotectants and antiarthritic agents. A novel peptidomimetic inhibitor of caspase-3, has been designed, which still has the properties of a reversible inhibitor, while the P1 site at the C-terminal remains, and only L-amino acid has been replaced by D-amino acid. Also presented here is the synthesis of the inhibitor and its inhibitory activity against caspase-3, which was tested by the fluorescent activity assay.

关键词： Caspase-3 Inhibitor Retro-inverso Peptidomimetie Synthesis

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Inhibitory effect of modified citrus pectin on liver metastases in a mouse colon cancer model

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World Journal of Gastroenterology 2008年第48期14卷 7386-7391页

作者： Hai-Ying Liu Zhi-Liang huang guo-hua yang Wei-Qun Lu Nan-Rong Yu Department of Abdominal Surgery Affiliated Tumor Hospital of Guangzhou Medical College Guangzhou 510095 Guangdong Province China

AIM: To discuss the expression of glactin-3 in liver metastasis of colon cancer and its inhibition by modi- fied citrus pectin (MCP) in mice. METHODS: Seventy-five Balb/c mice were randomly di- vided into negative control group (n = 15), positive con- trol group (n = 15), low MCP concentration group (n = 15), middle MCP concentration group (n = 15) and high MCP concentration group (n = 15). CT26 colon cancer cells were injected into the subcapsule of mouse spleen in positive control group, low, middle and high MCP concentrations groups, except in negative control, to set up a colon cancer liver metastasis model. The concen- tration of MCP in drinking water was 0.0%, 0.0%, 1.0%, 2.5% and 5.0% (wt/vol), respectively. Liver metastasis of colon cancer was observed after 3 wk. Enzyme-linked immunosorbent assay (ELISA) was used to detect the concentration of galectin-3 in serum. Expression of ga- lectin-3 in liver metastasis was detected by immunohis- tochemistry. RESULTS: Except for the negative group, the percent- age of liver metastasis in the other 4 groups was 100%, 80%, 73.3% and 60%, respectively. The number of liver metastases in high MCP concentration group was significantly less than that in positive control group (P = 0.008). Except for the negative group, the median volume of implanted spleen tumor in the other 4 groups was 1.51 cm3, 0.93 cm3, 0.77 cm3 and 0.70 cm3, respec- tively. The volume of implanted tumor in middle and high MCP concentration groups was significantly smaller than that in positive control group (P = 0.019; P = 0.003). The concentration of serum galectin-3 in positive control and MCP treatment groups was significantly higher than that in the negative control group. However, there was no significant difference between them. Except for the negative control group, the expression of galectin-3 in liver metastases of the other 4 groups showed no sig- nificant difference. CONCLUSION: Expression of galetin-3 increases sig- nificantly in liver meta

关键词： Pectin Colonic neoplasms Metastasis Liver Mice

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RELATIONSHIP BETWEEN HEMOGLOBIN A1C AND BLOOD GLUCOSE THROUGHOUT THE DAY IN WELL-GLYCEMIC-CONTROLLED MEDICAL NUTRITION THERAPY ALONE TYPE 2 DIABETIC PATIENTS

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Chinese Medical Sciences Journal 2006年第2期21卷 90-94页

作者： Wen-hui Li Xin-hua Xiao Qi Sun guo-hua yang Heng Wang Department of Endocrinology Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730

Objective To investigate the relationship between glycosylated hemoglobin A1 c （HbA1 c） and blood glucose levels of eight different points throughout the day in well-glycemic-controlled medical nutrition therapy （MNT） alone type 2 diabetic pafients. Methods Data were collected as＂ capillary blood glucose value of eight different sample points among sixteen observing days in thirty MNT alone type 2 diabetic patients. The correlation between HbAI c and capillary blood glucose value was evaluated by Pearson＇s correlation method. Results The r-values between HbA1c and capillary blood glucose of 3：00, 6：00, and bedtime （22：00-23：00） were 0. 81,0. 79, and 0. 78, respectively（P 〈0. 001 ）. The best correlation was found between the mean value of 8- point blood glucose value throughout the day and HbA1c （ r=0. 84, P 〈0. 001 ）. Conclustion Fasting blood glucose and postabsorptive blood glucose have better correlations with HbAlc compared with other points in this group of well-glycemic-controlled MNT alone type 2 diabetic patients.

关键词： type 2 diabetes medical nutrition therapy hemoglobin Alc blood glucose

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EFFECTS OF GLUCAGON ON ISLET β CELL FUNCTION IN PATIENTS WITH DIABETES MELLITUS

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Chinese Medical Sciences Journal 2008年第2期23卷 117-120页

作者： Tong Wang Xin-hua Xiao Wen-hui Li Heng Wang Qi Sun Tao Yuan guo-hua yang Key Laboratory of Endocrinology Peking Union Medical CollegePeking Unionof Ministry of Health Department of EndocrinologyHospital Chinese Academy of Medical Sciences ＆Medical College Beijing 100730

Objective To evaluate islet β cell response to intravenous glucagon （ a non-glucose secretagogue） stimulation in diabetes mellitus. Methods Nineteen patients with type 1 diabetes （T1 D） and 131 patients with type 2 diabetes （T2D） were recruited in this study. T2D patients were divided into two groups according to therapy： 36 cases treated with insulin and 95 cases treated with diet or oral therapy. The serum C-peptide levels were determined at fasting and six minutes after intra- venous injection of 1 mg of ghicagon. Results Both fasting and 6-minute post-ghicagon-stimulated C-peptide levels in T1D patients were significantly lower than those of T2D patients （0. 76±0. 36 ng/mL vs. 1.81±0. 78 ng/mL, P 〈 0.05 ; 0.88±0.42 ng/mL vs. 3.68±0. 98 ng/mL, P 〈 0. 05 ）. In T1D patients, the C-peptide level after injection of ghicagon was similar to the fasting level. In T2D, patients treated with diet or oral drug had a significantly greater fasting and stimulated C-peptide level than those patients received insulin therapy （2.45±0. 93 ng/mL vs. 1.61±0. 68 ng/mL, P 〈 0.05 ; 5.26±1.24 ng/mL vs. 2.15±0.76 ng/mL, P 〈 0.05 ）. The serum C-peptide level after ghicagon stimulation was positively correlated with C-peptide levels at fasting in all three groups （ r = 0.76, P 〈 0.05 ）. Conclusions The 6-minute ghicagon test is valuable in assessing the function of islet β cell in patients with diabetes mellitus. It is helpful for diagnosis and treatment of diabetes mellitus.

关键词： glucagon diabetes mellitus C-peptide islet β cell function

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Cr-assisted low-temperature densification of(Ti,Zr,Nb,Ta,Mo)C high-entropy carbides with ultrafine grain and enhanced hardness

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Journal of Advanced Ceramics 2024年第6期13卷 780-788页

作者： yang Liu Jiaji Liang Weiming guo Shikuan Sun Yu Tian hua-Tay Lin School of Electromechanical Engineering Guangdong University of TechnologyGuangzhou 510006China State Key Laboratory of High Performance Tools Guangdong University of TechnologyGuangzhou 510006China School of Material Science and Energy Engineering Foshan UniversityFoshan 528000China

While the use of low-melting-point metals as sintering aids for high-entropy carbide(HEC)ceramics has been well established,their existence can compromise hardness due to residual metallic *** study demonstrates an innovative strategy to meet this challenge,where(Ti,Zr,Nb,Ta,Mo)C high-entropy carbide ceramics with ultrafine grains and enhanced hardness are obtained through chromium(Cr)-metal-assisted spark plasma sintering(SPS)at a temperature as low as 1600℃.The results show that the addition of 5 vol%Cr promotes the formation of highly densified single HEC phase ceramics with a high relative density(98.4%)and an ultrafine-grained microstructure(0.17μm).This low-temperature densification mechanism can be attributed to Cr’s solid-solution effect within the matrix and the increased carbon vacancies generated during *** grain size of the(Ti,Zr,Nb,Ta,Mo)C ceramics with 5 vol%Cr metal addition is significantly smaller than that of Cr-free(Ti,Zr,Nb,Ta,Mo)C ceramics sintered at 2000℃(3.03μm)or via traditional low-temperature liquid-phase sintering(1.3–1.5μm).Importantly,the addition of 5 vol%Cr substantially increased the hardness of the ceramics,with a remarkable increase from 23.57 to 28.16 GPa compared to that of the pure(Ti,Zr,Nb,Ta,Mo)C ceramics,owing to the fine-grain strengthening and solid-solution strengthening *** work highlights the uniqueness of Cr metal as a sintering aid in achieving densification and hardness improvements in(Ti,Zr,Nb,Ta,Mo)C ceramics,offering a promising strategy for improving the properties of HEC materials for further development in the near future.

关键词： solid solution sinterability hardness enhancement (Ti,Zr,Nb,Ta,Mo)C high-entropy carbide(HEC)ceramics

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JAK2 V617F, MPL W515L and JAK2 Exon 12 Mutations in Chinese Patients with Primary Myelofibrosis

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Chinese Journal of Cancer Research 2012年第1期24卷 72-76页

作者： Jun Xia Mi-ze Lu Yuan-qiang Jiang guo-hua yang Yun Zhuang Hong-li Sun Yun-feng Shen Department of Hematology Wuxi People's HospitalNanjing Medical UniversityWuxi 214023China

Objective： JAK2 V617F, MPL W515L and JAK2 exon 12 mutations are novel acquired mutations that induce constitutive cytokine-independent activation of the JAK-STAT pathway in myeloproliferative disorders （MPD）. The discovery of these mutations provides novel mechanism for activation of signal transduction in hematopoietic malignancies. This research was to investigate their prevalence in Chinese patients with primary myelofibrosis （PMF）. Methods： We introduced allele-specific PCR （AS-PCR） combined with sequence analysis to simultaneously screen JAK2 V617F, MPL W515L and JAK2 exon 12 mutations in 30 patients with PMF. Results： Fifteen PMF patients （50.0%） carried JAK2 V617F mutation, and only two JAK2 V617F-negative patients （6.7%） harbored MPL W515L mutation. None had JAK2 exon 12 mutations. Furthermore, these three mutations were not detected in 50 healthy controls. Conclusion： MPL W515L and JAK2 V617F mutations existed in PMF patients but JAK2 exon 12 mutations not. JAK2 V617F and MPL W515L and mutations might contribute to the primary molecular pathogenesis in patients with PMF.

关键词： Primary myelofibrosis JAK2 V617F MPL W515L JAK2 exon 12 mutation

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EFFECTS OF VITAMIN D RECEPTOR GENE POLYMORPHISMS ON SUSCEPTIBILITY TO TYPE 1 DIABETES MELLITUS

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Chinese Medical Sciences Journal 2006年第2期21卷 95-98页

作者： Xin-hua Xiao Zhe-long Liu Heng Wang Qi Sun Wen-hui Li guo-hua yang Qiu-ying Liu Department of Endocrinology Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 Department of Endocrinology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030

Objective To investigate the influence of vitamin D receptor （VDR） gene polymorphisms on susceptibility to type 1 diabetes mellitus （T1DM） in the Chinese Han population. Method One hundred and thirty-six Chinese Han people, including 54 T1DM patients and 82 unrelated healthy subjects as control were genotyped by polymerase chain reaction-restriction fragment length polymorphism for three restriction sites in the VDR gene, which were ApaI, TaqI, and BamL Results The frequency of B allele of BsmI site in VDR gene was significantly higher in T1DM patients than in healthy subjects （ P = 0. 033 ） while no difference was found between the two groups in the distribution of ApaI and TaqI polymorphisms. Conclusion The BsmI polymorphism of VDR gene may be associated with the susceptibihty to T1DM in the Chinese Han population of Beijing.

关键词： type 1 diabetes mellitus vitamin D receptor gene polymorphism

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Vortex identification based on the Liutex method and its effect on fish passage upstream

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Journal of Hydrodynamics 2024年第1期36卷 130-141页

作者： Chun-ying Shen Rui-guo yang Xiao-tao Shi Ming-ming Wang Shi-hua He Faculty of Electrical Power Engineering Kunming University of Science and TechnologyKunming650500China Hubei International Science and Technology Cooperation Base of Fish Passage China Three Gorges UniversityYichang443002China Shanghai Investigation Design and Research Institute Co.LtShanghai200434China

Fishway research is important for mitigating the fragmentation of river habitats caused by hydraulic *** vertical slit fishway is a broadly used fishway type because of its high efficiency and adaptability to water ***,the resulting vortex current disrupts the fish passage hence directly affecting fish *** study aims to accurately capture the vortex structure in the fishway and analyze the effect of vortex elements(vortex structure,vortex intensity,etc.)on *** conducted an analysis of the 3-D current flow field in the fishway through the utilization of an experimental model and the large eddy simulation(LES)***,we captured the vortex information in the fishway at different flow rates using the Liutex vortex identification method and investigated the effect of the vortex on fish *** results revealed that the structures inside the fishway pool occupy most of the room,however,the areas with higher vortex strength were primarily located in the vortex near the vertical seam and the mainstream,the vortex strength inside the fishway gradually increases with increasing flow,suppressing fish *** experienced significantly increased resistance when encountering strong *** suggests that the vortex may act as a physical barrier to fish *** findings highlight the potential negative effects of vortex on fish movement and reiterate the importance of understanding vortex dynamics for aquatic environmental *** an effective tool for identifying vortices in fluid flow,the Liutex method demonstrates features of vortex within the fishway,thereby providing important insights into the interaction between fluid dynamics and aquatic organisms.

关键词： Vertical slit fishway vortex identification method Liutex large eddy simulation(LES) fish experiment computational fluid dynamics

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