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Aspartoacylase suppresses prostate cancer progression by blocking LYN activation

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Military Medical Research 2024年第2期11卷 180-205页

作者： Hong Weng Kang-Ping Xiong Wang Wang Kai-Yu Qian Shuai Yuan gang Wang Fang Yu Jun Luo Meng‑Xin Lu Zhong‑Hua Yang Tao Liu xing Huang Hang Zheng xing-Huan Wang Department of Urology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Center for Evidence‑Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Biological Repositories Zhongnan Hospital of Wuhan UniversityWuhan 430071China Hubei Key Laboratory of Tumor Biological Behaviors Wuhan 430071China Department of Pathology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Center for Pathology and Molecular Diagnostics Wuhan UniversityWuhan 430071China Wuhan Research Center for Infectious Diseases and Cancer Chinese Academy of Medical SciencesWuhan 430071China

Background:Globally,despite prostate cancer(PCa)representing second most prevalent malignancy in male,the precise molecular mechanisms implicated in its pathogenesis remain ***,elucidating the key molecular regulators that govern disease progression could substantially contribute to the establishment of novel therapeutic strategies,ultimately advancing the management of ***:A total of 49 PCa tissues and 43 adjacent normal tissues were collected from January 2017 to December 2021 at Zhongnan Hospital of Wuhan *** advanced transcriptomic methodologies were employed to identify differentially expressed mRNAs in *** expression of aspartoacylase(ASPA)in PCa was thoroughly evaluated using quantitative real-time PCR and Western blotting *** elucidate the inhibitory role of ASPA in PCa cell proliferation and metastasis,a comprehensive set of in vitro and in vivo assays were conducted,including orthotopic and tumor-bearing mouse models(n=8 for each group).A combination of experimental approaches,such as Western blotting,luciferase assays,immunoprecipitation assays,mass spectrometry,glutathione S-transferase pulldown experiments,and rescue studies,were employed to investigate the underlying molecular mechanisms of ASPA's action in *** Student‘s t-test was employed to assess the statistical significance between two distinct groups,while one-way analysis of variance was utilized for comparisons involving more than two groups.A two-sided P<0.05 was deemed to indicate statistical ***:ASPA was identified as a novel inhibitor of PCa *** expression of ASPA was found to be significantly down-regulated in PCa tissue samples,and its decreased expression was independently associated with patients’prognosis(HR=0.60,95%CI 0.40–0.92,P=0.018).Our experiments demonstrated that modulation of ASPA activity,either through gain-or loss-of-function,led to the suppression or enhancement of PCa cell proliferation,mig

关键词： Prostate cancer Aspartoacylase LYN JNK AP-1 C-Jun Phosphorylation

Sustainability-oriented prioritization of nuclear fuel cycle transitions in China:a holistic MCDM framework under uncertainties

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Nuclear Science and Techniques 2024年第9期35卷 196-212页

作者： Lei Wang Ru-xing Gao Hyo On Nam Hong Jang Won Il Ko Chun-Dong Zhang guo-An Ye Wen-Heng Jing State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 211816China

A sustainability-oriented assessment of the nuclear energy system can provide informative and convincing decision-making support for nuclear development strategies in *** our previous study,four authentic nuclear fuel cycle(NFC)transi-tion scenarios were proposed,featuring different development stages and exhibiting distinct environmental,economic,and technical ***,because of the multiple and often conflicting criteria embedded therein,determining the top-priority NFC alternative for a sustainability orientation remains *** address this issue,this study proposed a novel hybrid multi-criteria decision-making framework comprising fuzzy AHP,PROMETHEE GAIA,and ***,an improved fuzzy AHP weighting model was developed to determine criteria weights under uncertainty and investigate the influence of various weight aggregation and defuzzification ***,PROMETHEE GAIA was used to address conflicts among the criteria and prioritize alternatives on a visualized k-dimensional GAIA *** a result,the alternative for direct recycling PWR spent fuel in fast reactors is considered the most ***,a sensitivity analysis was conducted to examine the influence of criteria weight variation and validate the screening ***,using MOORA,some significant optimization ideas and valuable insights were provided to support decision-makers in shaping nuclear development strategies.

关键词： Nuclear energy systems Nuclear fuel cycle Fuzzy AHP PROMETHEE GAIA

TRPV1 in the spinal dorsal horn participates in the central sensitization in inflammatory pain rats

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TRPV1 in the spinal dorsal horn participates in the central ...

Circulating cell-free mtDNA as a new biomarker for cancer detection and management

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Fei YANG,Jia guo,guo-gang xing,Feng-Yu LIU,Jie CAI,You WAN~* Neuroscience Research Institute,Peking University,Beijing 100191,China

＜正＞Several studies have shown that TRPV1 receptors in the spinal dorsal horn play a key role in inflammatory pain, long-term potentiation（LTP） in the spinal cord is considered to be a potential mechanism for chronic pain,but little is known about the relationship between TRPV1 receptor and LTP in the spinal *** using the extra-cellular electrophysiological recording,we found that 5%formalin and CFA injected subcutaneously to the plantar induced spinal LTP of the C-fiber-evoked field ***1 receptor antagonist,CPZ,inhibited the development of *** also found that conditioning stimulation at C-fiber intensity at high（100 Hz） or low（2 Hz） frequencies induced LTP of C-fiber-evoked field *** induced by low-frequency or high-frequency is entirely or partially inhibited by *** results indicate that TRPV1 receptors in the spinal dorsal horn participate in the development of LTP induced by natural irritant or conditioning stimulus.

关键词： TRPV1 LTP inflammatory pain

来源： cnki会议评论

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Cancer Biology & Medicine 2024年第2期21卷 105-110页

作者： Fan Peng Siyuan Wang Zehui Feng Kaixiang Zhou Huanqin Zhang Xu guo Jinliang xing Yang Liu State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and Xijing Hospital of Digestive Diseases Fourth Military Medical UniversityXi’an 710032China Department of Clinical Diagnosis Tangdu HospitalFourth Military Medical UniversityXi’an 710038China

Cancer is a major cause of death worldwide,and was responsible for 19.29 million new cases and 9.96 million deaths in 2020 *** total number of patients with cancer worldwide is estimated to reach 28 million by *** Ame... 详细信息

关键词： Cancer cancer death

Damping capacity of Fe_(83)Ga_(17) magnetostrictive alloy under magnetic field

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Rare Metals 2024年第1期43卷 402-409页

作者： Shao-Wen Yan xing Mu Bing-Jie Liu Li-Hong Xu Shi-Hai guo Yan Qi Hong-Ping Zhang Department of Functional Material Research Central Iron and Steel Research InstituteBeijing 100081China

The damping performance of Fe_(83)Ga_(17) alloys has been investigated in the static magnetic field (H). The results demonstrate that the damping peak value can be adjusted between 0.020 and 0.085 under the magnetic f... 详细信息

关键词： alloy magnetic alloys

Enhancing thermoelectric performance of p-type SnTe through manipulating energy band structures and decreasing electronic thermal conductivity

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Rare Metals 2024年第7期43卷 3232-3241页

作者： Xin Qian Hao-Ran guo Jia-Xin Lyu Bang-Fu Ding xing-Yuan San Xiao Zhang Jiang-Long Wang Shu-Fang Wang Hebei Key Lab of Optic-Electronic Information and Materials College of Physics Science and TechnologyHebei UniversityBaoding 071002China College of Electron and Information Engineering Hebei UniversityBaoding 071002China Research Institute for Frontier Science Beihang UniversityBeijing100191China

SnTe has received considerable attention as an environmentally friendly alternative to the representative thermoelectric material of ***,excessive hole carrier concentration in SnTe results in an extremely low Seebeck coefficient and high thermal conductivity,which makes it exhibit relatively inferior thermoelectric *** this work,the thermoelectric performance of p-type SnTe is enhanced through regulating its energy band structures and reducing its electronic thermal conductivity by combining Bi doping with CdSe ***,the carrier concentration of SnTe is successfully suppressed via Bi doping,which significantly decreases the electronic thermal ***,the convergence and flattening of the valence bands by alloying CdSe effectively improves the effective mass of SnTe while restraining its carrier ***,a maximum figure of merit(ZT) of~ 0.87 at 823 K and an average ZT of~ 0.51 at 300-823 K have been achieved in Sn_(0.96)Bi_(0.04)Te-5%*** results indicate that decreasing the electronic thermal conductivity is an effective means of improving the performance of thermoelectric materials with a high carrier concentration.

关键词： Thermoelectric materials SnTe Energy band structure Electronic thermal conductivity ZT value

Performance Analysis of an Efficient Integration System of Coal-Fired Power Plant,Solar Thermal Energy and CO_(2)Capture

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Journal of Thermal Science 2024年第4期33卷 1509-1522页

作者： WANG Yuhao WANG Ruilin LIU Lanhua xing Chenjian guo Yafei YANG Qingshan YING Jiaheng SUN Jian LI Wenjia LIU Yuanyuan ZHAO Chuanwen School of Energy and Mechanical Engineering Nanjing Normal UniversityNanjing210023China China Huadian Group Co.LTD.Shanghai Branch Shanghai200120China Key Laboratory of Efficient Utilization of Low and Medium Grade Energy(Tianjin University) Ministry of Education of ChinaTianjin300350China Huadian Zhengzhou Mechanical Design Institute Company Limited Zhengzhou450046China

Coal-fired power plant is a major contributor to greenhouse gas *** post-combustion capture is a promising method for CO_(2)emission reduction but the high thermal demand is *** address this issue,solar thermal energy and CO_(2)capture are jointly integrated into the coal-fired power plant in this *** solar thermal energy is employed to meet the heat requirement of the CO_(2)capture process,thereby avoiding the electricity loss caused by self-driven CO_(2)***,the heat released from the carbonation reaction of MgO adsorbent is integrated into the steam Rankine *** partially substituting the extracted steam for feedwater heating,the electricity output of the power plant is further *** to the results from the developed model,the system could achieve a CO_(2)capture rate of 86.5%and an electricity output enhancement of 9.8%compared to the reference system,which consists of a self-driven CO_(2)capture coal-fired power plant and PV generation *** operational strategy is also optimized and the amount of CO_(2)emission reduction on a typical day is increased by 11.06%.This work shows a way to combine fossil fuels and renewable energy for low carbon emissions and efficient power generation.

关键词： CO_(2)capture parabolic trough collector solar aided coal-fired electricity generation

Needs and challenges of optical atmospheric monitoring on the background of carbon neutrality in China

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Frontiers of Environmental Science & Engineering 2024年第6期18卷 49-62页

作者： Wenqing Liu Chengzhi xing Anhui Institute of Optics and Fine Mechanics Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 23001China

The achievement of the targets of coordinated control of PM2.5 and O3 and the carbon peaking and carbon neutrality depend on the development of pollution and greenhouse gas monitoring *** monitoring technology,based on its technical characteristics of high scalability,high sensitivity and wide-targets detection,has obvious advantages in pollution/greenhouse gases monitoring and has become an important direction in the development of environmental monitoring *** present,a system of environmental optical monitoring technology with differential optical absorption spectroscopy(DOAS),cavity ring-down spectroscopy(CRDS),light detection and ranging(LIDAR),laser heterodyne spectroscopy(LHS),tunable diode laser absorption spectroscopy(TDLAS),fourier transform infrared spectroscopy(FTIR)and fluorescence assay by gas expansion(FAGE)as the main body has been ***,with the promotion of“reduction of pollution and carbon emissions”strategy,there have been significant changes in the sources of pollution/greenhouse gases,emission components and emission concentrations,which have put forward new and higher requirements for the development of monitoring *** the future,we should pay more attention to the development of new optical monitoring techniques and the construction of stereoscopic monitoring system,the interdisciplinarity(among mathematics,physics,chemistry and biology,etc.),and the monitoring of greenhouse gases and research on atmospheric chemistry.

关键词： Pollution Greenhouse gas Optical atmospheric monitoring Needs and challenges

Distributed Fault-Tolerant Control of Uncertain Multi-Agent Systems with Connectivity Maintenance

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Journal of Systems Science & Complexity 2024年第1期37卷 40-62页

作者： xing Xueyan HU guoqiang Continental-NTU Corporate Lab Nanyang Technological UniversitySingapore 639798Singapore Continental-NTU Corporate Lab and the School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore 639798Singapore

In this paper,a distributed cooperative control protocol is presented to deal with actuator failures of multi-agent systems in the presence of connectivity *** the developed strategy,each agent can track the reference trajectory of the leader in the presence of actuator failures,disturbances and *** connectivity of the multi-agent system can always be ensured during the control *** achieve the aforementioned control objectives,a potential function is introduced to the distributed adaptive fault-tolerant control algorithm to preserve the initial connected network among the *** uncertainty of the multi-agent system,which is allowed to be described by discontinuous functions,is approximated and compensated using the fuzzy logic *** asymptotic stability of the closed-loop system is demonstrated through the use of Cellina’s approximate selection theorem of nonsmooth *** to the developed adaptive laws,the upper bound of the disturbance is allowed to be uncertain,which facilitates the implementation of the control ***,simulation results are provided to verify the effectiveness of the proposed control scheme.

关键词： Actuator failure connectivity maintenance coordination control uncertainties