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Prognostic impact of hypernatremia for septic shock patients in the intensive care unit

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World Journal of Clinical Cases 2025年第7期13卷 28-38页

作者： Mai-Qing Shi Jun Chen fu-Hai Ji Hao Zhou Ke Peng Jun Wang Chun-Lei Fan xu Wang Yang Wang Department of Anesthesiology The First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Department of General Surgery The First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Intensive Care Medicine The First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina

BACKGROUND Hypernatremia represents a significant electrolyte imbalance associated with numerous adverse outcomes,particularly in cases of intensive care unit(ICU)-acquired hypernatremia(IAH).Nevertheless,its relevance in patients with septic shock remains *** To identify independent risk factors and their predictive efficacy for IAH to improve outcomes in patients with septic *** In the present retrospective single-center study,a cohort of 157 septic shock patients with concurrent hypernatremia in the ICU at The First Affiliated Hospital of Soochow University,between August 1,2018,and May 31,2023,were *** were categorized based on the timing of hypernatremia occurrence into the IAH group(n=62),the non-IAH group(n=41),and the normonatremia group(n=54).RESULTS In the present study,there was a significant association between the high serum sodium concentrations,excessive persistent inflammation,immunosuppression and catabolism syndrome and chronic critical illness,while rapid recovery had an apparent association with ***,multivariable analyses revealed the following independent risk factors for IAH:Total urinary output over the preceding three days[odds ratio(OR)=1.09;95%CI:1.02–1.17;P=0.014],enteral nutrition(EN)sodium content of 500 mg(OR=2.93;95%CI:1.13–7.60;P=0.027),and EN sodium content of 670 mg(OR=6.19;95%CI:1.75–21.98;P=0.005)were positively correlated with the development of ***,the area under the curve for total urinary output over the preceding three days was 0.800(95%CI:0.678–0.922,P=0.001).furthermore,maximum serum sodium levels,the duration of hypernatremia,and varying sodium correction rates were significantly associated with 28-day in-hospital mortality in septic shock patients(P<0.05).CONCLUSION The present findings illustrate that elevated serum sodium level was significantly associated with a poor prognosis in septic shock patients in the *** is highly recommended that hypernatremia be

关键词： Hypernatremia Hypernatremia acquired in the intensive care unit Septic shock Persistent inflammation Immunosuppression Catabolism syndrome Chronic critical illness Prognosis

Incorporating Lasso Regression to Physics-Informed Neural Network for Inverse PDE Problem

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Computer Modeling in Engineering & Sciences 2024年第10期141卷 385-399页

作者： Meng Ma Liu fu xu guo Zhi Zhai National Key Lab of Aerospace Power System and Plasma Technology Xi’an Jiaotong UniversityXi’an710049China School of Mechanical Engineering Xi’an Jiaotong UniversityXi’an710049China Department of Electrical and Computer Engineering University of Massachusetts LowellLowellMA 01854USA

Partial Differential Equation(PDE)is among the most fundamental tools employed to model dynamic *** PDE modeling methods are typically derived from established knowledge and known phenomena,which are time-consuming and ***,discovering governing PDEs from collected actual data via Physics Informed Neural Networks(PINNs)provides a more efficient way to analyze fresh dynamic systems and establish *** study proposes Sequentially Threshold Least Squares-Lasso(STLasso),a module constructed by incorporating Lasso regression into the Sequentially Threshold Least Squares(STLS)algorithm,which can complete sparse regression of PDE coefficients with the constraints of l0 *** further introduces PINN-STLasso,a physics informed neural network combined with Lasso sparse regression,able to find underlying PDEs from data with reduced data requirements and better *** addition,this research conducts experiments on canonical inverse PDE problems and compares the results to several recent *** results demonstrated that the proposed PINN-STLasso outperforms other methods,achieving lower error rates even with less data.

关键词： Physics-informed neural network inverse partial differential equation Lasso regression scientific machine learning

Effects of diamond particle size on microstructure and properties of diamond/Al-12Si composites prepared by vacuum-assisted pressure infiltration

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China Foundry 2024年第4期21卷 360-368页

作者： Jia-ping fu Can-xu Zhou guo-fa Mi Yuan Liu School of Materials Science and Engineering Henan Polytechnic UniversityJiaozuo 454100HenanChina School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China Key Laboratory for Advanced Materials Processing Technology Ministry of EducationBeijing 100084China

Diamond/aluminium composites have attracted attention in the field of thermal management of electronic packaging for their excellent *** order to solve the interfacial problem between diamond and aluminium,a novel process combining pressure infiltration with vacuum-assisted technology was proposed to prepare diamond/aluminum *** effect of diamond particle size on the microstructure and properties of the diamond/Al-12Si composites was *** results show that the diamond/Al-12Si composites exhibit high relative density and a uniform *** thermal conductivity and coefficient of thermal expansion increase with increasing particle size,while the bending strength exhibits the opposite *** the average diamond particle size increases from 45μm to 425μm,the thermal conductivity of the composites increases from 455 W·m^(-1)·K^(-1)to 713 W·m^(-1)·K^(-1)and the coefficient of thermal expansion increases from 4.97×10^(-6)K^(-1)to 6.72×10^(-6)K^(-1),while the bending strength decreases from 353 MPa to 246 *** research demonstrates that high-quality composites can be prepared by the vacuum-assisted pressure infiltration process and the thermal conductivity of the composites can be effectively improved by increasing the diamond particle size.

关键词： diamond/aluminum composites thermal conductivity electronic packaging vacuum-assisted pressure infiltration

Single Crystal Castability and Undercoolability of PWA1483 Superalloy

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Acta Metallurgica Sinica(English Letters) 2019年第11期32卷 1415-1420页

作者： De-Xin Ma fu Wang Jian-Zheng guo Wen-Liang xu Wedge Central South Research Institute Shenzhen 518045China State Key Laboratory for Powder Metallurgy Central South UniversityChangsha 410083China State Key Laboratory for Manufacturing System Engineering School of Mechanical EngineeringXi'an Jiaotong UniversityXi'an 710049China

Both of the single crystal(SX) castability and undercoolability of PWA1383 superalloy were investigated during the directional solidifi cation and isothermal cooling. In all the six SX parts of a casting cluster, no stray grains were found, revealing a defect-free SX structure. This excellent SX castability of the superalloy was attributed to its good undercoolability. The melting point(T_L) and the critical nucleation temperature( T_N) of the alloy were measured to be 1327 °C and 1306 °C, respectively. The statistic average of the critical nucleation undercooling Δ T_N = T_L-T_N of the alloy was determined to be about 21 K, exhibiting a relatively great capacity to be deeply cooled to a temperature below the melting point without the onset of solidifi cation.

关键词： Superalloys Crystal growth Phase transitions

Deposited sediment settlement and consolidation mechanisms

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Water Science and Engineering 2015年第4期8卷 335-344页

作者： Shuai-jie guo fu-hai Zhang xu-guo Song Bao-tian Wang The Third Railway Survey and Design Institute Group Corporation School of Civil Engineering Southwest Jiaotong University Geotechnical Research Institute Hohai University

In order to study deposited sediment settlement and consolidation mechanisms, sediment settlement experiments were conducted using a settlement column. Based on the experimental results, sediment settlement stage definition, excessive pore pressure （EPP） dissipation, and consolidation constitutive equations are discussed. Three stages, including the free settlement, hindered settlement, and self-weight consolidation settlement stages, are defined. The results of this study show that sediment settlement is mainly affected by the initial sediment concentration and initial settlement height, and the interface settlement rate is linearly attenuated with time on bilogarithmic scales during the hindered settlement and self-weight consolidation settlement stages. Moreover, the deposited sediment layer in the self-weight consolidation settlement stage experiences large strains, and the settlement amount in this stage is about 32% to 59% of the initial height of deposited sediment. EPP is nonlinearly distributed in the settlement direction, and consolidation settlement is faster than EPP dissipation in the self-weight consolidation settlement stage. Consolidation constitutive equations for the hydraulic conductivity and effective stress, applicable to large-strain consolidation calculation, were also determined and fitted in the power function form.

关键词： Sediment settlement experiment Deposited sediment Self-weight consolidation Large-strain consolidation Interface settlement rate Consolidationconstitutive equation

Unbound^(28)O,the heaviest oxygen isotope observed:a cutting-edge probe for testing nuclear models

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Nuclear Science and Techniques 2024年第2期35卷 1-2页

作者： Jian-guo Li Bai-Shan Hu Shuang Zhang fu-Rong xu School of Physics and State Key Laboratory of Nuclear Physics and TechnologyPeking UniversityBeijing 100871China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Southern Center for Nuclear-Science Theory(SCNT) Institute of Modern PhysicsChinese Academy of SciencesHuizhou 516000China

The beyond-dripline oxygen isotopes^(27,28)O were recently observed at RIKEN,and were found to be unbound decaying into^(24)O by emitting *** unbound feature of the heaviest oxygen isotope,^(28)O,provides an excellent test for stateof-the-art nuclear *** atomic nucleus is a self-organized quantum manybody system comprising specific numbers of protons Z and neutrons N.

关键词： testing quantum system

Rock fracture mechanism of buffer blasting with cushion layer at the borehole bottom

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International Journal of Minerals,Metallurgy and Materials 2025年第02期 325-334页

作者： Xinguang Zhu Chenxi Ding Zhe Sui Hong Su xu guo School of Civil and Resources Engineering University of Science and Technology Beijing Key Laboratory for Mechanics in Fluid Solid Coupling Systems Institute of MechanicsChinese Academy of Sciences School of Mechanics and Civil Engineering China University of Mining and Technology (Beijing) School of Chemical and Blasting Engineering Anhui University of Science and Technology

This study primarily investigates the rock fracture mechanism of bottom cushion layer blasting and explores the effects of the bottom cushion layer on rock fragmentation. It involves analyses of the evolution patterns of blasting stress, characteristics of crack distribution, and rock fracture features in the specimens. First, blasting model experiments were carried out using the dynamic caustics principle to investigate the influence of bottom cushion layers and initiation methods on the integrity of the bottom rock mass. The experimental results indicate that the combined use of bottom cushion layers and inverse initiation effectively protects the integrity of the bottom rock mass. Subsequently, the process of stress wave propagation and dynamic crack propagation in rocks was simulated using the continuum–discontinuum element method(CDEM) and the Landau explosion source model, with varying thicknesses of bottom cushion layers. The numerical simulation results indicate that with increasing cushion thickness, the absorption of energy generated by the explosion becomes more pronounced, resulting in fewer cracks in the bottom rock mass. This illustrates the positive role of the cushion layer in protecting the integrity of the bottom rock mass.

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Twin and twin intersection phenomena in a creep deformed microalloyed directionally solidified high Nb containing TiAl alloy

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Journal of Materials Science & Technology 2022年第32期127卷 115-123页

作者： xuesong xu Hongsheng Ding Haitao Huang He Liang Hao guo Ruirun Chen Jingjie guo Hengzhi fu National Key Laboratory for Precision Hot Processing of Metals School of Materials Science and EngineeringHarbin Institute of TechnologyHarbin 150001China

The creep behavior of a directionally solidified TiAl alloy with a high Nb content after microalloying by the addition of small amounts of W,Cr,and B elements was investigated by scanning electron microscopy and transmission electron *** means of directional solidification and microalloying,a TiAl alloy with a fine and uniform microstructure and continuous columnar crystals was ***-density dislocations,deformation nanotwins,and twin intersections were observed inγ*** results show that,in comparison with the ternary TiAl alloy,the microalloyed high Nb containing TiAl alloy exhibited better creep properties at 760℃and 275 *** decrease in stacking fault energy can promote dislocation dissociation and the formation of deformation twins,and the twin intersections can hinder the movement of dislocation to enhance the creep performance of the TiAl alloy.

关键词： TiAl alloy Directional solidification Deformation nanotwins Twin intersections Creep Stacking fault

The Enantioselective Addition of Diethylzinc to Aldehydes Catalyzed by 2-Methylquinoline Derived Chiral Ligands

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Chinese Chemical Letters 2001年第5期12卷 395-396页

作者： Qian Yong xu guo Xing WANG Xin fu PAN Department of Chemistry National Laboratory of Applied Organic ChemistryLanzhou UniversityLanzhou 730000

Readily available 2-methylquinoline derived chiral ligands 1 and 2 have been applied in the enantioselective addition of diethylzinc to aldehydes with up to 91.4% ee being recorded.

关键词： Methylquinoline enantioselective addition diethylzinc.