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Particuology 2024年第4期87卷 124-132页

作者： Fangling Hu Liangliang fu Qingjin zhang Guangwen Xu Dingrong Bai Key Laboratory on Resources Chermticals and Material of Ministry of Education Sheryang Unfversity of Chemical Technology.Shenyang110142China School of Chemical Engineering University of Science and Technology Liaoning.Anshan 114051China School of Materials Science and Engineering Shenyang University of Technology.Shenyang110142China

Forsterite is a highly demanded material in high-temperature industries due to its superior performance in elevated *** study proposes synthesizing high-quality forsterite via high-temperature thermochemical reactions using abundant boron mud *** new synthesis method capitalizes on the high reactivity of fine raw powder materials,enabling the reaction to reach completion at low temperatures *** chemical characteristics,microscopic morphology,and structure of synthe-sized samples are systematically studied using XRD and *** results confirm that boron mud can be efficiently transformed into forsterite after 10 min of reactions at 1500℃.The synthesized products attain over 98.7%densification and contain more than 85.0%forsterite with well-developed *** activation energy of forsterite grain growth in the 1100-1500℃temperature range is 165.5 kJ/*** study provides a low-cost method for producing forsterite and an efficient and environmentally friendly solution for treating solid waste.

关键词： Fluidized bed Boron mud Forsterite Solid state reaction Activation energy Grain growth

Effect of Ti and Ta content on the oxidation resistance of Co-Ni-based superalloys

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International Journal of Minerals,Metallurgy and Materials 2024年第2期31卷 351-361页

作者： Yuheng zhang Zixin Li Yunwei Gui Huadong fu Jianxin Xie Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology BeijingBeijing 100083China Institute of Materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004China Key Laboratory for Advanced Materials Processing(MOE) University of Science and Technology BeijingBeijing 100083China Beijing Laboratory of Metallic Materials and Processing for Modern Transportation University of Science and Technology BeijingBeijing 100083China

Co-Ni-based superalloys are known for their capability to function at elevated temperatures and superior hot corrosion and thermal fatigue ***,these alloys show potential as crucial high-temperature structural materials for aeroengine and gas turbine hot-end *** previous work elucidated the influence of Ti and Ta on the high-temperature mechanical properties of ***,the intricate interaction among elements considerably affects the oxidation resistance of *** this paper,Co-35Ni-10Al-2W-5Cr-2Mo-1Nb-xTi-(5−x)Ta alloys(x=1,2,3,4)with varying Ti and Ta contents were designed and compounded,and their oxidation resistance was investigated at the temperature range from 800 to 1000℃.After oxidation at three test conditions,namely,800℃for 200 h,900℃for 200 h,and 1000℃for 50 h,the main structure of the oxide layer of the alloy consisted of spinel,Cr_(2)O_(3),and Al_(2)O_(3)from outside to *** consisting of Ta,W,and Mo formed below the Cr_(2)O_(3)*** interaction of Ti and Ta imparted the highest oxidation resistance to 3Ti2Ta ***,an excessive amount of Ti or Ta resulted in an adverse effect on the oxidation resistance of the *** study reports the volatilization of W and Mo oxides during the oxidation process of Co-Ni-based cast superalloys with a high Al content for the first time and explains the formation mechanism of holes in the oxide *** results provide a basis for gaining insights into the effects of the interaction of alloying elements on the oxidation resistance of the alloys they form.

关键词： Co-Ni-based superalloys high-temperature oxidation Ti and Ta elements formation mechanism of holes

Myosteatosis is associated with coronary artery calcification in patients with type 2 diabetes

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World Journal of Diabetes 2024年第3期15卷 429-439页

作者： fu-Peng Liu Mu-Jie guo Qing Yang Yan-Ying Li Yan-Gang Wang Mei zhang The Affiliated Hospital of Medical College Qingdao University Qingdao UniversityQingdao 266071Shandong ProvinceChina Department of Endocrinology The Affiliated Hospital of Jining Medical UniversityJining 272029Shandong ProvinceChina Department of Medical Imaging The Affiliated Hospital of Jining Medical UniversityJining 272029Shandong ProvinceChina Department of Clinical Nutrition The Affiliated Hospital of Jining Medical UniversityJining 272029Shandong ProvinceChina Department of Endocrinology The Affiliated Hospital of Qingdao UniversityQingdao 266003Shandong ProvinceChina

BACKGROUND Myosteatosis,rather than low muscle mass,is the primary etiologic factor of sarcopenia in patients with type 2 diabetes mellitus(T2DM).Myosteatosis may lead to a series of metabolic dysfunctions,such as insulin resistance,systematic inflammation,and oxidative stress,and all these dysfunctions are closely associated with the acceleration of T2DM and *** To investigate the association between myosteatosis and coronary artery calcification(CAC)in patients with *** Patients with T2DM,who had not experienced major cardiovascular events and had undergone both abdominal and thoracic computed tomography(CT)scans,were *** mean skeletal muscle attenuation was assessed using abdominal CT images at the L3 *** CAC score was determined from thoracic CT images using the Agatston scoring *** was diagnosed according to Martin’s *** CAC(SCAC)was defined when the CAC score exceeded *** regression and decision tree analyses were *** A total of 652 patients with T2DM were *** them,167(25.6%)patients had *** regression analysis demonstrated that myosteatosis,age,duration of diabetes,cigarette smoking,and alcohol consumption were independent risk factors of *** was significantly associated with an increased risk of SCAC(OR=2.381,P=0.003).The association between myosteatosis and SCAC was significant in the younger patients(OR=2.672,95%CI:1.477-4.834,P=0.002),but not the older patients(OR=1.456,95%CI:0.863-2.455,P=0.188),and was more prominent in the population with lower risks of *** decision tree analyses prioritized older age as the primary variable for *** older patients,cigarette smoking was the main contributing factor for SCAC,while in younger patients,it was *** Myosteatosis is a novel risk factor for atherosclerosis in patients with T2DM,especially in the population with younger ages and fewer traditional ri

关键词： Type 2 diabetes Myosteatosis Muscle quality Coronary artery calcification Atherosclerosis Cardiovascular diseases

Disturbance Observer-Based Predictive Tracking Control of Uncertain HOFA Cyber-Physical Systems

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IEEE/CAA Journal of Automatica Sinica 2024年第7期11卷 1711-1713页

作者： Da-Wei zhang guo-Ping Liu IEEE the Center for Control Theory and Guidance Technology Harbin Institute of TechnologyHarbin 150001China the Center for Control Science and Technology Southern University of Science and TechnologyShenzhen 518055China

Dear Editor,In this letter,an output tracking control problem of uncertain cyber-physical systems(CPSs)is considered in the perspective of high-order fully actuated(HOFA)system theory,where a lumped disturbance is use... 详细信息

关键词： Observer Uncertain letter

SCAB1 coordinates sequential Ca^(2+) and ABA signals during osmotic stress induced stomatal closure in Arabidopsis

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Science China(Life Sciences) 2024年第1期67卷 1-18页

作者： Tianren zhang Li Bai Yan guo State Key Laboratory of Plant Environmental Resilience College of Biological SciencesChina Agricultural UniversityBeijing 100193China

Hyperosmotic stress caused by drought is a detrimental threat to plant growth and agricultural productivity due to limited water *** are gateways of transpiration and gas exchange,the swift adjustment of stomatal aperture has a strong influence on plant drought *** intensive investigations of stomatal closure during drought stress in past decades,little is known about how sequential signals are integrated during complete ***,we discovered that the rapid Ca^(2+) signaling and subsequent abscisic acid(ABA)signaling contribute to the kinetics of both F-actin reorganizations and stomatal closure in Arabidopsis thaliana,while STOMATAL CLOSURE-RELATED ACTIN BINDING PROTEIN1(SCAB1)is the molecular switch for this entire *** the early stage of osmotic shock responses,swift elevated calcium signaling promotes SCAB1 phosphorylation through calcium sensors CALCIUM DEPENDENT PROTEIN KINASE3(CPK3)and *** phosphorylation restrained the microfilament binding affinity of SCAB1,which bring about the Factin disassembly and stomatal closure *** the osmotic stress signal continued,both the kinase activity of CPK3 and the phosphorylation level of SCAB1 attenuated *** further found that ABA signaling is indispensable for these attenuations,which presumably contributed to the actin filament reassembly process as well as completion of stomatal ***,the dynamic changes of SCAB1 phosphorylation status are crucial for the kinetics of stomatal *** together,our results support a model in which SCAB1 works as a molecular switch,and directs the microfilament rearrangement through integrating the sequentially generated Ca^(2+) and ABA signals during osmotic stress induced stomatal closure.

关键词： calcium signal ABA stomatal movement microfilaments kinase

Mechanical Behavior Based on Aggregates Microstructure of Ultra-high Performance Concrete

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Journal of Wuhan University of Technology(Materials Science) 2024年第3期39卷 673-681页

作者：丁庆军 ZHOU Changsheng 张高展 guo Hong LI Yang zhang Yongyuan guo Kaizheng School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070China Advanced Building Materials Key Laboratory of Anhui Province School of Material Science and Chemical EngineeringAnhui Jianzhu UniversityHefei 230601China China Railway 17th Bureau Group Co. Ltd.Taiyuan 030006China

We developed ultra-high performance concrete(UHPC)incorporating mullite sand and brown corundum sand(BCS),and the quartz sand UHPC was utilized to prepare for *** properties of compressive strength,elastic modulus,ultrasonic pulse velocity,flexural strength,and toughness were *** electron microscopy and nanoindentation were also conducted to reveal the underlying mechanisms affecting macroscopic *** to the superior interface bonding properties between mullite sand and matrix,the compressive strength and flexural toughness of UHPC have been significantly *** sand and BCS aggregates have higher stiffness than quartz sand,contributing to the excellent elastic modulus exhibited by *** stiffness and volume of aggregates have a more significant impact on the elastic modulus of UHPC than interface performance,and the latter contributes more to the strength of *** study will provide a reference for developing UHPC with superior elastic modulus for structural engineering.

关键词： ultra-high performance concrete mechanical properties fine aggregates microstructure nanoindentation

EvolveKG:a general framework to learn evolving knowledge graphs

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Frontiers of Computer Science 2024年第3期18卷 43-59页

作者： Jiaqi LIU Zhiwen YU Bin guo Cheng DENG Luoyi fu Xinbing WANG Chenghu ZHOU School of Computer Science Northwestern Polytechnical UniversityXi’an 710129China Department of Computer Science Shanghai Jiao Tong UniversityShanghai 200240China Institute of Geographical Science and Natural Resources Research Chinese Academy of SciencesBejjing 100864China

A great many practical applications have observed knowledge evolution,i.e.,continuous born of new knowledge,with its formation influenced by the structure of historical *** observation gives rise to evolving knowledge graphs whose structure temporally grows over ***,both the modal characterization and the algorithmic implementation of evolving knowledge graphs remain *** this end,we propose EvolveKG–a general framework that enables algorithms in the static knowledge graphs to learn the evolving *** quantifies the influence of a historical fact on a current one,called the effectiveness of the fact,and makes knowledge prediction by leveraging all the cross-time knowledge *** novelty of EvolveKG lies in Derivative Graph–a weighted snapshot of evolution at a certain ***,each weight quantifies knowledge effectiveness through a temporarily decaying function of consistency and attenuation,two proposed factors depicting whether or not the effectiveness of a fact fades away with ***,considering both knowledge creation and loss,we obtain higher prediction accuracy when the effectiveness of all the facts increases with time or remains *** four real datasets,the superiority of EvolveKG is confirmed in prediction accuracy.

关键词： knowledge graph evolution modal characterization algorithmic implementation

Wireless electrical stimulation generated by piezoelectric nanomaterial promotes the dental pulp regeneration via regulating mitochondrial Ca^(2+)/PKA signaling pathway

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Journal of Materials Science & Technology 2024年第1期168卷 24-34页

作者： Jianmao Zheng Jiyuan Zuo Cairong Xiao Qining guo Xiaobin fu Chengyun Ning Peng Yu Guangdong Provincial Key Laboratory of Stomatology Hospital of StomatologySun Yat-Sen UniversityGuangzhou 510080China School of Materials Science and Engineering National Engineering Research Center for Tissue Restoration and ReconstructionSouth China University of TechnologyGuangzhou 510641China

The induction of dental pulp stem cells(DPSCs)into odontogenic differentiation is a cutting-edge method of dental pulp regeneration ***,it remains a challenge to develop biomaterials and ther-apies that can induce odontogenic ***,we propose a wireless electrical stimulation strat-egy to induce DPSCs odontogenic differentiation via K_(0.5)Na_(0.5)NbO_(3)piezoelectric nanoparticles(KNN)and polarized KNN(PKNN),which can be endocytosed by *** vitro,several odontogenic differentiation indexes were also increased in DPSCs treated with KNN and PKNN,and the increase was more obvious in the PKNN *** wireless electrical field promoted mitochondrial calcium concentration via mitochondrial calcium unidirectional transporter(MCU),increased the production of adenosine triphos-phate(ATP),and induced odontogenic differentiation through the activation of the cAMP-PKA signaling *** vivo,dental pulp-like tissue was induced by electrical stimulation wirelessly with KNN and PKNN,which was more clinically friendly compared with the wired device,and the induction was more obvious in the PKNN group consistent with in vitro *** conclusion,this work demonstrates the potential of PKNN as an effective stimulus that can induce odontogenic differentiation of DPSCs and be applied to dental pulp regeneration treatment.

关键词： Piezoelectric nanoparticles Dental pulp stem cells Odontogenic differentiation

Establishment of a cholangiocarcinoma risk evaluation model based on mucin expression levels

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1344-1360页

作者： Chun-Yuan Yang Li-Mei guo Yang Li Guang-Xi Wang Xiao-Wei Tang Qiu-Lu zhang Ling-fu zhang Jian-Yuan Luo Department of Pathology Institute of Systems BiomedicineSchool of Basic Medical Sciences Peking UniversityPeking University Third HospitalPeking University Health Science CenterBeijing 100191China Department of General Surgery Peking University Third HospitalBeijing 100191China Department of Medical Genetics Department of Biochemistry and BiophysicsSchool of Basic Medical Sciences Peking UniversityPeking University Health Science CenterBeijing 100191China

BACKGROUND Cholangiocarcinoma(CCA)is a highly malignant cancer,characterized by frequent mucin ***1 has been identified as a critical oncogene in the progression of ***,the comprehensive understanding of how the mucin family influences CCA progression and prognosis is still *** To investigate the functions of mucins on the progression of CCA and to establish a risk evaluation formula for stratifying CCA *** Single-cell RNA sequencing data from 14 CCA samples were employed for elucidating the roles of mucins,complemented by bioinformatic ***-quent validations were conducted through spatial transcriptomics and *** construction of a risk evaluation model utilized the least absolute shrinkage and selection operator regression algorithm,which was further confirmed by independent cohorts and diverse data *** CCA tumor cells with elevated levels of MUC1 and MUC4 showed activated nucleotide metabolic pathways and increased ***5AC-high cells were found to promote CCA progression through WNT ***5B-high cells exhibited robust cellular oxidation activities,leading to resistance against antitumoral ***13-high cells were observed to secret chemokines,recruiting and transforming macrophages into the M2-polarized state,thereby suppressing antitumor ***16-high cells were found to promote tumor progression through interleukin-1/nuclear factor kappa-light-chain-enhancer of activated B cells signaling upon interaction with *** the expression levels of these mucins,a risk factor evaluation formula for CCA was developed and validated across multiple *** samples with higher risk factors exhibited stronger metastatic potential,chemotherapy resistance,and poorer *** Our study elucidates the functional mechanisms through which mucins contribute to CCA development,and provides tools for risk stratification in CCA.

关键词： Mucin Cholangiocarcinoma Single-cell RNA sequencing Spatial transcriptomics Prognosis

Study on the Performance of the GRANDProto300 Particle Detector Array by Simulation

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Research in Astronomy and Astrophysics 2024年第1期24卷 173-177页

作者： fu-Lin Dai Quan-Bu Gou Xiaoyuan Huang Yi-Qing guo Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China

The Giant Radio Array for Neutrino Detection(GRAND)is a proposed large-scale observatory designed to detect cosmic rays,gamma-rays,and neutrinos with energies exceeding 100 Pe *** GRANDProto300 experiment is proposed as the early stage of the GRAND project,consisting of a hybrid array of radio antennas and scintillator *** latter,as a mature and traditional detector,is used to cross-check the nature of the candidate events selected from radio *** this study,we developed a simulation software called G4GRANDProto300,based on the Geant4 software package,to optimize the spacing of the scintillator detector array and to investigate its effective *** analysis was conducted at various zenith angles under different detector spacings,including 300,500,600,700,and 900 *** results indicate that,for large zenith angles used to search for cosmic-ray in the GRAND project,the optimized effective area is with a detector spacing of 500 *** G4GRANDProto300 software that we developed could be used to further optimize the layout of the particle detector array in future work.

关键词： astroparticle physics instrumentation:detectors (ISM:)cosmic rays