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Acetaminophen overdose-induced acute liver injury can be alleviated by static magnetic field

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Zoological Research 2024年第3期45卷 478-490页

作者： Han-Xiao Chen Xin-Yu Wang Biao Yu Chuan-Lin feng guo-feng cheng Lei Zhang Jun-Jun Wang Ying Wang Ruo-Wen guo Xin-Miao Ji Wen-Jing Xie Wei-Li Chen Chao Song Xin Zhang CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology High Magnetic Field LaboratoryHefei Institutes of Physical ScienceChinese Academy of SciencesHefeiAnhui 230031China Science Island Branch of Graduate School University of Science and Technology of ChinaHefeiAnhui 230026China Institutes of Physical Science and Information Technology Anhui UniversityHefeiAnhui 230601China

Acetaminophen(APAP),the most frequently used mild analgesic and antipyretic drug worldwide,is implicated in causing 46%of all acute liver failures in the USA and between 40%and 70%in *** predominant pharmacological intervention approved for mitigating such overdose is the antioxidant N-acetylcysteine(NAC);however,its efficacy is limited in cases of advanced liver injury or when administered at a late *** the current study,we discovered that treatment with a moderate intensity static magnetic field(SMF)notably reduced the mortality rate in mice subjected to high-dose APAP from 40%to 0%,proving effective at both the initial liver injury stage and the subsequent recovery *** the early phase of liver injury,SMF markedly reduced APAPinduced oxidative stress,free radicals,and liver damage,resulting in a reduction in multiple oxidative stress markers and an increase in the antioxidant glutathione(GSH).During the later stage of liver recovery,application of vertically downward SMF increased DNA synthesis and hepatocyte ***,the combination of NAC and SMF significantly mitigated liver damage induced by high-dose APAP and increased liver recovery,even 24 h post overdose,when the effectiveness of NAC alone substantially ***,this study provides a noninvasive non-pharmaceutical tool that offers dual benefits in the injury and repair stages following APAP *** note,this tool can work as an alternative to or in combination with NAC to prevent or minimize liver damage induced by APAP,and potentially other toxic overdoses.

关键词： Acetaminophen Acute liver injury Static magnetic fields Oxidative stress DNA synthesis

A SYSTEM DYNAMICS APPROACH FOR SUSTAINABLE DEVELOPMENT IN THE MIYUN RESERVOIR AREA, CHINA

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Chinese Geographical Science 2002年第2期12卷 157-165页

作者： SUN Yan feng,guo Huai cheng,QU Guang yi(Center for Environmental Sciences,Peking University,Beijing 100871,P. R. China) Center for Environmental Sciences Peking University Beijing P. R. China

Miyun Reservoir was designated as the water source of Beijing City in 1982. Since that time, socio economic development in Miyun Area has been slowing due to the restriction of severe environmental standards. More and more attention from the public and government has been paid to the regional sustainable development. And an effective planning for the local society management system is urgently desired. In this study, a regional sustainable development system dynamics model, named MiyunSD, is developed for supporting this planning task. MiyunSD consists of dynamic simulation models that explicitly consider information feedback that governs interactions in the system. Such models are capable of simulating the system′s behavior and predicting its developing situation of the future. For the study case, interactions among a number of system components within a time frame of fifteen years are examined dynamically. Three planning alternatives are carefully considered. The base run is based on an assumption that the existing pattern of human activities will prevail in the entire planning horizon, and the other alternatives are based on previous and present planning studies. The different alternatives will get different system′s environmental and socio economic results. Through analyzing these dynamic results, local authorities may find an optimal way to realize the objectives that the regional environment will be well protected and at the same time the economy will be rapidly developed.

关键词： Miyun reservoir sustainable development model policy management system dynamics

Effects of gradient high-field static magnetic fields on diabetic mice

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Zoological Research 2023年第2期44卷 249-258页

作者： Biao Yu Chao Song Chuan-Lin feng Jing Zhang Ying Wang Yi-Ming Zhu Lei Zhang Xin-Miao Ji Xiao-Fei Tian guo-feng cheng Wei-Li Chen Vitalii Zablotskii Hua Wang Xin Zhang High Magnetic Field Laboratory CAS Key Laboratory of High Magnetic Field and Ion Beam Physical BiologyHefei Institutes of Physical ScienceChinese Academy of SciencesHefeiAnhui 230031China Science Island Branch of Graduate School University of Science and Technology of ChinaHefeiAnhui 230026China Institutes of Physical Science and Information Technology Anhui UniversityHefeiAnhui230601China Institute of Physics of the Czech Academy of Sciences Prague18221Czech Republic Department of Oncology First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230022China International Magnetobiology Frontier Research Center Science IslandHefeiAnhui 230031China

Although 9.4 T magnetic resonance imaging(MRI) has been tested in healthy volunteers,its safety in diabetic patients is ***,the effects of high static magnetic fields(SMFs),especially gradient *** fields,have not been investigated in ***,we investigated the consequences of exposure to 1.0-9.4 T high SMFs of different gradients(>10 T/m vs.0-10 T/m)on type 1 diabetic(T1D) and type 2 diabetic(T2D) *** found that 14 h of prolonged treatment of gradient(as high as 55.5 T/m) high SMFs(1.0-8.6 T) had negative effects on T1D and T2D mice,including spleen,hepatic,and renal tissue impairment and elevated glycosylated serum protein,blood glucose,inflammation,and anxiety,while 9.4 T quasi-uniform SMFs at 0-10 T/m did not induce the same *** regular T1D mice(blood glucose>16.7 mmol/L),the>10 T/m gradient high SMFs increased malondialdehyde(P10 T/m gradient high SMFs significantly increased tissue damage and reduced survival *** vitro cellular studies showed that gradient high SMFs increased cellular reactive oxygen species and apoptosis and reduced MS-1 cell number and ***,this study showed that prolonged exposure to high-field(1.0-8.6 T)>10 T/m gradient SMFs(35-1 380 times higher than that of current clinical MRI)can have negative effects on diabetic mice,especially mice with severe T1D,whereas 9.4 T high SMFs at 0-10T/m did not produce the same effects,providing important information for the future development and clinical application of SMFs,especially high-field MRI.

关键词： Type 2 diabetes Type 1 diabetes Magnetic resonance imaging(MRI) Gradient static magnetic field Quasi-uniform static magnetic field

Entropic stochastic resonance in a confined structure driven by dichotomous noise and white noises

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Chinese Physics B 2012年第8期21卷 71-77页

作者：郭锋程晓锋李少甫曹文黎恒 School of Information Engineering Southwest University of Science and Technology Research Center of Laser Fusion China Academy of Engineering Physics

The entropic stochastic resonance （ESR） in a confined system subjected to dichotomous noise and white noise and driven by a periodic sinusoidal force along the x axis of the structure and a time-dependent force in the declining direction, is investigated. Under the adiabatic approximation condition and based on the two-state theory, the expression of the output signal-to-noise ratio （SNR） is obtained. The results show that the SNR is a non-monotonic function of the strengths of dichotomous noise, white noise, and correlated strength of correlated noise. In addition, the SNR varies non-monotonically with the increase of the shape parameters of the confined structure, and also with the increase of the constant force along the y axis of the structure. The influence of the correlation rate of the dichotomous noise, and that of the frequency of the periodic force on the SNR are discussed.

关键词： entropic stochastic resonance dichotomous noise correlated noise square-wave signal,signal-to-noise ratio

VTI介质纯P波混合法正演模拟及稳定性分析

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地球物理学报 2015年第4期58卷 1290-1304页

作者：杜启振郭成锋公绪飞中国石油大学(华东)地球科学与技术学院青岛266580

各向异性介质纯P波方程完全不受横波的干扰,在一定程度上可以减缓由于介质各向异性引起的数值不稳定,本文推导了具有垂直对称轴的横向各向同性(VTI)介质纯P波一阶速度-应力方程.由于纯P波方程存在一个分数形式的伪微分算子,无法直接采... 详细信息

各向异性介质纯P波方程完全不受横波的干扰,在一定程度上可以减缓由于介质各向异性引起的数值不稳定,本文推导了具有垂直对称轴的横向各向同性(VTI)介质纯P波一阶速度-应力方程.由于纯P波方程存在一个分数形式的伪微分算子,无法直接采用有限差分法求解.针对该问题,本文采用伪谱法和高阶有限差分法联合求解波动方程,重点分析了混合法求解纯P波一阶速度-应力方程的稳定性问题,并给出了混合法求解纯P波方程的稳定性条件.数值模拟结果表明纯P波方程伪谱法和高阶有限差分混合法能够进行复杂介质的正演模拟,在强变速度、变密度的地球介质中仍然具有较好的稳定性.

关键词： VTI介质纯P波方程稳定性条件有限差分法伪谱法

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加强分工协作与协调推进东北经济一体化

经济纵横 2005年第7期 25-29页

作者：郭凤城邸焕双中共吉林省委政策研究室吉林长春130055 长春理工大学文法学院吉林长春130022

加强东北地区的分工协作,加快推进经济一体化进程,促进区域经济的协调发展,已成为东北三省面临的一个重要课题。本文围绕东北经济一体化的目标和原则、主要内容、推进方式等问题进行探讨。

关键词：东北经济一体化协调发展研究

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网板填料复合旋转床的传质性能

高校化学工程学报 2013年第3期27卷 386-392页

作者：姚文李育敏郭成峰刘学军敖翔计建炳浙江工业大学化学工程与材料学院浙江省生物燃料利用技术研究重点实验室浙江杭州310014

网板填料复合旋转床(RCB)是一种有别于填料床和折流床的新型旋转床,具有传质效率高和压降小的特点。以乙醇-水溶液为物系,在常压、全回流操作条件下,对同心环网板、同心环网板间径向填充鲍尔环、轴向填充鲍尔环、周向填充鲍尔环的这四... 详细信息

网板填料复合旋转床(RCB)是一种有别于填料床和折流床的新型旋转床,具有传质效率高和压降小的特点。以乙醇-水溶液为物系,在常压、全回流操作条件下,对同心环网板、同心环网板间径向填充鲍尔环、轴向填充鲍尔环、周向填充鲍尔环的这四种转子进行精馏实验。结果表明:网板填料复合旋转床的等板高度随气相表观动能因子和转速的增大出现最小值,在转速800 r min 1,气相表观动能因子1.3 kg0.5 m 0.5 s 1时,其值为28 mm。鲍尔环的填充有利气液传质,其不同填充方式的气相总体积传质系数由大到小的顺序为:周向填充、轴向填充、径向填充、无填充。

关键词：复合旋转床超重力鲍尔环堆积方式传质精馏

Pancreatic stent improves the success rate of needle-knife papillotomy in patients with difficult biliary cannulation

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World Journal of Gastroenterology 2025年第1期31卷 58-67页

作者： Mu-Hsien Lee cheng-Hui Lin Chi-Huan Wu Yung-Kuan Tsou Kai-feng Sung Sheng-Fu Wang Nai-Jen Liu Department of Gastroenterology and Hepatology Chang Gung Memorial Hospital and Chang Gung University College of MedicineTaoyuan 33305Taiwan School of Medicine Chang Gung UniversityTaoyuan 33305Taiwan

BACKGROUND Needle-knife precut papillotomy(NKP)is typically performed ***,it remains unclear whether pancreatic stent(PS)placement can improve the outcomes of *** To explore whether PS placement improves the success rate of NKP in patients with difficult biliary *** This single-center retrospective study included 190 patients who underwent NKP between January 2017 and December 2021 after failed conventional biliary *** cases with incidental pancreatic duct cannulation during conventional biliary cannulation,the decision for pre-NKP PS placement was made at the endoscopist's *** primary outcome was the difference in the NKP success rate between patients with and without PS placement;the secondary outcome was the adverse event *** Among the 190 participants,82 received pre-NKP PS(PS-NKP group)whereas 108 did not[freehand or freehand NKP(FH-NKP)group].Post-NKP selective biliary cannulation was successful in 167(87.9%)patients,and the PS-NKP had a significantly higher success rate than the FH-NKP group(93.9%vs 83.3%,P=0.027).The overall adverse event rates were 7.3%and 11.1%in the PS-NKP and FH-NKP groups,respectively(P=0.493).A periampullary diverticulum(PAD)and significant intraoperative bleeding during NKP were independently associated with NKP failure;however,a pre-NKP PS was the only predictor of NKP *** the 44 participants with PADs,the PS-NKP group had a non-significantly higher NKP success rate than the FH-NKP group(87.5%and 65%,respectively;P=0.076).CONCLUSION PS significantly improved the success rate of NKP in patients with difficult biliary cannulation.

关键词： Difficult biliary cannulation Endoscopic retrograde cholangiopancreatography Needle-knife papillotomy Pancreatic stent Selective biliary cannulation

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电工电子产品盐雾腐蚀试验方法

电子质量 2021年第6期 115-117页

作者：郭凤诚丛林宗阳山东省产品质量检验研究院山东济南250102

电工电子产品进行盐雾腐蚀主要考核其抗盐雾腐蚀的能力及在盐雾环境下的性能变化,是检验其性能的重要试验。该文从适用标准及范围、试验准备及预处理、试验设备及注意事项、技术要求及影响因素、试后处理及检查五个方面探讨了电工电子... 详细信息

电工电子产品进行盐雾腐蚀主要考核其抗盐雾腐蚀的能力及在盐雾环境下的性能变化,是检验其性能的重要试验。该文从适用标准及范围、试验准备及预处理、试验设备及注意事项、技术要求及影响因素、试后处理及检查五个方面探讨了电工电子产品盐雾腐蚀试验方法,对规范化检验流程具有重要的现实意义。

关键词：电工电子产品盐雾腐蚀性能规范化