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Cronkhite-Canada syndrome with steroid dependency: A case report

World Journal of Clinical Cases 2021年第14期9卷 3466-3471页

作者： Dan Jiang guo-du tang Ming-Yu Lai Zhen-Ning Huang Zhi-Hai Liang Department of Gastroenterology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Cronkhite-Canada syndrome(CCS)is a rare nonhereditary disease characterized by chronic diarrhoea,diffuse gastrointestinal polyposis and ectodermal manifestations.The lethality of CCS can be up to 50%if it is untreated or if treatment is delayed or inadequate.More than 35%of the patients do not achieve long-term clinical remission after corticosteroid administration,with relapse occurring during or after the cessation of glucocorticoid use.The optimal strategy of maintenance therapy of this disease is controversial.CASE SUMMARY A 47-year-old man presented to the hospital with a 3-mo history of frequent watery diarrhoea,accompanied by macular skin pigmentation that included the palms and soles,and onychodystrophy of the fingernails and toenails.Gastroscopy and colonoscopy revealed numerous polyps in the stomach and colon.After other possibilities were ruled out by a series of examinations,CCS was diagnosed and treated with prednisone.The patient took prednisone for more than 1 year before achieving complete resolution of his symptoms and endoscopic findings.The patient was then given prednisone 5 mg/d for 6 mo of maintenance therapy.With clinical improvement and polyp regression,prednisone was discontinued.Eight mo after the discontinuation of prednisone,the diarrhoea and gastrointestinal polyps relapsed.Therefore,the patient was given the same dose of prednisone,and complete remission was achieved again.CONCLUSION It is necessary to extend the duration of prednisone maintenance therapy for CCS.Prednisone is still effective when readministered after relapse.Surveillance endoscopy at intervals of 1 year or less is recommended to assess mucosal disease activity.

关键词： Cronkhite-Canada syndrome Endoscopy Prednisone Relapse Maintenance therapy Case report

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Ghrelin inhibits IKKβ/NF-κB activation and reduces pro-inflammatory cytokine production in pancreatic acinar AR42J cells treated with cerulein

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Hepatobiliary & Pancreatic Diseases International 2021年第4期20卷 366-375页

作者： Ren-Jie Chang Hui-Lin Wang Meng-Bin Qin Zhi-Hai Liang Jia-Ping He Yu-Le Wei Hong-Zong Fu guo-du tang Department of Gastroenterology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021China Department of Gastroenterology The First People’s Hospital of Nanning CityThe Fifth Affiliated Hospital of Guangxi Medical UniversityNanning 530022China Department of Chemotherapy Affiliated Tumor Hospital of Guangxi Medical UniversityNanning 530021China Department of Gastroenterology Second Affiliated Hospital of Guangxi Medical UniversityNanning 530007China Department of Gastroenterology Liuzhou General HospitalLiuzhou 545006China Department of Gastroenterology Guangxi International Zhuang Medical HospitalNanning 530001China

Background: Previous studies have provided conflicting results regarding whether the serum ghrelin concentration can reflect the severity of acute pancreatitis(AP). The present study examined the correlation between the serum ghrelin concentration and AP severity in animal models and investigated whether altered ghrelin expression in pancreatic acinar cells influences IKK β/NF-κ B signaling and pro-inflammatory cytokine production. Methods: Mild or severe AP was induced in rats by intraperitoneal injection of cerulein or retrograde cholangiopancreatic duct injection of sodium taurocholate, respectively. After successful model induction, serum ghrelin, tumor necrosis factor-α(TNF-α), and interleukin-6(IL-6) concentrations were determined by enzyme-linked immunosorbent assay, and IKK β/NF-κ B activation was assessed by immunohistochemistry. Subsequently, stable overexpression or knockdown of ghrelin in AR42 J cells was achieved by lentiviral transfection. After transfected cells and control cells were treated with cerulein for 24 h, the TNF-αand IL-1 β levels in the supernatants were determined by enzyme-linked immunosorbent assay, and the expression levels of p-p65, IKK β, and p-IKK β were detected by Western blotting. Results: In rat AP models, AP severity was correlated with increased IKK β/NF-κ B activation, proinflammatory cytokine production, and ghrelin secretion. The levels of pro-inflammatory cytokines TNF-αand IL-1 β as well as IKK β/NF-κ B signaling activity were increased upon knockdown of ghrelin in the AP acinar cell model and decreased with ghrelin overexpression. Conclusions: Serum ghrelin is related to the severity of AP. Ghrelin may play a protective role in the pathogenesis of AP by inhibiting the pro-inflammatory cytokines and the activation of the IKK β/NF-κ B signaling pathway.

关键词： Acute pancreatitis Ghrelin Inflammatory cytokine Acinar cells

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Effects of ginsenoside Rh2 on growth and migration of pancreatic cancer cells

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World Journal of Gastroenterology 2013年第10期19卷 1582-1592页

作者： Xi-Ping tang guo-du tang Chun-Yun Fang Zhi-Hai Liang Lu-Yi Zhang Department of Gastroenterology First Affiliated HospitalGuangxi Medical University

AIM:To investigate the effects of ginsenoside Rh2 on the human pancreatic cancer cell line Bxpc-3.METHODS:The human pancreatic cancer cell line Bxpc-3 was cultured in vitro and treated with or without ginsenoside Rh2.Growth rates for Bxpc-3 cells were assessed by methyl thiazolyl tetrazolium(MTT) and colony formation assays.Cell cycle changes were analyzed by flow cytometry.Apoptosis was measured by flow cytometry and Hoechst 33258 fluorescence staining.A scratch assay and a Matrigel invasion assay were used to detect cell migration and invasion.Expression of Bax,Bcl-2,survivin,cyclin D1,matrix metalloproteinase(MMP)-2,MMP-9,cleaved caspase-3,caspase-8,and caspase-9 mRNA were determined by reverse transcriptase-polymerase chain reaction(RT-PCR).Bax,Bcl-2,survivin,cyclin D1,cleaved caspase-3,caspase-8 and caspase-9 protein levels were examined by western blotting.Expression of MMP-2 and MMP-9 proteins in culture supernatants were determined by enzymelinked immunosorbent assay(ELISA).RESULTS:Rh2 significantly inhibited Bxpc-3 cell proliferation in a dose-and time-dependent manner,as evaluated by the MTT(P < 0.05) and colony formation assays(P < 0.05).Compared to the control group,Rh2 significantly increased the percentage of Bxpc-3 cells in the G 0 /G 1 phase from 43.32% ± 2.17% to 71.32% ± 1.16%,which was accompanied by a decrease in S phase(from 50.86% ± 1.29% to 28.48% ± 1.18%) and G 2 /M phase(from 5.81% ± 1.19% to 0.20% ± 0.05%) in a dose-dependent manner(P < 0.05),suggesting that Rh2 arrested cell cycle progression at the G 0 /G 1 phase,as measured by flow cytometry.Compared to the control group,cells treated with Rh2 showed significantly higher apoptosis ratios in a dosedependent manner(percentage of early apoptotic cells:from 5.29% ± 2.28% to 38.90% ± 3.42%(F = 56.20,P < 0.05);percentage of late apoptotic cells:from 4.58% ± 1.42% to 36.32% ± 2.73%(F = 86.70,P < 0.05).Rh2 inhibited Bxpc-3 cell migration and invasion,as detected by scratch wound healing assay and Matrigel invasion assay [percentages of scratc

关键词： Ginsenoside Rh2 Human pancreatic cancer Bxpc-3 cell Proliferation Apoptosis Migration

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Placement of prophylactic pancreatic stents to prevent post-endoscopic retrograde cholangiopancreatography pancreatitis in high-risk patients: A meta-analysis

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World Journal of Gastroenterology 2014年第22期20卷 7040-7048页

作者： Qing-Qing Shi Xiao-Yi Ning Ling-Ling Zhan guo-du tang Xiao-Ping Lv Department of Gastro-entero-lo-gy the First Affiliated Ho-spital o-f Guangxi Medical University Department o-f Hemato-lo-gy the First Affiliated Ho-spital o-f Guangxi Medical University Department o-f Clinical Experimental Medicine the First Affiliated Ho-spital o-f Guangxi Medical University

AIM:To assess the effectiveness of pancreatic stents for preventing pancreatitis in high-risk patients after endoscopic retrograde cholangiopancreatography(ERCP).METHODS:PubMed,Embase,Science Citation Index,and Cochrane Controlled Trials Register were searched to identify relevant trials published in English.Inclu-sion and exclusion criteria were used to screen for suitable studies.Two reviewers independently judged the study eligibility while screening the citations.The methodological quality of the included trials was assessed using the Jadad scoring system.All results were expressed as OR and 95%CI.Data were analyzed using Stata12.0 software.RESULTS:Ten eligible randomized controlled trials were selected,including 1176 patients.A fixed-effects model in meta-analysis supported that pancreatic duct stents significantly decreased the incidence of postERCP pancreatitis(PEP)in high-risk patients(OR=0.25;95%CI:0.17-0.38;P<0.001).Pancreatic stents also alleviated the severity of PEP(mild pancreatitis after ERCP:OR=0.33;95%CI:0.21-0.54;P<0.001;moderate pancreatitis after ERCP:OR=0.30;95%CI:0.13-0.67;P=0.004).The result of severe pancreatitis after ERCP was handled more rigorously(OR=0.24;95%CI:0.05-1.16;P=0.077).Serum amylase levels were not different between patients with pancreatic stents and control patients(OR=1.08;95%CI:0.82-1.41;P=0.586).CONCLUSION:Placement of prophylactic pancreatic stents may lower the incidence of post-ERCP pancreatitis in high-risk patients and alleviate the severity of this condition.

关键词： Pancreatic stent Endoscopic retrograde cholangiopa

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Relationship between onset of peptic ulcer and meteorological factors

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World Journal of Gastroenterology 2006年第9期12卷 1463-1467页

作者： Da-Yun Liu An-Ning Gao guo-du tang Wang-Yue Yang Jiang Qin Xin-guo Wu Dong-Cai Zhu Gui-Ning Wang Jin-Jiang Liu Zhong-Hui Liang Department of Gastroenterology Nanning First People's Hospital Nannig 530022 Guangxi Zhuang Autonomous Region China Meteorological Observation Station Nannig 530022 Guangxi Zhuang Autonomous Region China Department of Gastroenterology First Affiliated Hospital Guangxi Medical University Nannig 530012 Guangxi Zhuang Autonomous Region China Department Of Gastroenterology Hospital of Guangxi Zhuang Autonomous Region Nannig 530022 Guangxi Zhuang Autonomous Region China Department of Gastroenterology 303 Hospital of Chinese PLA Nannig 530022 Guangxi Zhuang Autonomous Region China

瞄准：讨论在消化性溃疡(PU ) 和气象学的因素(MF ) 的发作之间的关系。方法：24,252 个病人的一个总数从 1992 ～ 1997 在南宁从 17 所医院在胃镜检查的 104,121 件样品与活跃 PU 被发现。PU (DRPU ) 的可检测的率每个月，每十天和每... 详细信息

瞄准：讨论在消化性溃疡(PU ) 和气象学的因素(MF ) 的发作之间的关系。方法：24,252 个病人的一个总数从 1992 ～ 1997 在南宁从 17 所医院在胃镜检查的 104,121 件样品与活跃 PU 被发现。PU (DRPU ) 的可检测的率每个月，每十天和每五天被计算。DRPU 和 MF 的分析在一年的一样的时期被做。一个预报模型基于以前的月的 MF 被建立。真实并且预报价值被测试并且验证。结果：在 6 年期间，到 4 月的从 11 月的 DRPU 是 24.4 -28.8% 。山峰价值(28.8%) 在 1 月。到 10 月的从 5 月的 DRPU 是 20.0-22.6% ，与它在 6 月的低山峰(20.0%) 。DRPU 从冬季和春天减少了到夏天和秋天(P<0.005 ) 。在 DRPU 和平均温度价值之间的相关系数是 -0.8704,-0.6624,-0.5384 一个月，十天，五天分别地(P<0.01 ) 。在 DRPU 和平均最高的温度价值之间的相关系数分别地是 -0.8000,-0.6470,-0.5167 (P<0.01 ) 。在 DRPU 和平均最低温度价值之间的相关系数分别地是 -0.8091,-0.6617,-0.5384 (P<0.01 ) 。在 DRPU 和平均露点温度之间的相关系数分别地是 -0.7812,-0.6246,-0.4936 (P<0.01 ) 。在 DRPU 和平均气压价值之间的相关系数是 0.7320， 0.5777， 0.4579 分别地(P<0.01 ) 。平均温度，平均最高、最低的温度，平均气压和以前的月，十天和五天的平均露点温度价值能预报 PU 的发作，与它的真实并且相应于 71.8% ， 67.9% 和 66.6% 的预报价值分别地。结论：DRPU 仔细为一样的时期与平均温度，平均最高、最低的温度，平均气压和每个月，每十天和每五天的平均露点温度被联系。当 MF 被改变时，人的身体生产 PU 的发作的长期、中部术语的基于的医药气象学的预报能根据这更精确地被做的一系列压力 actions.A。

关键词：胃蛋白酶胃溃疡气象因子病理机制

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Inverse design of mechanical metamaterial achieving a prescribedconstitutive curve

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Theoretical & Applied Mechanics Letters 2024年第1期14卷 16-22页

作者： Zongliang du tanghuai Bian Xiaoqiang Ren Yibo Jia Shan tang Tianchen Cui Xu guo State Key Laboratory of Structural Analysis Optimization and CAE Software for Industrial EquipmentDepartment of Engineering MechanicsDalian University of TechnologyDalian 116023China Ningbo Institute of Dalian University of Technology Ningbo 315016China

Besides exhibiting excellent capabilities such as energy absorption,phase-transforming metamaterials offer a vast design space for achieving nonlinear constitutive relations.This is facilitated by switching between different patterns under deformation.However,the related inverse design problem is quite challenging,due to the lack of appropriate mathematical formulation and the convergence issue in the post-buckling analysis of intermediate designs.In this work,periodic unit cells are explicitly described by the moving morphable voids method and effectively analyzed by eliminating the degrees of freedom in void regions.Furthermore,by exploring the Pareto frontiers between error and cost,an inverse design formulation is proposed for unit cells.This formulation aims to achieve a prescribed constitutive curve and is validated through numerical examples and experimental results.The design approach presented here can be extended to the inverse design of other types of mechanical metamaterials with prescribed nonlinear effective properties.

关键词： MetamaterialPattern-transformationConstitutive curveInverse design

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Advantages of nanocarriers for basic research in the field of traumatic brain injury

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Neural Regeneration Research 2024年第2期19卷 237-245页

作者： Xingshuang Song Yizhi Zhang Ziyan tang Lina du School of Pharmaceutical Sciences Shandong University of Traditional Chinese MedicineJinanShandong ProvinceChina Department of Pharmaceutics Beijing Institute of Radiation MedicineBeijingChina

A major challenge for the efficient treatment of traumatic brain injury is the need for therapeutic molecules to cross the blood-brain barrier to enter and accumulate in brain tissue.To overcome this problem,researchers have begun to focus on nanocarriers and other brain-targeting drug delivery systems.In this review,we summarize the epidemiology,basic pathophysiology,current clinical treatment,the establishment of models,and the evaluation indicators that are commonly used for traumatic brain injury.We also report the current status of traumatic brain injury when treated with nanocarriers such as liposomes and vesicles.Nanocarriers can overcome a variety of key biological barriers,improve drug bioavailability,increase intracellular penetration and retention time,achieve drug enrichment,control drug release,and achieve brain-targeting drug delivery.However,the application of nanocarriers remains in the basic research stage and has yet to be fully translated to the clinic.

关键词： blood-brain barriers brain targeting central nervous system extracellular vesicles inflammatory factor microglial cell nanocarriers nanoparticles neural restoration traumatic brain injury

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Research progress on metal-organic framework compounds(MOFs)in electrocatalysis

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Journal of Environmental Sciences 2024年第7期141卷 261-276页

作者： Yutong guo Shunzheng Zhao Xiaolong tang Honghong Yi Department of Environmental Science and Engineering School of Energy and Environmental EngineeringUniversity of Science and Technology BeijingBeijing 100083China Beijing Key Laboratory of Resource-oriented Treatment of Industrial Pollutants Beijing 100083China

Metal-organic frameworks(MOFs)have favorable characteristics such as large specific surface area,high porosity,structural diversity,and pore surface modification,giving them great potential for development and attractive prospects in the research area of modern materials electrocatalysis.However,unsatisfactory catalytic activity and poor electronic conductivity are the main challenges facing MOFs.This review focuses on MOF-based materials used in electrocatalysis,based on the types of catalytic reactions that have used MOF-based materials in recent years along with their applications,and also looks at some new electrocatalytic materials and their future development prospects.

关键词： Metal-organic frame compounds Electrocatalysis Oxidation-reduction Nitrogen fixation to synthesize ammonia Carbon dioxide reduction

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Promoting effect of FeOx addition on the mechanochemically prepared vanadium-based catalyst for real PCDD/Fs removal and mechanism insight

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Journal of Environmental Sciences 2024年第3期137卷 478-487页

作者： Minghui tang Ling Wang Hongxian Li Xinlei Huang Cuicui du Shengyong Lu State Key Laboratory for Clean Energy Utilization Institute for Thermal Power EngineeringZhejiang UniversityHangzhou 310027China

Industrial-use VOx-based catalysts usually have a higher active temperature window (>250-300℃),which becomes a“bottleneck”for the practical application of PCDD/Fs catalytic degradation technology.In this work,VO_(x)-FeO_(x)/TiO_(2) catalyst prepared via mechanochemically method was investigated for the catalytic removal of PCDD/Fs.The removal efficiency of 1,2-DCBz,pure PCDD/Fs gas generated in the lab,PCDD/Fs from actual fue gas,long-term were studied,and the degradation mechanism was explored using FTIR and TOFMS.The degradation efficiency of 1,2-DCBz and PCDD/Fs on VO_(x)-FeO_(x)/TiO_(2) were higher than that of VO_(x)/TiO_(2)catalyst,and the optimal FeOx addition ratio was 3 wt.%.The characterization results show that the addition of FeOx can effectively improve the pore structure,surface acidity,and VOx dispersion of the catalyst,thus contributing to increasing the V^(5+)content and surface-active oxygen,which is conducive to the improvement of adsorption and redox performance of the catalyst.Under the actual MSWI (municipal solid waste incineration)fue gas,the PCDD/Fs removal efficiency over VTi-3Fe-MC maintained long-term stability,higher than 85%for 240 min.This result was not significantly reduced compared with the data obtained in the laboratory.According to the analysis results of intermediate products by FTIR and GC-TOFMS,it can be inferred that the epoxidation fracture of benzene ring is the rate-limiting step of dioxin catalytic degradation reaction.This work gives an in-depth view into the PCDD/Fs removal over VO_(x)-FeO_(x)/TiO_(2) catalysts and could provide guidelines for the rational design of reliable catalysts for industrial applications.

关键词： PCDD/F removal MSWI fue gas VO_(x)-FeO_(x)/TiO_(2) Mechanochemical GC-TOFMS

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Recent Advances in Mechanistic Understanding of Metal-Free Carbon Thermocatalysis and Electrocatalysis with Model Molecules

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Nano-Micro Letters 2024年第7期16卷 74-97页

作者： Wei guo Linhui Yu Ling tang Yan Wan Yangming Lin CAS Key Laboratory of Design and Assembly of Functional Nanostructures Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002People’s Republic of China Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth MaterialsHaixi InstituteChinese Academy of SciencesXiamen 361021People’s Republic of China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002People’s Republic of China Institute of Urban Environment Chinese Academy of SciencesXiamen 361021People’s Republic of China

Metal-free carbon,as the most representative heterogeneous metal-free catalysts,have received considerable interests in electro-and thermo-catalytic reac-tions due to their impressive performance and sustainability.Over the past decade,well-designed carbon catalysts with tunable structures and heteroatom groups coupled with various characterization techniques have proposed numerous reaction mechanisms.However,active sites,key intermediate species,precise structure-activity relationships and dynamic evolution processes of carbon catalysts are still rife with controversies due to the monotony and limitation of used experimental methods.In this Review,we sum-marize the extensive efforts on model catalysts since the 2000s,particularly in the past decade,to overcome the influences of material and structure limitations in metal-free carbon catalysis.Using both nanomolecule model and bulk model,the real contribution of each alien species,defect and edge configuration to a series of fundamentally important reactions,such as thermocatalytic reactions,electrocatalytic reactions,were systematically studied.Combined with in situ techniques,isotope labeling and size control,the detailed reaction mechanisms,the precise 2D structure-activity relationships and the rate-determining steps were revealed at a molecular level.Furthermore,the outlook of model carbon catalysis has also been proposed in this work.

关键词： Metal-free carbon catalysts Model catalyst Electrocatalysis Active site Reaction mechanisms

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