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Chinese Journal of Chemistry 2024年第19期42卷 2316-2322页

作者： Tongyue Wang Weiwei Shi guo-chao chu Yi-Ming Li Ministry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology Department of ChemistryTsinghua UniversityBeijing 100084China School of Food and Biological Engineering Engineering Research Center of Bio-processMinistry of EducationKey Laboratory of Animal Source of Anhui ProvinceHefei University of TechnologyHefeiAnhui 230009China

Comprehensive Summary The strategy of removable glycosylation modification was used to overcome the low-efficiency problem encountered in the chemical synthesis of the mirror-image D-version of the immunoglobulin(Ig)-like domain of tropomyosin receptor kinase A(DlgCTrkA),a protein molecule needed for mirror-image screening of D-peptide ligands targeting this cell membrane *** was found that O-linked-β-N-acetyl-D-glucosamine(O-GlcNAc)modification at^(D)Ser^(312),or^(D)Ser^(320)can significantly improve the efficiency of DlgCTrkA synthesis and folding,while O-GlcNAc modification at^(D)Ser^(330)showed barely any *** study provides a new example demonstrating the power of the removable glycosylation modification strategy in the chemical synthesis and folding of difficult-to-obtain *** also presents evidence that removable glycosylation modification at different sites would significantly affect the efficiency of protein folding promoted by this strategy.

关键词： Chemical protein synthesis Removable glycosylation modification Synthetic methods Protein folding D-protein

Thermal conductivity of diamond/copper composites with a bimodal distribution of diamond particle sizes prepared by pressure infiltration method

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Rare Metals 2011年第4期30卷 408-413页

作者： CHEN chao guo Hong chu Ke YIN Fazhang ZHANG Ximing HAN Yuanyuan FAN Yeming The General Research Institute of Nonferrous Metals Beijing Beijing 100088 China

The thermal conductivity of diamond/copper composites with bimodal particle sizes was studied. The composites were prepared through pressure infiltration of liquid copper into diamond preforms with a mixture of 40 and 100 pm-size diamonds. The permeability of the preforms with different coarse-to-fine volume ratios of diamonds was investigated. The thermal conductivity of the diamond/copper composites with bimodal size distribution was compared to the theoretical value derived from an analytical model developed by chu. It is predicted that the diamond/copper composites could reach a higher thermal conductivity and their surface roughness could be improved by applying bimodal diamond particle sizes.

关键词： metallic matrix composites thermal conductivity diamonds copper size distribution pressure infiltration

Ferricyanide-Promoted Oxidative Activation and Ligation of Protein Thioacids in Neutral Aqueous Media

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CCS Chemistry 2024年第8期6卷 2031-2043页

作者： guo-chao chu Lu-Jun Liang Rui Zhao Yan-Yan guo chun-Tong Li Chong Zuo Huasong Ai Xiao Hua Zi-Chen Li Yi-Ming Li Lei Liu NewCornerstone Science Laboratory Tsinghua-Peking Center for Life SciencesMinistry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical BiologyCenter for Synthetic and Systems BiologyDepartment of ChemistryTsinghua UniversityBeijing 100084 School of Food and Biological Engineering Hefei University of TechnologyHefei 230009 Center for BioAnalytical Chemistry Hefei National Laboratory of Physical Science at MicroscaleUniversity of Science and Technology of ChinaHefei 230026 Department of Chemistry University of Science and Technology of ChinaHefei 230026

Ferricyanide-promoted oxidative activation of Nacylatedα-aminothioacids for amide bond formation withα-aminonitriles was recently shown to be a plausible pathway for prebiotic peptide *** we describe the finding that by adding sodium azide and thiols,ferricyanide oxidation can elicit highly efficient and clean conversion of fully unprotected peptide or protein thioacids in neutral aqueous media to the corresponding *** transformation enables the development of ferricyanide-promoted thioacid-based native chemical ligation(NCL)as a new redox-based method for chemical protein synthesis,which does not need to change pH and is therefore operationally easy for ligation at small *** effectiveness of the ferricyanide-promoted thioacid-based NCL was illustrated by synthesis of an ISG15-modified MDA5 segment under nondenaturing conditions and synthesis of an acetylated ubiquitin(Ub)-modified histone H2A through an N-to-C sequential *** work broadens the concept of on-demand oxidative activation strategy for protein ligation and provides a new useful supplement to the repertoire of methods for chemical protein synthesis,particularly for studies on proteins carrying Ub family modifications.

关键词： chemical protein synthesis protein thioacid ferricyanide oxidation native chemical ligation ubiquitin family modifications

Smart Cellulose‑Based Janus Fabrics with Switchable Liquid Transportation for Personal Moisture and Thermal Management

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Nano-Micro Letters 2025年第1期17卷 333-347页

作者： Jianfeng Xi Yanling Lou Liucheng Meng chao Deng Youlu chu Zhaoyang Xu Huining Xiao Weibing Wu Jiangsu Co‑Innovation Center of Efficient Processing and Utilization of Forest Resources International Innovation Center for Forest Chemicals and MaterialsJiangsu Provincial Key Lab of Sustainable Pulp and Paper Technology and Biomass MaterialsNanjing Forestry UniversityNanjing 210037People’s Republic of China College of Materials Science and Engineering Nanjing Forestry UniversityNanjing 210037People’s Republic of China Department of Chemical Engineering University of New BrunswickFrederictonNB E3B 5A3Canada Macromolecular Chemistry and Bavarian Polymer Institute University of BayreuthBayreuth 95440Germany

The Janus fabrics designed for personal moisture/thermal regulation have garnered significant attention for their potential to enhance human ***,the development of smart and dynamic fabrics capable of managing personal moisture/thermal comfort in response to changing external environments remains a ***,a smart cellulose-based Janus fabric was designed to dynamically manage personal moisture/*** cotton fabric was grafted with N-isopropylacrylamide to construct a temperature-stimulated transport ***,hydrophobic ethyl cellulose and hydrophilic cellulose nanofiber were sprayed on the bottom and top sides of the fabric to obtain wettability *** fabric exhibits anti-gravity directional liquid transportation from hydrophobic side to hydrophilic side,and can dynamically and continuously control the transportation time in a wide range of 3–66 s as the temperature increases from 10 to 40℃.This smart fabric can quickly dissipate heat at high temperatures,while at low temperatures,it can slow down the heat dissipation rate and prevent the human from becoming too *** addition,the fabric has UV shielding and photodynamic antibacterial properties through depositing graphitic carbon nitride nanosheets on the hydrophilic *** smart fabric offers an innovative approach to maximizing personal comfort in environments with significant temperature variations.

关键词： Directional water transport Cotton fabric Anti-gravity directional liquid transportation Janus wettability

Treadmill exercise in combination with acousto-optic and olfactory stimulation improves cognitive function in APP/PS1 mice through the brain-derived neurotrophic factor-and Cygb-associated signaling pathways

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Neural Regeneration Research 2025年第9期20卷 2706-2726页

作者： Biao Xiao chaoyang chu Zhicheng Lin Tianyuan Fang Yuyu Zhou chuxia Zhang Jianghui Shan Shiyu Chen Liping Li Department of Physiology and Pharmacology Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Ningbo Key Laboratory of Behavioral Neuroscience Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Key Laboratory of Addiction Research of Zhejiang Province NingboZhejiang ProvinceChina

A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's ***,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and ***,nonpharmacological interventions aimed at inducing adult neurogenesis are currently *** individual non-pharmacological interventions,such as aerobic exercise,acousto-optic stimulation,and olfactory stimulation,have shown limited capacity to improve neurogenesis and cognitive function in patients with Alzheimer's disease,the therapeutic effect of a strategy that combines these interventions has not been fully *** this study,we observed an age-dependent decrease in adult neurogenesis and a concurrent increase in amyloid-beta accumulation in the hippocampus of amyloid precursor protein/presenilin 1 mice aged 2-8 *** deposition became evident at 4 months,while neurogenesis declined by 6 months,further deteriorating as the disease ***,following a 4-week multifactor stimulation protocol,which encompassed treadmill running(46 min/d,10 m/min,6 days per week),40 Hz acousto-optic stimulation(1 hour/day,6 days/week),and olfactory stimulation(1 hour/day,6 days/week),we found a significant increase in the number of newborn cells(5'-bromo-2'-deoxyuridine-positive cells),immature neurons(doublecortin-positive cells),newborn immature neurons(5'-bromo-2'-deoxyuridine-positive/doublecortin-positive cells),and newborn astrocytes(5'-bromo-2'-deoxyuridine-positive/glial fibrillary acidic protein-positive cells).Additionally,the amyloid-beta load in the hippocampus *** findings suggest that multifactor stimulation can enhance adult hippocampal neurogenesis and mitigate amyloid-beta neuropathology in amyloid precursor protein/presenilin 1 ***,cognitive abilities were improved,and depressive symptoms were alleviated in amyloid precursor protein/presenilin 1 mice

关键词： acousto-optic stimulation adult neurogenesis Alzheimer's disease amyloid precursor protein/presenilin 1 mice amyloid-beta deposition brain cell apoptosis cognitive impairment depression-like behavior involuntary treadmill exercise olfactory stimulation serum metabolites

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翻译课及其他——爱荷华大学作家工作坊见闻

当代文坛 2025年第1期 103-109页

作者：张楚天津市作家协会

通过作者参加爱荷华大学作家工作坊(Iowa Writers’Workshop)两堂英语翻译课的经历,真实、细致地记录了该校作家工作坊的授课方式和特点,进而延宕到作家工作坊的创办历史、招生方式、教学内容等具体情况。通过工作坊的课程安排与国内高... 详细信息

通过作者参加爱荷华大学作家工作坊(Iowa Writers’Workshop)两堂英语翻译课的经历,真实、细致地记录了该校作家工作坊的授课方式和特点,进而延宕到作家工作坊的创办历史、招生方式、教学内容等具体情况。通过工作坊的课程安排与国内高校创写专业课程的比较,从小切口反思了中外创意写作教学中存在的一些共性问题和个性问题,并对中外地域性写作做了剖析,一方面地域性写作的共性叙事主题与美学风格在不断彰显中呈现出新的气象,超越了个体表达的局限性。另外一方面,对写作者按地域分类忽略了小说作为一种艺术表达方式的个性。

关键词：作家工作坊创意写作地域性写作

Degradation behaviors of surface modified magnesium alloy wires in different simulated physiological environments

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Frontiers of Materials Science 2014年第3期8卷 281-294页

作者： Xuan LI chao SHI Jing BAI chao guo Feng XUE Ping-Hua LIN Cheng-Lin chu School of Materials Science and Engineering and Jiangsu Key Laboratory for Advanced Metallic Materials Southeast University Nanjing 211189 China

The degradation behaviors of the novel high-strength AZ31B magnesium alloy wires after surface modification using micro-arc-oxidization （MAO） and subse- quently sealing with poly-L-lactic acid （PLLA） in different simulated physiological environments were investigated. The results show the surface MAO micropores could be physically sealed by PLLA, thus forming an effective protection to corrosion resistance for the wires. In simulated gastric fluid （SGF） at a low pH value （1.5 or 2.5）, the treated wires have a high degradation rate with a rapid decrease of mass, diameter, mechanical properties and a significant increase of pH value of the immersion fluid. However, surface modification could effectively reduce the degradation rate of the treated wires in SGF with a pH value above 4.0. For the treated wires in simulated intestinal fluid at pH =8.5, their strength retention ability is higher than that in strong acidic SGF. And the loss rate of mass is faster than that of diameter, while the pH value of the immersion fluid decreases. It should be noted that the modified wires in simulated body environment have the best strength retention ability. The wires show the different degradation behaviors indicating their different degradation mechanisms, which are also proposed in this work.

关键词： magnesium alloy wire degradation behavior surface modification simulated physiological environment

Carbon steel slag as cementitious material for self-consolidating concrete

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第7期11卷 488-494页

作者： Yu-chu PENG chao-Lung HWANG Graduate Institute of Construction Engineering National Taiwan University of Science and Technology Taipei Department of Leisure Management Taiwan Hospitality and Tourism College Taipei

This study deals with the recycling of carbon steel slag (CSS) to produce self-consolidating concrete (SCC). Since the chemical composition of CSS is similar to that of Portland cement or blast furnace slag (BFS), it is expected to behave similarly. In the current study, the pozzolanic activity index of CSS is examined. Furthermore, the use of CSS as a pozzolanic material to partially replace Portland cement in the production of SCC is tested. We designed concrete mixtures with different water-tocementitious material ratios (w/cm) keeping water and superplasticizer (SP) contents constant. Results showed that the design and performance of all the concrete mixtures used in this investigation were comparable to those of SCC and high performance concrete (HPC). However, compared to ordinary plain concrete (OPC), the additional CSS content increases the setting time. In the CSS mixtures set for 90 d, compressive strengths of 86%, 134% and 121% were attained as compared to the control concrete; the corresponding w/cm ratios were 0.28, 0.32 and 0.40, respectively. Verifying the soundness of the SCC for meeting the criteria for HPC, the ultrasonic pulse velocity (UPV) of CSS was found to be comparable to that of ordinary concrete. In conclusion, the recycling of CSS can be advantageously employed in the production of SCC.

关键词： Carbon steel slag (CSS) Self-consolidating concrete (SCC) Pozzolanic Recycling

Development of high performance and high strength heavy concrete for radiation shielding structures

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International Journal of Minerals,Metallurgy and Materials 2011年第1期18卷 89-93页

作者： Yu-chu Peng chao-Lung Hwang Graduate Institute of Construction Engineering Taiwan University of Science and Technology Taipei 11243 China Taipei Department of Resort and Leisure Management Taiwan Hospitality ＆ Tourism College Taipei 11243 China Taipei

Heavy concrete currently used for construction contains special materials that are expensive and difficult to work *** study replaced natural aggregate（stones） in concrete with round steel balls,which are inexpensive and easily *** diameters of the steel balls were 0.5 and 1 cm,and their density was 7.8 kg/*** packing mixture methods were used to produce heavy concrete with densities of 3500 and 5000 kg/*** various properties of this concrete were tested according to the standards of the American Society for Testing and Materials（ASTM）.The results indicated that the construction slump of the concrete could reach 260-280 mm and its slump flow could reach 610-710 *** important,its compressive strength could reach 8848 *** results will significantly alter traditional construction methods that use heavy concrete and enhance innovative ideas for structural design.

关键词： radiation shielding composite structures concretes concrete construction materials properties

Security and privacy threats in RFID traceability network

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Journal of Southeast University(English Edition) 2008年第S1期24卷 132-135页

作者： chu chao-Hsien College of Information Science and Technology The Pennsylvania State UniversityUniversity Park

To address security and privacy issues in radio frequency identification (RFID) traceability networks, a multi-layer privacy and security framework is proposed, which includes four facets: a security model, a communication protocol, access permission and privacy preservation. According to the security requirements that are needed in an RFID system, a security model that incorporates security requirements that include privacy of tag data, privacy of ownership, and availability of tag identity is introduced. Using this model, a secure communication protocol that can be used for anti-counterfeiting, automatic identification and privacy preservation is then developed. In order to manage the number of parties, data records of items, and complicated transitions of access permissions in an item-level traceability context, a well-designed access control protocol is proposed to parties that can prove the physical possession of an item;meanwhile, to address the privacy issues during data sharing in an RFID network, a vision of database systems that take responsibility for the privacy of the data they manage is also presented.

关键词： traceability network radio frequency identification (RFID) security protocol privacy protection strategy