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Spliceosomal GTPase Eftud2 regulates microglial activation and polarization

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Neural Regeneration Research 2023年第4期18卷 856-862页

作者： guo-chao yang Yuan Shi chao-Nan Fan Ying Li Meng-Qi Yuan Jie Pei Yan Wu Hai-Tao Wu School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina Department of Neurobiology Beijing Institute of Basic Medical SciencesBeijingChina Institute of Neuroscience Hengyang Medical CollegeUniversity of South ChinaHengyangHunan ProvinceChina School of Basic Medicine Anhui Medical UniversityHefeiAnhui ProvinceChina Key Laboratory of Neuroregeneration Co-innovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina

Elongation factor Tu GTP binding domain protein 2(Eftud2)is a spliceosomal GTPase that serves as an innate immune modulator restricting virus *** are the resident innate immune cells and the key players of immune response in the central nervous ***,the role of Eftud2 in microglia has not been *** this study,we performed immunofluorescent staining and western blot assay and found that Eftud2 was upregulated in microglia of a 5xFAD transgenic mouse model of Alzheimer’s ***,we generated an inducible microglia-specific Eftud2 conditional knockout mouse line(CX3CR1-CreER;Eftud2^(f/f) cKO)via Cre/loxP recombination and found that Eftud2 deficiency resulted in abnormal proliferation and promoted anti-inflammatory phenotype activation of ***,we knocked down Eftud2 in BV2 microglia with siRNA specifically targeting Eftud2 and found that Eftud2-mediated regulation of microglial proinflammatory/anti-inflammatory phenotype activation in response to inflammation might be dependent on the NF-κB signaling *** findings suggest that Eftud2 plays a key role in regulating microglial polarization and homeostasis possibly through the NF-κB signaling pathway.

关键词： Alzheimer’s disease anti-inflammatory phenotype BV2 Eftud2 inflammation lipopolysaccharide microglia nuclear factor-kappaB proinflammatory phenotype spliceosomal GTPase

Pollution tracks of r-process material in[Sr/Ba]vs.[Ba/Fe]space for the early Galaxy

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Research in Astronomy and Astrophysics 2021年第5期21卷 91-100页

作者： Wan-Qiang Han guo-chao yang Lu Zhang Wen-Yuan Cui Ping Niu Fang Wen Bo Zhang Department of Physics Hebei Normal UniversityShijiazhuang 050024China Department of Physics Shijiazhuang UniversityShijiazhuang 050035China School of Sciences Hebei University of Science and TechnologyShijiazhuang 050018China College of Mathematics and Information Science Hebei Normal UniversityShijiazhuang 050024China

In the early Galaxy,elemental abundances of the extremely metal-poor(EMP)stars contain abundant information about the neutron-capture nucleosynthesis and the chemical enrichment *** this work,we study the abundance characteristics of Sr and Ba for the EMP stars in the[Sr/Ba]vs.[Ba/Fe]*** find that there are three boundaries for the distribution region of the EMP *** weak rprocess star CS 22897-008 lies on the upper end and the main r-process stars lie on the right end of the *** the right boundary of the distribution region,there is an Fe-normal *** the EMP stars in the belt,element Fe dominantly originates from the normal massive *** low-Sr stars([Sr/Fe]6−0.3)distribute in the region of the lower left of the Fe-normal belt and their Fe should originate partly from the prompt *** find that the formation of the lower boundary of the distribution region is due to the pollution of the main r-process material and the formation of the right boundary could be explained by the combination of the weak r-and main r-process ***,the formation of the left boundary is due to the pollution of the weak r-process *** the[Sr/Ba]ratios are related to the relative importance of the weak r-process material,the scatter of[Sr/Ba]ratios for the EMP stars mainly depends on the abundance ratio of the weak r-process.

关键词： stars:abundances stars:formation stars:massive

Multiwavelength study of nearly face-on low surface brightness disk galaxies

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Research in Astronomy and Astrophysics 2010年第12期10卷 1223-1241页

作者： Dong Gao Yan-Chun Liang Shun-Fang Liu guo-Hu Zhong Xiao-Yan Chen Yan-Bin yang Francois Hammer guo-chao yang Li-Cai Deng Jing-Yao Hu National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China ycliang @ nao. cas. cn dgao @ nao. cas. cn Key Laboratory of Optical Astronomy National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China Graduate University of Chinese Academy of Sciences Beijing 100049 China GEPI Observatoire de Paris-Meudon 92195 Meudon France Department of Physics Hebei Normal University Shijiazhuang 050016 China

We study the ages of a large sample （1802） of nearly face-on disk low surface brightness galaxies （LSBGs） using the evolutionary population synthesis （EPS） model PEGASE with an exponentially decreasing star formation rate to fit their mul- tiwavelength spectral energy distributions （SEDs） from far-ultraviolet （FUV） to nearinfrared （NIR）. The derived ages of LSBGs are 1-5 Gyr for most of the sample no matter if constant or varying dust extinction is adopted, which are similar to most of the previous studies on smaller samples. This means that these LSBGs formed the majority of their stars quite recently. However, a small part of the sample （~2%-3%） has larger ages of 5-8 Gyr, meaning their major star forming process may have occurred earlier. At the same time, a large sample （5886） of high surface brightness galaxies （HSBGs） are selected and studied using the same method for comparisons. The de- rived ages are 1-5 Gyr for most of the sample （97%） as well. These results probably mean that these LSBGs have not much different star formation histories from their HSBGs counterparts. However, we should notice that the HSBGs are generally about 0.2 Gyr younger, which could mean that the HSBGs may have undergone more recent star forming activities than the LSBGs.

关键词： galaxies: evolution -- galaxies: formation -- galaxies: photometry --galaxies: spiral -- galaxies: statistics -- ultraviolet: galaxies

Design of broadband beamformers based on an expected response interpolation technique

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Chinese Journal of Acoustics 2006年第3期25卷 258-266页

作者： guo qili SUN chao yang Yixin Institute of Acoustic Engineering Northwestern Polytechnical University Xi'an 710072

A method for designing broadband beamformers based on an expected response interpolation technique was proposed, with the aim of reducing the heavy optimization burden in the broadband beamformer design problem. In the method, some typical frequencies in the designing frequency band are selected and the optimal array weights are designed on these typical frequencies, based on which a broadband expected response function is constructed. Then, FIR filters are designed to realize the broadband beamforming over the whole designing frequency band, via the interpolation technique which is utilized to the expected responses of the FIR filters. Broadband beamforming can be fulfilled by applying these filters to each of the sensors in the array. By using the proposed method, designers need not to divide the whole designing frequency band into narrow subbands so as to make the narrow band assumption valid, which not only reduces the heavy designing burden, but also releases the requirement for measurements at fine frequency grids in the robust beamformer design. Results of both computer simulations and watertank experiments verify the effectiveness of the proposed method.

关键词： broadband beamforming beamformer design computer simulations response function narrow band

Chemical abundance analysis of 19 barium stars

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Research in Astronomy and Astrophysics 2016年第1期16卷 159-174页

作者： guo-chao yang Yan-Chun Liang Monique Spite Yu-Qin Chen Gang Zhao Bo Zhang guo-Qing Liu Yu-Juan Liu Nian Liu Li-Cai Deng Francois Spite Vanessa Hill Cai-Xia Zhang College of Physics and Information Engineering Hebei Normal University Shijiazhuang 050024 China Key Laboratory of Optical Astronomy National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China University of Chinese Academy of Sciences Beijing 100049 China GEPI Observatoire de Paris-Meudon 92195 Meudon France Physics Department and Tsinghua Center for Astrophysics Tsinghua University Beijing 100084 China Astronomy Department Beijing Normal University Beijing 100875 China Department of Physics Shijiazhuang University Shijiazhuang 050035 China

We aim at deriving accurate atmospheric parameters and chemical abundances of 19 barium（Ba） stars, including both strong and mild Ba stars, based on the high signal-to-noise ratio and high resolution Echelle spectra obtained from the 2.16 m telescope at Xinglong station of National Astronomical Observatories, Chinese Academy of Sciences. The chemical abundances of the sample stars were obtained from an LTE, plane-parallel and line-blanketed atmospheric model by inputting the atmospheric parameters（effective temperatures Teff, surface gravities log g, metallicity [Fe/H] and microturbulence velocity ξt） and equivalent widths of stellar absorption lines. These samples of Ba stars are giants as indicated by atmospheric parameters, metallicities and kinematic analysis about UVW velocity. Chemical abundances of 17 elements were obtained for these Ba stars. Their Na, Al, α- and iron-peak elements（O, Na, Mg, Al, Si, Ca,Sc, Ti, V, Cr, Mn, Ni） are similar to the solar abundances. Our samples of Ba stars show obvious overabundances of neutron-capture（n-capture） process elements relative to the Sun. Their median abundances of[Ba/Fe], [La/Fe] and [Eu/Fe] are 0.54, 0.65 and 0.40, respectively. The Y I and Zr I abundances are lower than Ba, La and Eu, but higher than the α- and iron-peak elements for the strong Ba stars and similar to the iron-peak elements for the mild stars. There exists a positive correlation between Ba intensity and [Ba/Fe].For the n-capture elements（Y, Zr, Ba, La）, there is an anti-correlation between their [X/Fe] and [Fe/H]. We identify nine of our sample stars as strong Ba stars with [Ba/Fe]〉0.6 where seven of them have Ba intensity Ba=2-5, one has Ba=1.5 and another one has Ba=1.0. The remaining ten stars are classified as mild Ba stars with 0.17〈[Ba/Fe]〈0.54.

关键词： methods: observational - stars: abundances - stars: atmospheres - stars: chemically peculiar- stars: kinematics and dynamics - stars: late-type

Sr-Nd isotopic characteristics and their significance in provenance tracing of detrital sediment in major rivers and marginal seas of eastern China

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Science China Earth Sciences 2025年

作者： Xiaobao GAO chao LI Zhifei DUAN Yulong guo Shouye yang State Key Laboratory of Marine Geology Tongji University

Sr-Nd isotopes are widely utilized as reliable tracers in sediment provenance *** this study,we compiled 304Sr and 335 Nd isotope data of fine-grained surface sediments collected from major rivers in eastern China,including the Huanghe River,Changjiang River,southeastern coastal rivers,and rivers in Taiwan Island,as well as from marginal seas （Yellow Sea and East China Sea） and the Okinawa *** comprehensive dataset allowed us to examine the spatial distribution patterns of these isotopes and their implications for provenance *** variations of εNd values in the sediments in Changjiang and Huanghe Basins primarily reflect the diversity of sediment sources,whereas the87Sr/86Sr ratios are influenced by both grain size and source ***,the reduction in87Sr/86Sr ratios observed in the middle and lower Changjiang River is attributed to the inputs of sources characterized by distinct87Sr/86Sr signatures beyond mere grain size *** the southeastern coastal and Taiwan rivers,sediments in the tidal reaches of the Jiao River exhibit hybrid characteristics,a mix of Changjiang-derived sediment and those originating from local ***,the Min River and Jiulong River sediments predominantly reflect local sources,with minimal influence from the Changjiang *** significant isotopic variation of Sr-Nd isotopic characteristics observed between riverine sediments on the eastern and western sides of Taiwan Island underscores the diverse provenance heterogeneity of source rocks in the *** the marginal seas,our data indicates that the surface sediments in the central mud area of the South Yellow Sea and the southern Yellow Sea are predominantly sourced from the Changjiang River catchment,potentially augmented by inputs from Korean *** inner shelf sediments of the East China Sea are primarily influenced by Changjiang River inputs,whereas rivers in eastern Taiwan Island contribute to the sediments on the middle and

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Force and impulse multi-sensor based on flexible gate dielectric field effect transistor

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 214-220页

作者： chao Tan Junling Lü Chunchi Zhang Dong Liang Lei yang Zegao Wang College of Materials Science and Engineering Sichuan UniversityChengdu 610065China The 54th Research Institute of China Electronics Technology Group Corporation Shijiazhuang 050081China

Nowadays,force sensors play an important role in industrial production,electronic information,medical health,and many other ***-dimensional material-based filed effect transistor(2D-FET)sensors are competitive with nano-level size,lower power consumption,and accurate ***,few of them has the capability of impulse detection which is a path function,expressing the cumulative effect of the force on the particle over a period of *** we fabricated the flexible polymethyl methacrylate(PMMA)gate dielectric MoS_(2)-FET for force and impulse sensor *** systematically investigated the responses of the sensor to constant force and varying forces,and achieved the conversion factors of the drain current signals(I_(ds))to the detected impulse(I).The applied force was detected and recorded by I_(ds)with a low power consumption of~30 *** sensitivity of the device can reach~8000%and the 4×1 sensor array is able to detect and locate the normal force applied on ***,there was almost no performance loss for the device as left in the air for two months.

关键词： flexible gate dielectric transistor force sensor impulse sensor force sensor array

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各民族美食类短视频对民族文化交融的促进

中央民族大学学报（哲学社会科学版） 2024年第1期51卷 79-87页

作者：金强郭朝阳河北大学新闻传播学院河北保定071000 河北大学跨文化传播研究中心河北保定071000

以铸牢中华民族共同体意识为主线,本文关注以短视频为表现手段,在抖音、快手等主流短视频平台上呈现的少数民族美食及其相关民族个体与群体的日常生活,分析少数民族美食影像生态的基本特征及其所表现出的精神面貌与情感体验。以少数民... 详细信息

以铸牢中华民族共同体意识为主线,本文关注以短视频为表现手段,在抖音、快手等主流短视频平台上呈现的少数民族美食及其相关民族个体与群体的日常生活,分析少数民族美食影像生态的基本特征及其所表现出的精神面貌与情感体验。以少数民族个体在新媒体语境中围绕美食展开的数字交往实践为基点,本文旨在探索民族个体与群体在社交媒体互动中所呈达出的民族文化、交往规制与心理认同,相较服饰、节日、建筑等类型,美食类短视频跨民族的共通价值更为显著,且具有更持久的跨族群传播生命力。加强少数民族美食类短视频的生产实践和传播动力,对铸牢中华民族共同体意识有明显促进作用,既有利于促进民族饮食文化认知与提升民族文化亲和力,积极助推各民族饮食经济发展,客观上亦可使民族交流交往交融工作走深走细走实。

关键词：铸牢中华民族共同体少数民族美食短视频抖音

创业型经济背景下的创业营销:研究述评与未来研究展望

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商业经济与管理 2014年第9期 52-60页

作者：焦晓波郭朝阳安徽财经大学工商管理学院安徽蚌埠233030 厦门大学管理学院福建厦门361005

自德鲁克提出创业型经济以来,创业逐渐形成一股热潮并受到各国高度重视。中国改革开放以来的巨大变化,说明了创业在经济发展中的重要作用。由于传统的市场营销出现了中年危机,而创业营销在组织层面较少官僚化,在动态环境中具有更好的适... 详细信息

自德鲁克提出创业型经济以来,创业逐渐形成一股热潮并受到各国高度重视。中国改革开放以来的巨大变化,说明了创业在经济发展中的重要作用。由于传统的市场营销出现了中年危机,而创业营销在组织层面较少官僚化,在动态环境中具有更好的适应性,因此能够成为竞争优势的源泉。文章回顾了创业营销研究的历程,介绍了创业营销概念的界定、内涵、维度和创业营销所经历的过程,并对国外学者已经取得的成果加以评述,最后指出现有研究的不足和未来研究的展望。

关键词：创业创业型经济创业营销