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Sex-dependent alterations in extracellular vesicles linking chronic spinal cord injury to brain neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第2期20卷 483-484页

作者： Yun Li Junfang wu Department of Anesthesiology&Shock Trauma and Anesthesiology Research(STAR)CenterUniversity of Maryland School of MedicineBaltimoreMDUSA

Traumatic spinal cord injury(SCI)is a devastating exogenous injury with long-lasting consequences and a leading cause of death and disability *** in assistive technology,rehabilitative interventions,and the ability to identify and intervene in secondary conditions have significantly increased the long-term survival rate of SCI patients,with some people even living well into their seventh or eighth *** survival changes have led neurotrauma researchers to examine how SCI interacts with brain *** health and epidemiological data showed that patients with long-term SCI can have a lower life expectancy and quality of life,along with a higher risk of comorbidities and complications.

关键词： alterations inflammation injury

Ultrasonic beam steering using Neumann boundary condition in multiplysics

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Acta Mechanica Sinica 2012年第1期28卷 146-150页

作者： Zhao-guo Qiu bin wu Cun-Fu He College of Mechanical Engineeringand Applied Electronics Technology Beijing University of Technology100124 BeijingChina

The traditional one-dimensional ultrasonic beam steering has time delay and is thus a complicated problem. A numerical model of ultrasonic beam steering using Neumann boundary condition in multiplysics is presented in the present paper. This model is based on the discrete wave number method that has been proved theoretically to satisfy the continuous conditions. The propagating angle of novel model is a function of the distance instead of the time domain. The propagating wave fronts at desired angles are simulated with the single line sources for plane wave. The result indicates that any beam angle can be steered by discrete line elements resources without any time delay.

关键词： Ultrasonic beam steering Desired angle Line element Time delay

Ammonia pyrolysis oxidation excited by nanosecond pulsed discharge:Global/fluid models hybrid solution

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Journal of Energy Chemistry 2025年第1期100卷 385-396页

作者： Mingming Zhang Hanyu wu Qi Chen Jiaxin Yang Bonan Liu School of Mechanical Electronic and Control Engineering Beijing Jiaotong University China University of Petroleum

The kinetic characteristics of plasma-assisted oxidative pyrolysis of ammonia are studied by using the global/fluid models hybrid solution ***,the stable products of plasma-assisted oxidative pyrolysis of ammonia are *** results show that the consumption of NH3/O2and the production of N2/H2change linearly with the increase of voltage,which indicates the decoupling of nonequilibrium molecular excitation and oxidative pyrolysis of ammonia at low ***,the detailed reaction kinetics mechanism of ammonia oxidative pyrolysis stimulated by a nanosecond pulse voltage at low pressure and room temperature is *** on the reaction path analysis,the simplified mechanism is *** detailed and simplified mechanism simulation results are compared with experimental data to verify the accuracy of the simplified ***,based on the simplified mechanism,the fluid model of ammonia oxidative pyrolysis stimulated by the nanosecond pulse plasma is established to study the pre-sheath/sheath behavior and the resultant consumption and formation of key *** results show that the generation,development,and propagation of the pre-sheath have a great influence on the formation and consumption of *** consumption of NH3by the cathode pre-sheath is greater than that by the anode pre-sheath,but the opposite is true for OH and O（1S）.However,within the sheath,almost all reactions do not ***,by changing the parameters of nanosecond pulse power supply voltage,it is found that the electron number density,electron current density,and applied peak voltages are not the direct reasons for the structural changes of the sheath and ***,the discharge interval has little effect on the sheath structure and gas mixture *** research results of this paper not only help to understand the kinetic promotion of non-equilibrium excitation in the process of oxidative pyrolysis but also help to explore th

关键词： Nanosecond pulsed discharge Ammonia Oxidative pyrolysis Fluid model Global model

Dose rate effects on shape memory epoxy resin during 1 Me V electron irradiation in air

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Journal of Materials Science & Technology 2021年第8期67卷 61-69页

作者： Longyan Hou Yiyong wu Debin Shan bin guo Yingying Zong State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001China National Key Laboratory of Materials Behavior and Evaluation Technology in Space Environments Harbin Institute of TechnologyHarbin 150001China

The effects of 1 Me V electron irradiation in air at a fixed accumulated dose and dose rates of 393.8,196.9,78.8,and 39.4 Gy s^(-1)on a shape memory epoxy(SMEP)resin were *** low-dose-rate irradiation,accelerated degradation of the shape memory performance was observed;specifically,the shape recovery ratio decreased exponentially with increasing irradiation time(that is,with decreasing dose rate).In addition,the glass transition temperature of the SMEP,as measured by dynamic mechanical analysis,decreased overall with decreasing dose *** dose rate effects of 1 Me V electron irradiation on the SMEP were confirmed by structural analysis using electron paramagnetic resonance(EPR)spectroscopy and Fourier transform infrared(FTIR)*** EPR spectra showed that the concentration of free radicals increased exponentially with increasing irradiation ***,the FTIR spectra showed higher intensities of the peaks at 1660 and 1720 cm^(-1),which are attributed to stretching vibrations of amide C=O and ketone/acid C=O,at lower dose *** intensities of the IR peaks at 1660 and 1720 cm^(-1) increased exponentially with increasing irradiation time,and the relative intensity of the IR peak at 2926 cm^(-1)decreased exponentially with increasing irradiation *** solid-state13 C nuclear magnetic resonance(NMR)spectra of the SMEP before and after 1 Me V electron irradiation at a dose of 1970 k Gy and a dose rate of 78.8 Gy s^(-1) indicated damage to the CH_(2)–N groups and aliphatic isopropanol *** result is consistent with the detection of nitrogenous free radicals,a phenoxy-type free radical,and several types of pyrolytic carbon radicals by *** the subsequent propagation process,the free radicals produced at lower dose rates were more likely to react with oxygen,which was present at higher concentrations,and form the more destructive peroxy free radicals and oxidation products such as acids,amides,and *** increase in peroxy

关键词： Shape memory epoxy resin Shape memory effect Electron irradiation Dose rate effect Free radical Chain scission

Neutrino Mass from a Higher-Dimensional Operator

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Chinese Physics Letters 2011年第6期28卷 78-81页

作者： NING guo-Zhu wu Yuan-bin School of Physics Nankai UniversityTianjin 300071

We calculate the neutrino mass induced at one loop in the cascade seesaw *** ratio between the two neutrino masses,which are respectively generated from an operator of mass dimension(3+4n)occurring at one loop and an operator of dimension(5+4n)at tree level,is also *** studies show that a relatively low new physics scale could accommodate the tiny neutrino mass of desired order without demanding small *** also find that the ratio will reach order one when the new physics scale is higher than several TeV and n is *** this case,the contribution to neutrino mass from higher order quantum effects becomes important and cannot be ignored.

关键词： mechanism dimension operator

Synthesis and Crystal Structure of a Co(II) Complex with Schiff Base and Imidazole Ligand

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Chinese Journal of Structural Chemistry 2006年第5期25卷 567-571页

作者： wu Lian-bin HU Zi-Qiang LAI guo-Qiao Key Laboratory of Organosilicon Chemistry and Material Technology of Education Ministry Hangzhou Teachers University Hangzhou 310012 China

The title compound, [Co（C3H4N2）2（C22H18N2O4）]·5H2O （Mr = 659.56）, has been prepared and its crystal structure was determined by X-ray diffraction method. The crystal belongs to monoclinic, space group P21/n, a = 9.6808（2）, b = 26.7204（5）, c = 12.7993（3） A, β = 100.9340（10）°, V= 3250.75（12） A^3, Z = 4, Dc = 1.348 g/cm^3,μ = 0.586 mm^-1, F（000） = 1380, S = 1.131, R = 0.0689 and wR = 0.1883 for 4782 observed reflections （Ⅰ 〉 2σ（Ⅰ））. The title crystal consists of Co（Ⅱ） complex and lattice water molecules. The Co（Ⅱ） complex assumes a distorted octahedral coordination geometry, formed by one Schiff base dianion phenylenediamine-3-methoxysali-cylaldehyde and two imidazole ligands. The π-π stacking interaction occurs between nearly parallel benzene rings of the neighboring complexes.

关键词： cobalt(Ⅱ) complex Schiff base crystal structure π-π stacking

Near-infrared brain functional characteristics of mild cognitive impairment with sleep disorders

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World Journal of Psychiatry 2025年第1期15卷 106-116页

作者： Heng Liao Sha Liao Yu-Jiao Gao Xi Wang Li-Hong guo Su Zheng wu Yang Yi-Nan Dai Sleep Psychosomatic Medicine Center Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Integrated Chinese and Western Medicine Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Orthopaedics Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Rehabilitation Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina

BACKGROUND Mild cognitive impairment(MCI)has a high risk of progression to Alzheimer’s *** disease is often accompanied by sleep disorders,and whether sleep disorders have an effect on brain function in patients with MCI is *** To explore the near-infrared brain function characteristics of MCI with sleep *** A total of 120 patients with MCI(MCI group)and 50 healthy subjects(control group)were *** subjects underwent the functional near-infrared spec-troscopy *** baseline data,Mini-Mental State Examination,Montreal Cognitive Assessment scale,fatigue severity scale(FSS)score,sleep parameter,and oxyhemoglobin(Oxy-Hb)concentration and peak time of functional near-infrared spectroscopy test during the task *** relationship between Oxy-RESULTS Compared with the control group,the FSS score of the MCI group was higher(t=11.310),and the scores of Pittsburgh sleep quality index,sleep time,sleep efficiency,nocturnal sleep disturbance,and daytime dysfunction were higher(Z=-10.518,-10.368,-9.035,-10.661,-10.088).Subjective sleep quality and total sleep time scores were lower(Z=-11.592,-9.924).The sleep efficiency of the MCI group was lower,and the awakening frequency,rem sleep latency period,total sleep time,and oxygen desaturation index were higher(t=5.969,5.829,2.887,3.003,5.937).The Oxy-Hb concentration at T0,T1,and T2 in the MCI group was lower(t=14.940,11.280,5.721),and the peak time was higher(t=18.800,13.350,9.827).In MCI patients,the concentration of Oxy-Hb during T0 was negatively correlated with the scores of Pittsburgh sleep quality index,sleep time,total sleep time,and sleep efficiency(r=-0.611,-0.388,-0.563,-0.356).It was positively correlated with sleep efficiency and total sleep time(r=0.754,0.650),and negatively correlated with oxygen desaturation index(r=-0.561)and FSS score(r=-0.526).All comparisons were P<*** Patients with MCI and sleep disorders have lower near-infrared brain function than norm

关键词： Mild Cognitive impairment Sleep disorders Near-infrared Brain functional Characteristics

Clay mineralogy of an Eocene fluvial-lacustrine sequence in Xining Basin, Northwest China, and its paleoclimatic implications

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Science China Earth Sciences 2019年第3期62卷 571-584页

作者： bin HU Chunxia ZHANG Haibin wu Qingzhen HAO Zhengtang guo Key Laboratory of Cenozoic Geology and Environment Institute of Geology and Geophysics Chinese Academy of Sciences Institution of Earth Science Chinese Academy of Science College of Earth Science and Engineering Shandong University of Science and Technology CAS Center for Excellence in Life and Paleoenvironment University of Chinese Academy of Sciences

The Eocene was marked by significant cooling during which the global climate was transformed from greenhouse to icehouse conditions. Notable coeval events were the India-Asia collision and the retreat of the Paratethys Sea in Asia. The Eocene section of the long and continuous sedimentary succession of the Xining Basin in Northwest China is characterized by red mudstones with intercalated gypsum and muddy-gypsiferous layers. In this study, we conducted a semi-quantitative analysis of the mineralogy of bulk samples and the clay fraction using X-ray diffraction, with the aim of characterizing the Eocene climatic evolution of the northeastern margin of the Tibetan Plateau and inland Asia. We used a new pretreatment method to address the problem of extracting sufficient clay particles from the gypsum and gypsiferous layers. The bulk mineralogy is dominated by quartz, feldspar, calcite, gypsum and dolomite; and the clay mineralogy is dominated by illite, chlorite, and smectite(including irregular mixed-layer illite-smectite(I/S)). The variations of the clay mineral assemblages indicate the occurrence of alternations between warm humid conditions and hot dry conditions, with relatively high humidity during ～52–50,～41.5–39 and ～35–34 Ma. Comparison of the results with the timing of Tibetan Plateau uplift, transgressions and regressions of the Paratethys Sea, and the marine oxygen isotope record suggest that the Eocene climatic evolution of the study region was driven fundamentally by global climate change.

关键词： Eocene Xining Basin Clay minerals Paleoclimate

Footprints of axion-like particle in pulsar timing array data and James Webb Space Telescope observations

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Science China(Physics,Mechanics & Astronomy) 2024年第11期67卷 55-62页

作者： Shu-Yuan guo Maxim Khlopov Xuewen Liu Lei wu Yongcheng wu bin Zhu Department of Physics Yantai UniversityYantai 264005 China Institute of Physics Southern Federal UniversityRostov on Don 344090 Russia National Research Nuclear University MEPhI(Moscow Engineering Physics Institute) Moscow 115409 Russia Virtual Institute of Astroparticle Physics Paris 75018 France Department of Physics and Institute of Theoretical Physics Nanjing Normal UniversityNanjing 210023 China

Several pulsar timing array(PTA) collaborations have recently reported the evidence for a stochastic gravitational-wave background(SGWB), which can unveil the formation of primordial seeds of inhomogeneities in the early universe. With the SGWB parameters inferred from PTAs data, we can make a prediction of the seeds for early galaxy formation from the domain walls in the axion-like particles(ALPs) field distribution. This also naturally provides a solution to the observation of high redshifts by the James Webb Space Telescope. The predicted photon coupling of the ALP is within the reach of future experimental searches.

关键词： stochastic gravitational-wave background pulsar timing array axion-like particle JWST