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World Journal of Gastroenterology 2022年第40期28卷 5784-5800页

作者： guo-Qing yin Ke-Ping Chen Xiao-Chun Gu Center of Hepatology Zhong-Da HospitalSoutheast UniversityNanjing 210009Jiangsu ProvinceChina

Hepatitis B virus(HBV)infection is a global public health ***-α(IFN-α)treatment has been used to treat hepatitis B for over 20 years,but fewer than 5%of Asians receiving IFN-αtreatment achieve functional ***,IFN-αretreatment has been introduced to enhance antiviral *** recent years,immune-related studies have found that the complex interactions between immune cells and cytokines could modulate immune response networks,including both innate and adaptive immunity,triggering immune responses that control HBV ***,heterogeneity of the immune system to control HBV infection,particularly HBV-specific CD8^(+)T cell heterogeneity,has consequential effects on T cell-based immunotherapy for treating HBV ***,the host’s genetic variants,negative-feedback regulators and HBV components affecting the immune system's ability to control *** this study,we reviewed the literature on potential immune mechanisms affecting the immune control of HBV and the clinical effects of IFN-αtreatment and retreatment.

关键词： Hepatitis B virus Chronic Functional cure Heterogeneity Immunity Immune control Interferon-α Retreatment

Molecular Cloning, and Characterization of an Adenylyl Cyclase-Associated Protein from Gossypium arboreum L.

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Agricultural Sciences in China 2009年第7期8卷 777-783页

作者： WANG Sheng ZHAO guo-hong JIA yin-hua DU Xiong-ming Cotton Germplasm Division Cotton Research Institute Chinese Academy of Agricultural Sciences Anyang 455000 P.R.China

The aim of this study was to clone CAP （adenylyl cyclase-associated protein） gene from Gossypium arboreum L. and develop a platform for expressing and purifying CAP protein, which is a base for the construction and function researches of CAP. In this work, a CAP homolog from cotton （DPL971） ovule was identified and cloned. And the cDNA sequence consisted of an open reading frame of 1 416 nucleotides encoding a protein of 471 amino acid residues with a calculated molecular weight of 50.6 kDa. To gain insight on the CAP role in cotton fiber development, the cloned CAP cDNA was expressed. A significant higher yield pure protein was obtained with the chromatographic method. Further experiments showed that the purified protein can bind with the actin in vitro indicating that the recombinant cotton CAP is functional. The procedure described here produced high yield pure protein through one chromatographic step, suitable for further structure-function studies.

关键词： adenylyl cyclase-associated protein CAP cotton fiber protein expression protein purification Gossypiumarboreum L.

Swarm Intelligence Research:From Bio-inspired Single-population Swarm Intelligence to Human-machine Hybrid Swarm Intelligence

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Machine Intelligence Research 2023年第1期20卷 121-144页

作者： guo-yin Wang Dong-Dong Cheng De-You Xia Hai-Huan Jiang Chongqing Key Laboratory of Computational Intelligence Chongqing University of Posts and TelecommunicationsChongqing 400065China College of Big Data and Intelligent Engineering Yangtze Normal UniversityChongqing 408100China

Swarm intelligence has become a hot research field of artificial *** the importance of swarm intelli-gence for the future development of artificial intelligence,we discuss and analyze swarm intelligence from a broader and deeper *** a broader sense,we are talking about not only bio-inspired swarm intelligence,but also human-machine hybrid swarm *** a deeper sense,we discuss the research using a three-layer hierarchy:in the first layer,we divide the research of swarm intelli-gence into bio-inspired swarm intelligence and human-machine hybrid swarm intelligence;in the second layer,the bio-inspired swarm intelligence is divided into single-population swarm intelligence and multi-population swarm intelligence;and in the third layer,we re-view single-population,multi-population and human-machine hybrid models from different ***-population swarm intel-ligence is inspired by biological *** further solve complex optimization problems,researchers have made preliminary explor-ations in multi-population swarm ***,it is difficult for bio-inspired swarm intelligence to realize dynamic cognitive in-telligent behavior that meets the needs of human *** have introduced human intelligence into computing systems and proposed human-machine hybrid swarm *** addition to single-population swarm intelligence,we thoroughly review multi-population and human-machine hybrid swarm intelligence in this *** also discuss the applications of swarm intelligence in optimization,big data analysis,unmanned systems and other ***,we discuss future research directions and key issues to be studied in swarm intelligence.

关键词： Swarm intelligence single-population multi-population human-machine hybrid multi-granularity

Functionalized Metal-organic Frameworks for White Light Emission and Highly Sensitive Sensing of PA and Fe^(3+)/Al^(3+)

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Chinese Journal of Structural Chemistry 2022年第3期41卷 30-39,I0007页

作者： HUANG Jing-Jing ZHAO Dan yin guo-Jie Luoyang Institute of Science and Technology Luoyang 471023China

Three isomorphic Ln-MOFs[Ln(bcbob)(H_(2)O)(DMF)](Ln=Tb for 1,Eu for 2,Gd for 3;DMF=N,N-dimethylformamide)have been constructed from a semi-rigid V-shaped organic linker 3,5-bis((4'-carboxyl-benzyl)oxy)benzoilate acid(H3bcbob)under solvothermal conditions.X-ray single-crystal diffraction analysis re-veals that they exhibit a two-dimensional(2D)layered *** 1~3 show the characteristic green and red emissions of Ln^(3+)and blue emission arising from the organic ligand,*** on their photo-luminescence properties,the white-light emitting materials 4 and 5 with longer fluorescence lifetime(ms grade)and higher quantum yield(e.g.40.61%for 4)are ***,1 exhibits good sensing ability on ni-troaromatic compounds,especially for picric acid(PA).In addition,1 is still a highly selective sensing material for Fe^(3+)and Al^(3+).

关键词： lanthanide organic frameworks aromatic carboxylic acid fluorescence doping chemical sensingdiiron

Differential gene expression profile in ischemic myo-cardium of Wistar rats with acute myocardial infarction

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Chinese Science Bulletin 2008年第16期53卷 2488-2495页

作者： guo ChunYu yin HuiJun JIANG YueRong XUE Mei SHI DaZhuo Cardiovascular Center Xiyuan Hospital of Chinese Academy of Medical Sciences Beijing 100091 China

To determine the differential genes in ischemic myocardium of Wistar rats with acute myocardial in- farction (AMI), we constructed two differential gene expression profiles. AMI model was generated by ligation of the left anterior descending coronary artery in Wistar rats. Total RNA was extracted from the normal and the ischemic heart tissues under the ligation point at the 8th day after the operation. Dif- ferential gene expression profiles of the two samples were constructed by using long serial analysis of gene expression (LongSAGE). Real time fluorescence quantitative PCR (Q-PCR) was used to confirm the expression changes of partial target genes. The main results were as follows: a total of 15966 tags were screened from the normal and the ischemic LongSAGE maps, and 9646 tags in the normal tissue and 9563 tags in the ischemic tissue were obtained. Among them, 7665 novel tags were identified by NCBI BLAST search. In the ischemic tissue, 142 genes significantly changed compared to those in the normal tissue (P<0.05). These differentially expressed genes may play important roles in the pathways of oxidation and phosphorylation, ATP synthesis and glycolysis and so on. Partial genes identified by the LongSAGE were confirmed by Q-PCR. The results show that AMI causes a series of gene expres- sion changes in the regulation of the pathways related to energy metabolism.

关键词：微分函数基因表达心肌膜急性心肌梗死

Synthesis and cercaricidal activities of a serial of novel self-diffused cercaricides derived from niphensamide

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Chinese Chemical Letters 2008年第4期19卷 406-408页

作者： Wei guo Lv yin Zheng Yong Quan Wu Xiao Lin Fan Key Laboratory of Organo-pharmaceutical Chemistry of Jiangxi Province Gannan Normal UniversityGanzhou 341000China

A serial of novel cercaricides that can self-diffuse on the water surface were designed and synthesized according to the special habit of cercariae *** compounds were derived from *** the compounds were dropped on the surface of water,the liquor diffused along the air-water interface and formed thin membranes floating on the water surface *** strong cercaricidal activities against the cereariae larvae of Schistosome japonicum of these compounds have been revealed by further experiments.

关键词： Niphensamide Self-diffused cercaricide Cercariae larvae

Bandgaps of the Chalcogenide Glass Hollow-Core Photonic Crystal Fiber

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Chinese Physics Letters 2011年第11期28卷 113-116页

作者： LI Shu-Guang ZHOU Hong-Song yin guo-Bing Key Laboratory of Metastable Materials Science and Technology College of ScienceYanshan UniversityQinhuangdao 066004

Bandgaps of chalcogenide glass hollow-core photonic crystal fibers(GLS HC-PCFs)are analyzed by using the plane-wave expansion method.A mid-infrared laser can propagate in these low confinement loss fibers when the wavelength falls into the *** enlarging the bandgap width,an improved GLS HC-PCF is put forward,the normalized frequency𝑘Λof the improved fiber is from 7.2 to 8.5 in its first *** improved GLS HC-PCF with pitch of 4.2μm can transmit the lights with wavelengths ranging from 3.1m to 3.7μm.

关键词： fiber Crystal fibers

Length optimization of straight line connecting turnout on main line in high-speed railway station yard

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Journal of Central South University 2017年第5期24卷 1111-1120页

作者： yin guo-dong SHI Jin WEI Qing-chao LAI Lin School of Civil Engineering Beijing Jiaotong UniversityBeijing 100044China China Railway Design Corporation Tianjin 300142China

Taking the development of high-speed railway in China as background, and referring to the dynamic theory and wheel-rail contact mode, dynamic analysis model was established, considering the setting position of straight lines and running conditions of train in high-speed railway station yard. Using the established model, and choosing vehicle lateral acceleration and wheel suspension as the evaluation indexes, dynamic characteristic of vehicle traveling in turnout and adjacent area on main line was analyzed, and effects on travelling safety and stability of train aroused by length variation of straight lines were calculated based on analyzing the damping rules of vibration. The results show that, a certain length of straight lines can alleviate the vibration aroused in turnout and curve(turnout), length of straight lines connecting turnouts in different sections on main line was proposed to meet the demand of traveling stability, and shortening or cancelation of straight line for the scale limitation of station yard has less influence on operation safety of train.

关键词： high-speed railway station yard straight line turnout dynamic theory length optimization

Transcriptomic analysis in Anemone flaccida rhizomes reveals ancillary pathway for triterpene saponins biosynthesis and differential responsiveness to phytohormones

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Chinese Journal of Natural Medicines 2019年第2期17卷 131-144页

作者： MO guo-Yan HUANG Fang FANG yin HAN Lin-Tao Kayla K.Pennerman BU Li-Jing DU Xiao-Wei Joan W.Bennett yin guo-Hua China Key Laboratory of TCM Resource and Prescription Ministry of EducationHubei University of Chinese Medicine Department of Plant Biology and Pathology RutgersThe State University of New Jersey Department of Biology University of New Mexico Department of Pharmacy Heilongjiang University of Chinese Medicine

Anemone flaccida Fr. Schmidt is a perennial medicinal herb that contains pentacyclic triterpenoid saponins as the major bioactive constituents. In China, the rhizomes are used as treatments for a variety of ailments including arthritis. However, yields of the saponins are low, and little is known about the plant's genetic background or phytohormonal responsiveness. Using one-quarter of the 454 pyrosequencing information from the Roche GS FLX Titanium platform, we performed a transcriptomic analysis to identify 157 genes putatively encoding 26 enzymes involved in the synthesis of the bioactive compounds. It was revealed that there are two biosynthetic pathways of triterpene saponins in A. flaccida. One pathway depends on β-amyrin synthase and is similar to that found in other plants. The second, subsidiary("backburner") pathway is catalyzed by camelliol C synthase and yields β-amyrin as minor byproduct. Both pathways used cytochrome P450-dependent monooxygenases(CYPs) and family 1 uridine diphosphate glycosyltransferases(UGTs) to modify the triterpenoid backbone. The expression of CYPs and UGTs were quite different in roots treated with the phytohormones methyl jasmonate, salicylic acid and indole-3-acetic acid. This study provides the first large-scale transcriptional dataset for the biosynthetic pathways of triterpene saponins and their phytohormonal responsiveness in the genus Anemone.

关键词： Anemone flaccida Fr.Schmidt Triterpenoid saponins Biosynthetic pathways Transcriptomic analysis Phytohormonal responsiveness

A new hierarchical software architecture towards safety-critical aspects of a drone system

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Frontiers of Information Technology & Electronic Engineering 2019年第3期20卷 353-362页

作者： Xiao-rui ZHU Chen LIANG Zhen-guo yin Zhong SHAO Meng-qi LIU Hao CHEN Department of Mechanical Engineering and Automation Harbin Institute of Technology (Shenzhen) Department of Computer Science Yale University

A new hierarchical software architecture is proposed to improve the safety and reliability of a safetycritical drone system from the perspective of its source code. The proposed architecture uses formal verification methods to ensure that the implementation of each module satisfies its expected design specification, so that it prevents a drone from crashing due to unexpected software failures. This study builds on top of a formally verified operating system kernel, certified kit operating system(CertiKOS). Since device drivers are considered the most important parts affecting the safety of the drone system, we focus mainly on verifying bus drivers such as the serial peripheral interface and the inter-integrated circuit drivers in a drone system using a rigorous formal verification method. Experiments have been carried out to demonstrate the improvement in reliability in case of device anomalies.

关键词： Safety-critical Drone Software architecture Formal verification