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Effect of Shen-Fu Injection Pretreatment to Myocardial Metabolism During Untreated Ventricular Fibrillation in a Porcine Model

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Chinese Medical Journal 2015年第22期128卷 3076-3082页

作者： Wei Yuan Jun-Yuan Wu guo-xing wang Qian Zhang Chun-Sheng Li Department of Emergency Beijing Chao-Yang Hospital Capital Medical University Beijing Key Laboratory for Cardiopulmonary Resuscitation Beijing 100020 China Department of Emergency Beijing Friendship Hospital Capital Medical University Beijing 100050 China

Background： Shen-Fu injection （SFI） can attenuate ischemia-reperfusion injury, protect cardiac function, and improve microcirculation during cardiopulmonary resuscitation. We hypothesized that SFI may also have an influence on myocardial metabolism during ventrictdar fibrillation （VF）. In this study, we used SFI pretreatment prior to VF to discuss the changes of myocardial metabolism and catecholamine （CA） levels during untreated VF, trying to provide new evidence to the protection of SFI to myocardiurn. Methods： Twenty-four pigs were divided into three groups： Saline group （SA group）, SFI group, and SHAM operation group （SHAM group）. Thirty minutes prior to the induction of VF, the SFI group received 0.24 mg/ml SFI through an intravenous injection： the SA group received an equal amount of sodium chloride solution. The interstitial fluid from the left ventricle （LV） wall was collected through the microdialysis tubes during VF. Adenosine diphosphate （ADP）, adenosine triphosphate （ATP）, and Na^＋-K^＋-ATPase and Ca2^＋-ATPase enzyme activities were measured after untreated VF. Peak-to-trough VF amplitude and median frequency were analyzed for each of these 5-s intervals. Results： The levels of glucose and glutamate were lower after VF in both the SA and SFI groups, compared with baseline, and the levels in the SFI group were higher than those in the SA group. Compared with baseline, the levels of lactate and the lactate/pyruvate ratio increased after VF in both SA and SFI groups, and the levels in the SFI group were lower than those in the SA group. In both the SA and SFI groups, the levers of dopamine, norepinephrine, and epinephrine increased significantly. There were no statistical differences between the two groups. The content of ATE ADE and phosphocreatine in the SF1 group was higher than those in the SA group. The activity ofLV Na^＋-K^＋-ATPase was significantly higher in the SFI group than in the SA group. Amplitude mean spectrum area （AMSA） was significantly lowe

关键词： Cardiac Arrest Catecholamine Energy Metabolism Microdialysis Shen-Fu Injection

Increasing angiotensin-converting enzyme(ACE)2/ACE axes ratio alleviates early pulmonary vascular remodeling in a porcine model of acute pulmonary embolism with cardiac arrest

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World Journal of Emergency Medicine 2022年第3期13卷 208-214页

作者： Hong-li Xiao Lian-xing Zhao Jun Yang Nan Tong Le An guo-xing wang Miao-rong Xie Chun-sheng Li Department of Emergency Medicine Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Emergency Internal Medicine the Affiliated Hospital of Qingdao UniversityQingdao 266000China Department of Emergency Medicine Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100050China

BACKGROUND:Acute pulmonary embolism(APE)with cardiac arrest(CA)is characterized by high mortality in emergency due to pulmonary arterial hypertension(PAH).This study aims to determine whether early pulmonary artery remodeling occurs in PAH caused by massive APE with CA and the protective effects of increasing angiotensin-converting enzyme(ACE)2-angiotensin(Ang)(1-7)-Mas receptor axis and ACE-Ang II-Ang II type 1 receptor(AT1)axis(ACE2/ACE axes)ratio on pulmonary artery lesion after return of spontaneous circulation(ROSC).METHODS:To establish a porcine massive APE with CA model,autologous thrombus was injected into the external jugular vein until mean arterial pressure dropped below 30 mmHg(1 mmHg=0.133 kPa).Cardiopulmonary resuscitation and thrombolysis were delivered to regain spontaneous *** were divided into four groups of five pigs each:control group,APE-CA group,ROSC-saline group,and ROSC-captopril group,to examine the endothelial pathological changes and expression of ACE2/ACE axes in pulmonary artery with or without ***:Histological analysis of samples from the APE-CA and ROSC-saline groups showed that pulmonary arterioles were almost completely occluded by accumulated endothelial *** blotting analysis revealed a decrease in the pulmonary arterial ACE2/ACE axes ratio and increases in angiopoietin-2/angiopoietin-1 ratio and expression of vascular endothelial growth factor(VEGF)in the APE-CA group compared with the control *** significantly suppressed the activation of angiopoietin-2/angiopoietin-1 and VEGF in plexiform lesions formed by proliferative endothelial cells after *** also alleviated endothelial cell apoptosis by increasing the B-cell lymphoma-2(Bcl-2)/Bcl-2-associated X(Bax)ratio and decreasing cleaved caspase-3 ***:Increasing the ACE2/ACE axes ratio may ameliorate pulmonary arterial remodeling by inhibiting the apoptosis and proliferation of endothelial cells after ROSC i

关键词： Acute pulmonary embolism Cardiac arrest Early pulmonary vascular remodeling Angiotensin-converting enzyme

Optimal timing of biliary drainage based on the severity of acute cholangitis:A single-center retrospective cohort study

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World Journal of Gastroenterology 2022年第29期28卷 3934-3945页

作者： Zhao-Qing Lu Han-Yu Zhang Chen-Fen Su Yue-Yan xing guo-xing wang Chun-Sheng Li Department of Emergency Medicine Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Emergency and Critical Care Center Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China

BACKGROUND Biliary decompression is well known to greatly decrease the risks of mortality in acute cholangitis(AC).Although early biliary drainage is recommended by the treatment guidelines for AC,the best time for performing this procedure is yet to be ***,since the clinical outcomes of patients with severe AC vary dramatically,screening for patients that could benefit the most from early drainage would be more beneficial than the drainage performed based on the severity grade *** To investigate the optimal drainage timing for AC patients with each disease severity grade and organ *** In this retrospective monocenter cohort analysis,we reviewed 1305 patients who were diagnosed with AC according to the Tokyo guidelines 2018 at a Chinese tertiary hospital between July 2016 and December *** characteristics including age and sex,clinical and laboratory characteristics,and imaging findings of each patient were obtained from electronic medical *** investigated the all-cause in-hospital mortality(IHM),hospital length of stay(LOS),and hospitalization costs associated with the timing of biliary drainage according to the severity grading and different dysfunctioning organs and predictors[age,white blood cell(WBC)count,total bilirubin,albumin,lactate,malignant obstruction,and Charlton comorbidity index(CCI)].RESULTS Biliary drainage within 24 or 48 h in Grade Ⅲ AC patients could dramatically decrease IHM(3.9%vs 9.0%,P=0.041;4%vs 9.9%,P=0.018,respectively),while increasing LOS and hospitalization *** logistic analysis revealed that neurological,respiratory,renal,and cardiovascular dysfunctions,hypoalbuminemia,and malignant obstruction were significantly associated with IHM(odds ratio=5.32,2.541,6.356,4.021,5.655,and 7.522;P<0.001,P=0.016,P<0.001,P=0.012,P<0.001,and P<0.001;respectively).Biliary decompression performed within 12 h of admission significantly decreased the IHM in AC patients with neur

关键词： Acute cholangitis Endoscopic retrograde cholangiopancreatography Mortality Biliary drainage Organ dysfunction

Collective Movement Simulation:Methods and Applications

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Machine Intelligence Research 2024年第3期21卷 452-480页

作者： Hua wang xing-Yu guo Hao Tao Ming-Liang Xu School of Computer and Artificial Intelligence Zhengzhou UniversityZhengzhou450001China Engineering Research Center of Intelligent Swarm Systems Ministry of EducationZhengzhou450001China National Supercomputing Center in Zhengzhou Zhengzhou450001China China Ship Development and Design Center Wuhan430060China

Collective movement simulations are challenging and important in many areas,including life science,mathematics,physics,information science and public *** this survey,we provide a comprehensive review of the state-of-the-art techniques for collective movement *** start with a discussion on certain concepts to help beginners understand it more ***,we analyze the intelligence among different collective objects and the emphasis in different ***,we classify existing collective movement simulation methods into four categories according to their effects,namely versatility,accuracy,dynamic adaptability,and assessment feedback ***,we introduce five applications of layout optimization,emergency control,dispatching,unmanned systems,and other derivative ***,we summarize possible future research directions.

关键词： Collective movement simulation multiple objects multiple discipline simulation effect collective intelligence

Presepsin as a biomarker for risk stratification for acute cholangitis in emergency department: A single-center study

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World Journal of Clinical Cases 2021年第32期9卷 9857-9868页

作者： Han-Yu Zhang Zhao-Qing Lu guo-xing wang Miao-Rong Xie Chun-Sheng Li Department of Emergency Medicine Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China

BACKGROUND Acute cholangitis is caused by bacterial infection and has high morbidity and mortality *** grade of cholangitis can guide clinical treatment from single antibiotic treatment to biliary *** the introduction of white blood cell(WBC)count,C-reactive protein(CRP),and total bilirubin(T-Bil)into the diagnostic criteria and severity grading for acute cholangitis,the diagnosis rate and grading have significantly ***,early risk stratification assessments are challenging in the emergency ***,we hope to find an ideal predictive biomarker for cholangitis *** is a promising biomarker for the early diagnosis,severity,and prognosis of acute bacterial *** To assess the grading value of presepsin in patients with acute *** This clinical study was conducted at the Beijing Friendship Hospital,a 2000-bed teaching hospital with approximately 200000 emergency admissions per *** this prospective observational study,336 patients with acute cholangitis meeting the Tokyo Guidelines 2018 diagnostic criteria in the emergency department from May 2019 to December 2020 were *** count,CRP,procalcitonin(PCT),presepsin,T-Bil,and blood culture results were *** values were compared using the Pearsonχ2 test,Fisher’s exact test,or Mann-Whitney U *** area under the receiver operating characteristic curve(AUC)of the value was examined using the Delong *** correlations among the key research indicators were determined using Pearson *** In total,336 patients were examined,which included 107,106,and 123 patients classified as having mild,moderate,and severe cholangitis,*** count,CRP,PCT,presepsin,T-Bil,direct bilirubin,and sequential organ failure assessment scores of moderate and severe cholangitis patients were higher than those of mild cholangitis patients(P=0.000).The AUC of presepsin in predicting moderate acute cholangitis was 0.728,which was high

关键词： C-reactive protein Procalcitonin Presepsin Acute cholangitis Risk stratification

Long-term outcomes and independent predictors of mortality in patients presenting to emergency departments with acute heart failure in Beijing:a multicenter cohort study with a 5-year follow-up

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Chinese Medical Journal 2021年第15期134卷 1803-1811页

作者： Yang Li Xiao-Lu Sun Hong Qiu Jian Qin Chun-Sheng Li Xue-Zhong Yu guo-xing wang Yan Fu Ya-An Zheng Bin Zhao Dong-Ming Yu Si-Jia wang guo-Gan wang Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Department of Emergency Xuanwu HospitalCapital Medical UniversityBeijing 100037China Department of Emergency Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China Department of Emergency Peking Union Medical College HospitalBeijing 100730China Department of Emergency Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Emergency Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Emergency Peking University Third HospitalBeijing 100191China Department of Emergency Beijing Jishuitan HospitalBeijing 100035China Department of Emergency Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China

Background:Acute heart failure(AHF)is the most common disease in emergency departments(EDs).However,clinical data exploring the outcomes of patients presenting AHF in EDs are limited,especially the long-term *** purposes of this study were to describe the long-term outcomes of patients with AHF in the EDs and further analyze their prognostic ***:This prospective,multicenter,cohort study consecutively enrolled 3335 patients with AHF who were admitted to EDs of 14 hospitals from Beijing between January 1,2011 and September 23,***-Meier and Cox regression analysis were adopted to evaluate 5-year outcomes and associated ***:The 5-year mortality and cardiovascular death rates were 55.4%and 49.6%,*** median overall survival was 34 *** predictors of 5-year mortality were patient age(hazard ratio[HR]:1.027,95 confidence interval[CI]:1.023-1.030),body mass index(BMI)(HR:0.971,95%CI:0.958-0.983),fatigue(HR:1.127,95%CI:1.009-1.258),ascites(HR:1.190,95%CI:1.057-1.340),hepatic jugular reflux(HR:1.339,95%CI:1.140-1.572),New York Heart Association(NYHA)class III to IV(HR:1.511,95%CI:1.291-1.769),heart rate(HR:1.003,95%CI:1.001-1.005),diastolic blood pressure(DBP)(HR:0.996,95%CI:0.993-0.999),blood urea nitrogen(BUN)(HR:1.014,95%CI:1.008-1.020),B-type natriuretic peptide(BNP)/N-terminal pro-B-type natriuretic peptide(NT-proBNP)level in the third(HR:1.426,95%CI:1.220-1.668)or fourth quartile(HR:1.437,95%CI:1.223-1.690),serum sodium(HR:0.980,95%CI:0.972-0.988),serum albumin(HR:0.981,95%CI:0.971-0.992),ischemic heart diseases(HR:1.195,95%CI:1.073-1.331),primary cardiomyopathy(HR:1.382,95%CI:1.183-1.614),diabetes(HR:1.118,95%CI:1.010-1.237),stroke(HR:1.252,95%CI:1.121-1.397),and the use of diuretics(HR:0.714,95%CI:0.626-0.814),(3-blockers(HR:0.673,95%CI:0.588-0.769),angiotensin-converting enzyme inhibitors(ACEIs)(HR:0.714,95%CI:0.604-0.845),angiotensin-II receptor blockers(ARBs)(HR:0.790,95%CI:0.646-0.965),spironola

关键词： Heart failure Mortality Emergency service

Evolution of microstructure and texture of AZ80 magnesium alloy under hot torsion with constant decreasing temperature rate

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Journal of Magnesium and Alloys 2024年第4期12卷 1619-1637页

作者： Yongbiao Yang Jinxuan guo Cuiying wang Wenxuan Jiang Zhimin Zhang Qiang wang xing Zhang College of Materials Science and Engineering North University of ChinaLane 3Xueyuan RoadTaiyuanShanxi 030051China North Hongyang mechanical and electronic limited company of Henan Province China

Hot torsion tests for AZ80 magnesium alloy were carried out in the temperature range of 380℃-260℃,with a constant decreasing temperature rate of 10℃/s in order to weaken the basal texture and refine the *** results indicated that the average grain sizes were refined forming gradient structure with increasing specimen radial position from center(12.2-5.4μm),and that the initial basal texture intensity of the extruded magnesium alloy was weakened from 46.2 to ***,the extension twins(ETs)could be disintegrated from the twins forming separated twins with smaller ***,ETs with the same twin variant intersecting with each other could be coalesced forming grains with similar orientation,while ETs with different twin variants were separated by twins boundaries contributing to grain ***,in addition to the conventional continuous dynamic recrystallized(CDRX)grains with 30˚orientation rotated around C-axis of the parent grains,CDRXed grains with 30˚rotation around a-axis and random rotation axis were also ***,the CDRX evolution induced twins were also elaborated,exhibiting the complex competition between CDRX and *** torsion deformation with constant decreasing temperatures rate is an effective way of grain refinement and texture modification.

关键词： Texture Microstructure Hot torsion Decreasing temperature AZ80

Boosting charge transfer via interface charge reconstruction between amorphous NiFe-LDH and crystalline NiCo_(2)O_(4)for efficient alkaline water/seawater oxidation

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Nano Research 2024年第6期17卷 4856-4863页

作者： Zhonghang xing Yi Zhao Yunhai wang Xiaohe Liu Zhiqiang guo Qingyun Chen International Research Center for Renewable Energy and State Key Laboratory of Multiphase Flow in Power Engineering Xi’an Jiaotong UniversityXi’an 710049China Department of Environmental Science and Engineering Xi’an Jiaotong UniversityXi’an 710049China China School of Geology and Environment Xi’an University of Science and TechnologyXi’an 710049China Changqing Engineering Design Co. Ltd.Xi’an 710018China

Electrocatalysts with optimal efficiency and durability for the oxygen evolution reaction(OER)are becoming increasingly important as the demand for alkaline water/seawater electrolysis technology ***,a novel rose-shaped NiFe-layered double hydroxide(LDH)/NiCo_(2)O_(4)composed of amorphous wrinkled NiFe-LDH and highly crystalline NiCo_(2)O_(4)was synthesized with rich *** unsaturated metal sites are generated due to significant charge reconstruction at the heterointerface between the crystalline and amorphous *** metal sites could trigger and provide more active *** density functional theory(DFT)reveals that a new charge transfer channel(Co-Fe)was formed at the heterointerface between NiFe-LDH as electron acceptor and NiCo_(2)O_(4)as electron *** new charge transfer channel boosts interfacial charge transfer and enhances catalytic *** NiFe-LDH/NiCo_(2)O_(4)/nickel foam(NF)drives current densities of 10 and 100 mA·cm−2 with overpotentials of 193 and 236 mV,*** composite electrode demonstrates a fast turnover frequency(0.0143 s−1)at 1.45 V ***(RHE=reversible hydrogen electrode),which is 5.5 times greater than pure NiCo_(2)O_(4),suggesting its superior intrinsic ***,NiFe-LDH/NiCo_(2)O_(4)/NF electrode exhibited negligible degradation after 150 h of uninterrupted running in alkaline seawater *** study introduces a method for preparing high-efficiency electrocatalysts utilized in alkaline water/seawater electrolysis.

关键词： NiFe-layered double hydroxide(LDH)/NiCo_(2)O_(4)/nickel foam(NF) heterogeneous interfaces charge reconstruction water/seawater electrolysis

Configuration Synthesis and Grasping Performance Analysis of Multi-Loop Coupling Capture Mechanism for Launch and Recovery of Torpedo-Shaped Autonomous Underwater Vehicle

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China Ocean Engineering 2024年第3期38卷 453-466页

作者： ZHANG guo-xing XIA Xin-lu guo Jin-wei School of Mechanical Engineering Jiangsu University of Science and TechnologyZhenjiang 212100China

Research of capture mechanisms with strong capture adaptability and stable grasp is important to solve the problem of launch and recovery of torpedo-shaped autonomous underwater vehicles(AUVs).A multi-loop coupling capture mechanism with strong adaptability and high retraction rate has been proposed for the launch and recovery of torpedo-shaped AUVs with different morphological ***,the principle of capturing motion retraction is described based on the appearance characteristics of torpedo-shaped AUVs,and the configuration synthesis of the capture mechanism is carried out using the method of constrained chain ***,the screw theory is employed to analyze the degree of freedom(DoF)of the capture ***,the 3D model of the capture mechanism is established,and the kinematics and dynamics simulations are carried *** with the capture orientation requirements of the capture mechanism,the statics and vibration characteristics analyses are carried ***,considering the capture process and the underwater working environment,the motion characteristics and hydraulics characteristics of the capture mechanism are ***,a principle prototype is developed and the torpedo-shaped AUVs capture experiment is *** work provides technical reserves for the research and development of AUV capture special equipment.

关键词： capture mechanism torpedo-shaped AUVs configuration synthesis launch and recovery grasping performance analysis