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Exosomes:the next-generation therapeutic platform for ischemic stroke

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Neural Regeneration Research 2025年第5期20卷 1221-1235页

作者： Wenjing Yin Hongyin Ma Yang Qu Jiaxin Ren Yingying Sun zhen-Ni guo Yi Yang Stroke Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional ***,there is an urgent need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological *** have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain *** physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic *** rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages *** in technology have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction ***,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified *** optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic stroke mesenchymal stem cells microglia neuroprotection stents

Stochastic Generalized Porous Media Equations with Levy Jump

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Acta Mathematica Sinica,English Series 2011年第9期27卷 1671-1696页

作者： guo li ZHOU zhen TingHOU College of Mathematics and Statistics Chongqing University Chongqing 401331 P. R. China and School of Mathematics Central South University Changsha 410075 P. R. China School of Mathematics Central South University Changsha 410075 P. R. China

In this paper, we first prove the existence and uniqueness of a general stochastic differential equation in finite dimension, then extend the result to the infinite dimension by the classical Galerkin method. As an application, we prove the existence and uniqueness of the generalized stochastic porous medium equation perturbed by Levy process.

关键词： Stochastic porous medium equation Levy processes

Moment Method with Wavelet Expansions for Fractal Rough Surface Scattering

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Chinese Physics Letters 2002年第11期19卷 1617-1620页

作者： guo li-Xin Wu zhen-Sen School of Science Xidian University Xi'an 710071

We study the moment method (MM) to deal with Harr wavelet basis due to the problem of electromagnetic scattering from the fractal rough surface. The vanishing moment properties and the capability of the wavelets to adjust themselves to the fractal surface lead to a sparse impedance matrix and faster computation. Compared to the measured data and the conventional MM, the result shows that the wavelet basis functions provide substantial reductions in both memory requirements and computation time.

关键词： Method of moments

For Mega-Constellations: Edge Computing and Safety Management Based on Blockchain Technology

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China Communications 2024年第2期21卷 59-73页

作者： zhen Zhang Bing guo Chengjie li College of Computer Science Sichuan UniversityChengdu 610064China The Key Laboratory for Computer Systems of State Ethnic Affairs Commission School of Computer Science and TechnologySouthwest Minzu UniversityChengdu 610225China National Key Laboratory of Science and Technology on Communications University of Electronic Science and Technology of ChinaChengdu 611731China

In mega-constellation Communication Systems, efficient routing algorithms and data transmission technologies are employed to ensure fast and reliable data transfer. However, the limited computational resources of satellites necessitate the use of edge computing to enhance secure *** edge computing reduces the burden on cloud computing, it introduces security and reliability challenges in open satellite communication channels. To address these challenges, we propose a blockchain architecture specifically designed for edge computing in mega-constellation communication systems. This architecture narrows down the consensus scope of the blockchain to meet the requirements of edge computing while ensuring comprehensive log storage across the network. Additionally, we introduce a reputation management mechanism for nodes within the blockchain, evaluating their trustworthiness, workload, and efficiency. Nodes with higher reputation scores are selected to participate in tasks and are appropriately incentivized. Simulation results demonstrate that our approach achieves a task result reliability of 95% while improving computational speed.

关键词： blockchain consensus mechanism edge computing mega-constellation reputation management

Efficient Knowledge Graph Embedding Training Framework with Multiple GPUs

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Tsinghua Science and Technology 2023年第1期28卷 167-175页

作者： Ding Sun zhen Huang Dongsheng li Min guo College of Computer National University of Defense TechnologyChangsha 410073China

When training a large-scale knowledge graph embedding(KGE)model with multiple graphics processing units(GPUs),the partition-based method is necessary for parallel ***,existing partition-based training methods suffer from low GPU utilization and high input/output(IO)overhead between the memory and *** a high IO overhead between the disk and memory problem,we optimized the twice partitioning with fine-grained GPU scheduling to reduce the IO overhead between the CPU memory and *** low GPU utilization caused by the GPU load imbalance problem,we proposed balanced partitioning and dynamic scheduling methods to accelerate the training speed in different *** the above methods,we proposed fine-grained partitioning KGE,an efficient KGE training framework with multiple *** conducted experiments on some benchmarks of the knowledge graph,and the results show that our method achieves speedup compared to existing framework on the training of KGE.

关键词： knowledge graph embedding parallel algorithm partitioning graph framework graphics processing unit(GPU)

Deformation and stability of the seawall,considering the strength uncertainty of cement mixing piles

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第6期25卷 483-501页

作者： Yuansheng YU lingling li Xiangmiao KONG Chengyuan li zhen guo Key Laboratory of Offshore Geotechnics and Material of Zhejiang Province College of Civil Engineering and ArchitectureZhejiang UniversityHangzhou310058China Hainan Institute Zhejiang UniversitySanya572000China Ninghai Highway and Transportation Management Center Ningbo315600China Ninghai Traffic Engineering Construction Management Institute Ningbo315600China

The cement mixing (CM) pile is a common method of improving soft offshore ground. The strength growth of CM piles under complex conditions is affected by many factors, especially the cement and moisture contents, and shows significant uncertainty. To investigate the stochasticity of the early strength of CM piles and its impact on the displacement and stability of a seawall, a series of laboratory tests and numerical analyses were carried out in this study. Vane shear tests were conducted on the cement-solidified soil to determine the relationships between the undrained shear strength s_(u) of the cement soil curing in the seawater and the cement content a_(c), as well as the in situ soil moisture content w. It can be inferred that the 24 h undrained shear strength follows a normal distribution. A numerical model considering the random CM pile strength was established to investigate the deformation of the seawall. Due to the uncertainty of CM pile strength, the displacement of the seawall demonstrates a certain discreteness. The decrease of the mean undrained shear strength of CM piles causes a corresponding increase in the average displacement of the seawall. When the mean strength of CM piles is lower than a certain threshold, there is a risk of instability. Furthermore, the heterogeneity of the strength within an individual CM pile also has an impact on seawall displacement. Attention should be paid to the uncertainty of CM pile strength to control displacement and stability.

关键词： Construction uncertainty Cement mixing(CM)pile Strength of cement soil Seawall stability Random finite element method(RFEM) Monte Carlo simulation(MCS)

The Ergodicity of Stochastic Partial Differential Equations with Levy Jump

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Acta Mathematica Sinica,English Series 2011年第12期27卷 2415-2436页

作者： guo li ZHOU zhen Ting HOU College of Mathematics and Statistics Chongqing University Chongqing 401331 P. R. China School of Mathematics Central South University Changsha 410075 P. R. China

In this article, the authors prove the uniqueness in law of a class of stochastic equations in infinite dimension, then we apply it to establish the existence and uniqueness of invariant measure of the generalized sto... 详细信息

关键词： Stochastic partial differential equation Levy processes

Phylogenomic analyses reveal intractable evolutionary history of a temperate bamboo genus (Poaceae: Bambusoideae)

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Plant Diversity 2019年第4期41卷 213-219页

作者： Cen guo zhen-Hua guo De-Zhu li Germplasm Bank of Wild Species Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan650201China Kunming College of life Science University of Chinese Academy of SciencesKunmingYunnan650201China

Shibataea is a genus of temperate bamboos(Poaceae:Bambusoideae)endemic to China,but little is known about its phylogenetic position and interspecific *** elucidate the phylogenetic relationship of the bamboo genus Shibataea,we performed genome-scale phylogenetic analysis of all seven species and one variety of the genus using double digest restriction-site associated DNA sequencing(dd RAD-seq)and whole plastid genomes generated using genome *** phylogenomic analyses based on dd RAD-seq and plastome data congruently recovered Shibataea as *** nuclear data resolved *** as the earliest diverged species,followed by ***,while the rest of Shibataea can be further divided into two ***,the plastid and nuclear topologies conflict *** comparing the results of network analysis and topologies reconstructed from different datasets,we identify *** as the most admixed species,which may be caused by incomplete lineage sorting(ILS)or interspecific gene flow with four sympatric *** study highlights the power of dd RAD and plastome data in resolving complex relationships in the intractable bamboo genus.

关键词： Shibataea ddRAD-seq Genome skimming Phylogeny Incongruence

Influence of relative phase on the nonsequential double ionization process of CO_(2) molecules by counter-rotating two-color circularly polarized laser fields

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Communications in Theoretical Physics 2021年第7期73卷 121-126页

作者： Mian Peng li-Hua Bai zhen guo Department of Physics College of SciencesShanghai UniversityShanghai 200444China

We investigate the nonsequential double ionization(NSDI) of linear triatomic molecules by the counter-rotating two-color circularly polarized(CRTC) laser fields with a classical ensemble method. The results of the simulation reveal that NSDI yield strongly connected with the relative phase. The trajectory tracking method shows that the return time of the electron is controlled by the relative phase. In addition, when we change the CRTC laser wavelengths, the relative phase of the maximum and minimum yield of NSDI also changes. This shows that the influence of the Coulomb potential in the triatomic molecules on the electron return process cannot be ignored. This work will effectively promote the electronic dynamics study of NSDI for the triatomic molecule.

关键词： linear triatomic molecules relative phase two-color laser fields nonsequential double ionization