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MicroRNA调节免疫性血小板减少症CD4^(+)T细胞亚群免疫功能的研究进展

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中国免疫学杂志 2024年第3期40卷 663-667页

作者：宋辉郭一慧许家威曾清程纬民广西中医药大学研究生院南宁530222 广西中医药大学第一附属医院血液内科南宁530023

MicroRNA(miRNA)是一种小分子非编码单链RNA,可广泛参与多种生物学过程,对调节机体的免疫功能具有重要作用。免疫性血小板减少症(ITP)是一种自身免疫性疾病,其发生和进展与miRNA介导CD4^(+)T细胞亚群的异常免疫调节密切相关。ITP患者mi... 详细信息

MicroRNA(miRNA)是一种小分子非编码单链RNA,可广泛参与多种生物学过程,对调节机体的免疫功能具有重要作用。免疫性血小板减少症(ITP)是一种自身免疫性疾病,其发生和进展与miRNA介导CD4^(+)T细胞亚群的异常免疫调节密切相关。ITP患者miRNA的不同表达情况可影响CD4^(+)T细胞亚群的免疫功能,导致Th1/Th2、Th17/Treg的调节失衡和TFH的过度分化,引起细胞因子分泌异常。本文就ITP中miRNA介导的CD4^(+)T细胞亚群免疫功能失衡机制进行总结,以期为探索ITP的免疫机制和免疫治疗提供启发。

关键词： MicroRNA 免疫性血小板减少症 CD4^(+)T细胞亚群

西非Termit盆地石油地质特征及成藏主控因素

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西北地质 2024年第3期57卷 223-236页

作者：陈长伟汤戈周博宇苏俊青郭怡辉滑双君葛维中国石油大港油田公司勘探开发研究院天津300280 中国石油工程技术研究有限公司天津300450 天津中油渤星工程科技有限公司天津300450

西非Termit盆地是中国石油在非洲极为重要的勘探开发区块。在充分利用钻井、分析化验和地震资料基础上,开展了Termit盆地石油地质特征和成藏主控因素研究,研究表明:①Ter-mit盆地历经前裂谷期、同裂谷期、后裂谷期三大构造演化阶段,同... 详细信息

西非Termit盆地是中国石油在非洲极为重要的勘探开发区块。在充分利用钻井、分析化验和地震资料基础上,开展了Termit盆地石油地质特征和成藏主控因素研究,研究表明:①Ter-mit盆地历经前裂谷期、同裂谷期、后裂谷期三大构造演化阶段,同裂谷期发育早晚两期裂谷作用形成中生代—新生代叠置裂谷盆地,宏观具有“东西分带、南北分块”的构造结构特征,控制圈闭的形成与分布。②发育上白垩统Yogou组分布广(18000 km^(2))、厚度大(600~1400 m)、成熟度适中(Ro值为0.7%~1.3%)的海相烃源岩,配置上白垩统Yogou组顶部发育的海相三角洲、古近系Sokor1组辫状河三角洲砂体,及古近系Sokor2组区域性分布的泥岩盖层,形成了上、下两套成藏组合;③明确古近系、白垩系成藏主控因素,古近系为“下生上储”的次生油气藏,油气平面和垂向分布受生烃灶、区域盖层、油源断层和优势沉积相控制,白垩系为“自生自储”原生油藏,油气富集受区域构造活动强度和白垩系内幕构造控制。④构建了基于海相广覆式烃源岩的跨世代油气成藏模式,明确Dinga断阶带、Fana凸起和Araga地堑是古近系油气勘探的有利区带,造活动相对较弱的Moul凹陷及Dinga断阶带南部是白垩系油气勘探的有利区带。地质认识指导勘探部署,在尼日尔Termit盆地获得了重大勘探突破,累计探明石油地质储量超7亿t,为中国石油海外油气增储上产奠定了坚实的基础。

关键词：石油地质 Termit盆地地质特征主控因素油气富集

Microstructure, martensitic transformation and shape memory effect of polycrystalline Cu-Al-Mn-Fe alloys

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Science China(Technological Sciences) 2021年第2期64卷 400-406页

作者： YANG ShuiYuan HONG Shen LI MingPei QING XinYu guo LiPeng guo yihui WANG CuiPing LIU XingJun College of Materials of Xiamen University Shenzhen Research Institute of Xiamen UniversityXiamen 361005China Fujian Key Laboratory of Materials Genome Xiamen UniversityXiamen 361005China State Key Laboratory of Advanced Welding and Joining Harbin Institute of Technology(Shenzhen)Shenzhen 518055China

In this study, two Cu-Al-Mn-Fe polycrystalline alloys were prepared, and their microstructure, reversible martensitic transformation, mechanical properties and shape memory effects were investigated. The results show that the reversible martensitic transformation temperatures of the studied alloys are between room temperature and 373 K, which are suitable for practical applications. Two typed martensites of 18R and 2H coexist both in two alloys. The bcc β(FeAl) nanoparticles are Fe-rich, Mnrich and Cu-poor, whereas the martensite is Cu-rich, Fe-poor and Mn-poor. The size of nanoparticles ranges from tens to hundreds of nanometers. Full shape recovery property is displayed in Cu-12.9Al-4.5Mn-2.6Fe alloy all the time while applying different deformation from 5% to 8%. The maximum recoverable strain is up to 4.4% with a recovery rate of 100%.

关键词： shape memory alloy microstructure nanoparticles transmission electron microscopy martensitic transformation shape memory effect

Tensile Properties and Microstructure of DS NiAl-28Cr-5.8Mo-0.2Hf Alloy

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Journal of Materials Science & Technology 2002年第2期18卷 181-184页

作者： Chuanyong CUI, Jianting guo, yihui QI and Hengqiang YEInstitute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China [ Manuscript received March 12, 2001, in revised form April 6, 2001] Inst. of Metal Res. Chinese Acad. of Sci. Shenyang 110016 China

A multiphase alloy NiAI-28Cr-5.8Mo-0.2Hf was directionally solidified in Ar atmosphere in an Al2O3-SiC2 mold by standard Bridgman method. The fracture toughness and tensile properties at 980℃ as well as tensile creep at 1050℃ were studied. It was found that the strength of the present alloy is higher than that of many NiAI-based alloy and the stress exponent n for creep is about 6.69. Then the possible strengthening mechanism and creep mechanism are also discussed.

关键词： Intermetallic NiAl Microstructure Mechanical properties

Bioinspired 3D flexible devices and functional systems

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National Science Review 2024年第3期11卷 271-295页

作者： Xu Cheng Zhangming Shen yihui Zhang Applied Mechanics Laboratory Department of Engineering Mechanics Tsinghua University Laboratory of Flexible Electronics Technology Tsinghua University

Flexible devices and functional systems with elaborated three-dimensional(3D) architectures can endow better mechanical/electrical performances, more design freedom, and unique functionalities, when compared to their two-dimensional(2D) counterparts. Such 3D flexible devices/systems are rapidly evolving in three primary directions, including the miniaturization, the increasingly merged physical/artificial intelligence and the enhanced adaptability and capabilities of heterogeneous *** challenges exist in this emerging research area, such as relatively poor controllability in the locomotion of soft robotic systems, mismatch of bioelectronic interfaces, and signal coupling in multi-parameter sensing. By virtue of long-time–optimized materials, structures and processes, natural organisms provide rich sources of inspiration to address these challenges, enabling the design and manufacture of many bioinspired 3D flexible devices/systems. In this Review, we focus on bioinspired 3D flexible devices and functional systems, and summarize their representative design concepts, manufacturing methods, principles of structure-function relationship and broad-ranging applications. Discussions on existing challenges, potential solutions and future opportunities are also provided to usher in further research efforts toward realizing bioinspired 3D flexible devices/systems with precisely programmed shapes,enhanced mechanical/electrical performances, and high-level physical/artificial intelligence.

关键词： bioinspired designs biomimetic 3D structures 3D flexible electronics 3D functional systems direct 3D manufacture 2D-to-3D assembly

Discovery of TK-642 as a highly potent,selective,orally bioavailable pyrazolopyrazine-based allosteric SHP2 inhibitor

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3624-3642页

作者： Kai Tang Shu Wang Siqi Feng Xinyu Yang Yueyang guo Xiangli Ren Linyue Bai Bin Yu Hong-Min Liu yihui Song School of Pharmaceutical Sciences&Key Laboratory of Advanced Drug Preparation Technologies Ministry of EducationZhengzhou UniversityZhengzhou 450001China College of Chemistry Pingyuan LaboratoryState Key Laboratory of Antiviral DrugsZhengzhou UniversityZhengzhou 450001China Tianjian Laboratory of Advanced Biomedical Sciences Institute of Advanced Biomedical SciencesZhengzhou UniversityZhengzhou 450000China State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjing 210023China

Src homology-2-containing protein tyrosine phosphatase 2(SHP2)is a promising therapeutic target for cancer *** this work,we presented the structure-guided design of 5,6-fused bicyclic allosteric SHP2 inhibitors,leading to the identification of pyrazolopyrazine-based TK-642 as a highly potent,selective,orally bioavailable allosteric SHP2 inhibitor(SHP2WT IC_(50)=2.7 nmol/L)with favorable pharmacokinetic profiles(F=42.5%;t_(1/2)=2.47 h).Both dual inhibition biochemical assay and docking analysis indicated that TK-642 likely bound to the“tunnel”allosteric site of ***-642 could effectively suppress cell proliferation(KYSE-520 cells IC_(50)=5.73μmol/L)and induce apoptosis in esophageal cancer cells by targeting the SHP2-mediated AKT and ERK signaling ***,oral administration of TK-642 also demonstrated effective anti-tumor effects in the KYSE-520 xenograft mouse model,with a T/C value of 83.69%.Collectively,TK-642 may warrant further investigation as a promising lead compound for the treatment of esophageal cancer.

关键词： Protein tyrosine phosphatase Pyrazolopyrazine SHP2 inhibitor Esophageal cancer

Research status and progress of hot stamping

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Engineering Sciences 2012年第6期10卷 51-61页

作者： Song Leifeng Ma Mingtu guo yihui Fang Gang Liu Qiang Yao Zaiqi China Automotive Engineering Research Institute Co.Ltd. Geely Automobile Research Institute

In this article,current application,materials,key equipments,finite element(FE) simulation and parts properties of hot stamping are *** investigations of all processes and further excellent processes are *** survey of existing works,especially key equipments has revealed several *** new ideas and programs are proposed on the basis of traditional *** article aims at providing an insight into a whole process backgrounds and pointing out the great potential for further investigations and innovations of hot stamping.

关键词： hot stamping process material equipment simulation

The test device for heat friction coefficient of high strength steel

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Engineering Sciences 2012年第6期10卷 75-78页

作者： Sun Zhifu Ma Mingtu Ma Fangwu guo yihui Song Leifeng Yao Zaiqi Chongqing New Materials Engineering Center China Automotive Engineering Research Institute Co.Ltd. Geely Automobile Research Institute

Using high strength steel and ultra-high strength steel in hot stamping and automobile parts is one of the most important ways of the automobile lightweight,which is the development trend of automobiles *** this paper, the development of test device for heat friction coefficient by high strength steel can provide important technical parameters for hot stamping process,making the right selection of equipment types,mold design,technology optimization,and research and development of lubrication medium of press *** the same time,the experiments indicate that the instrument has not only accurate test result but also good repeatability.

关键词： automobile lightweight modern automobile heat friction coefficient

Numerical simulation of hot stamping of side impact beam

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Engineering Sciences 2012年第6期10卷 62-66页

作者： guo yihui Ma Mingtu Fang Gang Song Leifeng Liu Qiang Wang Xiaona Zhou Dianwu China Automotive Engineering Research Institute Co.Ltd. State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body Hunan University Geely Automobile Research Institute

Ls-DYNA software is adopted to conduct research of numerical simulation on hot stamping of side impact beam to calculate the temperature field distribution, stress field distribution, forming limit diagram （FLD） figure, etc. in the course of hot stamping so as to predict and analyze the formability of parts. ProCAST software is employed to conduct research of numerical simulation on solid quenching course concerning hot stamping to calculate temperature field distri- bution of tools and component of muhiple stamping cycles. The results obtained from numerical simulation can provide significant reference value to hot stamping part design, formability predication and tools cooling system design.

关键词： hot stamping numerical simulation FLD temperature field