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Analysis of Rolling Pressure in Asymmetrical Rolling Process by Slab Method

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Journal of Iron and Steel Research International 2009年第4期16卷 22-26,38页

作者： TIAN Yong guo yan-hui wang Zhao-dong wang guo-dong State Key Laboratory of Rolling and Automation Laboratory Northeastern University Shenyang 110004 Liaoning China

The plane strain asymmetrical rolling was analyzed using slab method. The contact arc was replaced by parabola, and the constant surface friction status was adopted during the analysis. The deformation area was divided into three zones according to the direction of the friction. Then, the three zones were studied, respectively. A rolling force model and a rolling torque model were developed based on the analysis, and they were used to analyze the influ- ence of asymmetrical rolling factors on deformation area and unit pressure if they had good precision which was determined by comparing the calculated results with the measured ones.

关键词： asymmetrical rolling slab method asymmetrical factor specific pressure distribution

Textures and Properties of Hot Rolled High Strength Ti-IF Steels

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Journal of Iron and Steel Research International 2008年第5期15卷 70-76页

作者： guo yan-hui wang Zhao-dong ZOU Wen-wen LIU Xiang-hua wang guo-dong State Key Laboratory of Rolling and Automation Northeastern University Shenyang 110004 Liaoning China

The texture evolution in a high strength Ti-IF steel during the processing of hot rolling, cold rolling, and annealing is studied. For comparison, both ferrite rolling and austenite rolling are employed. It is found that the texture type is the. same after ferrite rolling and austenite rolling, but the texture intensity is much higher in the ferrite rolled sample. Furthermore, texture characteristics at the surface are absolutely different from those at the mid sec tion in both ferrite rolled and austenite rolled samples, as well as under the cold rolled and annealed conditions. The shear texture { 110 } 〈001 〉 disappears and orientation rotates along { 110 } 〈001 〉→ { 554 } 〈 225 〉→ { 111 } 〈 112 〉→{111}〈110〉→{223}〈110〉 during cold rolling. Compared to the austenite rolled sample, the properties of the cold rolled and annealed sheet which is subjected to ferrite rolling are higher.

关键词： high strength Ti-IF steel ferrite rolling austenite rolling texture

Synthesis of novel redox calix[4]arene derivative with 1,3-substituted large conjugated ferrocene bridge

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Chinese Chemical Letters 2009年第9期20卷 1039-1041页

作者： Bi Qiong Hong Fa Fu yang Hong Yu guo yan Hua wang Xian Feng Chai College of Chemistry and Materials Fufian Normal University Fuzhou 350007 China

A novel redox calix[4]arene derivative with 1,3-substituted large conjugated ferrocene bridge was designed and synthesized in high yield. Its structure was characterized by element analysis, IR, ESI-MS, NMR spectrum, etc. The primary study of cyclic voltammetry showed it possessed excellent reversible electrochemistry response property. 2009 Fa Fu yang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

关键词： Calixarene Ferrocene Synthesis Cyclic voltammetry

Gene Expression Profiles Comparison between 2009 Pandemic and Seasonal H1N1 Influenza Viruses in A549 Cells

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Biomedical and Environmental Sciences 2010年第4期23卷 259-266页

作者： XIAO-XING yanG NING DU JIAN-FANG ZHOU ZI LI MIN wang JUN-FENG guo DA-yan wang YUE-LONG SHU State Key Laboratory for Molecular Virology and Genetic Engineering National Institute for Viral Disease Control and Prevention China CDC 100 Yingxin Street Xuanwu District Beijing 100052 China

Objective To perform gene expression profiles comparison so that to identify and understand the potential differences in pathogenesis between the pandemic and seasonal A （H1N1） influenza viruses. Methods A549 cells were infected with A/California/07/09 （H1N1） and A/GuangdongBaoan/51/08 （H1N1） respectively at the same MOI of 2 and collected at 2, 4, 8, and 24 h post infection （p.i.）. Gene expression profiles of A549 cells were obtained using the 22 K Human Genome Oligo Array, and differentially expressed genes were analyzed at selected time points. Results Microarrays results indicated that both of the viruses suppressed host immune response related pathways including cytokine production while pandemic H1N1 virus displayed weaker suppression of host immune response than seasonal H1N1 virus. Observation on similar anti-apoptotic events such as activation of apoptosis inhibitor and down-regulation of key genes of apoptosis pathways in both infections showed that activities of promoting apoptosis were different in later stage of infection. Conclusion The immuno-suppression and anti-apoptosis events of pandemic H1N1 virus were similar to those seen by seasonal H1N1 virus. The pandemic H1N1 virus had an ability to inhibit biological pathways associated with cytokine responses, NK activation and macrophage recognition .

关键词： Influenza A virus Pandemic H1N1 A549 Expression profiling array

Propionate promotes gluconeogenesis by regulating mechanistic target of rapamycin(mTOR)pathway in calf hepatocytes

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Animal Nutrition 2023年第4期15卷 88-98页

作者： guo yan wang Sen Lin Qin Yi Ning Zheng Hui Jun Geng Lei Chen Jun Hu Yao Lu Deng College of Animal Science and Technology Northwest A&F UniversityYanglingShaanxi 712100China

Enhancing hepatic gluconeogenesis is one of the main modes of meeting the glucose requirement of dairy *** study attempted to determine whether the gluconeogenesis precursor propionate had an effect on the expression of the main genes involved in gluconeogenesis in calf hepatocytes and elucidate the associated *** hepatocytes were obtained from 5 healthy calves(1 d old;30to 40 kg)and exposed to 0-,1-,2.5-,or 5-mM sodium propionate(NaP),which is known to promote the expression of genes involved in the gluconeogenesis pathway,including fructose 1,6-bisphosphatase,phosphoenolpyruvate carboxykinase,and *** regard to the underlying mechanism,propionate promoted the expression of peroxisome proliferator-activated receptor gamma coactivator 1-alpha,hepatocyte nuclear factor 4,and forkhead box O1(transcription factors that regulate the expression of hepatic gluconeogenic genes)by promoting mammalian target of rapamycin complex 1(mTORC1),but inhibiting mTORC2 activity(P<0.01).We also established a model of palmitic acid(PA)-induced hepatic injury in calf hepatocytes and found that PA could inhibit the gluconeogenic capacity of calf hepatocytes by suppressing the expression of gluconeogenic genes,inhibiting m TORC1,and promoting the activity of m TORC2(P<0.01).In contrast,NaP provided protection to calf hepatocytes by counteracting the inhibitory effect of PA on the gluconeogenic capacity of calf hepatocytes(P<0.05).Collectively,these findings indicate that NaP enhances the gluconeogenic capacity of calf hepatocytes by regulating the mTOR pathway ***,in addition to improving the glucose production potential,propionate may have therapeutic potential for the treatment of hepatic injury in dairy cows.

关键词： Propionate Gluconeogenesis Mechanistic target of rapamycin Palmitic acid

Effects of ketamine on proinflammatory cytokines and nuclear factor kappaB in polymicrobial sepsis rats

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World Journal of Gastroenterology 2006年第45期12卷 7350-7354页

作者： Xue-Min Song Jian-guo Li yan-Lin wang Qing Zhou Zhao-Hui Du Bao-Hui Jia Jian-Juan Ke Department of Anesthesiology Zhongnan Hospital of Wuhan University Wuhan 430071 Hubei Province China

AIM： To explore the effects of ketamine on hemodynamics, plasma proinflammatory cytokine （TNF-α and IL-6） levels and nuclear factor kappa B （NF-κB） activation during polymicrobial sepsis. METHODS： Male Sprague-Dawlay rats were subjected to cecal ligation and puncture （CLP） or sham operation. The rats were randomly assigned into four equal groups： sham CLP group, CLP group, ketamine （KT）Ⅰ group and KTⅡgroup. Thirty minutes before CLP, ketamine （5 mg/kg per hour and 10 mglkg per hour, respectively） was infused continuously through the left femoral vein cannula in KT Ⅰ group or KTⅡgroup. Sham CLP group and CLP group received 0.9% saline only （5 mL/kg per hour）. The right femoral artery was cannulated to monitor mean arterial pressure （MAP） and heart rates （HR）,and draw blood samples. The proinflammatory cytokine （TNF-α and IL-6） levels of plasma were measured using enzyme-linked immunosorbent assays （ELISA）. The hepatic NF-κB activation was determined by Western blot and HPIAS 2000 image analysis system. Twenty hours after CLP, the rats were killed by right femoral artery phlebotomization. RESULTS： CLP produced progressive hypotension, and a first increase followed by a decrease in HR. The hypotension was prevented, and the HR was slightly steady in ketamine treated rats. TNF-α levels of plasma reached a peak value at 2 h after CLP. Ketamine （KT Ⅰ group or KTⅡgroup） caused a significant decrease compared with CLP group at 2, 5 and 9 h time points after CLP （14.3 ± 1.9 vs 4.3 ± 0.9, 9.7 ± 1.4 vs 4.3 ± 0.9; 9.3 ± 1.5 vs 4.3 ± 0.9, 8.7 ± 1.4 vs 4.3 ±0.9; 6.0 ± 1.5 vs 5.0 ± 1.7, 5.3 ± 0.8 vs 5.0 ± 1.7; P 〈 0.01, respectively）. The IL-6 levels of plasma firstly ascended and then descended in CLP group, and reached a peak value at 9 h after CLP. Ketamine （KT I group or KTH group） caused a significant decrease compared with CLP group at 5, 9 or 20 h after CLP （135.0 ± 52.6 vs 60.0 ± 16.3, 112.5 ± 52.6 vs 60.0 ± 16.3; 410.0 ± 68.7 vs 62.5 ± 12.5, 250.0 ± 28.0 vs 62.5 ± 12.

关键词： Ketamine Sepsis Hemodynamics Tumor necrosis factor α Interleukin 6 Nuclear factor kappa B

An Asynchronous Messaging Model with Time Independent Invocation Based on Distributed Objects

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通讯和计算机（中英文版） 2006年第5期3卷 33-39页

作者： Yinzhang guo yan wang Jianchao Zeng School of System Simulation and Computer Applicatlan Taiyuan University of Science and Technology Taiyuan 030024 China

Management of head and neck hemangiomas in China

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Chinese Medical Journal 2008年第11期121卷 1037-1042页

作者： ZHENG Jia-wei ZHOU guo-yu wang yan-an ZHANG Zhi-yuan Department of Oral and Maxillofacial Surgery College of Stomatology Ninth People's Hospital School of MedicineShanghai Jiao Tong University Shanghai 200011 China

Hemangioma is a common benign vascular tumor,with an incidence of 2%-3% in the neonate and 10%in baby after 1 year.^1 The incidence of hemangiomas is approximately 22%-30% of preterm infants with birthweight less than 1000 g. The development of hemangioma is therefore supposed to be related to various intra- and extra-uterine factors.

关键词： hemangioma head and neck treatment

MoS2 synaptic transistor with one-step manufacture

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Science China(Information Sciences) 2025年第1期68卷 357-365页

作者： Yihao guo yang wang Wenjie DENG Yi WU Jingtao LI Kexin LI Yuehui ZHAO Songlin YU Xiaoting wang Yongzhe ZHANG Hui yan Key Laboratory of Optoelectronics Technology of Education Ministry of China Faculty of Information TechnologyBeijing University of Technology Key Laboratory of Advanced Functional Materials Ministry of Education Faculty of Materials and ManufacturingBeijing University of Technology The 11th Research Institute of Electronics Technology Group Corporation

The synaptic transistor,which is a neuromorphic device with brain-like functions,has garnered significant attention due to characteristics such as low energy consumption,high integration,multiple functions,and high computational ***,the current synaptic transistor possesses a complicated structure and involves complex manufacturing steps,which is not conducive to low-cost,large-scale bionic ***,we introduce a simple MoS2synaptic transistor exhibiting robust synaptic *** transistor utilizes magnetron sputtering manufacture to combine the process of device metal electrode deposition and the introduction of defect states,which helps streamline the manufacturing process into a single *** long-term potentiation and long-term depression in photoelectric coordination are initially ***,biological functions,such as double pulse facilitation and the transformation behavior of short-term memory to long-term memory,are thoroughly evaluated,along with learning-forgetting-relearning ***,the device exhibits robust synaptic plasticity until incident light angles down to 30° to imitate the multi-to-one axon-cellular ***,a classical simulation of Pavlov's dog conditioned reflex is demonstrated along with the multiview extraction *** experimental results demonstrate a promising synaptic transistor with a simple structure,manufacturing technique,and excellent *** further indicates the potential for large-scale integration of bionic neuromorphic systems.

关键词： process optimization artificial synaptic device one-stepmanufacture synaptic plasticity bionic simulation

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