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Activation of adult endogenous neurogenesis by a hyaluronic acid collagen gel containing basic fibroblast growth factor promotes remodeling and functional recovery of the injured cerebral cortex

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Neural Regeneration Research 2025年第10期20卷 2923-2937页

作者： yan Li Peng Hao Hongmei duan Fei Hao Wen Zhao Yudan Gao Zhaoyang yang Kwok-Fai So Xiaoguang Li Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina China Rehabilitation Science Institute China Rehabilitation Research CenterBeijing Key Laboratory of Neural Injury and RehabilitationBeijingChina Center of Neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina Beijing Key Laboratory for Biomaterials and Neural Regeneration School of Engineering MedicineBeihang UniversityBeijingChina Guangdong-HongKong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) GuangzhouGuangdong ProvinceChina Department of Ophthalmology and State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administration RegionChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-HongKong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina

The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after ***,whether it is possible to stimulate neurogenesis and reconstruct cortical layers II to VI in non-neurogenic regions,such as the cortex,remains *** this study,we implanted a hyaluronic acid collagen gel loaded with basic fibroblast growth factor into the motor cortex immediately following traumatic *** findings reveal that this gel effectively stimulated the proliferation and migration of endogenous neural stem/progenitor cells,as well as their differentiation into mature and functionally integrated ***,these new neurons reconstructed the architecture of cortical layers II to VI,integrated into the existing neural circuitry,and ultimately led to improved brain *** findings offer novel insight into potential clinical treatments for traumatic cerebral cortex injuries.

关键词： adult endogenous neurogenesis basic fibroblast growth factor-hyaluronic acid collagen gel cortical remodeling functional recovery migration motor cortex injury neural circuits neural stem cells newborn neurons proliferation

Clinical value of combining epirubicin with mindfulness intervention in patients with urinary system tumors and depression

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World Journal of Psychiatry 2025年第1期15卷 54-62页

作者： Juan Liu yan-Ping guo yan-Mei Lu Bei-Lin Wang Department of Urology Surgery Zhumadian Central HospitalZhumadian 463000Henan ProvinceChina Department of Psychiatry Zhumadian Mental HospitalZhumadian 463000Henan ProvinceChina

BACKGROUND Urinary system tumors often cause negative psychological symptoms,such as depression and dysphoria which significantly impact immune function and indirectly affect cancer *** epirubicin(EPI)is recommended by the European Association of Urology and can improve prognosis,its long-term use can cause toxic side effects,reduce treatment compliance,and increase psycho-logical ***,an appropriate intervention mode is *** This was a retrospective study including 110 patients with urinary system tumors and depression admitted to Zhumadian Central Hospital between March 2021 and July *** were divided into conventional(n=55)and joint inter-vention(n=55)*** conventional group received mitomycin and routine nursing,while the joint intervention group received EPI and mindfulness *** groups underwent three cycles of *** function(CD4+cells,CD8+cells,CD4+/CD8+ratio),tumor marker levels[urinary bladder cancer antigen(UBC),bladder tumor antigen(BTA)and nuclear matrix protein 22(NMP22)],quality of life questionnaire-core 30(QLQ-C30),17-item Hamilton depression scale(HAMD-17),and cancer-related fatigue[cancer fatigue scale(CFS)]were *** reactions and nursing satisfaction were recorded and *** Post-intervention,CD4+,CD8+,and CD4+/CD8+levels increased in both groups,with the joint intervention group showing more significant improvement(P<0.05).Tumor marker levels(NMP22,BTA,and UBC)were lower in the joint intervention group compared to the conventional group(P<0.05).The joint intervention group also showed a greater reduction in HAMD-17 scores(9.38±3.12 vs 15.45±4.86,P<0.05),higher QLQ-C30 scores,and lower CFS scores(both P<0.05).Additionally,the joint intervention group had a lower incidence of adverse reactions and higher nursing satisfaction(P<0.05).CONCLUSION EPI combined with mindfulness intervention significantly improved clinical outcomes in patients with urinar

关键词： Urinary system tumor Bladder cancer Prostate cancer Depression Epirubicin

Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui Yu yan Xie Jian Yu Kun-Ning Zhang Zhou-Bo guo Di Wang Zhao-Xian Li Wei-Qi Zhang Yu-Ying Tan Li Zhang Wen-Tao Jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

Connected Vehicles Computation Task Offloading Based on Opportunism in Cooperative Edge Computing

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Computers, Materials & Continua 2023年第4期75卷 609-631页

作者： duan Xue yan guo Ning Li Xiaoxiang Song College of Communications Engineering Army Engineering University of PLANanjing210007China College of Computer Science Liupanshui Normal UniversityLiupanshui553000China

The traditional multi-access edge computing (MEC) capacity isoverwhelmed by the increasing demand for vehicles, leading to acute degradationin task offloading performance. There is a tremendous number ofresource-rich and idle mobile connected vehicles (CVs) in the traffic network,and vehicles are created as opportunistic ad-hoc edge clouds to alleviatethe resource limitation of MEC by providing opportunistic computing *** this basis, a novel scalable system framework is proposed in thispaper for computation task offloading in opportunistic CV-assisted *** this framework, opportunistic ad-hoc edge cloud and fixed edge cloudcooperate to form a novel hybrid cloud. Meanwhile, offloading decision andresource allocation of the user CVs must be ascertained. Furthermore, thejoint offloading decision and resource allocation problem is described asa Mixed Integer Nonlinear Programming (MINLP) problem, which optimizesthe task response latency of user CVs under various constraints. Theoriginal problem is decomposed into two subproblems. First, the Lagrangedual method is used to acquire the best resource allocation with the fixedoffloading decision. Then, the satisfaction-driven method based on trial anderror (TE) learning is adopted to optimize the offloading decision. Finally, acomprehensive series of experiments are conducted to demonstrate that oursuggested scheme is more effective than other comparison schemes.

关键词： Multi-access edge computing opportunistic ad-hoc edge cloud offloading decision resource allocation TE learning

A comparative study on Sn macrosegregation behavior of ternary Al-Sn-Cu alloys prepared by gravity casting and squeeze casting

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China Foundry 2023年第1期20卷 63-70页

作者： Ming Xu yan-guo Yin Cong-min Li Cong-chong duan College of Mechanical Engineering Hefei University of TechnologyHefei 230002China Anhui Yihui New Materials Co. Ltd.Hefei 230000China

A comprehensive study on Sn macrosegregation behavior in ternary Al-Sn-Cu alloys was carried out by comparative analysis between gravity casting and squeeze casting *** microstructure and Sn distribution of the castings were characterized by metallography,scanning electron microscopy(SEM),energy-dispersive X-ray(EDX)spectroscopy,and a direct reading *** show that there are obvious differences in Sn morphology between gravity casting and squeeze casting *** squeeze casting condition,the grain size of the casting is smaller and the distribution ofβ(Sn)is *** effectively reduces the segregation of triangular grain boundary as well as the segregation of *** segregation types of Sn in gravity casting and squeeze casting samples are obviously *** upper surfaces of gravity casting samples show severe negative segregation,while all the lower surfaces have positive *** with gravity casting,squeeze casting solidifies under isostatic *** to the direct contact between the upper surface of the casting and the mold,the casting solidifies faster under higher undercooling degree and ***,the uniform distribution of Sn reduces the segregation phenomenon on the surface of the casting.

关键词： ternary Al-Sn-Cu alloy squeeze casting macrosegregation mechanism

不同盐浓度下AM真菌和禾草内生真菌对多年生黑麦草生长的影响

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草原与草坪 2018年第1期38卷 63-70页

作者：闫智臣李应德程维佳高萍郭艳娥段廷玉草地农业生态系统国家重点实验室农业部草牧业创新重点实验室兰州大学草地农业科技学院甘肃兰州730020

以多年生黑麦草(Lolium perenne)为材料,在温室内研究了不同盐浓度处理下丛枝菌根(arbuscular mycorrhizal,AM)真菌和禾草内生真菌(grass endophyte)对黑麦草生长的影响。试验设对照,无盐胁迫(0%)、轻度盐胁迫(0.2%NaCl)和重度盐胁迫(0.... 详细信息

以多年生黑麦草(Lolium perenne)为材料,在温室内研究了不同盐浓度处理下丛枝菌根(arbuscular mycorrhizal,AM)真菌和禾草内生真菌(grass endophyte)对黑麦草生长的影响。试验设对照,无盐胁迫(0%)、轻度盐胁迫(0.2%NaCl)和重度盐胁迫(0.5%NaCl)处理,AM真菌为摩西球囊霉(Glomus mosseae),禾草内生真菌处理以含有、不含有内生真菌种子建立。结果表明:盐分处理可显著降低黑麦草的株高、生物量、根冠比,以及AM真菌的菌根侵染率,禾草内生真菌与AM真菌均在不同盐分处理下对黑麦草的生长有一定的促进作用,两菌协同作用明显,其中禾草内生真菌处理下的多年生黑麦草的株高、地下生物量和根冠比较对照分别增加13.26%,15.30%和19.51%(P<0.05);AM真菌处理下黑麦草的株高、N、P含量分别提高9.76%,32.12%和12.45%(P<0.05);在无盐胁迫下,禾草内生真菌可促进丛枝菌根真菌侵染,使其侵染率提高5.53%。与两类共生微生物单独作用相比,AM真菌与禾草内生真菌互作,对多年生黑麦草生长、耐盐性有一定的提高,但差异不显著。

关键词：禾草内生真菌 AM真菌盐浓度多年生黑麦草

Effects of macrosegregation on mechanical and tribological properties of squeeze casting immiscible bearing alloys

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China Foundry 2023年第5期20卷 443-451页

作者： Ming Xu yan-guo Yin Cong-min Li guo-tao Zhang Cong-chong duan Institute of Tribology School of Mechanical EngineeringHefei University of TechnologyHefei 230002China School of Mechanical Engineering Anhui University of TechnologyMaanshan 243002AnhuiChina Anhui Yihui New Material Co. Ltd.Hefei 230000China

The macrosegregation behaviors of Al-Sn-Cu ternary immiscible alloy castings and their effects on mechanical and tribological properties were *** results demonstrate that Sn and Cu segregate in the casting simultaneously,and the mass fraction of the two elements has a"U"shaped ***,positive and negative segregation occur in the casting,with positive segregation appearing on the top and lower surfaces and negative segregation on the remaining surfaces,with the 1/2 surface(hot node location)having the highest degree of negative ***,the results of Vickers hardness,tensile strength,and elongation show that Sn and Cu cooperatively affect the mechanical properties of *** higher the mass fraction of Sn and Cu elements,the higher the hardness,the greater the tensile strength,and the better the *** findings of the step-by-step loading tests demonstrate that the segregation of Sn and Cu significantly impacts the tribological characteristics of the *** higher the mass fraction of Sn and Cu on the sample surface,the better the tribological characteristics.

关键词： squeeze casting Al-Sn-Cu macrosegregation mechanical properties tribological property

Research on Function and Mechanism of Tai Chion Cardiac Rehabilitation

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Chinese Journal of Integrative Medicine 2020年第5期26卷 393-400页

作者： CHENG duan WANG Bo LI Qian guo yan WANG Lei Department of Rehabilitation Acupuncture and Moxibustion and Massage College Health Preservation and Rehabilitation CollegeNanjing University of Chinese MedicineNanjing(210023)China W angjing Hospital China Academy of Chinese Medical SciencesBeijing(100102)China Xiyuan Hospital China Academy of Chinese Medical SciencesBeijing(100091)China

With the increasing number of cardiovascular patients,more and more people are living with *** rehabilitation(CR)is an effective treatment and prevention measure for cardiovascular disease(CVD),which aims to relieve both psychological and physiological stress of CVD,reduce risk of death from CVD,improve cardiovascular function and patients'quality of *** Chi is popular in China and mainly used as a daily leisure activity for the elderly to strengthen their *** review discusses whether Tai Chi could be taken as a positive intervention in CR and what is the exact role and its mechanisms as exercise therapy for *** authors detail the role of Tai Chi on CR from the aspects of exercise capacity,risk factors of CVD and psychological factors,etc.,as well as highlight the limitation of Tai Chi research at present.

关键词： Tai Chi cardiac rehabilitation cardiovascular disease non-medicine therapy review

A Pricing Model for Big Personal Data

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Tsinghua Science and Technology 2016年第5期21卷 482-490页

作者： Yuncheng Shen Bing guo yan Shen Xuliang duan Xiangqian Dong Hong Zhang College of Computer Science Sichuan University Chengdu 610065 China College of Information Science and Technology Zhaotong University Zhaotong 657000 China School of Control Engineering Chengdu University of Information Technology Chengdu 610225 China

Big Personal Data is growing explosively. Consequently, an increasing number of internet users are drowning in a sea of data. Big Personal Data has enormous commercial value; it is a new kind of data asset. An urgent problem has thus arisen in the data market： How to price Big Personal Data fairly and reasonably. This paper proposes a pricing model for Big Personal Data based on tuple granularity, with the help of comparative analysis of existing data pricing models and strategies. This model is put forward to implement positive rating and reverse pricing for Big Personal Data by investigating data attributes that affect data value, and analyzing how the value of data tuples varies with information entropy, weight value, data reference index, cost, and other factors. The model can be adjusted dynamically according to these parameters. With increases in data scale, reductions in its cost,and improvements in its quality, Big Personal Data users can thereby obtain greater benefits.

关键词： data tuple Big Personal Data positive grading reverse pricing pricing model