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A Comparison Study of Sensitivity on PJ and NPS Models in China Seas

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Journal of Ocean University of China 2019年第5期18卷 1022-1030页

作者： guo xiangming ZHAO Dongliang ZHANG Lijun WANG Hongguang KANG Shifeng College of Oceanic and Atmospheric Sciences Ocean University of ChinaQingdao 266100China National Key Laboratory of Electromagnetic Environment China Research Institute of Radiowave PropagationQingdao 266107China

Evaporation duct is an ubiquitous natural phenomenon over the ocean and can be diagnosed by evaporation duct *** model proposed by Paulus and Jeske and another model established by the American naval postgraduate school are the most widely *** are called PJ model and NPS model,*** methods are used to investigate the global sensitivity of PJ model and NPS model in China *** first method is based on meteorological and oceanographic observation data in China *** the system random error caused by sensor measurement inaccuracies,the mean relative error and mean absolute error are used as criterion for sensitivity *** second method,called Extended Fourier Amplitude Sensitivity Test(EFAST),takes into account the interaction between input parameters and is used for sensitivity *** results show that NPS model is more sensitive to the random errors of sensors than PJ *** mean relative errors of PJ model and NPS model are 11.43%and 14.81%,*** results of global sensitivity parameter analysis indicate that wind speed is the key factor of PJ model,while all input parameter of NPS model have relatively large total sensitivity *** addition,sensitivity analysis results confirm that wind speed is one of main driving factors for the formation of evaporation *** results are valuable for the selection of diagnosis models for evaporation duct,the evaluation of radio wave propagation in the marine atmospheric surface layer,and the prediction technique of evaporation duct based on numerical weather prediction(NWP)in China seas.

关键词： evaporation duct model EFAST method parameter sensitivity marine atmospheric boundary layer

A novel locus for autosomal dominant high hyperopia mapped to chromosomal 11

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A novel locus for autosomal dominant high hyperopia mapped t...

Modern Surgical Treatment of Congenital Subluxated Lenses

中华医学会第十五次全国医学遗传学学术会议暨中国医师协会医学遗传医师分会第一届全国学术会议暨2016年浙江省医学遗传学年会

作者： Xiao Xueshan Li Shiqiang Jia Xiaoyun guo xiangming Zhang Qingjiong State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-sen University

Objective High hyperopia is a common and severe refractive error associated with blurred vision, asthenopia, amblyopia and strabismus. This study is to map the genetic locus of autosomal domi nant high hyperopia in a large Chinese family Method An autosomal dominant high hyperopia was identified in five generation family with 16 aff ected patients. A genome wide linkage scan on 20 family members(14 affected) was performed by genotyping microsatellite markers at about 10 c M intervals, together with two-point linkage ana lysis. In the meantime, analysis of shared novel alleles on data from whole exome sequencing wa s used to confirm the linkage region and to search for potential candidate variants. Result High hyperopia in this family shows linkage to markers in 27.1 c M region on chromosome 11. All ten markers in the linkage interval gave positive lod scores, with maximum two-point lod scores of 4.68 at theta=0. Analysis of shared alleles identified only one region with multiple novel va riants, which also located in the linkage interval. Conclusion A novel locus for autosomal dominant high hyperopia is mapped to chromosomal 11. Analysis of additional families and functional study on candidate variants may lead to identificatio n of the gene responsible for autosomal dominant high hyperopia.

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眼科学报 1992年第3期8卷 113-116页

作者： xiangming guo Yuozhao Chen Linghua Zeng National Ophthalmological Laboratories,Ministry of Public Health,China Zhongshan Ophthalmic Center,Sun Yat-sen University of Medical Sciences,Guangzhou 510060,China National Ophthalmological Laboratories Ministry of Public Health China.

Traditional surgical management of subluxated lenses is usuallyassociated with a high incidence of operative and postoperative complicationand a poor visual *** treated a series of 14 patients(26 eyes)whose visual acuity could not be improved with optical correction(phakic oraphakic)with modern microsurgery and automated suction-cutting *** visual acuity ranged from 0.05 to *** in post-opera-tive visual acuity was documented in all operated eyes,ranging from 0.4 to 1....

关键词： ectopia lentis surgery pars plana visual acuity

Mutations in lens-specific genes: cataract and beyond

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Mutations in lens-specific genes: cataract and beyond

Genetic and clinical findings in a Chinese family with PROM1-associated Stargardt disease: Case report and review of the literature

中华医学会第十五次全国医学遗传学学术会议暨中国医师协会医学遗传医师分会第一届全国学术会议暨2016年浙江省医学遗传学年会

作者： Zhang Qingjiong Li Shiqiang Xiao Xueshan Jia Xiaoyun Wang Panfeng guo xiangming State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-sen University

Objective Mutations in lens-specific genes have been frequently reported to play major roles in th e development of congenital cataracts. So far, a number of mutations in these genes have been r eported, including those identified in our patients with cataract. Based on analysis of data from wh ole exome sequencing on 1629 probands with different forms of hereditary eye diseases, a numb ers of novel variants predicted to be damaging were identified. This study aims to clarify the relati onships between different variations in these genes and varied phenotypes in different patients. Method Variations in 32 genes known to cause isolated or primary congenital cataracts were sele cted from the dataset of whole exome sequencing for 1629 probands. After exclusion of polymor phisms and benign variants, rare variants predicted to be damaging were thoroughly analyzed ba sed on existing databases and associated phenotypes. Predicted damaging but unlikely causativ e variants will be summarized. Result Some mutations reported to cause cataracts were detected in patients without cataracts. Some rare damaging variants in these gene may not be causative. Rare variants in some genes are more likely to be pathogenic while such variants in other genes are ambiguous. Classification of these genes and its associated variants are suggested for variants-based genetic counseling. Conclusion Visible clear lens provides valuable model in evaluating effect of a variant on lens str ucture(transparency). Clarifying gene-or variant-specific genotype-phenotype is the prerequisite in making precision genetic counseling. International collaborative studies on such kind of data, pr obably through AEGC or other societies, may be of great help in differentiating rare variants from pathogenic mutations in lens-specific genes responsible for congenital cataracts.

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Genetic and clinical findings in a Chinese family with PROM1...

Retinoma and Phthisis Bulbi of Retinoblastoma *** and Genetic Analysis

中华医学会第十五次全国医学遗传学学术会议暨中国医师协会医学遗传医师分会第一届全国学术会议暨2016年浙江省医学遗传学年会

作者： Huang Li Xiao Xueshan Li Shiqiang Jia Xiaoyun Wang Panfeng Sun Wenmin guo xiangming Zhang Qingjiong 中山大学中山眼科中心眼科学国家重点实验室

Objective Stargardt disease(STGD) is the most common form of inherited juvenile macular dege neration. In this study, we try to explore the molecular genetics of STGD in a Chinese family and t o broaden the knowledge of PROM1 mutations and the associated phenotypes. Method Whole exome sequencing was conducted in four affected family members and clinical da ta including fundus photographs and Fundus Fluorescein Angiography were performed. Result Exome sequencing revealed a recurrent heterozygous mutation c.1117 C>T(p.R373 C) in PROM1 gene was the causative mutation of the family. After summarizing all the reported mutatio ns of PROM1, 31 pathogenic mutations in total were reported, including nine splicing, eight deleti on, seven nonsense, four missense and three insertion mutations. Mutation p.R373 C was not onl y the most common mutation, but also the only mutation which had an evidence of causing disea se in a single heterozygous state, all the others were homozygous or compound heterozygous. Al though p.R373 C was reported in different phenotypes, bull‘s eye maculopathy is the common sign. Conclusion We detected a p.R373 C mutation in PROM1 gene, and the mini-review of genotype and phenotype of PROM1 gene will benefit to the interpretation of the pathogenicity of PROM1 va riants.

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眼科学报 1992年第3期8卷 117-121页

作者： Qingjiong Zhang Youzhao Chen Zhongyao Wu Qiaoyun Ma Ruiping Zeng xiangming guo Danyang Li National Ophthalmological Laboratories,Ministry of Public Health,China Zhongshan Ophthalmic Center,Sun Yat-sen University of Medical Sciences,Guangzhou 510060,China National Ophthalmological Laboratories Ministry of Public Health China.

Retinoma and phthisis bulbi of retinoblastoma are rare entitiesfound in retinoblastoma patients and their *** cases of phthisisbulbi of retinoblastoma and 9 cases of retinoma were identified from 1966 to1991 in our *** clinic data show that retinoma and phthisis bulbi areclosely related to the retinoblastoma *** should be carried outas soon as possible without hesitation for the phthisis of eyes with *** counseling and frequent observation should be p...

关键词： Retinoma Retinoblastoma phthisis bulbi spontaneous regression

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微笑北京

北方音乐 2008年第2期 4-5页

作者：郭向明济南市长清区实验小学

动水及桩-土-结构相互作用对跨江大桥稳定性的地震影响分析

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岩石力学与工程学报 2006年第Z1期25卷 2713-2718页

作者：冯玉涛戎进章曹芳国详明于志军重庆交通大学土木建筑学院重庆400074 北京城建集团第四建设工程有限责任公司北京100101

为了得到更为符合实际情况的跨江大桥动力稳定性的地震反应分析,在桥梁抗震研究中必须综合考虑动水及桩–土–结构的相互作用。基于此,根据Poisson方程,利用Trefftz函数和微波理论建立求解地震中桥墩表面动水压力的计算方程;由线性化的M... 详细信息

为了得到更为符合实际情况的跨江大桥动力稳定性的地震反应分析,在桥梁抗震研究中必须综合考虑动水及桩–土–结构的相互作用。基于此,根据Poisson方程,利用Trefftz函数和微波理论建立求解地震中桥墩表面动水压力的计算方程;由线性化的Morison公式,给出计算地震中动水能量对桩体的波浪推力方程;同时,引入改进的Penzien模型,对桩–土–结构的地震效应进行分析。采用该方法对国内某跨江大桥进行动力反应时程分析,计算结果显示,该方法简单有效,且具有较高的计算精度。

关键词：土力学动水桩-土-结构动力稳定性跨江大桥

基于MM5V3的大气波导预报可靠性和准确度分析

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电波科学学报 2017年第6期32卷 725-734页

作者：郝晓静李清亮郭立新韩杰郭相明西安电子科技大学物理与光电工程学院中国电波传播研究所电波环境特性及模化技术重点实验室

利用GTS高空探测数据和FNL最终分析数据验证MM5V3中尺度数值天气预报模式预报大气波导的有效性,验证区域为东海关注区、南海关注区和亚丁湾关注区,并分别从可靠性和准确度两个方面进行了分析.1)用GTS高空探测数据对表面、悬空波导预报... 详细信息

利用GTS高空探测数据和FNL最终分析数据验证MM5V3中尺度数值天气预报模式预报大气波导的有效性,验证区域为东海关注区、南海关注区和亚丁湾关注区,并分别从可靠性和准确度两个方面进行了分析.1)用GTS高空探测数据对表面、悬空波导预报结果进行了验证,结果表明:对一般强度表面、悬空波导预报可靠度为60%;0%;对强波导预报可靠度为80%以上;对波导顶高预报均方根误差为500;00m;波导强度预报均方根误差为10;0 M.2)用4天的FNL数据对蒸发波导高发区预报结果进行了验证,结果表明:蒸发波导预报可靠度为90%以上;波导顶高预报均方根误差为2;m.总体而言,对于表面、悬空波导,MM5V3对强波导的预报可靠度较高,对一般强度的波导预报可靠度较低,且波导预报准确度很低;对于蒸发波导高发区,MM5V3可以初步实现波导的预报.上述结果为检验中尺度数值天气预报模式预报大气波导的有效性提供了参考,具有现实指导意义.

关键词：大气波导中尺度数值天气预报模式 GTS FNL 可靠性准确度