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Chinese Journal of Integrative Medicine 1995年第1期1卷 87-90页

作者： guo sai-shan (郭赛珊) Liang Xiao-chun (梁晓春) Yin Feng-hua (殷凤华) Wang Xiang-ding (王香定) (Peking Union Medical College Hospital, Beijing )(100730)guo sai-qi(郭赛琪) (Clinic of China News Press, Beijing) Peking Union Medical College Hospital Beijing Clinic of China News Press Beijing

Blood flow in the lower leg was determined in 50 cases of non-insulin dependent diabetesmellitus using an XLJ-2 bipolar rheoencephalometry impedance rheogram. In patients with leg pain (85legsi and diabetic foat (15 legs3, the blood flow of the lower leg was decreased as compared withhealthy legs (P<0. 01￣0. 001) . The group with diabetic foot showed a bigger decrease compared withthe leg pain group (PMO. 051 . Atter treatment with the principle of vitalizing blood and solubilizing throm-bus, 22 cases with leg pain (32 legs) showed a significant increase of blood flow in the lower leg (P<0. 001). The group with diabetic foot failed to show any significant increase, indicating the importance ofearly treatment. This method of determining blood flow in the lower leg will help early discovery of abnor-mal changes of blood supply in the lower leg. Treatment with the principle of vitalizing blood and solubiliz-ing thrombus can help improve the conditions of the patients.

关键词： blood flow in the lower leg diabetic foot qi-Yin deficiency with blood stasis deficien-cy of both Yin and Yang with blood stasis

Practical approach for detecting k-nonseparability of multipartite quantum states

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 32-48页

作者： Jie guo Jinchuan Hou Xiaofei qi Kan He College of Mathematics Taiyuan University of Technology School of Mathematics and Statistics Shanxi University Key Laboratory of Complex Systems and Data Science of Ministry of Education Shanxi University

The instantaneous detection of entanglement in quantum states poses a significant challenge in the fields of quantum computation and quantum information, and there are no practical methods or tools to complete this task satisfactorily so far. We propose a sufficient and necessary criterion of k-nonseparability for any n-partite finite or infinite dimensional systems, 2 ≤ k ≤ n. This criterion serves as the foundation for a practical scheme designed to detect entanglement and k-nonseparability across multipartite finite-dimensional systems. To exemplify the application of our scheme, we have developed a software tool that facilitates swift and precise identification of entanglement, k-nonseparability, and genuine entanglement within n-qubit systems, specifically tailored for systems with 2 ≤ n ≤ 4.

关键词： multipartite systems entanglement states entanglement witnesses ${\bm~k}$-nonseparability

Tunable non-Markovian and quantum coherence in the single-qubit dephasing noise channel

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Science China(Physics,Mechanics & Astronomy) 2025年

作者： Na-Na Zhang Chao-Yi Wu Xu Zhou qi-Yuan Liu Cheng-Ge Liu Yong-Rui guo Ren-Pu Li School of Optoelectronic Engineering Chongqing University of Posts and Telecommunications Department of Physics Applied Optics Beijing Area Major Laboratory Beijing Normal University

In this paper, we construct a single-qubit dephasing noise channel based on the nuclear magnetic resonance（NMR） system by employing the bath-engineering technology, and achieve the construction of the tunable non-Markovian environment in the dephasing noise channel. Our findings indicate that for the single-qubit system, the transition of system dynamics from Markovian to non-Markovian can be achieved by adjusting the base frequency of the noise power spectrum. However, the base frequency corresponding to this phase transition point is not fixed, and there is a certain relationship between it and the total evolution time of the single-qubit system. Through our research, we discovered a fundamental relationship: if the single-qubit system dynamics undergoe a transition from Markovian to non-Markovian at ω0within 0-2t ms, shortening the evolution time to 0-t ms results in an increase of the phase transition point to 2ω0. This insight offers crucial guidance for artificially crafting non-Markovian environments across arbitrary time scales in single-qubit systems, and it is not limited by the type of noise. Apart from system dynamics, quantum coherence is also a focal point of our research. We find that when the system dynamics exhibit non-Markovian behavior, the quantum coherence of the single-qubit system experiences revivals. Notably, the timing of these coherence revivals aligns with the instants of the non-Markovianity enhancement. Therefore, our research also serves as a pivotal foundation for the artificial manipulation and realization of quantum coherence revivals within diverse single-qubit systems.

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Deliberate design of MOF-based pre-catalyst rationalizing the structural reconstruction toward efficient oxygen evolution reaction

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Science China Chemistry 2025年

作者： Yunhui Chen Meng Tian Zhongqi Zhang Guangzhao Wang Yan guo Jing Wu Dawei qi Zhenhua Yan Xiangyu Liu Xi Liu State Key Laboratory of High-efficiency Coal Utilization and Green Chemical Engineering College of Chemistry and Chemical EngineeringNingxia University Key Laboratory of Extraordinary Bond Engineering and Advanced Materials Technology of Chongqing School of Electronic Information Engineering Yangtze Normal University Frontiers Science Center for New Organic Matter Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) State Key Laboratory of Advanced Chemical Power Sources College of Chemistry Nankai University School of Chemistry and Chemical Engineering In-situ Center for Physical Sciences Frontiers Science Center for Transformative Molecules Shanghai Jiao Tong University

Metal-organic frameworks （MOFs）,that have emerged as promising electrocatalysts in oxygen evolution reaction （OER）,usually undergo structural reconstruction to form metal hydroxides as active ***,it remains a great challenge to design and synthesize ideal MOF-based pre-catalysts for properly cognizing and utilizing the reconstruction process toward efficient OER ***,the well-defined MOF-808 is post-modified by 2-hydroxyphosphonoacetic acid （HPAA） to form a micro-adsorber that enables to capture of metal ions ***3+and Ni2+ions are synergistically anchored into the microadsorber,developing a Fe/Ni-containing pre-catalyst that can be dynamically electrooxidized to be an active and stable dual-site electrocatalyst denoted by R-MOF-HPAA@FeNi with abundant metal *** a result,R-MOF-HPAA@FeNi exhibits an excellent OER performance with a low overpotential of 272 mV and Tafel slope of 35.9 m V dec-1,as well as long-term stability over 300 h at 10 m A *** and theoretical calculations suggest the resulting catalyst mainly follows a lattice oxygen mechanism （LOM） of dual-metal-site mechanism （DMSM）.Owing to the chelating role of HPAA,the post-synthesized MOF-HPAA behaves as a trap to uniformly and firmly adhere Fe3+and Ni2+ions,leading to a functionalized MOF-based pre-catalyst which can be structurally evolved into atomic level-distributed OER electrocatalysts.

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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian guo Jian-Gang Shen Su-Hua qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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公平竞争审查、新质生产力与企业数字化转型

经济问题 2025年第1期 1-14页

作者：师博郭思琪南京大学数字经济与管理学院江苏苏州215163 西北大学经济管理学院陕西西安710127

数字经济是新质生产力的综合质态。公平竞争审查制度作为高水平社会主义市场经济体制的重要组成部分,能够激发企业创新活力和数字化转型动力,从而推动新质生产力发展。采用双重差分法评估公平竞争审查制度对上市公司数字化转型的影响。... 详细信息

数字经济是新质生产力的综合质态。公平竞争审查制度作为高水平社会主义市场经济体制的重要组成部分,能够激发企业创新活力和数字化转型动力,从而推动新质生产力发展。采用双重差分法评估公平竞争审查制度对上市公司数字化转型的影响。研究发现,该制度能够显著提升行政垄断程度高地区的企业数字化转型水平,并且以促进“底层技术运用”为支点撬动了企业数字化转型,凸显了竞争政策的基础性作用。机制检验表明,公平竞争审查制度能够通过促进创新要素流动、优化信贷资源配给、完善数字发展制度环境打通束缚新质生产力发展的“堵点”和“卡点”,从而驱动企业数字化转型。围绕公平竞争审查标准、方式和目标的异质性分析发现,政策呈现出对民营企业、较小规模企业的所有制和规模“偏好”,并且对于制度性交易成本较高的企业作用更加明显;地区自我审查与外部监督机制较为完善时,政策能够更好发挥作用。最后产业政策的叠加效果检验显示,中央与省级产业政策均与公平竞争审查形成了制度合力,有效市场和有为政府协同推进了企业数字化进程。研究结论能够为公平竞争审查制度促进各类先进生产要素向发展新质生产力集聚提供理论支撑和实证依据。

关键词：高质量发展高水平社会主义市场经济体制数字经济行政性垄断

Surface Integrity of Inconel 738LC Parts Manufactured by Selective Laser Melting Followed by High-speed Milling

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Chinese Journal of Mechanical Engineering 2023年第1期36卷 65-79页

作者： Guanhui Ren sai guo Bi Zhang Department of Mechanical and Energy Engineering Southern University of Science and TechnologyShenzhen518055China Shenzhen Key Laboratory for Additive Manufacturing of High-performance Materials Shenzhen518055China Research and Development Department Shenzhen Xinjinquan Precision Techonology Co.Ltd.Shenzhen518055China School of Mechanical Engineering Shandong UniversityJinan250061China

This study is concerned with the surface integrity of Inconel 738LC parts manufactured by selective laser melting(SLM)followed by high-speed milling(HSM).In the investigation process of surface integrity,the study employs ultradepth three-dimensional microscopy,laser scanning confocal microscopy,scanning electron microscopy,electron backscatter diffractometry,and energy dispersive spectroscopy to characterize the evolution of material microstructure,work hardening,residual stress coupling,and anisotropic effect of the building direction on surface integrity of the *** results show that SLM/HSM hybrid manufacturing can be an effective method to obtain better surface quality with a thinner machining metamorphic ***-speed machining is adopted to reduce cutting force and suppress machining heat,which is an effective way to produce better surface mechanical properties during the SLM/HSM hybrid manufacturing *** general,high-speed milling of the SLM-built Inconel 738LC samples offers better surface integrity,compared to simplex additive manufacturing or casting.

关键词： Surface integrity Inconel 738LC Selective laser melting High-speed milling

Subsurface Defect Evaluation of Selective-Laser-Melted Inconel 738LC Alloy Using Eddy Current Testing for Additive/Subtractive Hybrid Manufacturing

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Chinese Journal of Mechanical Engineering 2021年第6期34卷 224-239页

作者： sai guo Guanhui Ren Bi Zhang Department of Mechanical and Energy Engineering Southern University of Science and TechnologyShenzhenGuangdongChina State Key Laboratory of Ultra-precision Machining Technology Department of Industrial and Systems EngineeringThe Hong Kong Polytechnic UniversityKowloonHong KongChina

New materials and manufacturing technologies require applicable non-destructive techniques for quality assurance so as to achieve better *** study comprehensively investigated the effect of influencing factors includ-ing excitation frequency,lift-off distance,defect depth and size,residual heat,and surface roughness on the defect EC signals of an Inconel 738LC alloy produced by selective laser melting(SLM).The experimental investigations recorded the impedance amplitude and phase angle of EC signals for each defect to explore the feasibility of detecting sub-surface defects by merely analyzing these two key ***,this study revealed preliminary qualitative and roughly quantitative relationships between influencing factors and corresponding EC signals,which provided a prac-tical reference on how to quantitively inspect subsurface defects using eddy current testing(ECT)on SLMed parts,and also made solid progress toward on-line ECT in additive/subtractive hybrid manufacturing(ASHM)for fabricating SLMed parts with enhanced quality and better performance.

关键词： Eddy current testing Subsurface defect Additive/subtractive hybrid manufacturing Selective laser melting Inconel 738LC alloy

Enhanced subacute ischemic stroke treatment via multistage drug delivery system design for combination therapy

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Science China Chemistry 2025年

作者： Xihan Xu Juan-Juan Li Jiamin Li Hui-Yan Zhang Yilin qi Bing-Sen Shi Tianqi Li Shan-Shan Su Weitao Zhao Chang Chen Zhongying Gong Huiyu Liu Ke-Rang Wang Dong-Sheng guo Xue Xue State Key Laboratory of Medicinal Chemical Biology College of Pharmacy Nankai University College of Chemistry State Key Laboratory of Elemento-Organic Chemistry Key Laboratory of Functional Polymer Materials (Ministry of Education) Frontiers Science Center for New Organic Matter Collaborative Innovation Center of Chemical Science and EngineeringNankai University College of Chemistry and Materials Science State Key Laboratory of New Pharmaceutical Preparations and Excipients Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education) Key Laboratory of Chemical Biology of Hebei Province Hebei Research Center of the Basic Discipline of Synthetic Chemistry Hebei University Department of Neurology Tianjin First Central Hospital School of Medicine Nankai University Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic-Inorganic Composites Beijing Laboratory of Biomedical Materials Bionanomaterials & Translational Engineering Laboratory Beijing Key Laboratory of BioprocessBeijing University of Chemical Technology

The management of acute ischemic stroke remains challenging due to its abrupt onset and the narrow treatment window,resulting in high rates of disability and *** therapy for neuroprotection and neurorepair strategies provided new hopes for subacute stroke *** we designed a multistage nanodelivery system that matches the unique microenvironment of the subacute phase of stroke,which utilizes calixarene as a building block to effectively load the neuroprotective drug *** calixarene is designed with glycosidic linkages targeting the glucose transporter 1 (GLUT1)on the blood-brain barrier (BBB) and azo bonds that are responsive to hypoxic ***,the decomposed calixarene molecules themselves possess intrinsic bio-activation to modulate inflammatory responses,achieving a multistage therapeutic approach that transitions from targeting to release and finally to *** approach combines anti-inflammation and neuroprotection,providing a multi-level treatment *** system was validated in a rat model of permanent middle cerebral artery occlusion (pMCAO),demonstrating that intravenous administration of the nanodelivery system repairs brain damage and improves motor function 24 h post-pMCAO *** work offers a precise and integrative strategy for stroke patients missing the acute therapy window to improve functional recovery and enhance the effect of comprehensive treatment.

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New materials and designs for 2D-based infrared photodetectors

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Nano Research 2023年第2期16卷 3074-3103页

作者： Huitian guo Weihong qi State Key Laboratory of Solidification Processing Center of Advanced Lubrication and Seal MaterialsNorthwestern Polytechnical UniversityXi’an 710072China Shandong Laboratory of Yantai Advanced Materials and Green Manufacturing Yantai 264006China

Infrared photodetectors have attracted much attention considering their wide civil and military ***-dimensional(2D)materials offer new opportunities for the development of costless,high-level integration and high-performance infrared *** the advent of a broad investigation of infrared photodetectors based on graphene and transition metal chalcogenides(TMDs)exhibiting unique properties in recent decades,research on the better performance of 2D-based infrared photodetectors has been extended to a larger scale,including explorations of new materials and artificial structure *** this review,after a brief background introduction,some major working mechanisms,including the photovoltaic effect,photoconductive effect,photogating effect,photothermoelectric effect and bolometric effect,are briefly ***,the discussion mainly focuses on the recent progress of three categories of 2D materials beyond graphene and *** transition metal dichalcogenides,black phosphorus and arsenic black phosphorous and 2D ternary compounds are great examples of explorations of mid-wavelength or even long-wavelength 2D infrared ***,four types of rational structure designs,including type-II band alignments,photogating-enhanced designs,surface plasmon designs and ferroelectric-enhanced designs,are discussed to further enhance the performance via diverse mechanisms,which involve the narrower-bandgap-induced interlayer exciton transition,gate modulation by trapped carriers,surface plasmon polaritons and ferroelectric polarization in ***,applications including imaging,flexible devices and on-chip integration for 2D-based infrared photodetectors are ***,a summary of the state-of-the-art research status and personal discussion on the challenges are delivered.

关键词： two-dimensional(2D)materials infrared photodetectors noble transition metal dichalcogenides black phosphorus layered ternary compounds structure designs