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Nano Research 2025年第1期18卷 572-585页

作者： Qing Wang Shiyi Zuo Shufang Zheng Cuiyun Liu Yaqiao Li jiayu guo Danping Wang Shuo Wang Wenjing Wang Bowen Zhang Minglong Huang Xianbao Shi Jin Sun Zhonggui He Bingjun Sun Department of Pharmaceutics Wuya College of InnovationShenyang Pharmaceutical UniversityShenyang 110016China Joint International Research Laboratory of Intelligent Drug Delivery Systems Ministry of EducationShenyang Pharmaceutical UniversityShenyang 110016China School of Chemical Engineering The University of AdelaideAdelaideSA 5005Australia Department of Pharmacy The First Affiliated Hospital of Jinzhou Medical UniversityJinzhou 121001China

The clinical utility of irinotecan is restricted by individual variability in carboxylesterase *** administration of its active metabolite,7-ethyl-10-hydroxycamptothecin(SN38),presents an appealing alternative due to its potent anti-tumor ***,the undesirable properties of SN38,such as poor water solubility and nontarget toxicity,present significant hurdles to its clinical *** nanoassemblies based on modular design strategy show promise in overcoming these challenges by enhancing drug delivery and selective *** modular design,the modification module plays a crucial role in improving the self-assembly capability of *** current studies mainly focus on using straight aliphatic chains for prodrug design,branched aliphatic chains emerge as superior alternatives warranting further *** this study,we selected 2-heptylundecanol(BAlc18)as modification module to construct an SN38 *** exquisite design,SN38-SS-BAlc18 NPs integrated prominent properties in selfassembly capability,specific activation and biocompatibility,resolving the challenges of irinotecan and SN38,ultimately demonstrating excellent anti-tumor *** exploration enriched the design theory of prodrug nanoassemblies that can effectively balance safety and colorectal anti-tumor efficacy.

关键词： irinotecan SN38 prodrug nanoassemblies disulfide bonds branched aliphatic chains

Optimized Design Method of Sharing Two Grounding Electrodes by Multi UHVDC Converter Stations

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高电压技术 2012年第12期38卷 3171-3176页

作者： guo Jian LU jiayu ZHANG Wenliang China Electric Power Research Institute Wuhan 430074 China

Ultra high voltage direct current(UHVDC) electrode sites choosing become more and more difficult due to the limited land resource, and it results in an urgent requirement of common electrode technology. The optimized designing method of two kinds of electrodes commonly used by multi converter stations is studied in this paper. The performance criteria and the rational jointing style between electrode lines and electrodes are analysed and determined at first, based on which, the mathematical model of the two kinds of electrodes is established,and an inequality equation set is formed to satisfy the relative standards of environmental impact on ground electrodes. Consequently the optimized designing method is presented through simplification of the model. After all, a specific example is given based on the parameters of Southwest Hydroelectric Project in China, in which two electrode sites had been pre chosen. The results show that, tens of plans of the two kinds of electrodes together with their electrode performances can be provided based on the presented method. The errors of current distribution ratio in all the examined plans are maintained about 1%, the maximum error of earthing resistance is 7% and the maximum error of step voltage is 4%, which prove the engineering practicality of the method.

关键词：高压直流换流站优化设计方法接地极共享最大误差电极线数学模型特高压直流

Hepatocellular SETDB1 Regulates Hepatic Ischemia-Reperfusion Injury through Targeting Lysine Methylation of ASK1 Signal

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Research 2024年第3期6卷 305-317页

作者： Kang Xia Tianyu Wang Zhongbao Chen jiayu guo Bo Yu Qi Chen Tao Qiu Jiangqiao Zhou Shusen Zheng Department of Organ Transplantation Renmin Hospital of Wuhan UniversityWuhanChina Department of Urology Renmin Hospital of Wuhan UniversityWuhanChina. Department of general surgery Renmin Hospital of Wuhan UniversityWuhanChina Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryFirst Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouChina Key Laboratory of Combined Multi-Organ Transplantation Ministry of Public HealthHangzhouChina Key Laboratory of Organ Transplantation HangzhouZhejiang ProvinceChina Key Laboratory of the Diagnosis and Treatment of Organ Transplantation CAMSHangzhouChina.

Background: Hepatic ischemia-reperfusion injury (HIRI) stands as an unavoidable complication arising from liver surgery, profoundly intertwined with its prognosis. The role of lysine methyltransferase SET domain bifurcated 1 (SETDB1) in HIRI remains elusive, despite its confirmation as a potential therapeutic target for diverse diseases. Here, we investigated the mechanism by which SETDB1 regulated HIRI. Methods: RNA sequencing data were used to identify the expression and potential targets of SETDB1 through bioinformatics analysis. To elucidate the impact of SETDB1 on HIRI, both an in vivo model of HIRI in mice and an in vitro model of hepatocyte hypoxia/reoxygenation were established. Biochemical and histological analyses were used to investigate the influence of SETDB1 on liver damage mediated by HIRI. Chromatin immunoprecipitation and coimmunoprecipitation were implemented to explore the in-depth mechanism of SETDB1 regulating HIRI. Results: We confirmed that hepatocellular SETDB1 was up-regulated during HIRI and had a close correlation with HIRI-related inflammation and apoptosis. Moreover, inhibition of SETDB1 could mitigate HIRI-induced liver damage, inflammation, and apoptosis. Through our comprehensive mechanistic investigation, we revealed that SETDB1 interacts with apoptosis-signal-regulating kinase 1 (ASK1) and facilitates the methylation of its lysine residues. Inhibition of SETDB1 resulted in reduced phosphorylation of ASK1, leading to a marked suppression of downstream c-Jun N-terminal kinase (JNK)/p38 signaling pathway activation. The therapeutic effect on inflammation and apoptosis achieved through SETDB1 inhibition was nullified by the restoration of JNK/p38 signaling activation through ASK1 overexpression. Conclusions: The findings from our study indicate that SETDB1 mediates lysine methylation of ASK1 and modulates the activation of the ASK1–JNK/p38 pathway, thus involved in HIRI-induced inflammation and apoptosis. These results suggest that SETD

关键词： SETDB1 inflammation ASK1

Design of the UHVDC Corona Cage in China

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高电压技术 2013年第8期39卷 2022-2026页

作者： guo Jian LU jiayu ZHANG Wenliang China Electric Power Research Institute Beijing 100085 China

For the purpose of testing and analysing the corona characteristics of UHVDC bundle conductors, UHVDC corona cage would be built in China. Corona cage is one of the indispensable equipments for conductor corona performance researches. Tests of conductor co- rona characteristics in corona cages can overcome the shortages of those with test *** dimensions of several corona cages constructed overseas were introduced in this paper. Based on foreign experiences and the requirement of State Grid Corporation of China, the UHVDC corona cage was designed as double-cage, double-layer, three-sections, and catenary shape with the size of 70 m×22 m×13 m. The corona loss measurement system, radio interference measuring system, and the audible noise measuring system are also detailed, including the measurement theory, connection with the cage, the parameters and the designing basis. The UHVDC corona cage has been put into service. It now undergoes a large amount of audible noise and radio frequency interference tests.

关键词：特高压直流输电直流电晕设计中国国家电网公司测量系统电晕特性分裂导线

Dental Imaging With Near-Infrared Transillumination Using Random Fiber Laser

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Photonic Sensors 2020年第4期10卷 333-339页

作者： jiayu guo Yunjiang RAO Weili ZHANG Zewen CUI Anran LIU Yongmei YAN Key Laboratory of Optical Fiber Sensing&Communications(Ministry of Education) University of Electronic Science and Technology of ChinaChengdu 611731China

Contrary to the conventional detection method like radiography,the near infrared light source has been demonstrated to be suitable for dental imaging due to different reflectivity among enamel,dentin,and caries *** this paper,three light sources with different bandwidths based on a transillumination method are *** contrast among enamel,dentin,and caries lesion is calculated in different *** experimental results show that the random fiber laser has the best comprehensive quality in dental imaging due to its high spectral density,low coherence,and deep *** work provides a guidance for light source selection in dental imaging.

关键词： Random fiber laser near infrared dental imaging caries detection

Decoherence of fiber light sources using a single-trench fiber

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Chinese Physics B 2020年第12期29卷 281-285页

作者： Huahui Zhang Weili Zhang Zhao Wang Hongyang Zhu Chao Yu jiayu guo Shanshan Wang Yunjiang Rao School of Information and Communication Engineering University of Electronic Science and Technology of ChinaChengdu 611731China China Second Institute of Railway Engineering Group Co.LTD Chengdu 610031China

Decoherence of fiber laser sources is of great importance in imaging applications,and most current studies use ordinary multi-mode fibers(MMFs).Here,a newly designed single-trench fiber(STF)is investigated to reduce the spatial coherence of fiber light source and compared with *** bending two fibers with different turns,speckle contrast of a 0.8-m-long STF can be reduced from 0.13 to 0.08,while a 0.8-m-long MMF shows an inverse *** speckle contrast and decoupling-mode analysis,the reason of this inverse trend is ***,the STF supports more modes than the MMF due to its larger core ***,mode leak from the first core of the STF can couple to the second core when bending the ***,power distribution among high and low-order modes become more even,reducing the spatial coherence ***,in the MMF,high-order modes become leaky modes and decrease slightly when bending the *** work provides a new method to modulate coherence of light source and a new angle to study decoherence principle using special fibers.

关键词： single-trench fiber multi-mode fiber bending fiber speckle contrast

LncRNA DACH1 protects against pulmonary fibrosis by binding to SRSF1 to suppress CTNNB1 accumulation

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Acta Pharmaceutica Sinica B 2022年第9期12卷 3602-3617页

作者： Jian Sun Tongzhu Jin Zhihui Niu jiayu guo Yingying guo Ruoxuan Yang Qianqian Wang Huiying Gao Yuhan Zhang Tianyu Li Wenxin He Zhixin Li Wenchao Ma Wei Su Liangliang Li Xingxing Fan Hongli Shan Haihai Liang Department of Pharmacology(State-Province Key Laboratories of Biomedicine-Pharmaceutics of China Key Laboratory of Cardiovascular ResearchMinistry of Education)College of PharmacyHarbin Medical UniversityHarbin 150081China Northern Translational Medicine Research and Cooperation Center Heilongjiang Academy of Medical SciencesHarbin Medical UniversityHarbin 150081China Department of Thoracic Surgery Shanghai Pulmonary HospitalTongji UniversityShanghai 200433China State Key Laboratory of Quality Research in Chinese Medicine/Macao Institute for Applied Research in Medicine and Health Macao University of Science and TechnologyMacao(SAR)China Research Unit of Noninfectious Chronic Diseases in Frigid Zone(2019RU070) Chinese Academy of Medical SciencesHarbin 150081China Zhuhai People's Hospital Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and TreatmentZhuhai Hospital Affiliated with Jinan UniversityJinan UniversityZhuhai 519000China

Idiopathic pulmonary fibrosis(IPF)is a progressive disease with unknown etiology and limited therapeutic *** of fibroblasts is a prominent feature of pulmonary *** we report that lncRNA DACH1(dachshund homolog 1)is downregulated in the lungs of IPF patients and in an experimental mouse model of lung ***1 knockout mice develop spontaneous pulmonary fibrosis,whereas overexpression of LncDACH1 attenuated TGF-β1-induced aberrant activation,collagen deposition and differentiation of mouse lung ***,forced expression of LncDACH1 not only prevented bleomycin(BLM)-induced lung fibrosis,but also reversed established lung fibrosis in a BLM ***,LncDACH1 binding to the serine/arginine-rich splicing factor 1(SRSF1)protein decreases its activity and inhibits the accumulation of *** expression of SRSF1 blocked the anti-fibrotic effect of LncDACH1 in lung ***,loss of LncDACH1 promoted proliferation,differentiation,and extracellular matrix(ECM)deposition in mouse lung fibroblasts,whereas such effects were abolished by silencing of *** addition,a conserved fragment of LncDACH1 alleviated hyperproliferation,ECM deposition and differentiation of MRC-5 cells driven by TGF-β***,LncDACH1 inhibits lung fibrosis by interacting with SRSF1 to suppress CTNNB1 accumulation,suggesting that LncDACH1 might be a potential therapeutic target for pulmonary fibrosis.

关键词： Idiopathic pulmonary fibrosis LncRNA DACH1 SRSF1 CTNNB1 Fibroblast Myofibroblast Extracellular matrix Proliferation

Balancing efficacy and safety of doxorubicin-loaded albumin nanoparticles utilizing pH-sensitive doxorubicin-fatty acid prodrugs

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Nano Research 2024年第7期17卷 5491-5500页

作者： Yuanhao Yu Shiyi Zuo Jiaxuan Song Lingxiao Li Tian Liu jiayu guo Yaqiao Li Danping Wang Qi Lu Helin Wang Dun Zhou Zhonggui He Xiaohong Liu Bingjun Sun Jin Sun School of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang 110016China Department of Pharmacy The First Affiliated Hospital of Jinzhou Medical UniversityJinzhou 121001China Joint International Research Laboratory of Intelligent Drug Delivery Systems Ministry of EducationShenyang 110016China

Albumin nanoparticles(ANPs)offer unique advantages for antitumor drug delivery system,including non-immunogenicity and inherent tumor-targeting *** present,only a few products,such as ABRAXANE®and FYARRO™,have been approved for clinical *** poor affinity of doxorubicin(DOX)for albumin,coupled with its numerous severe adverse reactions,poses challenges in the fabrication of desirable albumin nanoparticles loaded with *** this study,we developed prodrugs by conjugating fatty acids of varying lengths with *** aim was to investigate the balance between efficacy and safety through the selection of appropriate *** synthesized five pH-sensitive doxorubicin-fatty acid *** to free DOX,all DOX prodrug ANPs exhibited a uniform size distribution with desirable sizes of 150 ***,DOX prodrugs with hydrazone bonds remained intact in blood circulation while releasing DOX within tumor ***,the characteristics of prodrug ANPs were considerably influenced by the length of fatty acids,impacting their in vivo pharmacokinetics,antitumor effectiveness and tumor *** research offers a detailed understanding of the length of fatty acid influence on DOX-fatty acid prodrug-based ANPs,and it builds a good platform for creating ANPs which prioritize high drug loading,high efficiency,and minimal side effects.

关键词： fatty acid prodrug albumin doxorubicin pH-sensitive bond nanomedicines

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利用位置信息加权词汇树的图像检索

系统仿真学报 2017年第10期29卷 2353-2359,2372页

作者：陈莹郭佳宇江南大学轻工过程先进控制教育部重点实验室江苏无锡214000

针对基于SIFT特征匹配的图像检索方法忽略空间位置信息的缺陷,提出了基于空间位置信息加权词汇树的图像检索方法。利用分层词汇树将图像SIFT特征量化为视觉单词,将图像匹配转换成视觉单词权值向量匹配。由于单纯的视觉单词权值向量匹配... 详细信息

针对基于SIFT特征匹配的图像检索方法忽略空间位置信息的缺陷,提出了基于空间位置信息加权词汇树的图像检索方法。利用分层词汇树将图像SIFT特征量化为视觉单词,将图像匹配转换成视觉单词权值向量匹配。由于单纯的视觉单词权值向量匹配忽略了视觉单词之间的相互位置影响,生成SIFT点的空间位置影响信息,根据SIFT点与视觉单词之间的从属关系,将SIFT点的空间位置影响信息聚类为视觉单词之间的位置影响,将视觉单词的空间位置信息作为加权系数,加入到视觉单词的权值匹配中去,细化特征之间的匹配得分,通过相似度排序检索相似图像。实验结果表明,该算法能有效提高图像检索的精确度。

关键词：词汇树位置信息向量匹配图像检索