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Mandarin fish von Hippel-Lindau protein regulates the NF-κB signaling pathway via interaction with IκB to promote fish ranavirus replication

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Zoological Research 2024年第5期45卷 990-1000页

作者： Zhi-Min Li Xiao-Wei Qin Qi Zhang Jian he Min-Cong Liang Chuan-Rui Li Yang Yu Weng-Hui Liu Shao-Ping Weng Jian-guo he Chang-Jun guo School of Marine Sciences State Key Laboratory for BiocontrolSouthern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Guangdong Province Key Laboratory of Aquatic Economic Animals&Guangdong Provincial Observation and Research Station for Marine Ranching of the Lingdingyang BaySun Yat-sen UniversityGuangzhouGuangdong 510275China Guangdong Laboratory for Lingnan Modern Agriculture South China Agricultural UniversityGuangzhouGuangdong 510640China

The von Hippel-Lindau tumor suppressor protein(VHL),an E3 ubiquitin ligase,functions as a critical regulator of the oxygen-sensing pathway for targeting hypoxia-inducible *** evidence suggests that mammalian VHL may also be critical to the NF-κB signaling pathway,although the specific molecular mechanisms remain ***,the roles of mandarin fish(Siniperca chuatsi)VHL(scVHL)in the NF-κB signaling pathway and mandarin fish ranavirus(MRV)replication were *** transcription of scVHL was induced by immune stimulation and MRV infection,indicating a potential role in innate ***-luciferase reporter gene assays and reverse transcription quantitative PCR(RT-qPCR)results demonstrated that scVHL evoked and positively regulated the NF-κB signaling *** with NF-κB signaling pathway inhibitors indicated that the role of scVHL may be mediated through scIKKα,scIKKβ,scIκBα,or ***-immunoprecipitation(Co-IP)analysis identified scIκBαas a novel target protein of ***,scVHL targeted scIκBαto catalyze the formation of K63-linked polyubiquitin chains to activate the NF-κB signaling *** MRV infection,NF-κB signaling remained activated,which,in turn,promoted MRV *** findings suggest that scVHL not only positively regulates NF-κB but also significantly enhances MRV *** study reveals a novel function of scVHL in NF-κB signaling and viral infection in fish.

关键词： VHL NF-κB IκBα Ranavirus Mandarin fish

Dynamic monitoring of surface water in the Tibetan Plateau from 1980s to 2019 based on satellite remote sensing images

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Journal of Mountain Science 2021年第11期18卷 2833-2841页

作者： LIU Hui-chan he guo-jin PENG Yan WANG Gui-zhou YIN Ran-yu Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100094China Hainan Key Laboratory for Earth Observation Sanya Institute of Remote SensingSanya 572029China University of Chinese Academy of Sciences Beijing 100049China

The Tibetan Plateau is known as the“Asian water tower”,and changes in its surface water distribution are important indicators of global climate change and the regional response to these *** monitoring of the surface water on the Tibetan Plateau is an important part of the research on the functions of the“third pole”of the earth and the Asian water *** the support of the Google Earth Engine cloud platform,this study used a spectral index-based fast extraction method to obtain surface water data from multi-temporal Landsat(Landsat 4,5,and 8)satellite remote sensing *** on the extracted surface water data,we analyzed the spatiotemporal variations in the surface water of the Tibetan Plateau from 1980s to *** this study,surface water area refers to the maximum coverage area of the surface water extracted from remote sensing images for one year,hereafter referred to as the surface water *** results show that since 1980s,the overall surface water area of the Tibetan Plateau has increased,but not in a linear *** a slight decrease from 1980s to 1995,the surface water area of the Tibetan Plateau increased steadily,except for a slight decrease in 2015,which may have been caused by the El Niño *** terms of spatiotemporal distribution,different patterns exist in the various ecological regions of the Tibetan *** Inner ecological region had the greatest changes of surface water area among the ten ecological regions,accounting for 71.0%of the total surface water area increase from 1980s to *** surface water bodies in the cold desert and the dry-winter subtropical climatic regions underwent the most changes,with their coefficients of variation being more than 20%.This study can provide data support for dynamic monitoring of surface water in the Tibetan Plateau.

关键词： Surface water Tibetan Plateau Remote sensing Landsat Climate change

A Retrospective Analysis on 1330Adverse Event Reports of Qingkailing in China:Further Perception of Its Risks and Rational Use

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Current Medical Science 2018年第6期38卷 1103-1108页

作者： Bi-li WU Wen-xi he Meng KE Xiao-fang SHANG-GUAN guo-fang he Rui HUANG Department of Oncology Tongii HospitalTongji Medical CollegeHuazhong Universityof Science and TechnologyWuhan 430030China Department of Pharmacy Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China School of Pharmacy Tongji Medical CollegeHuazhong University of Science and Technology.Wuhan 430030China

Qingkailing (QKL)is a modern preparation exploited according to the traditional Chinese medicine *** becomes the second leading cause of adverse drug events (ADEs)in all traditional Chinese medicine *** safety evaluation and rational use of QKL are of special *** retrospective study used data from Adverse Drug Reaction Monitoring Center of Hubei Province in China from January 2012 to December *** cases induced by QKL were collected and analyzed according to patients'demographics,characteristics of drugs involved,characteristics of ADEs,causality,and outcomes.A total of 1330 qualified ADEs were *** ADEs occurred within 30 min after administration and the 0-10 years old age group had the highest number of *** common ADEs included anaphylactic reaction,dyspnea and *** reactions accounted for 5.19%.Combination with cephalosporin (74/146,50.69%) caused more ADEs than other drugs *** attention should be paid when QKL is used for children,and combination with cephalosporin should be avoided.

关键词： adverse drug event anaphylaxis drug safety Qingkailing

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非晶及纳米结构钛合金研究进展

稀有金属材料与工程 2007年第5期36卷 753-758页

作者：何国上海交通大学上海200030

综述了钛基大块非晶的成分-非晶形成能力的对应关系,总结了已知的钛基大块非晶的一次结晶相及力学性能,并阐述了钛基大块非晶的塑性变形机制,以及造成低塑性的因素和改善塑性的方法,着重介绍了铸造纳米结构钛合金的成分、组织和力学性... 详细信息

综述了钛基大块非晶的成分-非晶形成能力的对应关系,总结了已知的钛基大块非晶的一次结晶相及力学性能,并阐述了钛基大块非晶的塑性变形机制,以及造成低塑性的因素和改善塑性的方法,着重介绍了铸造纳米结构钛合金的成分、组织和力学性能。通过精巧的成分设计,结合金属模铸造技术,制备出了直径小于5mm,并具有微米尺度β-Ti(M)一次树枝晶相+纳米尺度棒状β-Ti/γ-TiCu共晶结构的复合组织,其中棒状β-Ti相尺寸在30nm^300nm范围;γ-TiCu共晶基体相由小于10nm的晶粒或亚晶粒组成,这种多层次纳米结构的钛合金具有高强度,同时具有明显的延伸性。

关键词：钛合金大块非晶纳米材料先进材料力学性能

In Situ TiC/FeCrNiCu High-Entropy Alloy Matrix Composites:Reaction Mechanism,Microstructure and Mechanical Properties

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Acta Metallurgica Sinica(English Letters) 2020年第8期33卷 1091-1102页

作者： Hao Wu Si-Rui Huang Cheng-Yan Zhu Ji-Feng Zhang he-guo Zhu Zong-Han Xie College of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China School of Mechanical Engineering University of AdelaideSA 5005Australia School of Engineering Edith Cowan UniversityJoondalupWA 6027Australia

In situ TiC particles-reinforced FeCrNiCu high-entropy alloy matrix composites were prepared by vacuum induction melting *** reaction mechanisms of the mixed powder(Ti,Cu and C)were analyzed,and the mechanical properties of resultant composites were ***4Tiwere formed in the reaction of Cu and Ti when the temperature rose to 1160 *** the temperature further increased to 1182 K,newly formed Cu4Tireacted with C to give rise to TiC particles as reinforcement *** apparent activation energy for these two reactions was calculated to be 578.7 kJ/mol and 1443.2 kJ/mol,*** hardness,tensile yield strength and ultimate tensile strength of the 15 vol%TiC/FeCrNiCu composite are 797.3 HV,605.1 MPa and 769.2 MPa,respectively,representing an increase by 126.9%,65.9%and 36.0%as compared to the FeCrNiCu high-entropy base alloy at room ***,the elongation-to-failure is reduced from 21.5 to 6.1%with the formation of TiC *** was revealed that Orowan mechanism,dislocation strengthening and load-bearing effect are key factors responsible for a marked increase in the hardness and strength of the high-entropy alloy matrix composites.

关键词： High-entropy alloy matrix composite TiC particle Reaction mechanism Mechanical properties Strengthening mechanism

Microstructure,crystallography and nucleation mechanism of NANOBAIN steel

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International Journal of Minerals,Metallurgy and Materials 2013年第12期20卷 1155-1163页

作者： Yao Huang Ai-min Zhao Jian-guo he Xiao-pei Wang Zhi-gang Wang Liang Qi Metallurgy Engineering Research Institute University of Science and Technology Beijing School of Material Science and Engineering Jiangxi University of Science and Technology

The microstructure of bainite ferrite in NANOBAIN steel transformed at different temperatures was investigated by scanning electron microscopy, transmission electron microscopy, electron back-scattered diffraction, and vickers hardness tester in detail. It is found that the average width of bainitic ferrite （BF） plates can be refined to be thinner with the reduction of temperature （473-573 K）, and the bainitic ferrite plates can reach up to 20-74 nm at 473 K. Crystallographic analysis reveals that the bainitic ferrite laths are close to the Nishiyama-Wasserman orientation relationship with their parent austenite. Temperature shows a significant effect on the variant selection, and a decrease in temperature generally weakens the variant selection. Thermodynamic analyses indicates that the Lacher, Fowler and Guggenheim （LFG） model is more suitable than the Kaufman, Radcliffe and Cohen （KRC） model dealing with NANOBAIN steel at a low temperature range. The free energy change △G^γ→BF is about -1500 ***^-1 at 473 K, which indicates that nucleation in NANOBAIN steel is the shear mechanism. Finally, the formation of carbon poor regions is thermodynamically possible, and the existence of carbon poor regions can greatly increase the possibility of the shear mechanism.

关键词： nanostructured materials high strength steel bainitic transformations microstructure crystallography nucleation

Application of Bayesian regularized BP neural network model for analysis of aquatic ecological data—A case study of chlorophyll-a prediction in Nanzui water area of Dongting Lake

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Journal of Environmental Sciences 2005年第6期17卷 946-952页

作者： XU Min ZENG Guang-ming XU Xin-yi HUANG guo-he SUN Wei JIANG Xiao-yun College of Environmental Science and Engineering Hunan University Changsha 410082 China Sino-Canadian Center of Energy and Environment Research University of Regina Regina SK S4S 0A2 Canada

Bayesian regularized BP neural network（BRBPNN） technique was applied in the chlorophyll-α prediction of Nanzui water area in Dongting Lake. Through BP network interpolation method, the input and output samples of the network were obtained. After the selection of input variables using stepwise/multiple linear regression method in SPSS i1.0 software, the BRBPNN model was established between chlorophyll-α and environmental parameters, biological parameters. The achieved optimal network structure was 3-11-1 with the correlation coefficients and the mean square errors for the training set and the test set as 0.999 and 0.000？8426, 0.981 and 0.0216 respectively. The sum of square weights between each input neuron and the hidden layer of optimal BRBPNN models of different structures indicated that the effect of individual input parameter on chlorophyll- α declined in the order of alga amount 〉 secchi disc depth（SD）〉 electrical conductivity （EC）. Additionally, it also demonstrated that the contributions of these three factors were the maximal for the change of chlorophyll-α concentration, total phosphorus（TP） and total nitrogen（TN） were the minimal. All the results showed that BRBPNN model was capable of automated regularization parameter selection and thus it may ensure the excellent generation ability and robustness. Thus, this study laid the foundation for the application of BRBPNN model in the analysis of aquatic ecological data（chlorophyll-α prediction） and the explanation about the effective eutrophication treatment measures for Nanzui water area in Dongting Lake.

关键词： Dongting Lake chlorophyll-a Bayesian regularized BP neural network model sum of square weights

Adverse effect of niobium and boron on hot deformation behavior of sulfur-containing steel

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Journal of Iron and Steel Research International 2024年第1期31卷 252-263页

作者： guo-ning he Shi-qi Wan Bo Jiang Chao-lei Zhang Ya-zheng Liu Chun-jing Wu School of Materials Science and Engineering University of Science and Technology BeijingBeijing100083China Institute for Advanced Materials and Technology University of Science and Technology BeijingBeijing100083China

The hot deformation behaviors of sulfur-containing gear steel 20MnCr5 containing three different contents of Nb and B(0,0.021%Nb,and 0.024%Nb-0.0022%B)were *** compression and tenssion tests were carried out by Gleeble3800 at the austenite region from 850 to 1150℃and the adverse effects of Nb and B were analyzed by the fracture,microstructure and precipitate *** compression tests showed that the proportions of instable area in hot processing maps of 0.021%Nb and Nb-B steels were higher and the deformability of Nb free steel was *** tensile deformation experiments showed that the reduction areas of Nb free,0.021%Nb and Nb-B steels were 92%-99%,84%-98%and 67%-97%,*** addition of Nb or Nb and B inhibited the dynamic recrystallization during hot deformation,and consequently,more deformed grains were then formed in 0.021%Nb and Nb-B steels thus to obtain the microstructure with worse uniformity and then deteriorate the *** addition,the interaction between inclusions and microalloyed elements was also *** particles of 0.021%Nb and Nb-B steels dynamically precipitated during deformation and precipitated together with MnS thus to worsen the deformability,resulting in the decrease of reduction area.

关键词： Hot deformation Gear steel Processing map Dynamic recrystallization Microalloying

Effect of Nb on Microstructure and Mechanical Properties in Non-magnetic High Manganese Steel

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Journal of Iron and Steel Research International 2014年第6期21卷 600-605页

作者： Jia-li CAO Ai-min ZHAO Ji-xiong LIU Jian-guo he Ran DING National Engineering Research Center for Advanced Rolling Technology University of Science and Technology Beijing Beijing Laboratory of Metallic Materials and Processing for Modern Transportation Baotai Group Co. Ltd.

Microstructure and mechanical properties of two kinds of non-magnetic high manganese steels with and without Nb addition which experienced the same rolling and heating treatment were investigated by means of scan ning electron microscopy, electron back-scattered diffraction, transmission electron microscopy, X-ray diffraction and tensile test. It was found that the microstructure of the high manganese steel was refined by the Nb addition. Moreover, steel with Nb addition has a higher stacking fault energy which favors the deformation twinning, Twin ning is the most important deformation mechanism in the Nb-bearing steel. Therefore, steel with Nb addition has much higher strength and higher plasticity. The product of tensile strength and total elongation exceeds 61.8 GPa ·%. In addition, steel with Nb addition also has excellent non magnetic property.

关键词： non-magnetic high manganese steel Nb addition rolling twinning mechanical property