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Clinical and experimental study on regional administration of phosphorus32 glassmicrospheres in treating hepatic carcinoma

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World Journal of Gastroenterology 1999年第6期5卷 492-505页

作者： LIU Lu, JIANG Zao, TENG Gao Jun, SONG Ji Zhi, ZHANG Dong Sheng, guo Qing Ming, FANG Wen, he Shi Cheng and guo Jin he 南京铁道医科大学江苏苏州

AIM To study the therapeutical effectiveness, dosage range and toxic adverse effects of domestic phosphorus 32 glass microsphere and evaluate its clinical significance. METHODS Ⅰ. Fifty two BALB/*!c tumor bearing male nude mice were allocated into treatment group( n =38) and control group( n =14). In the former group different doses of 32 P GMS were injected into the tumor mass, while in the latter 31 P GMS or no treatment was given. The experimental animals were sacrificed in batches, and then the tumors and their nearby tissues were examined by light and electron microscopy. Ⅱ. Through selective catheterization of hepatic artery, 32 P GMS was infused to 5 healthy domestic pigs in a dosage equivalent to the therapeutic dose for human being, and 31 P GMS was infused to another 5 healthy domestic pigs. Two pigs infused with contrast medium served as whole course blank controls. One pig from each group was surrendered to euthanasia at week 1, 4, 8 and 16 respectively. The ultrastructural histopath ological changes in liver tissues taken from different sites were evaluated semiquan titatively. Ⅲ. One hundred and twenty seven times of 32 P GMS intrahepatic artery interventional therapies were performed on 93 patients with hepatic carcinoma, including 79 cases of primary hepatic carcinoma and 14 cases of secondary hepatic carcinoma. 32 P GMS ( n =30), and group B, 32 P GMS and half dose of trans hepatic artery embolization (TAE) ( n =49) , and 18 patients with HCC by TAE only as control group C. Fourteen patients with secondary hepatic carcinoma were treated in the same way as group B or C. RESULTS Ⅰ. Comparing with the control group, the treatment group of tumor bearing nude mice attained the tumor inhibition rates of 59 7%-93 7% ( F =579 62, P he tumor cells were completely destroyed. When the absorbed doses ranged from 1830Gy to 3660Gy, most of the tumor cells showed the evidences of injury or necrosis, but there appea

关键词： liver neoplasms/therapy phosphorus 32 glass microspheres ( 32 P GMS) 31 P GMS interventional therapy

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Structure and Properties of Medical Hollow Palm Sheath Fibril

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Journal of Donghua University(English Edition) 2014年第5期31卷 617-620页

作者： CheN Chang-jie ZHANG You WANG guo-he College of Textile and Clothing Engineering Soochow University Suzhou 215006 China National Engineering Laboratory for Modem Silk Suzhou 215123 China

The palm trunk fiber bundles were treated with glacial acetic acid solution and H2 02 to get the palm sheath fibril hardly with any lignin or hemi-cdlulose. The morphological, aggregation structure and moisture regain, water absorption; anti-bacterlal properties of palm sheath fibril were tested and analyzed. The results showed that the average length of palm sheath fibril was （643.6 ± 192.4 ） pro, while average diameter was （ 10.3 ± 1.9 ） pma. A lumen existed in the cross section of each natural fibril, and the average hollowness of fibril reached （47.1 ± 11.1 ） %. Fibril was mainly constituted by cellulose I which gibed palm fibril a good hygroscopieity and the degree of crystalfization was 62.3 %. The moisture regain of palm sheath fibril was about 12.1% while water absorption was 10. 68 g/g suitable for medical packing. Fibril antibacterial against staphylococcus aurous was 84.3 %, and against escherichia coli was 73.3 %. Palm sheath fibril can be used as a natural fiber material for nonwoven medical use.

关键词： palm sheath fibril hollowness medical antibacterialwater absorption

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Formation of Struvite Crystals in a Simulated Food Waste Aerobic Composting Process

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Chemical Research in Chinese Universities 2010年第2期26卷 210-216页

作者： DU Xian-yuan LIU Jian-lin HUANG guo-he LI YU Energy and Environmental Research Centre North China Electric Power University Beo＇ing 102206 P. R. China College of Environment and Resources Jilin University Changchun 130012 P. R. China Environmental Systems Engineering Program Faculty of Engineering University of Regina Regina SK S4S OA2 Canada

Bench-scale treatments with three mixtures of Mg and P salts, including K3PO4＋MgSO4, K2HPO4＋MgSO4, and KH2PO4＋MgSO4 as additives in a simulated food waste aerobic composting process, were conducted to test the magnesium ammonium phosphate（MAP） formation, and the compost products were analyzed by X-ray diffraction（XRD）, Scanning electron microscopy（SEM）, and Energy dispersive X-ray spectroscopy（EDS） analyses. The comparison results between XRD, SEM, and EDS analyses of MAPs in the dried compost and synthesized MAPs confirm the formation of MAP crystals in the simulated food waste aerobic composting process. The analysis of the compost also indicates that the addition of all the three mixtures of Mg and P salts in the aerobic composting process can increase nitrogen conservation and decrease nitrogen loss because of the formation of MAPs. The mechanism of MAP formation was verified as the reaction of ammonium（NH4＋） with magnesium（Mg^2＋） and phosphate[HnPO4^（3-n） , n=0, 1, and 2）.

关键词： Phosphate Magnesium sulphate Magnesium ammonium phosphate Food waste treatment Aerobic composting

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Characterization of a novel regulatory pathway for mannitol metabolism and its coordination with biofilm formation in Mycobacterium smegmatis

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Journal of Genetics and Genomics 2018年第9期45卷 477-488页

作者： Jialing Hu Hua Zhang Si Zhou Weihui Li Zheng-guo he National Key Laboratory of Agricultural Microbiology College of Life Science and TechnologyHuazhong Agricultural University

Biofilm formation has been implicated to be tightly regulated in bacteria. Mycobacterial species possess a unique cell-wall structure; however, the underlying regulation mechanism for their biofilm formation remains largely unclear. In this study, we characterized a hypothetical mannitol metabolism and transportation gene cluster（Ms5571-Ms5576）, designated as mmt operon, whose expression significantly contributes to the biofilm formation in Mycobacterium smegmatis. We showed that in the operon the Ms5575 gene encodes a GntR-like transcriptional repressor and the Ms5576 gene encodes a mannitol2-dehydrogenase which can produce D-mannitol from D-mannose. Strikingly, the D-mannitol molecule can derepress the negative regulation of Ms5575 on the mmt operon to stimulate the operon＇s expression. Consistently, addition of D-mannitol into the medium can obviously induce mycobacterial biofilm formation. Furthermore, we found that Ms0179 positively regulates the mmt operon through its downstream regulator Ms0180. Ms0180 directly binds the mmt operon to positively regulate its expression. Both Ms0179 and Ms0180 significantly affect the mycobacterial biofilm formation. Taken together, we explored a regulatory pathway for the mannitol metabolism and its coordination with the biofilm formation in M. smegmatis. This finding provides novel insights into the unique mechanism of biofilm formation regulation in mycobacteria.

关键词： Transcription regulation Biofilm formation Mannitol Mycobacteria

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MpbR,an essential transcriptional factor for Mycobacterium tuberculosis survival in the host,modulates PIM biosynthesis and reduces innate immune responses

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Journal of Genetics and Genomics 2019年第12期46卷 575-589页

作者： Yugang Li Weihui Li Zhiwei Xie Hui Xu Zheng-guo he National Key Laboratory of Agricultural Microbiology College of Life Science and TechnologyHuazhong Agricultural UniversityWuhan430070China State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources College of Life Science and TechnologyGuangxi UniversityNanning530004China

Mycobacterium tuberculosis possesses unique cellular envelope components that contribute to bacterial escape from host immune *** mannosides(PIMs)and their higher derivatives are important molecules implicated in host-pathogen interactions in the course of ***,the biosynthetic regulation of these specific lipids and its effect on the bacterial fate in the infected host remain ***,we show that a hypothetical *** transcriptional factor designated as MpbR negatively regulates two transporter genes and affects mycobacterial PIM biosynthesis and biofilm *** inhibits the accumulation of acylated PIM lipids and triggers the mycobacterium to reduce the production of reactive oxygen species and NO during infection,which enhances the survival of *** in *** deletion reduces *** lung burdens and inflammation of infected *** findings provide new insights into the regulation of mycobacterial lipid metabolism and its correlation with pathogenesis of ***.

关键词： Mycobacterium tuberculosis Transcriptional factor Lipid metabolism

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Quantum States Transfer by Analogous Bell States

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Communications in Theoretical Physics 2008年第2期49卷 347-350页

作者： MEI Di LI Chong YANG guo-Hui SONG he-Shan Department of Physics Dalian University of Technology Dalian 116023 China

Transmitting quantum states by channels of analogous Bell states is studied in this paper. We analyze the transmitting process. constructed the probabilitic unitary operator, and gain the largest successful transfer q... 详细信息

关键词： quantum state transfer analogous Bell state transfer quantum state probability

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Exploration of a MgO cathode for improving the intensity of pulsed discharge plasma at atmosphere

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Plasma Science and Technology 2018年第10期20卷 104-111页

作者： he guo Xiaomei YAO Jie LI Nan JIANG Yan WU Key Laboratory of Industrial Ecology and Environmental Engineering MOEDalian University of TechnologyDalian 116024People＇s Republic of China School of Electrical Engineering Dalian University of TechnologyDalian 116024People＇s Republic of China School of Environmental Science ＆ Technology Dalian University of TechnologyDalian 116024People＇s Republic of China

With regard to the lower density and energy of electrons in pulsed discharge plasma （PDP） at atmosphere, leading to the lower energy utilization of plasma, we propose a MgO cathode to enhance the plasma intensity according to field emission principle. The MgO cathode is prepared by an electro-depositing MgO film on a stainless steel plate. This way, the positive charges come to the cathode and accumulate on the surface of the MgO film, leading to the enhancement of the electric field intensity between the cathode and MgO film, and result in the strong emission of secondary electrons from the MgO cathode. As a result, the intensity of plasma can be enhanced. herein, the effect of the MgO cathode on the intensity of PDP is investigated. It was shown that the discharge peak current was improved by 20% compared with that of without the MgO cathode. With increasing the MgO film thickness, discharge intensity, including the peak current, transforming charge and spectrum intensity first increased and then decreased. Higher enhancement of peak current, transforming charge and spectrum intensity were acquired with a higher peak voltage. Compared to a cathode without MgO film, the ozone production is higher with MgO cathode employed. The research proposes a novel approach for improving the intensity of discharge plasma, and also provides a reference for further application of PDP.

关键词： discharge intensity pulsed discharge plasma MgO cathode secondary electron emission

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Searches for dark matter via charged Higgs pair production in the Inert Doublet Model at a γγ collider

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Chinese Physics C 2021年第10期45卷 16-24页

作者： guo-he Yang Mao Song Gang Li Yu Zhang Jian-You guo School of Physics and Material Science Anhui UniversityHefei 230601China School of physics Huazhong University of Science and TechnologyHefei 230601China Institutes of Physical Science and Information Technology Anhui UniversityWuhan 430074China

The Inert Doublet Model(IDM)is one of the simplest extensions beyond the Standard Model(SM)with an extended scalar sector,which provides a scalar dark matter particle *** this study,we investigated the double charged Higgs production at aγγ*** scanning the whole parameter space,we obtained the parameter points corresponding to the correct relic abundance of dark *** applying all theoretical and experimental constraints,the parameter space for the existence of dark matter was extremely *** performed an analysis of the signal of H+H-production in the IDM and the SM background,with the optimized selection conditions chosen for the kinematic variables to maximize the signal *** the signal with the background,we obtained the parameter points that may be detected in futureγγcollider experiments.

关键词： dark matter IDM large hadron collider

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Effect of vanadium content on microstructure and properties of in situ TiC reinforced V_(x)FeCoNiCu multi-principal-element alloy matrix composites

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Journal of Iron and Steel Research International 2021年第11期28卷 1471-1480页

作者： Chun-lei Tu Xiao-dong Sun Jie Li he-guo Zhu Xiang-dong Li College of Mechanical Engineering Southeast UniversityNanjing 210094JiangsuChina Special Equipment Safety Supervision Inspection Institute of Jiangsu Province Nanjing 210036JiangsuChina College of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing 210094JiangsuChina

V_(x)FeCoNiCu high entropy alloy matrix composites reinforced by in situ TiC particles(10 vol.%),i.e.,V_(x)FeCoNiCu/TiC composites,were fabricated from V–Fe–Co–Ni–Cu–Ti–C system using vacuum inductive melting *** the content of vanadium increasing,the size of TiC particles decreased ***,vanadium agglomeration occurred *** reaction mechanism of the mixed powder(Fe,V,Ti and C)and the mechanical properties of obtaining V_(x)FeCoNiCu/TiC composites were *** was found that three reactions occurred(Fe-Ti-FeTi-Fe_(2)Ti,FeTi-Fe_(2)Ti-Fe-Ti and Ti-C-TiC)in the heating *** apparent activation energy for these three reactions was calculated and found to be 26.4,698.3 and 1879.0 kJ/mol,*** room temperature,tensile strength and elongation increased first and then decreased with the increase in vanadium content and the microhardness increased *** maximum tensile strength of the composites was determined to be 666 MPa,representing a 17.7%increase over that of FeCoNiCu/TiC high entropy alloy composites.

关键词： High entropy alloy matrix composite Vacuum inductive melting Reaction mechanism Apparent activation energy Tensile strength

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Effect of titanium microalloying on microstructure and mechanical properties of vanadium microalloyed steels for hot forging

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Journal of Iron and Steel Research International 2022年第2期29卷 295-306页

作者： Fan Zhao guo-ning he Ya-zheng Liu Zhi-hao Zhang Jian-xin Xie Beijing Laboratory of Metallic Materials and Processing for Modern Transportation Institute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing100083China State Key Laboratory of Materials Processing and Die&Mould Technology Huazhong University of Science and TechnologyWuhan430074HubeiChina School of Materials Science and Engineering University of Science and Technology BeijingBeijing100083China

Effect of titanium microalloying on the microstructure and mechanical properties of vanadium microalloyed steels for hot forging was *** microalloying improves the mechanical properties mainly through refining the austenite *** the heating temperature is in the range of 1050–1300℃,the austenite grain diameter is decreased from 77–133 to 26–68μm by titanium *** the decrease in austenite grain diameter,the final microstructure is refined significantly,and the high misorientation boundaries are *** the steel is heated at 1200℃(the common hot forging temperature)and cooled slowly,titanium microalloying decreases the yield strength from 548.4 to 519.4 MPa,and the tensile strength decreases from 842.7 to 808.7 ***,the elongation increases from 19.0%to 21.4%,and the impact energy increases from 9.8 to 38.2 J.V–Ti steel has a better combination of strength,plasticity and toughness than V *** addition,the nucleation of intragranular ferrite idiomorphs is promoted by titanium microalloying,which may have a beneficial effect on the property of steels with coarse microstructure caused by the critical deformation in hot die forging.

关键词： Titanium microalloying Microalloyed steel Microstructure Mechanical property Intragranular ferrite

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