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第十四届中国体视学与图像分析学术会议

作者： Yang Mei Xu Dongping Liu Yuan guo Xiaodong Li Wenshu guo chaonan Zhang Hongping Gao Yinjie Mao Yuanli Zhao Jingmin Department of Pathology and Hepatology Beijing 302 Hospital Institute of Infectious Diseases/Liver Failure Medical Center Beijing 302 Hospital Center for Clinical Trial Beijing 302 Hospital Center for Clinical Laboratory Beijing 302 Hospital

Background Non-alcoholic steatoheaptitis(NASH),the critical stage of non-alcoholic fatty liver disease(NAFLD),is of chronic progression and can develop cirrhosis even hepatocellular carcinoma(HCC).However,non-invasive biomarkers for NASH diagnosis remain poorly applied in clinical *** study aims at testing the accuracy of the combination of cytokeratin-18 M30 fragment(CK-18-M30),fibroblast growth factor 21(FGF-21),interleukin 1 receptor antagonist(IL-1 Ra),pigment epithelium-derived factor(PEDF)and osteoprotegerin(OPG)in diagnosing NAFLD and *** 179 patients with biopsy-proven NAFLD were enrolled as training group,91 ageand gender-matched healthy subjects were recruited at the same time as controls.63 otherNAFLD patients were separately collected as validation group.45 alcoholic fatty liver disease(AFLD)patients,50hepatitis B virus(HBV)patients,52 hepatitis C virus(HCV)patients were also *** biomarker levels were measured by enzyme-linked immunosorbent *** Serum levels of CK-18-M30,FGF-21,IL-1Ra and PEDF increased,while OPG decreased in a stepwise fashion in controls,non-NASH NAFLD patients and NASH patients(P<0.01).The area under receiver-operating characteristics curve to diagnose NASH was 0.86 for CK-18-M30,O.89 for},0.89 for IL-1Ra,0.89 for PEDF and 0.89 for ***-18-M30 had 70%negative predictive value(NPV)and 79%positive predictive value(PPV)to diagnose NASH.A 5-step approach measuring CK-18-M30 followed by FGF21,IL-1Ra,PEDF and OPG gradually improved the NPV to 76%and PPV to 85%,which reached80%and 76%respectively in the validation *** Compared to single biomarker,stepwise combination of CK-18-M30,FGF-21,IL-1 Ra,PEDF and OPG can further improve the accuracy in diagnosing NASH.

关键词： Non-alcoholic steatohepatitis Non-invasive diagnosis Combined serum biomarker Accuracy

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Interleukin-22 mediates liver fibrosis via activating hepatic stellate cells in patients with hepatitis C

Interleukin-22 mediates liver fibrosis via activating hepati...

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中华医学会第四届全国病毒性肝炎慢性化、重症化基础与临床研究进展学术会议

作者： Jingmin Zhao Liyuan Wu Jin Li Shuhong Liu chaonan guo Wenshu Li Keming Zhang Lai Wei Department of Pathology and Hepatology Beijing 302 Hospital Beijing 302 Hospital Department of Clinical Trial Beijing 302 Hospital Department of Hepatobiliary Surgery Beijing 302 Hospital Liver Disease Research Center Peking University People’s Hospital

Background & Aims Interleukin-22(IL-22) is up-regulated in liver tissues of patients with hepatitis C virus(HCV) and demonstrates anti-fibrotic functions in mouse ***,the role of IL-22 i

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Interleukin-22 mediates liver fibrosis via activating hepatic stellate cells in patients with hepatitis C

Interleukin-22 mediates liver fibrosis via activating hepati...

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第四届全国病毒性肝炎慢性化、重症化基础与临床研究进展学术会议

作者： Jingmin Zhao Liyuan Wu Jin Li Shuhong Liu chaonan guo Wenshu Li Keming Zhang Lai Wei Department of Pathology and Hepatology Beijing 302 Hospital Department of Clinical Trial Beijing 302 Hospital Department of Hepatobiliary Surgery Beijing 302 Hospital Liver Disease Research Center Peking University People’s Hospital

Background&Aims Interleukin-22(IL-22)is up-regulated in liver tissues of patients with hepatitis C virus(HCV)and demonstrates anti-fibrotic functions in mouse ***,the role of IL-22 in HCV-associated liver fibrosis is poorly *** study is aimed to investigate the role of IL-22 in patients with HCV infection and the possible *** The levels of IL-22 in plasma and frequencies of peripheral IL-22-producing cells were analyzed in a cohort of HCV-infected patients including 32 with chronic hepatitis C(CHC),64 with HCV-

关键词： HCV Interleukin-22 mediates liver fibrosis via activating hepatic stellate cells in patients with hepatitis C CHC

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Hepatic Zbtb18 (Zinc Finger and BTB Domain Containing 18) alleviates hepatic steatohepatitis via FXR (Farnesoid X Receptor)

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Signal Transduction and Targeted Therapy 2024年第2期9卷 766-781页

作者： Lei Zhang Jiabing Chen Xiaoying Yang Chuangpeng Shen Jiawen Huang Dong Zhang Naihua Liu chaonan Liu Yadi Zhong Yingjian Chen Kaijia Tang Jingyi guo Tianqi Cui Siwei Duan Jiayu Li Shangyi Huang Huafeng Pan Huabing Zhang Xiaoqiang Tang Yongsheng Chang Yong Gao State Key Laboratory of Traditional Chinese Medicine Syndrome Science and Technology Innovation CenterGuangzhou University of Chinese MedicineGuangzhouChina Key Laboratory of Immune Microenvironment and Disease(Ministry of Education) Tianjin Key Laboratory of Cellular Homeostasis and DiseaseDepartment of Physiology and PathophysiologyTianjin Medical UniversityTianjinChina Jiangsu Key Laboratory of Immunity and Metabolism Department of Pathogen Biology and ImmunologyJiangsu International Laboratory of Immunity and MetabolismXuzhou Medical UniversityXuzhouChina Department of Endocrinology The First Clinical CollegeGuangzhou University of Chinese MedicineGuangdongChina The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine ShenzhenChina Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine in Prevention and Treatment of Tumor Nanjing University of Chinese MedicineNanjingChina Department of Biochemistry and Molecular Biology Metabolic Disease Research CenterSchool of Basic MedicineAnhui Medical UniversityHefeiChina Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE State Key Laboratory of BiotherapyWest China Second University HospitalSichuan UniversityChengduChina

A lasting imbalance between fatty acid synthesis and consumption leads to non-alcoholic fatty liver disease(NAFLD),coupled with hepatitis and insulin *** the details of the underlying mechanisms are not fully ***,we unraveled that the expression of the transcription factor Zbtb18 is markedly decreased in the livers of both patients and murine models of *** Zbtb18 knockout promoted NAFLD features like impaired energy expenditure and fatty acid oxidation(FAO),and induced insulin ***,hepatic Zbtb18 overexpression alleviated hepato-steatosis,insulin resistance,and hyperglycemia in mice fed on a high-fat diet(HFD)or in diabetic ***,in vitro and in vivo mechanistic studies revealed that Zbtb18 transcriptional activation of Farnesoid X receptor(FXR)mediated FAO and Clathrin Heavy Chain(CLTC)protein hinders NLRP3 inflammasome *** key mechanism by which hepatocyte’s Zbtb18 expression alleviates NAFLD and consequent liver fibrosis was further verified by FXR’s deletion and forced expression in mice and cultured mouse primary hepatocytes(MPHs).Moreover,CLTC deletion significantly abrogated the hepatic Zbtb18 overexpression-driven inhibition of NLRP3 inflammasome activity in ***,Zbtb18 transcriptionally activates the FXR-mediated FAO and CLTC expression,which inhibits NLRP3 inflammasome’s activity alleviating inflammatory stress and insulin resistance,representing an attractive remedy for hepatic steatosis and fibrosis.

关键词： hepatic Hepatic impaired

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Emerging direct current triboelectric nanogenerator for high-entropy mechanical energy harvesting

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Science China(Technological Sciences) 2024年第5期67卷 1297-1316页

作者： CHEN Jie guo RuiLong guo HengYu College of Physics and Electronic Engineering Chongqing Normal UniversityChongqing 401331China Department of Applied Physics Chongqing UniversityChongqing 401331China

In the era of the Internet of Things(IoT),the provision of sustainable power to distributed,mobile,and low-power-consumption electronic devices is a critical *** overcome this challenge,the triboelectric nanogenerator(TENG),a highly efficient high-entropy mechanical energy harvesting device,was developed in *** device enables the direct conversion of irregular and low-frequency mechanical energy into pulsed alternating current(AC)***,the incompatibility of most electronic devices with AC signals necessitates rectifier circuits or generators that deliver direct current(DC)*** recent years,DC-TENGs have undergone extensive development,achieving significant milestones in various application fields while also facing crucial challenges that require *** this review,three categories of DC-TENG devices with distinct operating mechanisms are comprehensively explored:multiphase coupling,mechanical rectification,and air *** typical structures and working mechanisms are thoroughly discussed,and specific output performance limitations,along with corresponding optimization strategies,are ***,the applications of DC-TENGs in various scenarios are ***,the challenges faced by DC-TENGs and potential solutions are analyzed to guide further advancements in this technology.

关键词： TENG direct current working mechanisms output performance limitations optimization strategies

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Physicochemical principles of hydrogen metallurgy in blast furnace

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Journal of Iron and Steel Research International 2024年第1期31卷 46-63页

作者： Han-jie guo School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China Beijing Key Laboratory of Special Melting and Preparation of High-End Metal Materials Beijing100083China

Based on the stoichiometric method and the free energy minimization method,an ideal model for the reduction of iron oxides by carbon and hydrogen under blast furnace conditions was established,and the reduction efficiency and theoretical energy consumption of the all-carbon blast furnace and the hydrogen-rich blast furnace were *** results show that after the reduction reaction is completed at the bottom of the blast furnace,the gas produced by reduction at 1600℃still has a certain excessive reduction capacity,which is due to the hydrogen brought in by the hydrogen-rich blast as well as the excess carbon monoxide generated by the reaction of the coke and the oxygen brought in by the *** the process of the gas with excessive reduction capacity rising from the bottom of the blast furnace and gas reduction process,the excessive reduction capacity of the gas gradually decreases with the increase in the dydrogen content in the *** the all-carbon blast furnace,the excess gas reduction capacity is the strongest,and the total energy consumption per ton of iron reduction is the *** shows that,for the current operation mode of the blast furnace,adding hydrogen in the blast furnace cannot reduce the consumption of carbon required for reduction per ton of iron,but rather increases the consumption of carbon.

关键词： Hydrogen metallurgy Excess gas reduction capacity Theoretical energy consumption Hydrogen-rich blast furnace Thermodynamic model Gibbs minimum free energy method

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Control Strategies for Digital Twin Systems

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IEEE/CAA Journal of Automatica Sinica 2024年第1期11卷 170-180页

作者： guo-Ping Liu IEEE the Center for Control Science and Technology Southern University of Science and TechnologyShenzhen 518055China

With the continuous breakthrough in information technology and its integration into practical applications, industrial digital twins are expected to accelerate their development in the near future. This paper studies various control strategies for digital twin systems from the viewpoint of practical *** make full use of advantages of digital twins for control systems, an architecture of digital twin control systems, adaptive model tracking scheme, performance prediction scheme, performance retention scheme, and fault tolerant control scheme are proposed. Those schemes are detailed to deal with different issues on model tracking, performance prediction, performance retention, and fault tolerant control of digital twin systems. Also, the stability of digital twin control systems is analysed. The proposed schemes for digital twin control systems are illustrated by examples.

关键词： Digital twin control systems fault tolerant control model tracking performance prediction performance retention

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Configuration Synthesis and Grasping Performance Analysis of Multi-Loop Coupling Capture Mechanism for Launch and Recovery of Torpedo-Shaped Autonomous Underwater Vehicle

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China Ocean Engineering 2024年第3期38卷 453-466页

作者： ZHANG guo-xing XIA Xin-lu guo Jin-wei School of Mechanical Engineering Jiangsu University of Science and TechnologyZhenjiang 212100China

Research of capture mechanisms with strong capture adaptability and stable grasp is important to solve the problem of launch and recovery of torpedo-shaped autonomous underwater vehicles(AUVs).A multi-loop coupling capture mechanism with strong adaptability and high retraction rate has been proposed for the launch and recovery of torpedo-shaped AUVs with different morphological ***,the principle of capturing motion retraction is described based on the appearance characteristics of torpedo-shaped AUVs,and the configuration synthesis of the capture mechanism is carried out using the method of constrained chain ***,the screw theory is employed to analyze the degree of freedom(DoF)of the capture ***,the 3D model of the capture mechanism is established,and the kinematics and dynamics simulations are carried *** with the capture orientation requirements of the capture mechanism,the statics and vibration characteristics analyses are carried ***,considering the capture process and the underwater working environment,the motion characteristics and hydraulics characteristics of the capture mechanism are ***,a principle prototype is developed and the torpedo-shaped AUVs capture experiment is *** work provides technical reserves for the research and development of AUV capture special equipment.

关键词： capture mechanism torpedo-shaped AUVs configuration synthesis launch and recovery grasping performance analysis

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Up-regulation of interleukin-22 mediatesliver fibrosis via activating hepatic stellate cells in patients with hepatitis C

Up-regulation of interleukin-22 mediatesliver fibrosis via a...

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第十四届中国体视学与图像分析学术会议

作者： Wu Liyuan Liu Shuhong Liu Yuan guo chaonan Li Hanwei Li Wenshu Jin Xueyuan Zhang Keming Zhao Ping Wei Lai Zhao Jingmin Department of Pathology and Hepatology Beijing 302 Hospital Liver Cirrhosis Diagnosis and Treatment Center Beijing 302 Hospital Center for Clinical Trial Beijing 302 Hospital International Center for Liver Disease Diagnosis and Treatment Beijing 302 Hospital Department of Hepatobiliary Surgery Beijing 302 Hospital Liver Disease Research Center Peking University People's Hospital

ObjectiveInterleukin-22(IL-22)is up-regulated in liver tissues of patients with hepatitis C virus(HCV)and demonstrates anti-fibrotic functions in mouse ***,the role of IL-22 in HCV-associatedliver fibrosis is poorly *** study is aimed to investigate the role of IL-22 in patients with HCV infection and the possible *** The levels of IL-22 in plasma and frequencies ofperipheral IL-22-producing cells were analyzed in acohort of HCV-infected patients including32 with chronic hepatitis C(CHC),64 withHCV-associated liver cirrhosis(LC),and 30 healthy subjects as *** distribution oflL-22+cells in situ in liver tissues was observed by ***-22 receptor expressionwas studied on liver biopsies and in human hepatic stellatecells as well as their response to recombinant IL-22 by flowcytometry and *** Patients withCHC and especially LC disclosed significant increases inperipheral numbers of IL-22-producing cells as well as in IL-22 *** increased intrahepatic IL-22+cells were positively correlatedwith fibrotic staging scores and clinical progressionfrom CHC to ***,the majority of IL-22+cellswere located in fibrotic areas in the liver of patients withcirrhosisand co-localized witheα-smooth muscle actin(α-SMA)positive hepatic stellate ceils(HSCs).In vitro,administration of IL-22 was accompanied with increased expression ofα-SMA,inhibitedLX-2 cells apoptosis,and up-regulated collagen production by LX-2 *** IL-22 may contribute to the fibrogenesis of HCV-associated liver fibrosis by activating the hepatic stellate *** findings appears to be relevant to the development of of novel therapies targeting IL-22/IL-22R1 for patients with HCV infection.

关键词： Interleukin-22 Hepatitis C virus Liver fibrosis Hepatic stellate cell

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A Deep Learning Method for Computing Eigenvalues of the Fractional Schrödinger Operator

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Journal of Systems Science & Complexity 2024年第2期37卷 391-412页

作者： guo Yixiao MING Pingbing LSEC Institute of Computational Mathematics and Scientific/Engineering ComputingAcademy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100049China

The authors present a novel deep learning method for computing eigenvalues of the fractional Schrödinger *** proposed approach combines a newly developed loss function with an innovative neural network architecture that incorporates prior knowledge of the *** improvements enable the proposed method to handle both high-dimensional problems and problems posed on irregular bounded *** authors successfully compute up to the first 30 eigenvalues for various fractional Schrödinger *** an application,the authors share a conjecture to the fractional order isospectral problem that has not yet been studied.

关键词： Eigenvalue problem deep learning fractional Schrödinger operator isospectral problem

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