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Spatiotemporal transformable nano-assembly for on-demand drug delivery to enhance anti-tumor immunotherapy

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Asian Journal of Pharmaceutical Sciences 2024年第1期19卷 103-118页

作者： Chenglin Liang Ge Zhang Linlin guo Xinyi Ding Heng Yang Hongling Zhang zhenzhong Zhang Lin Hou School of Pharmaceutical Sciences Key Laboratory of Targeting Therapy and Diagnosis for Critical DiseasesZhengzhou UniversityZhengzhou 450001China

Induction of tumor cell senescence has become a promising strategy for anti-tumor immunotherapy,but fibrotic matrix severely blocks senescence inducers penetration and immune cells ***,we designed a cancer-associated fibroblasts(CAFs)triggered structure-transformable nano-assembly(HSD-P@V),which can directionally deliver valsartan(Val,CAFs regulator)and doxorubicin(DOX,senescence inducer)to the specific *** detail,DOX is conjugated with hyaluronic acid(HA)via diselenide bonds(Se-Se)to form HSD micelles,while CAFs-sensitive peptide is grafted onto the HSD to form a hydrophilic polymer,which is coated on Val nanocrystals(VNs)surface for improving the stability and achieving responsive *** arriving at tumor microenvironment and touching CAFs,HSD-P@V disintegrates into VNs and HSD micelles due to sensitive peptide *** can degrade the extracellularmatrix,leading to the enhanced penetration of *** targets tumor cells,releases DOX to induce senescence,and recruits effector immune ***,senescent cells are cleared by the recruited immune cells to finish the integrated anti-tumor *** vitro and in vivo results show that the nanoassembly remarkably inhibits tumor growth as well as lungmetastasis,and extends tumorbearing mice *** work provides a promising paradigm of programmed delivering multi-site nanomedicine for cancer immunotherapy.

关键词： Cells senescence Tumor stroma Structure transformable Programmed delivery Anti-tumor immunotherapy

Earth's core-mantle boundary shaped by the crystallization of a hydrous terrestrial magma ocean

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National Science Review 2024年第7期11卷 73-75页

作者： Qingyang Hu Jie Deng Yukai Zhuang zhenzhong Yang Rong Huang Center for High Pressure Science and Technology Advanced Research(HPSTAR) Shanghai Advanced Research in Physical Sciences(SHARPS) Department of Geosciences Princeton University Institute of Atomic and Molecular Physics Sichuan University Key Laboratory of Polar Materials and Devices Department of Electronics East China Normal University

A water-rich global magma ocean(MO)likely existed in the early Hadean eon and subsequently cooled and *** water is an oxidant and is known to fundamentally affect liquid crystallization, the role of primordial water d... 详细信息

关键词： CROSSOVER MELT

Extreme climate sparks record boreal wildfires and carbon surge in 2023

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The Innovation 2024年第4期5卷 7-8页

作者： Lili Liang Shijing Liang zhenzhong Zeng School of Environmental Science and Engineering Southern University of Science and TechnologyShenzhen 518055China

While human activities,such as the burning of fossil fuels,are the primary contributors to the increase in atmospheric CO_(2) levels,large-scale wildfires can exacerbate this *** years with extensive and severe wildfires,additional carbon emissions can significantly perturb global carbon budgets,1 thereby impeding existing endeavors to mitigate climate ***,a recent investigation reported a notable surge in carbon emissions originating from boreal forests in 2021,2 reaching an estimated 0.48 gigatons of carbon(Gt C).However,this record proved *** 1 shows that by September 2023,the carbon emissions of boreal forests exhibited an unprecedented increase,primarily attributed to the Canadian boreal region,reaching 0.86 Gt *** consequences extend beyond geographical borders,as wildfires occurring hundreds of kilometers away resulted in the worst air quality in New York and *** increasing severity of boreal forest wildfires is accompanied by growing public concern,suggesting the potential proximity to or crossing of a critical tipping point in the ecological functioning of boreal forests.

关键词： surge record Figure

Carbon Fiber Breakage Mechanism in Aluminum(Al)/Carbon Fibers(CFs) Composite Sheet during Accumulative Roll Bonding(ARB) Process

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Journal of Wuhan University of Technology(Materials Science) 2024年第1期39卷 167-173页

作者：胡淑芬 SUN zhenzhong SHEN Fanghua DENG Jun 杨卫平杨浩坤 School of Engineering Jiangxi Agricultural UniversityNanchang 330045China School of Mechanical Engineering Dongguan University of TechnologyDongguan 510730China Guangdong-Hong Kong-Macao Joint Laboratory for Neutron Scattering Science and Technology Dongguan 510730China Smart Manufacturing Division Hong Kong Productivity Council78 Tat Chee AvenueHong Kong 5999075China

We put forward a method of fabricating Aluminum(Al)/carbon fibers(CFs) composite sheets by the accumulative roll bonding(ARB) method. The finished Al/CFs composite sheet has CFs and pure Al sheets as sandwich and surface layers. After cross-section observation of the Al/CFs composite sheet, we found that the CFs discretely distributed within the sandwich layer. Besides, the tensile test showed that the contribution of the sandwich CFs layer to tensile strength was less than 11% compared with annealed pure Al sheet. With ex-situ observation of the CFs breakage evolution with-16%,-32%, and-45% rolling reduction during the ARB process, the plastic instability of the Al layer was found to bring shear damages to the CFs. At last, the bridging strengthening mechanism introduced by CFs was sacrificed. We provide new insight into and instruction on Al/CFs composite sheet preparation method and processing parameters.

关键词： Al/CFs composite sheet accumulative roll bonding tensile strength plastic instability carbon fiber breakage

3D-structured carbon nanotube fibers as ultra-robust fabrics for adaptive electromagnetic shielding

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Nano Research 2024年第9期17卷 8521-8530页

作者： Dongping Li Ping Wang Yuanyuan Li zhenzhong Yong Kunjie Wu Yan Zhang Jin Wang Dongmei Hu Key Laboratory of Multifunctional and Smart Systems Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China College of Textile and Clothing Engineering of Soochow University Suzhou 215021China

Wireless communication technology is indispensable in our daily lives,but it also results in serious electromagnetic radiation ***,developing smart electromagnetic interference shielding materials with adjustable electromagnetic wave(EMW)responses holds significant promise for future electromagnetic shielding *** this study,we propose an electromagnetic shielding switch(ESS)characterized by tunable electromagnetic shielding performance achieved by fabricating a three-dimensional(3D)carbon nanotube-based spacer fabric(CNT-SF)and modifying CNT-SF with chemical vapor deposition(CCNT-SF).The CCNT-SF displays direction-dependent electrical conductivity by manipulating the warp and weft density,measuring 128 S/m transversely and 447 S/m *** characteristic allows the CCNT-SF to transmit or shield EMW by adjusting the angle of EMW incidence through fabric rotation,resulting in anisotropic electromagnetic shielding performance(33 dB transversely and 87 dB vertically).This feature enables switchable shielding with an on/off ratio of ***,the unique 3D structure confers excellent mechanical properties on the fabric,with compressive strength reaching 120 *** a flexible,lightweight,and mechanically robust ESS,the CCNT-SF holds promising prospects for mitigating the challenges of increasingly severe and intricate electromagnetic environments.

关键词： carbon nanotube spacer fabric electromagnetic shielding impact resistance joule heating electromagnetic shielding switch

Calculation of Mass Concrete Temperature Containing Cooling Water Pipe Based on Substructure and Iteration Algorithm

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工程与科学中的计算机建模(英文) 2024年第1期138卷 813-826页

作者： Heng Zhang Chao Su Zhizhong Song zhenzhong Shen Huiguang Lei Changjiang Institute of Survey PlanningDesign and ResearchWuhan430010China College ofWater Conservancy and Hydropower Engineering Hohai UniversityNanjing210098China Chief Engineer Office Wujiang Company of Goupitan Power Construction CooperationYuqing564408China

Mathematical physics equations are often utilized to describe physical phenomena in various fields of science and *** such equation is the Fourier equation,which is a commonly used and effective method for evaluating the effectiveness of temperature control measures for mass *** important measure for temperature control in mass concrete is the use of cooling water ***,the mismatch of grids between large-scale concrete models and small-scale cooling pipe models can result in a significant waste of calculation time when using the finite element ***,the temperature of the water in the cooling pipe needs to be iteratively calculated during the thermal transfer *** substructure method can effectively solve this problem,and it has been validated by *** Abaqus/Python secondary development technology provides engineers with enough flexibility to combine the substructure method with an iteration algorithm,which enables the creation of a parametric modeling calculation for cooling water *** paper proposes such a method,which involves iterating the water pipe boundary and establishing the water pipe unit substructure to numerically simulate the concrete temperature field that contains a cooling water *** verify the feasibility and accuracy of the proposed method,two classic numerical examples were *** results showed that this method has good applicability in cooling pipe *** the value of the iteration parameterαis 0.4,the boundary temperature of the cooling water pipes can meet the accuracy requirements after 4∼5 iterations,effectively improving the computational ***,this approach provides a useful tool for engineers to analyze the temperature control measures accurately and efficiently for mass concrete,such as cooling water pipes,using Abaqus/Python secondary development.

关键词： Fourier equation cooling water pipe mass concrete iteration algorithm

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基于SCI的科技创新领域文献同被引分析

现代情报 2016年第10期36卷 164-170页

作者：郭彬杨振中太原理工大学经济管理学院山西太原030024

本文以2010-2014年美国科学情报研究所开发的Web of Science数据库为数据源,以"科技创新"作为主题进行文献检索,在SCI(Science Citation Index)中共收集445篇文献。通过应用文献同被引分析、统计分析的方法对科技创新前沿的文章进行了... 详细信息

本文以2010-2014年美国科学情报研究所开发的Web of Science数据库为数据源,以"科技创新"作为主题进行文献检索,在SCI(Science Citation Index)中共收集445篇文献。通过应用文献同被引分析、统计分析的方法对科技创新前沿的文章进行了描述及研究,揭示了这5年科技创新研究的重点,主要集中在科技创新合作模式,产品绩效的影响因素和产品创新与工艺创新的关系,科技创新商业化,创新战略的选择,开放式创新下的知识管理,新产品开发,质量管理对创新的影响等方面。

关键词： SCI 科技创新同被引分析因子分析

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我国农村金融生态环境的优化研究

改革与战略 2017年第9期33卷 111-113页

作者：郭彬杨振中太原理工大学经济管理学院山西太原030024

当前农村金融生态环境缺乏政府全面的服务能力,农村信用环境不完善,农村金融服务质量整体不高,缺乏农村金融的有效供给。优化农村金融生态环境,需要进一步规范地方政府行为,优化信用环境,优化经济环境,加强制度设计和政策配套管理。

关键词：农村金融生态环境现状和问题优化对策

Efficient second and third harmonic generation in dual-layer lithium niobate microdisk resonator

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 33-38页

作者： zhenzhong Hao Xiao Wu Qiang Luo Zhang Li Rui Ma Fang Bo Feng Gao guoquan Zhang Jingjun Xu MOE Key Laboratory of Weak-Light Nonlinear Photonics TEDA Institute of Applied Physics and School of PhysicsNankai UniversityTianjin 300457China

Lithium niobate thin film frequency doubler has extensive applications in the preparation of classical and quantum *** this study,we successfully fabricated microdisk resonators with a quality factor of 2.2×10^(5) in reverse-polarization dual-layer x-cut lithium niobate for the first *** on the modal phase matching condition,efficient second harmonic generation with a record normalized conversion efficiency of~56000%W-1 and cascaded third harmonic generation with an efficiency of~6500%W-2 were obtained in the microdisk *** with the periodically poled lithium niobate microcavity,the complex domain structure preparation processes are *** work provides a scheme for achieving highly efficient second-order nonlinear effects in non-periodically poled microcavities.

关键词： harmonic lithium niobate